You have free access to this content

Cancer

Cover image for Cancer

15 January 2010

Volume 116, Issue 2

Pages 261–540

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. You have free access to this content
    2. You have free access to this content
      Tamoxifen use tied to aggressive second cancers (page 262)

      Carrie Printz

      Version of Record online: 20 JAN 2010 | DOI: 10.1002/cncr.24933

    3. You have free access to this content
  2. Commentary

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. You have free access to this content
      Addressing cancer health disparities using a global biopsychosocial approach (pages 264–269)

      Denae King, Patricia Miranda, Beverly Gor, Robin Fuchs-Young, Janice Chilton, Richard Hajek, Isabel Torres-Vigil, Mariá A. Hernández-Valero, S. Amy Snipes and Lovell Jones

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24765

      The Center for Research on Minority Health has translated the biopsychosocial framework to address global cancer health disparities through the integration of biological and behavioral determinants, along with community-based research and educational approaches. In this article, the authors illustrate how to implement the biopsychosocial approach to more comprehensively and effectively address cancer health disparities.

  3. Editorials

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. You have free access to this content
      We need better randomized comparison trials of prostate cancer (pages 270–272)

      W. Robert Lee

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24780

      More than 50 years after the first randomized oncology trial, the number of randomized trials comparing differing primary treatments for prostate cancer is disappointing. One of these rare, randomized primary treatment comparisons appears in this edition of Cancer, and the investigators are to be congratulated for their efforts comparing cryotherapy with external beam radiotherapy.

  4. Review Articles

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. You have free access to this content
      Radiotherapy for patients with the human immunodeficiency virus: Are special precautions necessary? (pages 273–283)

      Nadine Housri, Robert Yarchoan and Aradhana Kaushal

      Version of Record online: 15 DEC 2009 | DOI: 10.1002/cncr.24878

      Physicians are often concerned about the use of radiotherapy in human immunodeficiency virus-positive patients with cancer, for fear of treatment side effects. In the current study, the authors explore the evidence supporting these concerns, both in the basic and clinical literature.

  5. Original Articles

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. Disease Site

      Breast Disease
      You have free access to this content
      A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D3 in breast cancer patients with bone metastases (pages 284–291)

      Eitan Amir, Christine E. Simmons, Orit C. Freedman, George Dranitsaris, David E. C. Cole, Reinhold Vieth, Wei S. Ooi and Mark Clemons

      Version of Record online: 13 NOV 2009 | DOI: 10.1002/cncr.24749

      • original image
      • original image
      • original image
      • original image

      High-dose vitamin D is safe in patients without comorbid conditions causing hypersensitivity to vitamin D. However, when given to patients with metastatic breast cancer to bone, it did not reduce bone resorption markers, nor was it associated with a significant palliative benefit.

    2. You have free access to this content
      Results of the first phase 1 clinical trial of the HER-2/neu peptide (GP2) vaccine in disease-free breast cancer patients : United States Military Cancer Institute Clinical Trials Group Study I-04 (pages 292–301)

      Mark G. Carmichael, Linda C. Benavides, Jarrod P. Holmes, Jeremy D. Gates, Elizabeth A. Mittendorf, Sathibalan Ponniah and George E. Peoples

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24756

      • original image
      • original image
      • original image
      • original image
      • original image

      This article describes the results of the first phase 1 trial of the HER-2/neu peptide (GP2) vaccine in breast cancer patients. Results show that the vaccine appears safe and well tolerated, with minimal local/systemic toxicity, and that it elicits HER-2-neu–specific immune responses.

    3. You have free access to this content
      Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancer (pages 302–308)

      Kan Yonemori, Koji Tsuta, Makiko Ono, Chikako Shimizu, Akihiro Hirakawa, Tadashi Hasegawa, Yutaka Hatanaka, Yoshitaka Narita, Soichiro Shibui and Yasuhiro Fujiwara

      Version of Record online: 20 NOV 2009 | DOI: 10.1002/cncr.24735

      • original image
      • original image

      Brain metastases of triple-negative or basal-type breast cancers often may disrupt the blood brain barrier, whereas brain metastases of HER2/neu-positive breast cancer tend to preserve the blood brain barrier.

