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Cancer

Cover image for Cancer

15 October 2009

Volume 115, Issue 20

Pages 4645–4886

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Original Articles
    4. Correspondence
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      Clinical trials of note (page 4646)

      Carrie Printz

      Article first published online: 5 OCT 2009 | DOI: 10.1002/cncr.24673

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  2. Original Articles

    1. Top of page
    2. CancerScope
    3. Original Articles
    4. Correspondence
    1. Disease Site

      Breast Disease
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      Immediate postmastectomy reconstruction is associated with improved breast cancer-specific survival : Evidence and new challenges from the Surveillance, Epidemiology, and End Results database (pages 4648–4654)

      Michael Bezuhly, Claire Temple, Leif J. Sigurdson, Roger B. Davis, Gordon Flowerdew and E. Francis Cook Jr

      Article first published online: 24 JUL 2009 | DOI: 10.1002/cncr.24511

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      By using the Surveillance, Epidemiology, and End Results (SEER) database, Bezuhly and colleagues demonstrate improved breast cancer-specific survival for female unilateral mastectomy patients who underwent immediate breast reconstruction compared with those who did not, after adjusting for known demographic and disease severity variables. Despite the inherent limitations of retrospective data, the findings of Bezuhly et al suggest that reconstruction may be a surrogate marker for women destined to do better on the basis of socioeconomic or other unidentified factors.

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      Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate (pages 4655–4666)

      Muthusamy Thangaraju, Senthil K. Karunakaran, Shiro Itagaki, Elangovan Gopal, Selvakumar Elangovan, Puttur D. Prasad and Vadivel Ganapathy

      Article first published online: 27 JUL 2009 | DOI: 10.1002/cncr.24532

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      3-Bromopyruvate was transported into cells actively by SLC5A8 energized by an electrochemical sodium gradient and functioned inside the cells as an inhibitor of histone deacetylase 1 (HDAC1) and HDAC3. The current results provide a novel mechanism for the antitumor activity of this molecule.

    3. Gastrointestinal Disease
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      Prognostic impact of extracellular matrix metalloprotease inducer : Immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer (pages 4667–4678)

      Daniel Buergy, Tina Fuchs, Patryk Kambakamba, Giridhar Mudduluru, Gabriele Maurer, Stefan Post, Yi Tang, Marian T. Nakada, Li Yan and Heike Allgayer

      Article first published online: 30 JUN 2009 | DOI: 10.1002/cncr.24516

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      The results from this study indicated that increased extracellular matrix metalloprotease inducer staining intensity in primary tumors and bone marrow aspiration biopsies was associated with clinical markers of tumor progression in patients with colorectal cancer. Staining in primary tumors compared with staining in matched normal tissues was associated significantly with survival.

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      Clinical trial enrollment, patient characteristics, and survival differences in prospectively registered metastatic colorectal cancer patients (pages 4679–4687)

      Halfdan Sorbye, Per Pfeiffer, Nina Cavalli-Björkman, Camilla Qvortrup, Mari H. Holsen, Tore Wentzel-Larsen and Bengt Glimelius

      Article first published online: 26 JUN 2009 | DOI: 10.1002/cncr.24527

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      Metastatic colorectal cancer (mCRC) patients enrolled into clinical trials differ in characteristics from patients receiving chemotherapy outside a protocol and have better survival, even when given the same treatment. Although mCRC trial patients have a median survival close to 2 years, survival is lower for all patients receiving chemotherapy and much lower for all patients with mCRC.

    5. Genitourinary Disease
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      Partnership and outcomes in men with prostate cancer (pages 4688–4694)

      Jonathan Bergman, John L. Gore, Christopher S. Saigal, Lorna Kwan and Mark S. Litwin

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24544

      In men with prostate cancer, partnership status was not found to be associated with either physical or mental health, but partnered participants had less bowel bother and a lower fear of recurrence than unpartnered men. Subjects with fewer comorbid conditions scored better across almost all health-related quality of life domains.

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      A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer : Quality of life outcomes (pages 4695–4704)

      John W. Robinson, Bryan J. Donnelly, Jodi E. Siever, John C. Saliken, Scott D. Ernst, John C. Rewcastle, Kiril Trpkov, Harold Lau, Cheryl Scott and Bejoy Thomas

      Article first published online: 18 AUG 2009 | DOI: 10.1002/cncr.24523

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      In this randomized trial of cryoablation and external beam radiotherapy, no long-term quality of life advantage for either treatment was apparent with the exception of poorer sexual function reported by those treated with cryoablation.

