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Cancer

Cover image for Vol. 116 Issue 18

15 September 2010

Volume 116, Issue 18

Pages 4215–4432

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Commentary
    5. Original Articles
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  2. Editorials

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Commentary
    5. Original Articles
    1. You have full text access to this OnlineOpen article
      A population-based estimate of cancer survivors residing with minor children (pages 4218–4220)

      Paula Rauch and Cynthia Moore

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25360

      A new approach is needed to address the concerns of 1.5 million cancer patients parenting nearly 3 million minor children. Principles from a parent-guidance program are offered to support families in cancer care settings with various levels of clinical resources.

  3. Commentary

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Commentary
    5. Original Articles
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      Human papillomavirus status in head and neck cancer : The ethics of disclosure (pages 4221–4226)

      Andrew G. Shuman and Gregory T. Wolf

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25210

      Human papillomavirus (HPV) is an emerging causative factor for squamous cell carcinoma of the head and neck. This paper discusses the ethical issues involved with informing head and neck cancer patients of their HPV status, recognizing the dilemma posed by unresolved clinical questions and the need to respect patient autonomy.

  4. Original Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Commentary
    5. Original Articles
    1. Disease Site

      Breast Disease
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      Differential response of triple-negative breast cancer to a docetaxel and carboplatin-based neoadjuvant treatment (pages 4227–4237)

      Helena R. Chang, John Glaspy, Mary Ann Allison, Frederic C. Kass, Robert Elashoff, Debra U. Chung and Jeffrey Gornbein

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25309

      The results from this study indicated that differential tumor response to neoadjuvant therapy among patients with similar stage of breast cancer may aid in developing tailored therapy and identifying new targets for drug-resistant tumors.

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      Breast cancer subtypes and response to systemic treatment after whole-brain radiotherapy in patients with brain metastases (pages 4238–4247)

      Anna Niwińska, Magdalena Murawska and Katarzyna Pogoda

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25391

      Systemic therapy, sequenced by whole-brain radiotherapy (WBRT), was found to improve survival in patients with breast cancer of luminal A, luminal B, and human epidermal growth factor receptor 2 (HER2) subtypes with brain metastases. Targeted therapy appears to have an additional positive impact on survival. In triple-negative breast cancer subsets, the role of systematic treatment after WBRT appears to be less clear; therefore, this issue required further investigation.

    3. Gastrointestinal Disease
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      SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility (pages 4248–4255)

      Hyoungseok Ju, Byungho Lim, Minjin Kim, Seung-Moo Noh, Woo Ho Kim, Chunhwa Ihm, Bo Youl Choi, Yong Sung Kim and Changwon Kang

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25213

      A genetic association between SERPINE1 (serpin peptidase inhibitor, clade E, member 1) (a gene that encodes plasminogen activator inhibitor 1) and diffuse-type gastric cancer was discovered. The association was observed with 4 correlated variations in intron 7 that affected SERPINE1 expression rather than with the promoter 4G/5G polymorphism.

    4. Genitourinary Disease
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      Phase 3 trial of everolimus for metastatic renal cell carcinoma : Final results and analysis of prognostic factors (pages 4256–4265)

      Robert J. Motzer, Bernard Escudier, Stephane Oudard, Thomas E. Hutson, Camillo Porta, Sergio Bracarda, Viktor Grünwald, John A. Thompson, Robert A. Figlin, Norbert Hollaender, Andrea Kay, Alain Ravaud and for the RECORD-1 Study Group

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25219

      Final results and prognostic factor analysis of a phase 3 trial assessing everolimus in patients with metastatic renal cell cancer who progressed on sorafenib and/or sunitinib are reported. Median progression-free survival was 4.9 months with everolimus versus 1.9 months with placebo by independent central review. Survival was 1.9-fold longer with everolimus compared with placebo after correcting for 80% of patients in the placebo arm who crossed over to everolimus, using a rank-preserving structural failure time model. Independent prognostic factors for shorter overall survival included low performance status, high corrected calcium, low hemoglobin, and prior sunitinib.