    4. Gastrointestinal Disease
      You have free access to this content
      Extracapsular lymph node spread : A new prognostic factor in gastric cancer (pages 309–315)

      Hakan Alakus, Arnulf H. Hölscher, Guido Grass, Eva Hartmann, Christian Schulte, Uta Drebber, Stephan E. Baldus, Elfriede Bollschweiler, Ralf Metzger and Stefan P. Mönig

      Version of Record online: 30 NOV 2009 | DOI: 10.1002/cncr.24764

      • original image
      • original image
      • original image

      The present study demonstrated that infiltration of cancer cells beyond the capsule of the metastatic lymph nodes is of high prognostic value in gastric cancer, giving additional information to the International Union Against Cancer pN category and being helpful in the identification of gastric cancer patients with inferior prognosis. In future staging systems, the presence of extracapsular lymph node involvement should be considered for gastric cancer.

    5. You have free access to this content
      Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin : A single-institution experience (pages 316–322)

      Jamie F. Shapiro, Judy L. Chase, Robert A. Wolff, Laura A. Lambert, Paul F. Mansfield, Michael J. Overman, Aki Ohinata, Jun Liu, Xuemei Wang and Cathy Eng

      Version of Record online: 10 NOV 2009 | DOI: 10.1002/cncr.24715

      • original image
      • original image
      • original image

      Systemic chemotherapy may have a role for patients with surgically unresectable appendiceal neoplasms. Further trials using systemic chemotherapy are warranted in patients who are suboptimal surgical candidates with appendiceal neoplasms.

    6. Genitourinary Disease
      You have free access to this content
      A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer (pages 323–330)

      Bryan J. Donnelly, John C. Saliken, Penelope M. A. Brasher, Scott D. Ernst, John C. Rewcastle, Harold Lau, John Robinson and Kiril Trpkov

      Version of Record online: 24 NOV 2009 | DOI: 10.1002/cncr.24779

      • original image
      • original image

      Disease progression was similar in both arms initially, but with longer follow-up, the trend favored cryoablation. There were significantly fewer positive post-treatment biopsies in the cryoablation arm.

    7. You have free access to this content
      Urinary diversion and morbidity after radical cystectomy for bladder cancer (pages 331–339)

      John L. Gore, Hua-Yin Yu, Claude Setodji, Jan M. Hanley, Mark S. Litwin and Christopher S. Saigal

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24763

      The rate of continent urinary diversion after radical cystectomy for bladder cancer varies by patient and provider characteristics. In the current study, among patients undergoing radical cystectomy for muscle-invasive bladder cancer, postoperative morbidity and mortality outcomes did not vary by diversion type.

    8. You have free access to this content
      Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer (pages 340–346)

      Teruo Inamoto, Bogdan A. Czerniak, Colin P. Dinney and Ashish M. Kamat

      Version of Record online: 11 NOV 2009 | DOI: 10.1002/cncr.24737

      • original image
      • original image
      • original image

      A significant number of deaths from bladder cancer result from inability to predict which patients will have disease recurrence despite seemingly good response to therapy as well as lack of effective salvage therapies in those who do not respond to conventional agents. In this study, the authors demonstrated that the cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 was positively associated with tumor recurrence and poor prognosis in patients with bladder cancer.

    9. You have free access to this content
      Stage migration and increasing proportion of favorable-prognosis metastatic renal cell carcinoma patients : Implications for clinical trial design and interpretation (pages 347–354)

      Sujata Patil, Nicole Ishill, John Deluca and Robert J. Motzer

      Version of Record online: 17 NOV 2009 | DOI: 10.1002/cncr.24713

      • original image
      • original image
      • original image

      The risk-group distribution for metastatic renal cell carcinoma (RCC) patients in the clinical trial population at Memorial Sloan-Kettering Cancer Center has shifted from 1975 to 2007. These shifts have direct implications for data analysis, interpretation of metastatic RCC trends, and drug development.

