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Cancer

Cover image for Vol. 116 Issue 19

1 October 2010

Volume 116, Issue 19

Pages 4433–4665

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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  2. Editorials

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Understanding social obstacles to early breast cancer detection is critical to improving breast cancer outcome in low- and middle-resource countries (pages 4436–4439)

      Benjamin O. Anderson

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25361

      In low- and middle-resource countries worsened cancer survival is attributable largely to late-stage presentation, which leads to particularly poor outcome when coupled with limited diagnostic and treatment capacity. The identification of social obstacles linked to public awareness programs educating women that breast cancer outcomes are improved through early detection is critical to broadening participation in early detection programs.

  3. Review Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Translating research into evidence-based practice : The National Cancer Institute Community Clinical Oncology Program (pages 4440–4449)

      Lori M. Minasian, William R. Carpenter, Bryan J. Weiner, Darrell E. Anderson, Worta McCaskill-Stevens, Stefanie Nelson, Cynthia Whitman, Joseph Kelaghan, Ann M. O'Mara and Arnold D. Kaluzny

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25248

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      The National Institutes of Health and other programs are increasingly emphasizing research that involves evidence development, comparative effectiveness, translational research, and accelerating the translation of research into evidence-based practice as well as building successful research networks to support these efforts. In this review, the authors describe the National Cancer Institute Community Clinical Oncology Program and its history of successfully extending research into the community, facilitating the translation of research into practice, and providing practical guidance to provider-based research networks in cancer and other disciplines.

  4. Original Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. Disease Site

      Breast Disease
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      Utility of the GeneSearch breast lymph node assay for the rapid evaluation of sentinel lymph nodes in breast cancer (pages 4450–4455)

      Yawara Funasako, Yoshikazu Uenosono, Munetsugu Hirata, Takaaki Arigami, Shigehiro Yanagita, Hideo Arima, Katsuhiko Ehi, Yuko Kijima, Heiji Yoshinaka and Shoji Natsugoe

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25479

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      Half of each sentinel lymph node from 117 breast cancer patients was examined by a real-time reverse transcriptase-polymerase chain reaction assay using 2 markers. This assay may be a more accurate diagnostic tool compared with current pathologic examination.

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      The impact of a national program to provide free mammograms to low-income, uninsured women on breast cancer mortality rates (pages 4456–4462)

      David H. Howard, Donatus U. Ekwueme, James G. Gardner, Florence K. Tangka, Chunyu Li and Jacqueline W. Miller

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25208

      The authors examined the impact of a state-level program that provides free mammograms to low-income women on breast cancer mortality rates. Some of the evidence suggested that the National Breast and Cervical Cancer Early Detection Program led to a reduction in breast cancer mortality rates.

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      Invasive neuroendocrine carcinoma of the breast : A distinctive subtype of aggressive mammary carcinoma (pages 4463–4473)

      Bing Wei, Tian Ding, Yan Xing, Wei Wei, Zhen Tian, Feng Tang, Susan Abraham, Khazi Nayeemuddin, Kelly Hunt and Yun Wu

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25352

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      Neuroendocrine carcinoma is a distinct type of aggressive mammary carcinoma. Novel therapeutic approaches should be explored for this uniquely different clinical entity.

    4. Gastrointestinal Disease
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      Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups : A retrospective analysis of biomarkers in matched primary tumor and lymph node metastases (pages 4474–4486)

      Eva Karamitopoulou, Inti Zlobec, Anna Koumarianou, Efstratios S. Patsouris, George Peros and Alessandro Lugli

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25304

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      The objective of identifying protein biomarkers for patients with stage III colorectal cancer is to improve risk stratification and, thus, to identify patients in the postoperative setting who may benefit from a more targeted treatment. In this study, the authors demonstrated that, in patients who received adjuvant treatment for stage III colorectal cancer, negative expression of p16 in lymph node metastases had a highly negative impact on overall survival independent of pathologic tumor classification, age, or lymph node ratio, supporting the investigation of this biomarker in future prognostic and predictive studies.