    7. Head and Neck Disease
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      Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses : A single institution experience (pages 4705–4714)

      Akihiro Homma, Nobuhiko Oridate, Fumiyuki Suzuki, Shigenari Taki, Takeshi Asano, Daisuke Yoshida, Rikiya Onimaru, Takeshi Nishioka, Hiroki Shirato and Satoshi Fukuda

      Article first published online: 24 JUL 2009 | DOI: 10.1002/cncr.24515

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      Superselective high-dose cisplatin infusion with concomitant radiotherapy demonstrated high cure rates and organ preservation levels compared with earlier reports for previously untreated patients with advanced cancer of the nasal cavity and paranasal sinuses.

    8. Hematologic Malignancies
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      Risk score for outcome after allogeneic hematopoietic stem cell transplantation : A Retrospective Analysis (pages 4715–4726)

      Alois Gratwohl, Martin Stern, Ronald Brand, Jane Apperley, Helen Baldomero, Theo de Witte, Giorgio Dini, Vanderson Rocha, Jakob Passweg, Anna Sureda, André Tichelli, Dietger Niederwieser and for the European Group for Blood and Marrow Transplantation and the European Leukemia Net

      Article first published online: 29 JUL 2009 | DOI: 10.1002/cncr.24531

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      Five pretransplant risk factors, age of patient, disease stage, time interval from diagnosis to transplant, donor type, and donor-recipient sex combination, provide for a composite risk score for outcome after allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies. The score forms a basis for decision making between transplant and nontransplant strategies.

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      Expression of eukaryotic initiation factor 4E predicts clinical outcome in patients with mantle cell lymphoma treated with hyper-CVAD and rituximab, alternating with rituximab, high-dose methotrexate, and cytarabine (pages 4727–4736)

      Kedar V. Inamdar, Jorge E. Romaguera, Elias Drakos, Ronald J. Knoblock, Mar Garcia, Vasiliki Leventaki, L. Jeffrey Medeiros and George Z. Rassidakis

      Article first published online: 25 AUG 2009 | DOI: 10.1002/cncr.24506

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      The expression patterns and clinical significance of eukaryotic initiation factor 4E (eIF4E), a critical downstream target of the mammalian target of rapamycin pathway, was investigated in mantle cell lymphoma. The authors report that high eIF4E expression is an adverse independent prognostic factor in patients with mantle cell lymphoma treated with hyper-CVAD and rituximab, alternating with rituximab, high-dose methotrexate, and cytarabine.

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      Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis (pages 4737–4744)

      Sergej Konoplev, Xuelin Huang, Harry A. Drabkin, Hartmut Koeppen, Dan Jones, Hagop M. Kantarjian, Guillermo Garcia-Manero, Weina Chen, L. Jeffrey Medeiros and Carlos E. Bueso-Ramos

      Article first published online: 27 JUL 2009 | DOI: 10.1002/cncr.24543

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      We used immunohistochemistry to assess for cytoplasmic nucleophosmin (NPM) expression in bone marrow biopsy specimens of 252 acute myeloid leukemia patients. Cytoplasmic NPM expression did not predict favorable prognosis and was discordant with NPM1 sequencing in 17% of cases.

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      Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001-2007) : Stable incidence but changing epidemiology of a still frequently lethal infection (pages 4745–4752)

      Nikolaos V. Sipsas, Russell E. Lewis, Jeffrey Tarrand, Ray Hachem, Kenneth V. Rolston, Issam I. Raad and Dimitrios P. Kontoyiannis

      Article first published online: 24 JUL 2009 | DOI: 10.1002/cncr.24507

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      The authors retrospectively analyzed 173 episodes of candidemia among patients with hematologic malignancies at The University of Texas M. D. Anderson Cancer Center from March 2001 to February 2007. Despite the introduction of new antifungal agents, the incidence and mortality of candidemia remained stable, but its epidemiology shifted, with Candida parapsilosis and C. tropicalis becoming more common.

