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Cancer

Cover image for Cancer

15 September 2009

Volume 115, Issue 18

Pages 4043–4263

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Review Article
    4. Original Articles
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      Clinical trials of note (page 4044)

      Carrie Printz

      Article first published online: 4 SEP 2009 | DOI: 10.1002/cncr.24648

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  2. Review Article

    1. Top of page
    2. CancerScope
    3. Review Article
    4. Original Articles
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      Bone and soft tissue sarcomas are often curable—But at what cost? : A call to arms (and legs) (pages 4046–4054)

      Ronald D. Barr and Jay S. Wunder

      Article first published online: 10 AUG 2009 | DOI: 10.1002/cncr.24458

      Even if the number of amputations per year has decreased with time, limb salvage surgery may not offer a better functional outcome and health-related quality of life for young people with bone and soft tissue sarcomas of the lower limb.

  3. Original Articles

    1. Top of page
    2. CancerScope
    3. Review Article
    4. Original Articles
    1. Disease Site

      Breast Disease
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      Secondary sarcomas after radiotherapy for breast cancer : Sustained risk and poor survival (pages 4055–4063)

      Carlos M. Mery, Suzanne George, Monica M. Bertagnolli and Chandrajit P. Raut

      Article first published online: 12 JUN 2009 | DOI: 10.1002/cncr.24462

      The use of radiotherapy (RT) for treatment of breast cancer was found to increase the risk of the development of soft tissue sarcomas, in particular angiosarcomas and malignant fibrous histiocytomas, for up to 23 years, although the overall risk was still low. There was no difference in survival noted between RT-induced and non–RT-induced angiosarcomas.

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      Assessment of the performance of the Stanford Online Calculator for the prediction of nonsentinel lymph node metastasis in sentinel lymph node-positive breast cancer patients (pages 4064–4070)

      Jeffrey S. Scow, Amy C. Degnim, Tanya L. Hoskin, Carol Reynolds and Judy C. Boughey

      Article first published online: 10 JUN 2009 | DOI: 10.1002/cncr.24469

      Despite using only 3 variables, the Stanford Online Calculator was found to perform on a par with the Memorial Sloan-Kettering Cancer Center and Mayo nomograms for the prediction of nonsentinel lymph node metastasis in sentinel lymph node–positive breast cancer patients.

    3. Gastrointestinal Disease
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      Colon cancer screening practices and disclosure after receipt of positive or inconclusive genetic test results for hereditary nonpolyposis colorectal cancer (pages 4071–4079)

      Anne L. Ersig, Donald W. Hadley and Laura M. Koehly

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24478

      Index cases with inconclusive genetic test results were less likely to have been screened at 12-month follow-up and less likely to share their test results with a healthcare provider at 6-month follow-up. Index cases who disclosed their test results to their children were more likely to have been screened at 12-month follow-up, after controlling for mutational status.

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      Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer (pages 4080–4089)

      James Helm, Barbara A. Centeno, Domenico Coppola, Marcovalerio Melis, Mark Lloyd, Jong Y. Park, Dung-Tsa Chen and Mokenge P. Malafa

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24503

      Individually predictive histologic features were incorporated into the American Joint Committee on Cancer tumor-node-metastasis classification of anatomic extent, and the simplest combination of tumor characteristics predicting survival was determined in 137 patients who underwent resection of pancreatic ductal adenocarcinoma with curative intent. A combination of tumor differentiation, lymphatic invasion within the tumor, and local extrapancreatic extension was found to predict survival after pancreatectomy.

    5. Genitourinary Disease
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      Phase 2 trial of sorafenib in patients with advanced urothelial cancer : A Trial of the Eastern Cooperative Oncology Group (pages 4090–4095)

      Robert Dreicer, Hailun Li, Mark Stein, Robert DiPaola, Michael Eleff, Bruce J. Roth and George Wilding

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24467

      In a phase 2 trial of sorafenib, 27 patients with advanced urothelial cancer after chemotherapy for metastatic disease received 400 mg twice daily. Therapy was relatively well tolerated; however, no objective responses were seen. The 4-month progression-free survival rate was 9.5%; median overall survival of the group was 6.8 months.

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      Key concerns about the current state of bladder cancer : A position paper from the Bladder Cancer Think Tank, the Bladder Cancer Advocacy Network, and the Society of Urologic Oncology (pages 4096–4103)

      Yair Lotan, Ashish M. Kamat, Michael P. Porter, Victoria L. Robinson, Neal Shore, Michael Jewett, Paul F. Schelhammer, Ralph deVere White, Diane Quale and Cheryl T. Lee

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24463

      Bladder cancer is the fifth most common cancer, but funding for it is low compared with other common malignancies, resulting in reduced research opportunities. A concerted effort to align bladder cancer advocates, clinicians, and urologic organizations is essential to define the greatest needs in bladder cancer and to develop related solutions.