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      Critical role of surgery in patients with gastroesophageal carcinoma with a poor prognosis after chemoradiation as defined by positron emission tomography (pages 4487–4494)

      Srikrishna V. Patnana, Santosh B. Murthy, Lianchun Xiao, Eric Rohren, Wayne L. Hofstetter, Stephen G. Swisher, Zhongxing Liao, Jeffrey H. Lee, Manoop S. Bhutani, Homer A. Macapinlac, Xuemei Wang and Jaffer A. Ajani

      Version of Record online: 13 JUL 2010 | DOI: 10.1002/cncr.25431

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      The prognosis of patients with localized gastroesophageal carcinoma can be defined after chemoradiation by the standardized uptake value (SUV) of positron emission tomography. In the current study, the authors retrospectively examined the role of surgery in patients with a high SUV after chemoradiation. Surgery was found to prolong survival in patients with esophageal cancer.

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      Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas (pages 4495–4501)

      Bogdan C. Paun, Debra Kukuruga, Zhe Jin, Yuriko Mori, Yulan Cheng, Mark Duncan, Sanford A. Stass, Elizabeth Montgomery, David Hutcheon and Stephen J. Meltzer

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25348

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      A prediction model was developed for the presence of colorectal adenomas based on gene methylation patterns in the normal rectum. The results indicated that normal rectal methylation may be useful as a biomarker for narrowing the population in greatest need of screening colonoscopy.

    7. Genitourinary Disease
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      Prognostic impact of plasminogen activator inhibitor type 1 expression in bladder cancer (pages 4502–4512)

      Markus Becker, Tibor Szarvas, Markus Wittschier, Frank vom Dorp, Martin Tötsch, Kurt Werner Schmid, Herbert Rübben and Süleyman Ergün

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25326

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      The prognostic impact of plasminogen activator inhibitor type 1 (PAI-1) was investigated in patients with bladder cancer. The results indicated that immunohistochemical detection of single PAI-1–positive cells may serve as a predictor of survival and a possible indicator of metastasis in these patients.

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      A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer (pages 4513–4519)

      Robert S. Svatek, Jay B. Shah, Jinliang Xing, David Chang, Jie Lin, David J. McConkey, Xifeng Wu and Colin P. Dinney

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25401

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      Multiplexed, particle-based flow cytometric assay allows for high-throughput measurement of multiple plasma or serum proteins simultaneously. By using this new technology in a cohort of patients with bladder cancer, the authors identified plasma levels of matrix metalloproteinase-7 to be significantly associated with time to cancer-related death.

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      Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults : A meta-analysis and systematic review (pages 4520–4532)

      Iain B. Tan, Kai K. Ang, Boon C. Ching, Chandra Mohan, Chee K. Toh and Min H. Tan

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25231

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      Testicular microlithiasis is a marker of risk of concurrent germ cell tumors and intratubular germ cell neoplasia of unclassified type. These risks should be considered in the clinical management of patients with testicular microlithiasis.

    10. Head and Neck Disease
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      Concomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer (pages 4533–4540)

      Heather E. Newlin, Robert J. Amdur, Charles E. Riggs, Christopher G. Morris, Jessica M. Kirwan and William M. Mendenhall

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25189

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      The authors reported efficacy and toxicity after weekly cisplatin (30 mg/m2/wk) concurrent with altered fractionation radiotherapy (RT). Concomitant weekly cisplatin with altered fractionation RT is a safe and effective treatment regimen.

    11. Hematologic Malignancies
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      Interim report of a phase 2 clinical trial of lenalidomide for T-cell non-Hodgkin lymphoma (pages 4541–4548)

      Greg Dueck, Neil Chua, Angeli Prasad, Daygen Finch, Doug Stewart, Darrell White, Richard van der Jagt, James Johnston, Andrew Belch and Tony Reiman

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25377

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      We report the interim results of a prospective multicenter phase 2 trial evaluating lenalidomide in recurrent and refractory T-cell lymphoma. Patients were prescribed oral lenalidomide on Days 1 to 21 of each 28-day cycle, and the primary endpoint of overall response rate was 7 (30%) of 23.

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      Clinical utility of multiparameter flow cytometry in the diagnosis of 1013 patients with suspected myelodysplastic syndrome : Correlation to cytomorphology, cytogenetics, and clinical data (pages 4549–4563)

      Wolfgang Kern, Claudia Haferlach, Susanne Schnittger and Torsten Haferlach

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25353

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      The diagnostic use of multiparameter flow cytometry (MFC) in patients with suspected myelodysplasia was analyzed and compared using cytomorphology and cytogenetics. The results indicated that MFC is capable of providing important additional information.