    12. Hepatobiliary Disease
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      Liver-intestine cadherin predicts microvascular invasion and poor prognosis of hepatitis B virus-positive hepatocellular carcinoma (pages 4753–4765)

      Zhen-Bin Ding, Ying-Hong Shi, Jian Zhou, Guo-Ming Shi, Ai-Wu Ke, Shuang-Jian Qiu, Xiao-Ying Wang, Zhi Dai, Yang Xu and Jia Fan

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24513

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      Liver-intestine cadherin expression correlated with invasive potentials of hepatitis B virus-positive hepatocellular carcinoma (HCC) cell lines. As an invasive marker, liver-intestine cadherin might have a role in tumor microvascular invasion, ultimately resulting in poor prognosis for hepatitis B virus-related HCC.

    13. Melanoma
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      A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma (pages 4766–4774)

      Georgia M. Beasley, Nicole McMahon, Gretchen Sanders, Christina K. Augustine, Maria A. Selim, Bercedis Peterson, Robin Norris, William P. Peters, Merrick I. Ross and Douglas S. Tyler

      Article first published online: 27 JUL 2009 | DOI: 10.1002/cncr.24509

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      A phase 1 dose escalation study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of systemic ADH-1 (ADH-1) in combination with melphalan via isolated limb infusion in patients with in-transit extremity melanoma was performed. Systemic ADH-1 at a dose of 4000 mg on Days 1 and 8 in combination with melphalan via isolated limb infusion is a well-tolerated, novel targeted therapy approach to regionally advanced melanoma.

    14. Neuro-Oncology
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      Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymoma (pages 4775–4782)

      Marc C. Chamberlain and Sandra K. Johnston

      Article first published online: 30 JUN 2009 | DOI: 10.1002/cncr.24524

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      Because there currently exists no standard therapy for platinum-resistant ependymoma, the authors conducted a retrospective evaluation of temozolomide (TMZ) in adults with recurrent, supratentorial, platinum-refractory, grade 2 ependymoma. However, TMZ was found to have little activity in these patients.

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      Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation : A prospective patient cohort (pages 4783–4794)

      Philippe Metellus, Bema Coulibaly, Isabelle Nanni, Frederic Fina, Nathalie Eudes, Roch Giorgi, Marylin Barrie, Olivier Chinot, Stephane Fuentes, Henry Dufour, L'houcine Ouafik and Dominique Figarella-Branger

      Article first published online: 27 JUL 2009 | DOI: 10.1002/cncr.24546

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      O6-methylguanine-DNA methyltransferase (MGMT) status was an important prognostic factor in patients with recurrent glioblastoma multiforme who underwent surgery plus carmustine wafer implantation. Methylation assays appeared to be more reliable for assessing the prognostic impact of MGMT status.

    16. Sarcoma
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      Genetically transforming human mesenchymal stem cells to sarcomas : Changes in cellular phenotype and multilineage differentiation potential (pages 4795–4806)

      Nan Li, Rui Yang, Wendong Zhang, Howard Dorfman, Pulivarthi Rao and Richard Gorlick

      Article first published online: 10 JUL 2009 | DOI: 10.1002/cncr.24519

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      In this study, the conversion of hMSC to a malignant phenotype with defined genetic elements is described. Two distinct cellular morphologies were observed.

    17. Discipline

      Disparities Research
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      Racial disparities and survival for nonsmall-cell lung cancer in a large cohort of black and white elderly patients (pages 4807–4818)

      Dale Hardy, Rui Xia, Chih-Chin Liu, Janice N. Cormier, Zhannat Nurgalieva and Xianglin L. Du

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24521

      There were no significant differences in survival between blacks and whites with nonsmall-cell lung cancer within stage stratifications after adjusting for covariates, except for black patients at overall stage for all-cause mortality and at stage III-IV diagnosed in 2000-2002. Receiving stage-specific evidence-based standard therapy was associated with significantly increased survival.

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      Breast reconstructive surgery in medically underserved women with breast cancer : The role of patient-physician communication (pages 4819–4827)

      Rose C. Maly, Yihang Liu, Elaine Kwong, Amardeep Thind and Allison L. Diamant

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24510

      Breast reconstructive surgery can improve mastectomy patients' emotional relationships and social functioning, but it may be underutilized in low-income, medically underserved women. In this study, significant associations of physician information giving and patient perceived self-efficacy with breast reconstructive surgery were found, suggesting interventions on empowering aspects of patient-physician communication could result in breast reconstructive surgery rates consistent with the general population and in improved quality of life among this disadvantaged group.