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      Quality of pathologic response and surgery correlate with survival for patients with completely resected bladder cancer after neoadjuvant chemotherapy (pages 4104–4109)

      Guru Sonpavde, Bryan H. Goldman, V. O. Speights, Seth P. Lerner, David P. Wood, Nicholas J. Vogelzang, Donald L. Trump, Ronald B. Natale, H. Barton Grossman and E. David Crawford

      Article first published online: 10 JUN 2009 | DOI: 10.1002/cncr.24466

      Neoadjuvant chemotherapy and radical cystectomy with negative surgical margins for patients with bladder cancer with pathologic P0 and lymph node negative–disease were found to correlate with improved survival. A combination of baseline clinical stage and postcystectomy pathologic stage may better predict survival.

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      Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma : Results of a large phase 2 study (pages 4110–4117)

      David J. Vaughn, Sandy Srinivas, Walter M. Stadler, Roberto Pili, Daniel Petrylak, Cora N. Sternberg, David C. Smith, Sarah Ringuette, Edwin de Wit, Virginie Pautret and Claude George

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24460

      Vinflunine was evaluated in patients with platinum-pretreated advanced urothelial carcinoma and demonstrated moderate activity. Toxicity was manageable and noncumulative.

    9. Gynecologic Oncology
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      Fertility preservation in young women with epithelial ovarian cancer (pages 4118–4126)

      Jason D. Wright, Monjri Shah, Leny Mathew, William M. Burke, Jennifer Culhane, Noah Goldman, Peter B. Schiff and Thomas J. Herzog

      Article first published online: 10 AUG 2009 | DOI: 10.1002/cncr.24461

      In this examination of the safety of fertility-conserving surgery in premenopausal women with epithelial ovarian cancers, the results indicated that ovarian and uterine-conserving surgery were safe in young women who had stage IA and IC ovarian cancer.

    10. Hematologic Malignancies
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      Predictors of avascular necrosis of bone in long-term survivors of hematopoietic cell transplantation (pages 4127–4135)

      Stephanie Campbell, Can-Lan Sun, Seira Kurian, Liton Francisco, Andrea Carter, Sameer Kulkarni, Pablo Parker, Chatchada Karanes, Stephen J. Forman and Smita Bhatia

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24474

      Avascular necrosis (AVN) is a debilitating condition reported after hematopoietic cell transplantation (HCT), resulting in significant morbidity. The authors found an increased risk of AVN in allogeneic HCT recipients with the characteristics male sex and exposure to cyclosporine, FK506, prednisone, and mycophenolate mofetil, thereby identifying subpopulations that could benefit from targeted screening.

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      Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily : Two-year follow-up of a randomized phase 2 study (START-R) (pages 4136–4147)

      Hagop Kantarjian, Ricardo Pasquini, Vincent Lévy, Saengsuree Jootar, Jerzy Holowiecki, Nelson Hamerschlak, Timothy Hughes, Eric Bleickardt, David Dejardin, Jorge Cortes and Neil P. Shah

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24504

      The current study was a follow-up of a phase 2, open-label study of 150 patients with chronic-phase chronic myeloid leukemia who were resistant to imatinib and were randomized (2:1) to receive either dasatinib at a dose of 70 mg twice daily (n = 101) or high-dose imatinib at a dose of 800 mg (400 mg twice daily; n = 49). After 2 years of follow-up, dasatinib demonstrated durable responses and improved response and progression-free survival rates relative to high-dose imatinib.

    12. Hepatobiliary Disease
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      Prognostic factors and predictive model in patients with advanced biliary tract adenocarcinoma receiving first-line palliative chemotherapy (pages 4148–4155)

      Inkeun Park, Jae-Lyun Lee, Min-Hee Ryu, Tae-Won Kim, Sung Sook Lee, Do Hyun Park, Sang Soo Lee, Dong Wan Seo, Sung Koo Lee and Myung-Hwan Kim

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24472

      Prognostic factors were identified for patients with advanced biliary tract adenocarcinoma receiving first-line palliative chemotherapy. These factors were used for the management of individual patients and to guide the design of future clinical trials.

    13. Lung Disease
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      Outcomes of patients with stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgery (pages 4156–4166)

      Hale B. Caglar, Elizabeth H. Baldini, Megan Othus, Michael S. Rabin, Raphael Bueno, David J. Sugarbaker, Steven J. Mentzer, Pasi A. Jänne, Bruce E. Johnson and Aaron M. Allen

      Article first published online: 23 JUN 2009 | DOI: 10.1002/cncr.24492

      The objective of this retrospective study was to identify the factors associated with improved outcome after treatment for stage III nonsmall cell lung cancer. The results indicated that the patients who were able to undergo resection appeared to have improved outcome after induction chemoradiation.

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      Hormone replacement therapy and survival in lung cancer in postmenopausal women in a rural population (pages 4167–4175)

      Bin Huang, Harry Carloss, Stephen W. Wyatt and Elizabeth Riley

      Article first published online: 12 JUN 2009 | DOI: 10.1002/cncr.24475

      Hormone replacement therapy has been reported to be associated with decreased survival in women with lung cancer. The objective of this study was to examine if this association exists in a postmenopausal rural female population.