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      Activity and tolerability of nilotinib : A retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerant (pages 4564–4572)

      Maya Koren-Michowitz, Philipp le Coutre, Justus Duyster, Christof Scheid, Panayiotis Panayiotidis, Witold Prejzner, Jacob M. Rowe, Michaela Schwarz, Neta Goldschmidt and Arnon Nagler

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25351

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      Nilotinib is an effective and safe treatment for chronic myeloid leukemia patients who are imatinib resistant or intolerant. Prior response to imatinib is predictive of the response to nilotinib.

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      Oxaliplatin-based chemotherapy (dexamethasone, high-dose cytarabine, and oxaliplatin) ± rituximab is an effective salvage regimen in patients with relapsed or refractory lymphoma (pages 4573–4579)

      Luigi Rigacci, Alberto Fabbri, Benedetta Puccini, Ida Chitarrelli, Annalisa Chiappella, Umberto Vitolo, Alessandro Levis, Francesco Lauria and Alberto Bosi

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25216

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      The study assessed the efficacy and safety of dexamethasone, high-dose cytarabine, and oxaliplatin as salvage therapy in lymphoma patients, replacing cisplatin with oxaliplatin in the standard dexamethasone, cytarabine, and cisplatin scheme. It confirmed that dexamethasone, high-dose cytarabine, and oxaliplatin ± rituximab is an effective and feasible outpatient regimen for salvage therapy in patients affected by relapsed or refractory lymphoma. Moreover, the feasibility and efficacy of this scheme as an in vivo chemosensitive test in patients in autotransplantation programs was confirmed.

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      Anthracycline dose intensification in adult acute lymphoblastic leukemia : Lack of benefit in the context of the fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen (pages 4580–4589)

      Deborah Thomas, Susan O'Brien, Stefan Faderl, Farhad Ravandi, Elias Jabbour, Sherry Pierce, Jorge Cortes and Hagop Kantarjian

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25319

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      Sixty-eight patients with newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma received the hyper-CVAD regimen (hyper-fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high dose methotrexate and cytarabine) with the addition of high-dose liposomal daunorubicin as postremission consolidation therapy (Course 2). The incorporation of early anthracycline intensification did not improve outcome.

    16. Hepatobiliary Disease
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      Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma (pages 4590–4596)

      Yu-Yun Shao, Zhong-Zhe Lin, Chiun Hsu, Ying-Chun Shen, Chih-Hung Hsu and Ann-Lii Cheng

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25257

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      Antiangiogenic therapy is the current standard therapy for patients with advanced hepatocellular carcinoma. In this study, the authors demonstrated that an early alpha-fetoprotein response predicted better response and disease-control rates and longer progression-free and overall survival in these patients.

    17. Lung Disease
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      The antitumor activity of NK012, an SN-38–incorporating micelle, in combination with bevacizumab against lung cancer xenografts (pages 4597–4604)

      Hirotsugu Kenmotsu, Masahiro Yasunaga, Koichi Goto, Tatsuya Nagano, Jun-ichiro Kuroda, Yoshikatsu Koga, Amane Takahashi, Yutaka Nishiwaki and Yasuhiro Matsumura

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25233

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      The combination of NK012 (a novel 7-ethyl-10-hydroxycamptothecin [SN-38]-incorporating polymeric micelle) with bevacizumab produced significantly greater antitumor activity against human lung cancer xenografts compared with NK012 alone. The pharmacokinetic profile of NK012 revealed that the coadministration of bevacizumab did not interfere with the accumulation of NK012 in tumors.

    18. Neuro-Oncology
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      Characteristics and outcomes of elderly patients with primary central nervous system lymphoma : The Memorial Sloan-Kettering Cancer Center experience (pages 4605–4612)

      Douglas E. Ney, Anne S. Reiner, Katherine S. Panageas, Hayley S. Brown, Lisa M. DeAngelis and Lauren E. Abrey

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25363

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      Approximately half of all patients with primary central nervous system lymphoma (PCNSL) are aged ≥65 years. This group is relatively understudied, and optimal therapy for older patients is not well defined. Patients aged ≥65 years with PCNSL are reported to have a 76% response rate to chemotherapy and a median survival of 25 months.

