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Cancer

Cover image for Vol. 117 Issue 17

1 September 2011

Volume 117, Issue 17

Pages 3869–4102

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Physician finds volunteer work rewarding (page 3870)

      Carrie Printz

      Version of Record online: 19 AUG 2011 | DOI: 10.1002/cncr.26464

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  2. Editorials

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Assessing the impact of comorbid illnesses on death within 10 years in prostate cancer treatment candidates (pages 3872–3874)

      Shabbir M. H. Alibhai

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25976

      Groome et al use the case-cohort design to study the contribution of comorbidity to death from causes other than prostate cancer in a large group of men treated for cure. They modify an existing comorbidity instrument, the CIRS-G, for use to predict risk of dying from nonprostate cancer causes.

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      Follow-up after chemoradiation for cervical cancer: Why? (pages 3875–3878)

      Lua R. Eiriksson and Allan Covens

      Version of Record online: 8 MAR 2011 | DOI: 10.1002/cncr.25990

      After treatment for cervical cancer, patients are followed to detect recurrent disease, to manage treatment-related complications, and to address patient needs. FDG-PET has been introduced as a potential tool in prognostication and selection of patients for “low-risk” follow-up.

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      Hypomethylating agents for the treatment of acute myeloid leukemia in the elderly : For all, none, or which patients? (pages 3879–3881)

      Felicetto Ferrara and Pellegrino Musto

      Version of Record online: 1 FEB 2011 | DOI: 10.1002/cncr.25934

      The research with new agents is particularly active in acute myeloid leukemia (AML) and different studies suggest a potential utility of hypomethylating agents (HMA) in this disease. In this article, we critically appraise some recent clinical data reported on the use of HMA for the treatment of AML in older patient.

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      Toward predictors of survival in castration-resistant prostate cancer (pages 3882–3884)

      Julie N. Graff and Tomasz M. Beer

      Version of Record online: 9 MAR 2011 | DOI: 10.1002/cncr.25986

      Overall survival is a widely accepted endpoint in phase 3 clinical trials of castration-resistant prostate cancer (CRPC). However, the use of this endpoint is becoming more difficult as more agents are shown to improve survival in patients with CRPC. This editorial describes the commonly used surrogates for overall survival in CRPC with a special emphasis on radiographic response.

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      Turning conventional wisdom upside-down : Low Serum testosterone and high-risk prostate cancer (pages 3885–3888)

      Abraham Morgentaler

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25975

      A revolution in traditional oncological concepts has shifted our gaze from high serum testosterone to low testosterone as a potential predictor of high-risk prostate cancer. The results of a study by Salonia et al add to a growing literature indicating that preoperative low serum T increases the likelihood of high-risk prostate cancer.

  3. Review Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer (pages 3889–3899)

      Ravi Salgia

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/cncr.25935

      In an effort to provide more personalized and, perhaps, more effective treatment for patients, multiple components of angiogenic pathways are currently under investigation as biomarkers in NSCLC.

  4. Original Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. Disease Site

      Breast Disease
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      Effectiveness of alternating mammography and magnetic resonance imaging for screening women with deleterious BRCA mutations at high risk of breast cancer (pages 3900–3907)

      Huong T. Le-Petross, Gary J. Whitman, Deanne P. Atchley, Ying Yuan, Angelica Gutierrez-Barrera, Gabriel N. Hortobagyi, Jennifer K. Litton and Banu K. Arun

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25971

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      Magnetic resonance imaging (MRI), as a supplemental screening examination to mammography and clinical breast examination, has become the standard of care in women who are at high risk for developing breast cancer. When MRI was alternated with mammography at 6-month intervals, MRI detected cancers that were not detected on mammography 6 months earlier.

    2. Gastrointestinal Disease
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      Improved survival in patients with lymph node-positive gastric cancer who received preoperative radiation : An analysis of the surveillance, epidemiology, and end results database (pages 3908–3916)

      Ravi Shridhar, George W. Dombi, Steven E. Finkelstein, Kenneth L. Meredith and Sarah E. Hoffe

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25995

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      This analysis of the Surveillance, Epidemiology, and End Results database revealed that preoperative radiation therapy was associated with improved survival in patients with lymph node-positive gastric cancer. The results supported the use of preoperative radiation in select patients with gastric cancer; however, additional trials will be needed to confirm these findings.