    5. Gynecologic Oncology
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      Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse (pages 4266–4274)

      Hung-Cheng Lai, Ya-Wen Lin, Rui-Lan Huang, Ming-Tzeung Chung, Hui-Chen Wang, Yu-Ping Liao, Po-Hsuan Su, Yung-Liang Liu and Mu-Hsien Yu

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25252

      Quantitative methylation analysis of 4 genes in a full spectrum of cervical lesions was able to detect cervical intraepithelial neoplasia type 3 or worse with high accuracy. The results validated the clinical potential of quantitative methylation analysis, and the authors believe that the application of these new biomarkers will be clinically important in the next generation of cervical cancer screening.

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      Telomere length and genetic analyses in population-based studies of endometrial cancer risk (pages 4275–4282)

      Jennifer Prescott, Monica McGrath, I-Min Lee, Julie E. Buring and Immaculata De Vivo

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25328

      Relative telomere length was not associated with endometrial cancer risk in this prospective population-based study. Elevated endometrial cancer risk associated with polymorphisms at telomere maintenance gene loci suggests that other aspects of telomere dynamics may be involved in endometrial carcinogenesis.

    7. Hematologic Malignancies
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      Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma (pages 4283–4290)

      Jeremy S. Abramson, Matthew Hellmann, Jeffrey A. Barnes, Peter Hammerman, Christiana Toomey, Tak Takvorian, Alona Muzikansky and Ephraim P. Hochberg

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25278

      Central nervous system (CNS) disease recurrence in patients with diffuse large B-cell lymphoma is a rare but devastating event. This article reports that intravenous methotrexate can be safely administered concurrently with cyclophosphamide, doxorubicin, vincristine, and prednisone with rituximab (R-CHOP) and is associated with decreased risk of CNS recurrence in high-risk patients.

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      Marginal zone lymphomas : Factors that affect the final outcome (pages 4291–4298)

      Ali Mazloom, L. Jeffrey Medeiros, Peter W. McLaughlin, Valerie Reed, Fernando F. Cabanillas, Luis E. Fayad, Barbara Pro, Graciela Gonzalez, Puneeth Iyengar, Diana L. Urbauer and Bouthaina S. Dabaja

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25325

      Patients with extranodal and nodal marginal zone lymphoma (MZL) have a similar prognosis, whereas patients with splenic MZL have a comparatively better prognosis. Three factors, B symptoms, β2-microglobulin, and gender, appear to be prognostic factors in patients with MZL.

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      Efficacy and safety of the combination of rituximab, fludarabine, and mitoxantrone for rituximab-naive, recurrent/refractory follicular non-Hodgkin lymphoma with high tumor burden : A multicenter phase 2 trial by the Groupe d'Etude des Lymphomes de l'Adulte (GELA) and Groupe Ouest Est des Leucémies et Autres Maladies du Sang (GOELAMS) (pages 4299–4308)

      Franck Morschhauser, Nicolas Mounier, Catherine Sebban, Pauline Brice, Phillippe Solal-Celigny, Herve Tilly, Pierre Feugier, Christophe Fermé, Marie Christine Copin and Thierry Lamy

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25280

      To the authors' knowledge, this is the first report of efficacy and safety findings from the combination of rituximab, fludarabine, and mitoxantrone (R-FM) in patients with recurrent/refractory follicular lymphoma who were selected on the basis of high tumor burden criteria at study entry. The results indicated that a 4-course R-FM induction was safe and yielded high overall and complete response rates.

    10. Lung Disease
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      Epidermal growth factor receptor mutations detected by denaturing high-performance liquid chromatography in nonsmall cell lung cancer : Impact on response to therapy with epidermal growth factor receptor-tyrosine kinase inhibitors (pages 4309–4317)

      Victor Cohen, Jason S. Agulnik, Celina Ang, Goulnar Kasymjanova, Gerald Batist, David Small, Guilherme Brandao, George Chong and Wilson H. Miller Jr

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25214

      Epidermal growth factor receptor (EGFR) mutation testing using denaturing high-performance liquid chromatography can be incorporated into the routine care of lung cancer patients. Clinical differences might exist between exon 19 deletions and L858R EGFR mutations in nonsmall cell lung cancer.