    19. Sarcoma
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      Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall : Radiation Therapy Oncology Group Trial 9514 (pages 4613–4621)

      William G. Kraybill, Jonathan Harris, Ira J. Spiro, David S. Ettinger, Thomas F. DeLaney, Ronald H. Blum, David R. Lucas, David C. Harmon, G. Douglas Letson and Burton Eisenberg

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25350

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      Sixty-four patients were managed with neoadjuvant mesna, doxorubicin, ifosfamide, and dacarbazine chemotherapy; radiation; resection; and adjuvant mesna, doxorubicin, ifosfamide, and dacarbazine chemotherapy for advanced high-grade extremity and torso soft tissue sarcomas. Although toxic, this long-term analysis demonstrates results somewhat better than might be expected for such high-risk tumors.

    20. Discipline

      Disparities Research
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      Racial disparities in colorectal cancer survival : To what extent are racial disparities explained by differences in treatment, tumor characteristics, or hospital characteristics? (pages 4622–4631)

      Arica White, Sally W. Vernon, Luisa Franzini and Xianglin L. Du

      Version of Record online: 12 JUL 2010 | DOI: 10.1002/cncr.25395

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      For patients with colorectal cancer (CRC), comorbidities and socioeconomic status (SES) appeared to be more important factors contributing to poorer survival among black patients relative to white and Asian patients. However, racial/ethnic disparities in CRC survival were not fully explained by differences in tumor characteristics, comorbidities, screening, treatment, and SES.

    21. Pediatric Oncology
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      Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma (pages 4632–4637)

      Alberto Broniscer, Justin N. Baker, Suzanne J. Baker, Susan N. Chi, J. Russell Geyer, E. Brannon Morris and Amar Gajjar

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25405

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      Brain tissue obtained at autopsy has been used in research for non-oncologic disorders. However, to our knowledge, this tool has never been used before for large investigational studies focused on cancer. In the current study, the authors demonstrated that DNA and RNA suitable for sophisticated genome-wide studies can be successfully obtained in multicenter biological studies based on tissue obtained at autopsy in children with diffuse intrinsic pontine glioma, a deadly pediatric brain cancer.

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      Attention and working memory abilities in children treated for acute lymphoblastic leukemia (pages 4638–4645)

      Jason Ashford, Corrie Schoffstall, Wilburn E. Reddick, Christina Leone, Fred H. Laningham, John O. Glass, Deqing Pei, Cheng Cheng, Ching-Hon Pui and Heather M. Conklin

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25343

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      Survivors of childhood acute lymphoblastic leukemia demonstrate working memory abilities that appear to be statistically lower than healthy peers and clinically fall below the average range. Working memory abilities are more sensitive to treatment effects than attention, make a unique contribution to intelligence, and are associated with cerebral white matter changes.

    23. Psychosocial Oncology
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      Factors associated with low screening for breast cancer in the Palestinian authority : Relations of availability, environmental barriers, and cancer-related fatalism (pages 4646–4655)

      Faisal Azaiza, Miri Cohen, Mariam Awad and Francoise Daoud

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25378

      This is the first study among Palestinian women in the West Bank on breast cancer screening. Rates of mammography and clinical breast examination attendance were very low, whereas a relatively high percentage of the women performed self breast examinations, probably because of low access to mammography and clinical breast examination. Cancer fatalism, higher religiosity, and lower education predicted lower performance of examinations.

    24. Symptom Control and Palliative Care
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      Influence of patients' preferences and treatment site on cancer patients' end-of-life care (pages 4656–4663)

      Alexi A. Wright, Jennifer W. Mack, Patricia A. Kritek, Tracy A. Balboni, Anthony F. Massaro, Ursula A. Matulonis, Susan D. Block and Holly G. Prigerson

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25217

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      Research suggests that patients' end-of-life care is determined primarily by the medical resources available and not by patient preferences. In this multisite, prospective, longitudinal cohort study, the authors observed that patients with advanced cancer who wanted life-extending care were 3 times more likely to receive cardiopulmonary resuscitation and/or mechanical ventilation and to die in an intensive care unit, independent of treatment site.

  5. Correspondence

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Reply to False-positivity in the sentinel lymph nodes in melanoma and breast cancer (pages 4664–4665)

      Simone Mocellin and Sandro Pasquali

      Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25471

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