  6. Original Article

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. Disease Site

      Gynecologic Oncology
      You have free access to this content
      Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer : A Gynecologic Oncology Group Study (pages 355–361)

      John H. Farley, Chunqiao Tian, G. Scott Rose, Carol L. Brown, Michael Birrer, John I. Risinger, J. Tate Thigpen, Gini F. Fleming, Holly H. Gallion and G. Larry Maxwell

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24769

      • original image

      Black patients with advanced stage or recurrent endometrial cancer, treated on 4 Gynecologic Oncology Group (GOG) protocols, had similar dose intensity and severe chemotherapy-related toxicity compared with white patients. This suggests that previously described racial disparities in survival among patients in GOG trials may have a novel etiology.

  7. Original Articles

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. Disease Site

      Head and Neck Disease
      You have free access to this content
      A phase 2 study of platinum and gemcitabine in patients with advanced salivary gland cancer : A Trial of the NCIC Clinical Trials Group (pages 362–368)

      Scott A. Laurie, Lillian L. Siu, Eric Winquist, Andrew Maksymiuk, Erica L. Harnett, Wendy Walsh, Dongsheng Tu and Wendy R. Parulekar

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24745

      • original image

      In patients with advanced salivary gland cancers, platinum-gemcitabine combination chemotherapy was found to have modest activity but was insufficient to warrant further study. Enrollment of patients with these rare cancers onto well-designed clinical trials remains an urgent priority.

    2. Hematologic Malignancies
      You have free access to this content
      Rapid and reliable confirmation of acute promyelocytic leukemia by immunofluorescence staining with an antipromyelocytic leukemia antibody : The M. D. Anderson Cancer Center experience of 349 patients (pages 369–376)

      Nikolay D. Dimov, L. Jeffrey Medeiros, Hagop M. Kantarjian, Jorge E. Cortes, Kun-Sang Chang, Carlos E. Bueso-Ramos and Farhad Ravandi

      Version of Record online: 30 NOV 2009 | DOI: 10.1002/cncr.24775

      • original image

      Promyelocytic leukemia immunofluorescence staining is a rapid (<4 hours turnaround time), reliable, sensitive (98.9%), and specific (98.7%) frontline diagnostic approach that can facilitate initiation of targeted therapy, particularly in clinical settings where cytogenetic and molecular testing are not readily available.

    3. You have free access to this content
      Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion (pages 377–386)

      Kimmo Porkka, H. Jean Khoury, Ronald L. Paquette, Yousif Matloub, Ritwik Sinha and Jorge E. Cortes

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24734

      • original image
      • original image
      • original image
      • original image
      • original image

      In patients with chronic myeloid leukemia in chronic phase, dasatinib 100 mg once daily significantly minimized the occurrence of pleural effusion. Dasatinib short-term and long-term efficacy was similar in patients with or without pleural effusion.

  8. Original articles

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. Disease Site

      Hematologic Malignancies
      You have free access to this content
      Expression of interleukin 15 in primary adult acute lymphoblastic leukemia (pages 387–392)

      Shuling Wu, Lars Fischer, Nicola Gökbuget, Stefan Schwartz, Thomas Burmeister, Michael Notter, Dieter Hoelzer, Hendrik Fuchs, Igor Wolfgang Blau, Wolf K Hofmann and Eckhard Thiel

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24729

      • original image

      High expression of IL-15 correlates with disease recurrence of adult B-lineage acute lymphoblastic leukemia.

  9. Original Articles

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. Disease Site

      Hepatobiliary Disease
      You have free access to this content
      Excellent outcomes with angiographic subsegmentectomy in the treatment of typical hepatocellular carcinoma : A retrospective study of local recurrence and long-term survival rates in 120 patients with hepatocellular carcinoma (pages 393–399)

      Shozo Iwamoto, Taizo Yamaguchi, Osamu Hongo, Hideki Iwamoto and Hayato Sanefuji

      Version of Record online: 11 NOV 2009 | DOI: 10.1002/cncr.24678

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      The authors report their successful results using angiographic subsegmentectomy (AS) for the treatment of hepatocellular carcinoma (HCC). The treatment involved the simultaneous embolization of the peripheral feeding artery and the portal vein, and almost all of the HCC and the peripheral liver parenchyma developed complete anatomic necrosis. The authors concluded that AS should be the first-line treatment for patients with stage I and II HCC.