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      Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer (pages 4318–4325)

      Tom Donnem, Khalid Al-Shibli, Sigve Andersen, Samer Al-Saad, Lill-Tove Busund and Roy M. Bremnes

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25333

      There is a close interplay between angiogenesis and the immune system. The authors of this report investigated for the first time the combination of angiogenic markers with in situ immunity markers and observed that this coexpression had an independent prognostic impact on nonsmall cell lung cancer.

    12. Melanoma
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      Correlation of molecular human leukocyte antigen typing and outcome in high-risk melanoma patients receiving adjuvant interferon (pages 4326–4333)

      Helen Gogas, John M. Kirkwood, Christine S. Falk, Urania Dafni, Vernon K. Sondak, Dimosthenis Tsoutsos, Alexandros Stratigos, Christos Markopoulos, Dimitrios Pectasides and Maria Spyropoulou-Vlachou

      Article first published online: 14 JUN 2010 | DOI: 10.1002/cncr.25211

      In this prospective analysis, which was performed to evaluate whether human leukocyte antigen (HLA) phenotype influences the likelihood of a favorable outcome or response, the presence of HLA-Cw*06 allele was associated with better relapse-free and overall survival and the appearance of autoimmunity. The Cw*06 allele has been correlated with psoriasis. These results, if validated in trials of adjuvant interferon conducted in separate US and European cooperative groups, could be used to identify patients who would benefit from adjuvant interferon.

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      Prognostic factors for melanoma in children and adolescents : A clinicopathologic, single-center study of 137 Patients (pages 4334–4344)

      Sabela Paradela, Eduardo Fonseca, Salvador Pita-Fernández, Sara M. Kantrow, Abdul H. Diwan, Cynthia Herzog and Victor G. Prieto

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25222

      In this retrospective, observational study, the authors investigated the prognostic significance of clinical and pathologic findings from 137 children with melanoma. The results indicated that Breslow thickness predicted an increased risk of metastases, whereas age and metastases at diagnosis predicted an increased risk of death.

    14. Discipline

      Epidemiology
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      Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health Study (pages 4345–4353)

      Leah M. Ferrucci, Rashmi Sinha, Mary H. Ward, Barry I. Graubard, Albert R. Hollenbeck, Briseis A. Kilfoy, Arthur Schatzkin, Dominique S. Michaud and Amanda J. Cross

      Article first published online: 2 AUG 2010 | DOI: 10.1002/cncr.25463

      In this prospective investigation of meat, nitrate, nitrite, and meat mutagens and bladder cancer in the NIH-AARP Diet and Health Study, the authors found modest support for involvement of total dietary nitrite and nitrate plus nitrite from processed meat in this malignancy. Findings also suggested a positive association between both red meat and 1 hetrocyclic amine and bladder carcinogenesis.

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      Increasing incidence of rectal cancer in patients aged younger than 40 years : An analysis of the surveillance, epidemiology, and end results database (pages 4354–4359)

      Joshua E. Meyer, Tarun Narang, Felice H. Schnoll-Sussman, Mark B. Pochapin, Paul J. Christos and David L. Sherr

      Article first published online: 23 AUG 2010 | DOI: 10.1002/cncr.25432

      Rectal and rectosigmoid cancer are increasing in the United States among young patients. This has been observed across races and in both sexes, but is in contrast to stable rates of colon cancer in the young population.

    16. Medical Oncology
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      A prospective study of aromatase inhibitor-associated musculoskeletal symptoms and abnormalities on serial high-resolution wrist ultrasonography (pages 4360–4367)

      N. Lynn Henry, Jon A. Jacobson, Mousumi Banerjee, Jill Hayden, Jeffrey B. Smerage, Catherine Van Poznak, Anna Maria Storniolo, Vered Stearns and Daniel F. Hayes

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25385

      Clinically relevant musculoskeletal symptoms develop in women treated with adjuvant aromatase inhibitors, leading to treatment discontinuation in a substantial percentage. The upper extremities are frequently affected, especially the wrists, hands, and fingers. In this pilot study, no statistically significant association was found between patient-reported musculoskeletal symptoms and abnormalities detected with wrist ultrasonography.

