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Cancer

Cover image for Cancer

15 July 2010

Volume 116, Issue 14

Pages 3307–3523

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Original Articles
    4. Correspondence
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  2. Original Articles

    1. Top of page
    2. CancerScope
    3. Original Articles
    4. Correspondence
    1. Disease Site

      Breast Disease
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      Breast cancer risk estimation with artificial neural networks revisited : Discrimination and calibration (pages 3310–3321)

      Turgay Ayer, Oguzhan Alagoz, Jagpreet Chhatwal, Jude W. Shavlik, Charles E. Kahn Jr and Elizabeth S. Burnside

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25081

      In the past, several artificial neural network (ANN) models have been developed for breast cancer-risk prediction based on discrimination performance, but none have assessed calibration, which is an equally important measure of accurate risk prediction. In this study, we show that an ANN trained on a large dataset of consecutive mammography findings can successfully discriminate malignant abnormalities from benign ones and accurately predict the probability of breast cancer for individual patients.

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      Number of lymph nodes identified at axillary dissection : Effect of neoadjuvant chemotherapy and other factors (pages 3322–3329)

      Judy C. Boughey, John H. Donohue, James W. Jakub, Christine M. Lohse and Amy C. Degnim

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25207

      The number of axillary lymph nodes recovered at axillary lymph node dissection was not found to be affected by neoadjuvant chemotherapy. Surgeons with oncologic fellowship training appear to retrieve more axillary lymph nodes.

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      Detection of minimal residual disease in blood and bone marrow in early stage breast cancer (pages 3330–3337)

      Savitri Krishnamurthy, Massimo Cristofanilli, Balraj Singh, James Reuben, Hui Gao, Evan N. Cohen, Eleni Andreopoulou, Carolyn S. Hall, Ashutosh Lodhi, Summer Jackson and Anthony Lucci

      Article first published online: 5 MAY 2010 | DOI: 10.1002/cncr.25145

      Minimal residual disease in blood and bone marrow was not correlated with standard prognostic indicators in women with early stage breast cancer. The lack of a correlation with positive lymph node status suggested independent modes of dissemination to these homing sites.

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      A prospective evaluation of the durability of palliative interventions for patients with metastatic breast cancer (pages 3338–3347)

      Mary Morrogh, Thomas J. Miner, Anna Park, Ann Jenckes, Mithat Gonen, Andrew Seidman, Monica Morrow, David P. Jaques and Tari A. King

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25034

      Palliative interventions for symptom control in patients with metastatic breast cancer are safe and provide durable palliation for the majority of patients. The longer median survival for these patients highlights the need to optimize symptom control and maintain quality of life in the setting of metastatic disease.

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      Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer (pages 3348–3356)

      Jeffrey S. Wefel, Angele K. Saleeba, Aman U. Buzdar and Christina A. Meyers

      Article first published online: 28 APR 2010 | DOI: 10.1002/cncr.25098

      Acute decline in cognitive function during and shortly after completion of chemotherapy, as well as late onset cognitive decline, occur in a large proportion of patients. Cognitive decline was not associated with mood changes, but it appears to be consistent with a developing body of animal research demonstrating both acute and late emerging structural brain changes associated with common chemotherapeutic agents.

    6. Discipline

      Gastrointestinal Disease
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      Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells (pages 3357–3368)

      Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Lin Cui, Naoki Ikenaga, Norihiro Sato and Masao Tanaka

      Article first published online: 28 APR 2010 | DOI: 10.1002/cncr.25121

      CD133+ cells in pancreatic cancer possess aggressive behavior such as increased cell proliferation, migration, and invasion, especially when cocultured with pancreatic stromal cells. Targeting therapy for the interaction between CD133+ cancer cells and stromal cells may be a new approach to the treatment of pancreatic cancer.