    2. You have free access to this content
      Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma (pages 400–405)

      Masayuki Nagahashi, Yoshio Shirai, Toshifumi Wakai, Jun Sakata, Yoichi Ajioka, Tatsuya Nomura, Yoshiaki Tsuchiya and Katsuyoshi Hatakeyama

      Version of Record online: 30 NOV 2009 | DOI: 10.1002/cncr.24766

      • original image
      • original image

      For pathologic T1 extrahepatic cholangiocarcinoma, the long-term outcomes postresection were significantly better for patients with mucosal tumors than for patients with tumors that have invaded (but not penetrated) the fibromuscular layer. This suggests that the depth of tumor invasion affects the postresection prognosis for patients with pathologic T1 extrahepatic cholangiocarcinoma.

    3. Lung Disease
      You have free access to this content
      Stage I nonsmall cell lung cancer in patients aged ≥75 years : Outcomes after stereotactic radiotherapy (pages 406–414)

      Cornelis J. A. Haasbeek, Frank J. Lagerwaard, Marilisa E. Antonisse, Ben J. Slotman and Suresh Senan

      Version of Record online: 30 NOV 2009 | DOI: 10.1002/cncr.24759

      • original image
      • original image

      Surgical resection of stage I lung cancer in elderly patients was associated with increased morbidity and mortality. Good local control with minimal toxicity was observed after stereotactic radiotherapy in these patients.

    4. Melanoma
      You have free access to this content
      Characteristics associated with early and late melanoma metastases (pages 415–423)

      Jeremy A. Brauer, Cooper C. Wriston, Andrea B. Troxel, Rosalie Elenitsas, Daniel B. Shin, DuPont Guerry and Michael E. Ming

      Version of Record online: 13 NOV 2009 | DOI: 10.1002/cncr.24724

      • original image

      The authors performed a nested case-control study comparing 549 patients who had melanoma and developed metastases, including 320 patients who developed metastasis within 3 years after undergoing definitive surgery (early metastasis [EM]) and 70 patients who developed metastasis ≥8 years after undergoing definitive surgery (late metastasis [LM]), with 549 patients who had melanoma and did not develop metastasis. Two previously undescribed risk factors for metastases at any time interval were identified: a personal history of nonmelanoma skin cancer (P = .006) and a history of cancer other than skin cancer (P = .020). The results indicated that, compared with LM patients, EM patients were more likely to have thicker lesions (P < .001), ulcerated lesions (P = .016), and a history of nonmelanoma skin cancer (P = .024).

    5. You have free access to this content
      Phase 2 trial of combination thalidomide plus temozolomide in patients with metastatic malignant melanoma: Southwest Oncology Group S0508 (pages 424–431)

      Joseph I. Clark, James Moon, Laura F. Hutchins, Jeffrey A. Sosman, W. Martin Kast, Diane M. Da Silva, P. Y. Liu, John A. Thompson, Lawrence E. Flaherty and Vernon K. Sondak

      Version of Record online: 13 NOV 2009 | DOI: 10.1002/cncr.24739

      • original image
      • original image

      This combination of thalidomide and temozolomide does not appear to have a clinical benefit that exceeds dacarbazine alone. We would not recommend it further for phase 3 trials or for standard community use.

    6. Neuro-Oncology
      You have free access to this content
      The role of postoperative radiotherapy for the treatment of gangliogliomas (pages 432–442)

      Dirk Rades, Lena Zwick, Jan Leppert, Matteo M Bonsanto, Volker Tronnier, Juergen Dunst and Steven E. Schild

      Version of Record online: 11 NOV 2009 | DOI: 10.1002/cncr.24716

      • original image
      • original image
      • original image

      This study investigated the potential benefit of postoperative radiotherapy for local control (LC) and overall survival (OS) in a series of 402 patients with ganglioglioma. In both low-grade and high-grade tumors, irradiation significantly improved LC but not OS after subtotal resection and should be considered for these patients; whereas, after gross total resection, irradiation did not significantly improve LC or OS and, thus, did not appear to be required.