    17. Pediatric Oncology
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      Severe neutropenia at time of port insertion is not a risk factor for catheter-associated infections in children with acute lymphoblastic leukemia (pages 4368–4375)

      Beatriz L. P. Junqueira, Bairbre Connolly, Oussama Abla, George Tomlinson and Joao G. Amaral

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25286

      Severe neutropenia on the day of port-a-catheter insertion did not increase the risk of catheter-associated infections in children with newly diagnosed acute lymphoblastic leukemia (ALL). High-risk precursor B-cell and T-cell ALL were identified as risk factors for late catheter-associated infections.

    18. You have full text access to this OnlineOpen article
      Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients (pages 4376–4384)

      Monika L. Metzger, Melissa M. Hudson, Matthew J. Krasin, Jianrong Wu, Sue C. Kaste, Larry E. Kun, John T. Sandlund and Scott C. Howard

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25225

      The authors investigated the prognostic significance of the initial response to salvage therapy in pediatric patients with relapsed Hodgkin lymphoma (HL). The results indicated that pediatric patients with relapsed HL who have an inadequate response after initial primary salvage chemotherapy have a very poor prognosis and should be considered for novel therapies directed at biologic or immunologic targets.

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      Secondary hematopoietic malignancies in survivors of childhood cancer : An analysis of 111 cases from the Surveillance, Epidemiology, and End Result-9 registry (pages 4385–4394)

      Rawad Rihani, Faiha Bazzeh, Nesreen Faqih and Iyad Sultan

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25313

      The Surveillance, Epidemiology, and End Result-9 registry was analyzed for incidence, histological subtypes, risk factors, outcomes, and changing risk trends of secondary malignancies in 111 survivors of childhood cancer. Survivors of childhood cancer are at increased risk of developing secondary hematological malignancies, particularly secondary acute myeloid leukemia; close long-term monitoring in these patients is warranted.

    20. Psychosocial Oncology
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      Parental cancer and the family : A population-based estimate of the number of US cancer survivors residing with their minor children (pages 4395–4401)

      Kathryn E. Weaver, Julia H. Rowland, Catherine M. Alfano and Timothy S. McNeel

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25368

      The authors estimate that 18% of newly diagnosed survivors and 14% of all US cancer survivors reside with 1 or more of their children younger than 18 years of age. This represents a population of 1.58 million survivors and 2.85 million children for whom cancer may pose special challenges and who may require additional resources.

    21. Symptom Control and Palliative Care
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      Timing of palliative care referral and symptom burden in phase 1 cancer patients : A retrospective cohort study (pages 4402–4409)

      David Hui, Henrique Parsons, Linh Nguyen, Shana L. Palla, Sriram Yennurajalingam, Razelle Kurzrock and Eduardo Bruera

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25389

      In this retrospective cohort study, the authors found that phase 1 outpatients referred to palliative care had a better performance status but similar symptom burden compared with non-phase 1 patients. Phase 1 involvement did not appear to delay palliative care referral compared with patients not in phase 1, supporting the development of a simultaneous care model.

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      Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer (pages 4410–4419)

      Aliza Z. Weinrib, Sandra E. Sephton, Koen DeGeest, Frank Penedo, David Bender, Bridget Zimmerman, Clemens Kirschbaum, Anil K. Sood, David M. Lubaroff and Susan K. Lutgendorf

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25299

      Dysregulations in diurnal cortisol levels were observed in ovarian cancer patients and were associated with greater functional disability and fatigue but not with life stress or depressed affect.

    23. Translational Research
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      Adenovirus-mediated expression of truncated E2F-1 suppresses tumor growth in vitro and in vivo (pages 4420–4432)

      Jorge G. Gomez-Gutierrez, Aracely Garcia-Garcia, Hongying Hao, Xiao-Mei Rao, Roberto Montes de Oca-Luna, Heshan S. Zhou and Kelly M. McMasters

      Article first published online: 19 AUG 2010 | DOI: 10.1002/cncr.25322

      The authors constructed an adenovirus (Ad) vector that expressed the truncated form of the E2F-1 gene (E2Ftr) under regulation of the tetracycline (Tet)-off system (AdTet-E2Ftr3). The results demonstrated that this vector is a novel anticancer agent with significant therapeutic activity in vitro and in vivo. AdTet-E2Ftr3 induced apoptosis in cancer cells independent of p53 status with low cytotoxicity in normal cells.

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