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      Knowledge, cultural, and attitudinal barriers to mammography screening among nonadherent immigrant Chinese women : Ever versus never screened status (pages 4828–4838)

      Judy H. Wang, Jeanne S. Mandelblatt, Wenchi Liang, Bin Yi, I-Jung Ma and Marc D. Schwartz

      Article first published online: 30 JUL 2009 | DOI: 10.1002/cncr.24517

      Chinese-American women who never had a mammogram experienced greater knowledge, cultural, and attitudinal barriers to breast cancer screening than those who had ever had a mammogram; these barriers also predicted the women's intention for future mammography screening.

    20. Medical Oncology
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      Comparison of hospitalization risk and associated costs among patients receiving sargramostim, filgrastim, and pegfilgrastim for chemotherapy-Induced neutropenia (pages 4839–4848)

      Mark L. Heaney, Edmond L. Toy, Francis Vekeman, François Laliberté, Bree L. Dority, Daniel Perlman, Victoria Barghout and Mei Sheng Duh

      Article first published online: 27 JUL 2009 | DOI: 10.1002/cncr.24535

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      Using retrospective data from health insurance claims, the authors examined the real-world use of myeloid growth factors for the prevention/treatment of chemotherapy-induced neutropenia. They found that granulocyte-macrophage–colony-stimulating factor (sargramostim) reduced the risk and cost of infection-related hospitalizations more than granulocyte–colony-stimulating factor (filgrastim and pegfilgrastim).

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      Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan-, and cetuximab-refractory colorectal cancer : A single-center phase 2 trial (pages 4849–4856)

      Bruno Vincenzi, Daniele Santini, Antonio Russo, Chiara Spoto, Olga Venditti, Simona Gasparro, Sergio Rizzo, Bruno Beomonte Zobel, Marco Caricato, Sergio Valeri, Roberto Coppola and Giuseppe Tonini

      Article first published online: 22 JUL 2009 | DOI: 10.1002/cncr.24540

      Some anticancer activity of the bevacizumab + de Gramont schedule was noted in patients who had received all other anticancer drugs available for metastatic colorectal cancer, with an acceptable safety profile.

    22. Outcomes Research
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      Assessment of factors that contribute to decreased quality of life in Gynecologic Oncology Group ovarian cancer trials (pages 4857–4864)

      Vivian E. von Gruenigen, Helen Q. Huang, Karen M. Gil, Heidi E. Gibbons, Bradley J. Monk, Peter G. Rose, Deborah K. Armstrong, David Cella and Lari Wenzel

      Article first published online: 18 AUG 2009 | DOI: 10.1002/cncr.24520

      The objective of this study was to assess which quality-of-life (QOL) line items on the Functional Assessment of Cancer-Therapy Ovarian (FACT-O) were associated with low QOL in women who were receiving chemotherapy for ovarian cancer. The results indicated that a large proportion of women with total FACT-O scores in the lowest quartile reported problems that potentially were amenable to clinical interventions, such as symptom management and psychosocial support.

    23. Radiation Oncology
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      Radiotherapy planning complexity and survival after treatment of advanced stage lung cancer in the elderly (pages 4865–4873)

      Benjamin Goldsmith, Jamie Cesaretti and Juan P. Wisnivesky

      Article first published online: 30 JUN 2009 | DOI: 10.1002/cncr.24512

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      The use of more complex radiation therapy planning and simulation methods is associated with better survival in elderly patients with stage IIIB non-small-cell lung cancer. These results should be validated in prospective clinical trials.

    24. Symptom Control and Palliative Care
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      Impact of a walking intervention on cardiorespiratory fitness, self-reported physical function, and pain in patients undergoing treatment for solid tumors (pages 4874–4884)

      Kathleen Griffith, Jennifer Wenzel, JingJing Shang, Carol Thompson, Kerry Stewart and Victoria Mock

      Article first published online: 27 JUL 2009 | DOI: 10.1002/cncr.24551

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      This randomized, controlled trial evaluated the impact of a home-based walking intervention on outcomes of cardiovascular and physical function, as well as pain, during chemotherapy/radiation treatment (N = 126). Exercise during cancer treatment improves cardiorespiratory fitness and self-reported physical function in patients with prostate cancer and younger patients, and may attenuate the loss of those capacities in patients undergoing chemotherapy.

      Corrected by:

      Erratum: Erratum

      Vol. 119, Issue 9, 1762, Article first published online: 18 JAN 2013

  3. Correspondence

    1. Top of page
    2. CancerScope
    3. Original Articles
    4. Correspondence
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