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      Is the N1c category of the new american joint committee on cancer staging system applicable to patients with rectal cancer who receive preoperative chemoradiotherapy? (pages 3917–3924)

      Joon Seon Song, Hee Jin Chang, Dae Yong Kim, Sun Young Kim, Ji Yeon Baek, Ji Won Park, Sung Chan Park, Hyo Seong Choi and Jae Hwan Oh

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/cncr.25968

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      To evaluate the prognostic significance of the pathologic lymph node classification of N1c (without regional lymph node metastasis) according to the pathologic extent of disease (ypN1c) in patients with rectal cancer after preoperative chemoradiotherapy (CRT), the authors reclassified 136 rectal cancers that were classified as ypT3N0M0 according to the new American Joint Committee on Cancer staging system and analyzed patient outcomes. The findings indicated that the category N1c may not be appropriate for patients who have rectal cancer after preoperative CRT, because the definition of N1c was confusing and did not have prognostic significance.

    4. Genitourinary Disease
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      Salvage radiation in men after prostate-specific antigen failure and the risk of death (pages 3925–3932)

      Shane E. Cotter, Ming Hui Chen, Judd W. Moul, W. Robert Lee, Bridget F. Koontz, Mitchell S. Anscher, Cary N. Robertson, Philip J. Walther, Thomas J. Polascik and Anthony V. D'Amico

      Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.25993

      Salvage radiation therapy in the setting of PSA failure after radical prostatectomy is associated with a decreased risk in all-cause mortality in men with PSA doubling times less than or in excess of 6 months.

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      Temporal trends and predictors of pelvic lymph node dissection in open or minimally invasive radical prostatectomy (pages 3933–3942)

      Andrew H. Feifer, Elena B. Elkin, William T. Lowrance, Brian Denton, Lindsay Jacks, David S. Yee, Jonathan A. Coleman, Vincent P. Laudone, Peter T. Scardino and James A. Eastham

      Version of Record online: 15 MAR 2011 | DOI: 10.1002/cncr.25981

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      The authors uncovered a significant disparity in the use of pelvic lymph node dissection among patients who underwent minimally invasive radical prostatectomy compared with patients who underwent comparable open radical prostatectomy. This disparity was noted in patients who had an elevated risk of lymph node metastasis, who require lymph node dissection according to National Comprehensive Cancer Network and American Urological Association guidelines, and was not limited to those patients who achieve marginal benefits from lymph node removal.

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      Assessing the impact of comorbid illnesses on death within 10 years in prostate cancer treatment candidates (pages 3943–3952)

      Patti A. Groome, Susan L. Rohland, D. Robert Siemens, Michael D. Brundage, Jeremy Heaton and William J. Mackillop

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/cncr.25984

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      This study provides estimates of the prognostic impact of individual comorbid illnesses in prostate cancer and a modified comorbidity index for possible use in the clinic and future research on this patient population.

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      Preoperative hypogonadism is not an independent predictor of high-risk disease in patients undergoing radical prostatectomy (pages 3953–3962)

      Andrea Salonia, Andrea Gallina, Alberto Briganti, Firas Abdollah, Nazareno Suardi, Umberto Capitanio, Renzo Colombo, Massimo Freschi, Patrizio Rigatti and Francesco Montorsi

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25985

      Preoperative circulating total testosterone levels are not correlated with high-risk prostate cancer in patients undergoing radical prostatectomy. Likewise, preoperative hypogonadism per se is not an independent predictor of high-risk prostate cancer.

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      The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy (pages 3963–3971)

      Guru Sonpavde, Gregory R. Pond, William R. Berry, Ronald de Wit, Mario A. Eisenberger, Ian F. Tannock and Andrew J. Armstrong

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25982

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      The study retrospectively evaluated the landmark TAX327 phase 3 trial and demonstrated the potential use of objective tumor response as a signal of activity for cytotoxic agents in castration-resistant prostate cancer. Radiologic response remained a significant prognostic factor for survival after adjusting for treatment, pain response, and ≥30% prostate-specific antigen decline.