    15. Melanoma
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      Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma (pages 4176–4185)

      William F. Anderson, Ruth M. Pfeiffer, Margaret A. Tucker and Philip S. Rosenberg

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24481

      This systematic examination of the effect of aging on the incidence of cutaneous malignant melanoma revealed divergent (bimodal) early-onset and late-onset cancer pathways. The authors concluded that future analytical studies should carefully consider this age interaction for both established and suspected melanoma risk factors.

    16. Sarcoma
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      Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups (pages 4186–4195)

      Jason C. Carvalho, Dafydd G. Thomas and David R. Lucas

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24486

      Immunophenotypic expression patterns demonstrated leiomyosarcomas clustered into groups of neoplasms that trended toward certain anatomic sites of origin and gender. Most notably, there was a group of estrogen receptor-positive uterine and retroperitoneal tumors from women that often expressed Wilms tumor-1 protein, which suggested a common line of differentiation as well as potential therapeutic targets.

    17. Discipline

      Disparities Research
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      Survival disparities among African American women with invasive bladder cancer in Florida (pages 4196–4209)

      Kathleen F. Brookfield, Michael C. Cheung, Christopher Gomez, Relin Yang, Alan M. Nieder, David J. Lee and Leonidas G. Koniaris

      Article first published online: 30 JUN 2009 | DOI: 10.1002/cncr.24497

      The authors have provided the most comprehensive analysis of bladder cancer to date using a data set that includes patient demographics, comorbidities, and clinical variables. They demonstrated that significant racial, gender, and socioeconomic status disparities exist in bladder cancer survival.

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      Race does not impact outcome for advanced ovarian cancer patients treated with cisplatin/paclitaxel : An Analysis of Gynecologic Oncology Group Trials (pages 4210–4217)

      John H. Farley, Chunqiao Tian, G. Scott Rose, Carol L. Brown, Michael Birrer and G. Larry Maxwell

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24482

      The objectives of this study were to confirm whether racial disparity exists with regard to outcome between black and white women with ovarian cancer and to identify factors associated with the administration of adjuvant treatment that had an impact on survival. In a retrospective review of 97 black women and 1392 white women who had International Federation of Gynecology and Obstetrics stage III or IV ovarian carcinoma, no differences were observed in the relative dose (0.90 vs 0.89), relative time (1.02 vs 0.99), or relative dose intensity (0.90 vs 0.91) received between black patients and white patients, respectively, and there was no difference in clinical outcome between black women and white women with advanced stage epithelial ovarian cancer when they received similar treatment as participants in a Gynecologic Oncology Group clinical trial.

    19. Pediatric Oncology
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      Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005 (pages 4218–4226)

      Simona Ognjanovic, Amy M. Linabery, Bridget Charbonneau and Julie A. Ross

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24465

      Incidence and survival rates of pediatric rhabdomyosarcoma and its 2 major subtypes were analyzed using Surveillance, Epidemiology, and End Results Program data for the period from 1975 to 2005. Age, sex, and racial/ethnic differences in both incidence and survival were observed, further supporting unique underlying etiologies for these tumors.

    20. Psychosocial Oncology
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      Parent-child communication patterns during the first year after a parent's cancer diagnosis : The effect on parents' functioning (pages 4227–4237)

      Stacey Gazendam-Donofrio, Harald Hoekstra, Winette van der Graaf, Harry van de Wiel, Annemieke Visser, Gea Huizinga and Josette Hoekstra-Weebers

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24502

      Parent-child communication remained stable after a parental cancer diagnosis; patients' and spouses' functioning improved. Parents' functioning in the first year after cancer is only limitedly affected by parent-adolescent communication patterns.

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      Sex-specific attention problems in long-term survivors of pediatric acute lymphoblastic leukemia (pages 4238–4245)

      Neelam Jain, Pim Brouwers, M. Fatih Okcu, Paul T. Cirino and Kevin R. Krull

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24464

      Children with pediatric acute lymphoblastic leukemia were found to perform poorly on select measures of attention and executive control, and this performance to be influenced by sex and treatment intensity.

    22. Translational Research
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      Pathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor-extracellular signal-regulated protein kinase pathway at altered protein levels (pages 4246–4263)

      Hu Li, Choong Yong Ung, Xiao Hua Ma, Xiang Hui Liu, Bao Wen Li, Boon Chuan Low and Yu Zong Chen

      Article first published online: 23 JUN 2009 | DOI: 10.1002/cncr.24485

      By using significantly prolonged extracellular signal-regulated protein kinase activation as an indicator for activities, the authors observed that 12 oncogenes at elevated levels and 4 tumor suppressors at reduced levels exhibited pro-proliferation activity. Pathway sensitivity analysis exhibited promising potential in detecting and distinguishing pro-proliferation activities of cancer proteins at altered levels.

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