    7. Sarcoma
      You have free access to this content
      The value of local treatment in patients with primary, disseminated, multifocal Ewing sarcoma (PDMES) (pages 443–450)

      Julia Haeusler, Andreas Ranft, Tobias Boelling, Georg Gosheger, Gabriele Braun-Munzinger, Volker Vieth, Stefan Burdach, Henk van den Berg, Heribert Juergens and Uta Dirksen

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24740

      • original image
      • original image
      • original image

      Our data on the value of local treatment in patients with primary, extrapulmonary, metastatic Ewing sarcoma suggest that local treatment of involved sites improves the prognosis and should complement systemic treatment whenever possible.

    8. Discpline

      Diagnostic Imaging
      You have free access to this content
      Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign (pages 451–458)

      Matthias R. Benz, Johannes Czernin, Sarah M. Dry, William D. Tap, Martin S. Allen-Auerbach, David Elashoff, Michael E. Phelps, Wolfgang A. Weber and Fritz C. Eilber

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24755

      • original image
      • original image
      • original image
      • original image

      Quantitative F18-fluorodeoxyglucose positron emission tomography imaging distinguished between malignant peripheral nerve sheath tumors and neurofibromas with high accuracy. In contrast, malignant peripheral nerve sheath tumors and schwannomas were less reliably distinguished.

      Corrected by:

      Erratum: Erratum

      Vol. 116, Issue 3, 775, Version of Record online: 15 DEC 2009

    9. Discipline

      Diagnostic Imaging
      You have free access to this content
      Isolated limb infusion with cytotoxic agents: A simplified approach for venous access (pages 459–464)

      Ajit Vyas, Rony Avritscher, Joe Ensor, Merrick Ross and Michael J. Wallace

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24736

      • original image
      • original image

      As evinced by the significantly lower fluoroscopy time needed for combined arterial and venous catheter placement for isolated limb infusion using a novel modified technique, our results demonstrate that the ipsilateral venous access approach is technically easier than the conventional contralateral venous approach.

    10. Disparities Research
      You have free access to this content
      Variations in gastric cancer care : A trend beyond racial disparities (pages 465–475)

      Waddah B. Al-Refaie, Greer Gay, Beth A. Virnig, Jennifer F. Tseng, Andrew Stewart, Selwyn M. Vickers, Todd. M. Tuttle and Barry W. Feig

      Version of Record online: 30 NOV 2009 | DOI: 10.1002/cncr.24772

      This United States multihospital study demonstrated that there were significant variations in treatment for gastric cancer among ethnic groups. It is noteworthy that gastric cancer treatment overall deviated from current recommended guidelines beyond racial disparities to a wider national problem.

    11. You have free access to this content
      The impact of health insurance status on the survival of patients with head and neck cancer (pages 476–485)

      Joseph Kwok, Scott M. Langevin, Athanassios Argiris, Jennifer R. Grandis, William E. Gooding and Emanuela Taioli

      Version of Record online: 20 NOV 2009 | DOI: 10.1002/cncr.24774

      • original image
      • original image
      • original image

      Health insurance status is an independent predictor of head and neck cancer survival.

    12. Medical Oncology
      You have free access to this content
      Gene expression signatures in breast cancer distinguish phenotype characteristics, histologic subtypes, and tumor invasiveness (pages 486–496)

      Vincente Pedraza, Jose A. Gomez-Capilla, Georgia Escaramis, Carolina Gomez, Pablo Torné, Jose M. Rivera, Angel Gil, Patricia Araque, Nicolas Olea, Xavier Estivill and M. Esther Fárez-Vidal

      Version of Record online: 22 DEC 2009 | DOI: 10.1002/cncr.24805

      • original image
      • original image
      • original image

      Differentially expressed gene sequences were investigated in different stages of breast cancer. The differential gene expression profiles observed in this study offer new insights into the molecular basis of breast cancer, especially the data obtained from comparisons of estrogen receptor-positive disease versus estrogen receptor-negative disease, ductal carcinoma versus lobular carcinoma, grade 1/2 tumors versus grade 3 tumors, and the genetic differences underlying the studied tumor phenotypes.