    9. Gynecologic Oncology
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      Incidence and mortality in epithelial ovarian cancer by family history of any cancer (pages 3972–3980)

      Kari Hemminki, Jan Sundquist and Andreas Brandt

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.26016

      Fatal familial risks were higher for concordant ovarian, ovarian-breast, and ovarian-prostate cancers than the corresponding incident risks. This may suggest that highly fatal subtypes exist for these cancers, calling for genetic dissection.

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      Impact of post-therapy positron emission tomography on prognostic stratification and surveillance after chemoradiotherapy for cervical cancer (pages 3981–3988)

      Shankar Siva, Alan Herschtal, Jessica M. Thomas, David M. Bernshaw, Suki Gill, Rodney J. Hicks and Kailash Narayan

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25991

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      A single post-therapy 18F-fluorodeoxyglucose positron emission tomography scan is a powerful predictor of survival after chemoradiotherapy of cervical cancer. Disease recurrence will rarely be detected by routine clinical follow-up after a complete metabolic response.

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      Up-regulation of microRNA-145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells (pages 3989–3998)

      Yanjing Wu, Shupeng Liu, Hong Xin, Jing Jiang, Edward Younglai, Shuhan Sun and Huilan Wang

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25944

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      Our study revealed the first evidence of the relationship between microRNA-145 (miR-145) and OCT4 in human endometrial cancer. miR-145 may become a strong candidate for tumor cells differentiation agent. miR-145 and OCT4 can be used as markers for the degree of differentiation in human endometrial cancer.

    12. Hematologic Malignancies
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      Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia (pages 3999–4008)

      Bang-Ning Lee, Hui Gao, Evan N. Cohen, Xavier Badoux, William G. Wierda, Zeev Estrov, Stefan H. Faderl, Michael J. Keating, Alessandra Ferrajoli and James M. Reuben

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/cncr.25983

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      Treatment with lenalidomide resulted in the normalization of functional T-cell subsets in responders suggesting that lenalidomide may modulate cell-mediated immunity in patients with chronic lymphocytic leukemia.

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      Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors (pages 4009–4017)

      Jesse Jaso, Deborah A. Thomas, Krista Cunningham, Jeffrey L. Jorgensen, Hagop M. Kantarjian, L. Jeffrey Medeiros and Sa A. Wang

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25978

      The prognostic significance of immunophenotypic, karytotypic, and molecular genetic features of previously established relevance in de novo adult Philadelphia chromosome (Ph)-positive B-lymphoblastic leukemia were reassessed in the context of intensive tyrosine kinase inhibitor (TKI)-based chemotherapy and compared with a contemporaneous cohort of adults with diploid karyotype B-lymphoblastic leukemia who received similar chemotherapy without TKIs. For Ph-positive acute lymphoblastic leukemia (ALL), cluster of differentiation 25 (CD25) (interleukin-2 receptor alpha chain) expression was associated initially with inferior survival. However, after adjusting for age, leukocyte count, and CD20 (B-lymphocyte antigen, nonglycosylated phosphoprotein) expression, CD25 expression no longer retained prognostic significance. Age remained the dominating factor in predicting outcome for adults with Ph-positive ALL.

    14. Hepatobiliary Disease
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      Prevention of intrahepatic distant recurrence by transcatheter arterial infusion chemotherapy with platinum agents for stage I/II hepatocellular carcinoma (pages 4018–4025)

      Toru Ishikawa, Kazuo Higuchi, Tomoyuki Kubota, Keiichi Seki, Terasu Honma, Toshiaki Yoshida and Tomoteru Kamimura

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.25989

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      The authors compared the efficacy of 2 platinum-based chemotherapeutic agents in combination with radical local treatment for preventing intrahepatic distant recurrence in patients with hepatocellular carcinoma (HCC). Hepatic arterial infusion (HAI) chemotherapy with cis-diamminedichloroplatinum (II) (cisplatin) before radical local treatment was effective in patients with HCC. The results indicated that radical local treatment with concurrent HAI using cisplatin may contribute to a longer progression-free period, which could be predicted with intrahepatic imaging in patients with stage I/II HCC.

