The influence of high body mass index on the prognosis of patients with esophageal cancer after surgery as primary therapy (pages 5619–5627)
Yuki Hayashi, Arlene M. Correa, Wayne L. Hofstetter, Ara A. Vaporciyan, David C. Rice, Garrett L. Walsh, Reza J. Mehran, Jeffrey H. Lee, Manoop S. Bhutani, Alexander Dekovich, Stephen G. Swisher and Jaffer A. Ajani
Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25745
The authors reviewed 301 consecutive esophageal cancer patients who underwent surgery but received no adjunctive therapy. Patients were segregated into 2 subgroups by baseline body mass index (BMI): normal/low (<25 kg/m2) and overweight (≥25 kg/m2). In the high BMI group, there were more men (P < .001), fewer upper esophageal tumors (P = .021), lower baseline clinical stage (P = .006), and frequent esophageal adenocarcinoma (P < .001). Postoperative morbidity was similar in both groups with the exception of gastrointestinal complications (P = .016). The 5-year overall survival (OS) rates were 44% in the normal/low BMI group and 60% in the high BMI group (P = .017). High BMI is common in patients with esophageal cancer and the better OS/disease-free survival rates noted in patients with a high BMI is because of the diagnosis of low baseline clinical stage. Confirmation of these findings is warranted.