    7. Disease Site

      Gastrointestinal Disease
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      Invasive intraductal papillary mucinous neoplasm versus sporadic pancreatic adenocarcinoma : A stage-matched comparison of outcomes (pages 3369–3377)

      Nabil Wasif, David J. Bentrem, James J. Farrell, Clifford Y. Ko, Oscar J. Hines, Howard A. Reber and James S. Tomlinson

      Article first published online: 21 APR 2010 | DOI: 10.1002/cncr.25070

      The Surveillance, Epidemiology, and End Results database was used to compare the natural history of invasive intraductal papillary mucinous neoplasm to stage-matched sporadic pancreatic adenocarcinoma. This study will help guide discussions regarding prognosis and decisions regarding adjuvant therapy.

    8. Genitourinary Disease
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      Can we better select patients with metastatic renal cell carcinoma for cytoreductive nephrectomy? (pages 3378–3388)

      Stephen H. Culp, Nizar M. Tannir, E. Jason Abel, Vitaly Margulis, Pheroze Tamboli, Surena F. Matin and Christopher G. Wood

      Article first published online: 17 MAY 2010 | DOI: 10.1002/cncr.25046

      The authors identified 7 preoperative variables that allowed them to select patients with metastatic renal cell carcinoma who were unlikely to benefit from cytoreductive nephrectomy. The results indicated that treatment for patients who have ≥4 of these risk factors should be directed toward upfront systemic therapy to help them avoid the unnecessary morbidity of surgical intervention.

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      Statin medication use and the risk of biochemical recurrence after radical prostatectomy : Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database (pages 3389–3398)

      Robert J. Hamilton, Lionel L. Banez, William J. Aronson, Martha K. Terris, Elizabeth A. Platz, Christopher J. Kane, Joseph C. Presti Jr, Christopher L. Amling and Stephen J. Freedland

      Article first published online: 28 JUN 2010 | DOI: 10.1002/cncr.25308

      In a cohort of men undergoing radical prostatectomy (RP), statin use was associated with a dose-dependent reduction in the risk of biochemical recurrence. If confirmed in other studies, these findings suggest statins may slow prostate cancer progression after RP.

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      Multifactorial, site-specific recurrence model after radical cystectomy for urothelial carcinoma (pages 3399–3407)

      Eric C. Umbreit, Paul L. Crispen, Mark S. Shimko, Sara A. Farmer, Michael L. Blute and Igor Frank

      Article first published online: 28 APR 2010 | DOI: 10.1002/cncr.25202

      A model predicting site-specific urothelial carcinoma recurrence after cystectomy is presented. The model allows for tailored, patient-specific disease surveillance based on clinicopathologic features noted at the time of cystectomy.

    11. Head and Neck Disease
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      Compliance with quality assurance measures in patients treated for early oral tongue cancer (pages 3408–3416)

      Amy C. Hessel, Mauricio A. Moreno, Ehab Y. Hanna, Dianna B. Roberts, Jan S. Lewin, Adel K. El-Naggar, David I. Rosenthal and Randal S. Weber

      Article first published online: 21 APR 2010 | DOI: 10.1002/cncr.25031

      This study evaluates compliance with a set of measures and clinical endpoints created to assess the quality of care that patients with oral tongue cancer receive at a tertiary cancer center. The authors found that overall compliance with these measures was >90%, demonstrating that these measures can be used to assess performance and identify areas for improvement in centers treating this disease.

    12. Hematologic Malignancies
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      A population-based study of follow-up care for Hodgkin lymphoma survivors : Opportunities to improve surveillance for relapse and late effects (pages 3417–3425)

      David C. Hodgson, Eva Grunfeld, Nadia Gunraj and Lisa Del Giudice

      Article first published online: 21 APR 2010 | DOI: 10.1002/cncr.25053

      This population-based study of 2071 Hodgkin lymphoma survivors indicated that, although computed tomography imaging is performed commonly during follow-up, it rarely leads to the provision of salvage chemotherapy. Despite frequent contact with both primary care providers and oncologists, many survivors did not receive established cancer screening tests, and the recommended early initiation of breast cancer screening among young women at high risk was not widely used.