    13. Pediatric Oncology
      You have free access to this content
      Health status of the oldest adult survivors of cancer during childhood (pages 497–505)

      Lisa B Kenney, Cheryl Medeiros Nancarrow, Julie Najita, Lynda M. Vrooman, Monica Rothwell, Christopher Recklitis, Frederick P. Li and Lisa Diller

      Version of Record online: 11 NOV 2009 | DOI: 10.1002/cncr.24718

      Adult survivors of childhood cancer aged >50 years report a higher prevalence of cardiovascular disease, physical impairments, and fatigue compared with their age-matched relatives, and they remain at risk for treatment-associated premature mortality 40 years after their initial therapy.

    14. You have free access to this content
      A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL) (pages 506–513)

      Elena J. Ladas, David J. Kroll, Nicholas H. Oberlies, Bin Cheng, Deborah H. Ndao, Susan R. Rheingold and Kara M. Kelly

      Version of Record online: 14 DEC 2009 | DOI: 10.1002/cncr.24723

      • original image
      • original image
      • original image

      This study is the first double-blind, randomized, controlled trial to provide preliminary evidence that milk thistle may be a safe, effective, supportive-care agent for cancer patients with hepatoxicity. Future investigations are needed to determine the appropriate dose and duration and to identify populations who may gain the largest clinical benefit.

    15. Radiation Oncology
      You have free access to this content
      Survey on human papillomavirus/p16 screening use in oropharyngeal carcinoma patients in the United States (pages 514–519)

      Asal N. Shoushtari, Nina P. Rahimi, David J. Schlesinger and Paul W. Read

      Version of Record online: 24 NOV 2009 | DOI: 10.1002/cncr.24752

      • original image
      • original image
      • original image
      • original image

      According to a nationwide survey, approximately 40.4% of radiation oncology practices in the United States screen for human papillomavirus (HPV) DNA or p16 in oropharyngeal carcinomas, whereas only 12.4% of those use it to further direct care. Clinical trials to further elucidate how HPV or p16 DNA status should direct care in oropharyngeal carcinoma are warranted.

    16. Symptom Control and Palliative Care
      You have free access to this content
      Methadone initiation and rotation in the outpatient setting for patients with cancer pain (pages 520–528)

      Henrique A. Parsons, Maxine de la Cruz, Badi El Osta, Zhijun Li, Bianca Calderon, J. Lynn Palmer and Eduardo Bruera

      Version of Record online: 18 NOV 2009 | DOI: 10.1002/cncr.24754

      • original image
      • original image
      • original image
      • original image

      Outpatient methadone initiation and rotation for cancer pain treatment showed very high success rates (92% and 84%, respectively). The use of methadone was associated with decreased frequency of opioid toxicities.

    17. You have free access to this content
      A multidimensional examination of correlates of fatigue during radiotherapy (pages 529–537)

      Amanda Purcell, Jennifer Fleming, Sally Bennett, Kathleen McGuane, Bryan Burmeister and Terry Haines

      Version of Record online: 17 NOV 2009 | DOI: 10.1002/cncr.24731

      • original image

      Fatigue is comprised of multiple dimensions. The objective of the current study was to investigate cancer-related fatigue in a radiotherapy sample using a multidimensional conceptualization to determine whether correlates of fatigue are consistent across all dimensions or whether each fatigue dimension has its own unique pattern of correlates.

  10. Correspondence

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. You have free access to this content
    2. You have free access to this content
  11. Errata

    1. Top of page
    2. CancerScope
    3. Commentary
    4. Editorials
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original articles
    10. Original Articles
    11. Correspondence
    12. Errata
    1. You have free access to this content
      Erratum (page 540)

      Version of Record online: 15 DEC 2009 | DOI: 10.1002/cncr.24910

    2. You have free access to this content
      Erratum (page 540)

      Version of Record online: 20 NOV 2009 | DOI: 10.1002/cncr.24825

      This article corrects:

      Cost effectiveness of mammography screening for Chinese women

      Vol. 110, Issue 4, 885–895, Version of Record online: 2 JUL 2007

SEARCH

SEARCH BY CITATION