Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis (pages 3955–3968)
Thomas Palm, Dominique Figarella-Branger, Françoise Chapon, Catherine Lacroix, Françoise Gray, Francesco Scaravilli, David W. Ellison, Isabelle Salmon, Miikka Vikkula and Catherine Godfraind
Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24476
By analyzing microarray-based expression profiles of a series of frozen ependymomas, the authors defined gene signatures specific to tumor localization and to World Health Organization grades. On the basis of these signatures, the authors related dysregulation of developmental—stem cell controlling—pathways to tumor localization, and the Wnt/β-catenin signaling pathway and several of its downstream or interacting pathways to anaplastic ependymomas.