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      Protein kinase gene expression profiling and in vitro functional experiments identify novel potential therapeutic targets in adult acute lymphoblastic leukemia (pages 3426–3437)

      Monica Messina, Sabina Chiaretti, Simona Tavolaro, Nadia Peragine, Antonella Vitale, Loredana Elia, Simona Sica, Alessandro Levis, Anna Guarini and Robin Foà

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25113

      Gene expression profiling was evaluated, and specific protein kinase gene signatures were identified for adult acute lymphoblastic leukemia (ALL) subgroups. These results, coupled with those from in vitro experiments, suggest a potential role for second-generation tyrosine kinase inhibitors in ALL subgroups, other than Philadelphia+ ALL.

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      A critical analysis of prognostic factors in North American patients with human T-cell lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma : A multicenter clinicopathologic experience and new prognostic score (pages 3438–3446)

      Adrienne A. Phillips, Iuliana Shapira, Robert D. Willim, Jasotha Sanmugarajah, William B. Solomon, Steven M. Horwitz, David G. Savage, Govind Bhagat, Gerald Soff, Jasmine M. Zain, Bachir Alobeid, Venkatraman E. Seshan and Owen A. O'Connor

      Article first published online: 4 MAY 2010 | DOI: 10.1002/cncr.25147

      The results of this review suggested that human T-cell lymphotropic virus type-1 (HTLV-1) infection and its disease manifestations are an emerging public health problem in urban communities of the United States with a significant Caribbean and Latin American population. A new prognostic model for patients with HTLV-1–related adult T-cell leukemia/lymphoma is proposed.

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      Management of adult patients with acute lymphoblastic leukemia in first complete remission : Systematic review and meta-analysis (pages 3447–3457)

      Ron Ram, Anat Gafter-Gvili, Liat Vidal, Mical Paul, Isaac Ben-Bassat, Ofer Shpilberg and Pia Raanani

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25136

      In this systematic review and meta-analysis of randomized controlled trials that have reported on the management of adult patients with acute lymphoblastic leukemia in first complete remission, the results indicated that, mainly for the subgroup of standard-risk patients, allogenic stem cell transplantation was superior to autologous stem cell transplantation or chemotherapy.

    16. Discipline

      Lung Disease
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      Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk (pages 3458–3462)

      Jian Wang, Margaret R. Spitz, Christopher I. Amos, Anna V. Wilkinson, Xifeng Wu and Sanjay Shete

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25085

      The single nucleotide polymorphism (SNP) rs1051730 has a strong direct association with the risk of lung cancer, but also an indirect association through smoking and chronic obstructive pulmonary disease (COPD). The SNP is also associated with the risk of COPD directly and through smoking.

    17. Disease Site

      Melanoma
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      A study of paclitaxel, carboplatin, and bortezomib in the treatment of metastatic malignant melanoma : A phase 2 Consortium study (pages 3463–3468)

      Gary A. Croghan, Vera J. Suman, William J. Maples, Mark Albertini, Gerald Linette, Lawrence Flaherty, John Eckardt, Cynthia Ma, Svetomir N. Markovic and Charles Erlichman

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25191

      Paclitaxel, carboplatin, and bortezomib were given to patients with metastatic melanoma. This phase 2 trial demonstrated limited clinical benefit and was associated with significant toxicity.

    18. Discipline

      Disparities Research
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      Access to hematopoietic stem cell transplantation : Effect of race and sex (pages 3469–3476)

      Thomas V. Joshua, J. Douglas Rizzo, Mei-Jie Zhang, Parameswaran N. Hari, Seira Kurian, Marcelo Pasquini, Navneet S. Majhail, Stephanie J. Lee and Mary M. Horowitz

      Article first published online: 24 MAY 2010 | DOI: 10.1002/cncr.25297

      Hematopoietic stem cell transplantation (HCT) is more frequently used to treat leukemia, lymphoma, and multiple myeloma in Caucasians than in African Americans. Women are also less likely than men to receive autologous HCT for reasons unexplained by age or disease status.

    19. Disease Site

      Disparities Research
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      Cancer treatment cost in the United States : Has the burden shifted over time? (pages 3477–3484)

      Florence K. Tangka, Justin G. Trogdon, Lisa C. Richardson, David Howard, Susan A. Sabatino and Eric A. Finkelstein

      Article first published online: 10 MAY 2010 | DOI: 10.1002/cncr.25150

      The medical costs of cancer have nearly doubled between 1987 and 2005. During the same time period, cancer costs shifted away from the inpatient setting to the outpatient setting, and the share of these costs paid for by private insurance and Medicaid increased.

    20. Discipline

      Disparities Research
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      Differences in disease presentation, management techniques, treatment outcome, and toxicities in African-American women with early stage breast cancer treated with breast-conserving therapy (pages 3485–3492)

      Frank Vicini, Pamela Jones, Aeisha Rivers, Michelle Wallace, Chris Mitchell, Larry Kestin, Ishmael Jaiyesimi, Nayana Dekhne and Alvaro Martinez

      Article first published online: 28 APR 2010 | DOI: 10.1002/cncr.25088

      In this study, African-American women presented with larger and more aggressive breast tumors and, consequently, more frequently received adjuvant chemotherapy and lymph node irradiation. Small differences in treatment-related toxicities and cosmesis were observed, but no differences in efficacy were identified.

    21. Medical Oncology
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      Forgoing medical care because of cost : Assessing disparities in healthcare access among cancer survivors living in the United States (pages 3493–3504)

      Kathryn E. Weaver, Julia H. Rowland, Keith M. Bellizzi and Noreen M. Aziz

      Article first published online: 14 JUN 2010 | DOI: 10.1002/cncr.25209

      Cancer survivors aged <65 years were more likely to delay or forgo all types of medical care compared with adults who did not have a history of cancer. More than 2 million cancer survivors living in the United States did not receive 1 or more needed medical service because of financial concerns.

    22. Radiation Oncology
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      Evaluation of trends in the use of intensity-modulated radiotherapy for head and neck cancer from 2000 through 2005 : Socioeconomic disparity and geographic variation in a large population-based cohort (pages 3505–3512)

      B. Ashleigh Guadagnolo, Chih-Chin Liu, Janice N. Cormier and Xianglin L. Du

      Article first published online: 21 APR 2010 | DOI: 10.1002/cncr.25205

      Patients in the poorest socioeconomic subgroup were less likely to receive intensity-modulated radiotherapy (IMRT), even though there was otherwise rapid diffusion of this technology into clinical practice. Findings of the current study also demonstrated significant geographic variation in the utilization of IMRT for head and neck cancer.

    23. Symptom Control and Palliative Care
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      A phase 3 randomized, placebo-controlled, double-blind, clinical trial of the effect of modafinil on cancer-related fatigue among 631 patients receiving chemotherapy : A University of Rochester Cancer Center Community Clinical Oncology Program Research base study (pages 3513–3520)

      Pascal Jean-Pierre, Gary R. Morrow, Joseph A. Roscoe, Charles Heckler, Supriya Mohile, Michelle Janelsins, Luke Peppone, Amy Hemstad, Benjamin T. Esparaz and Judith O. Hopkins

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25083

      Cancer-related fatigue is a debilitating symptom that affects the psychosocial functioning and quality of life of 70% to 100% of cancer patients during and after treatment. Modafinil may be useful for patients with severe fatigue.

  3. Correspondence

    1. Top of page
    2. CancerScope
    3. Original Articles
    4. Correspondence
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      Primary central nervous system post-transplantation lymphoproliferative disorder (page 3521)

      Daan Dierickx, Thomas Tousseyn and Gregor Verhoef

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25340

      Corrected by:

      Erratum: Erratum: Nervous System Post-Transplantation Lymphoproliferative Disorder

      Vol. 117, Issue 1, 230, Article first published online: 27 AUG 2010

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      Latitude may modify the effect of TP53 codon 72 polymorphism on cancer risk (page 3523)

      Theodoros N. Sergentanis and Konstantinos P. Economopoulos

      Article first published online: 27 APR 2010 | DOI: 10.1002/cncr.25080

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