    15. Neuro-Oncology
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      Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for bevacizumab (pages 4026–4032)

      Satoshi Matsusaka, Yuji Mishima, Mitsukuni Suenaga, Yasuhito Terui, Ryoko Kuniyoshi, Nobuyuki Mizunuma and Kiyohiko Hatake

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/cncr.25977

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      Levels of circulating endothelial progenitors on day 4 and the proportion of CXCR4-positive circulating endothelial cells at baseline were correlated with the prognosis of bevacizumab combination chemotherapy, suggesting that these surrogate markers may play a core role in the selection of candidates for bevacizumab treatment.

    16. Sarcoma
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      Age-related disparities in the use of radiotherapy for treatment of localized soft tissue sarcoma (pages 4033–4040)

      Janet K. Horton, John F. Gleason Jr., Heidi D. Klepin, Scott Isom, Daniel B. Fried and Ann M. Geiger

      Version of Record online: 8 MAR 2011 | DOI: 10.1002/cncr.25996

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      In this study, 1354 patients from the Surveillance, Epidemiology, and End Results database who underwent limb-sparing surgery for localized, high-grade soft tissue sarcoma of the extremity were stratified according to age and were evaluated for treatment with radiotherapy. Radiotherapy use decreased with increasing age, and a trend toward decreased disease-specific survival was observed among older adults who did not receive radiation treatment.

    17. Discipline

      Diagnostic Imaging
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      Diagnostic yield of percutaneous image-guided tissue biopsy of focal hepatic lesions in cancer patients : Ten percent are not metastases from the primary malignancy (pages 4041–4048)

      Khaled M. Elsayes, James H. Ellis, Tohamy Elkhouly, Justin M. Ream, Michyla Bowerson, Asra Khan and Elaine M. Caoili

      Version of Record online: 8 MAR 2011 | DOI: 10.1002/cncr.25980

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      The diagnostic yield was evaluated of percutaneous image-guided tissue biopsy of hepatic lesions identified on computed tomography performed for staging of a primary malignancy. The authors suggest that liver biopsy should still be performed in the types of cases studied, although the vast majority of biopsies produced the expected result and presumably did not change patient management.

    18. Medical Oncology
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      Farnesyl transferase expression determines clinical response to the docetaxel-lonafarnib combination in patients with advanced malignancies (pages 4049–4059)

      John Kauh, Chantal Chanel-Vos, Daniel Escuin, Michael P. Fanucchi, R. Donald Harvey, Nabil Saba, Dong M. Shin, Anthony Gal, Lin Pan, Michael Kutner, Suresh S. Ramalingam, Laura Bender, Adam Marcus, Paraskevi Giannakakou and Fadlo R. Khuri

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.26004

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      Farnesyl transferase mRNA expression levels may be a predictive biomarker for the combination of a farnesyl transferase inhibitor and docetaxel.

    19. Radiation Oncology
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      Stereotactic body radiotherapy for colorectal liver metastases : A pooled analysis (pages 4060–4069)

      Daniel T. Chang, Anand Swaminath, Margaret Kozak, Julie Weintraub, Albert C. Koong, John Kim, Rob Dinniwell, James Brierley, Brian D. Kavanagh, Laura A. Dawson and Tracey E. Schefter

      Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.25997

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      Sixty-five patients with colorectal liver metastases treated with stereotactic body radiotherapy from 3 institutions were analyzed. Higher local control was associated with higher total dose (P = .0015), and better overall survival was associated with lack of active extrahepatic disease (P = .046) and sustained local control (P = .06).

      Corrected by:

      Erratum: Erratum: Stereotactic body radiotherapy for colorectal liver metastases

      Vol. 118, Issue 10, 2776, Version of Record online: 20 SEP 2011

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      Upfront observation versus radiation for adult pilocytic astrocytoma (pages 4070–4079)

      Adrian Ishkanian, Normand J. Laperriere, Wei Xu, Barbara-Ann Millar, David Payne, Warren Mason and Arjun Sahgal

      Version of Record online: 9 MAR 2011 | DOI: 10.1002/cncr.25988

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      Adjuvant radiotherapy for pilocytic astrocytoma significantly prolonged progression-free survival at both 5 years and 10 years compared with observation but did not have an impact on overall survival. The current findings indicated that, because 85% of patients who have these tumors will survive for at least 10 years, observation with radiation reserved at the time of progression for noneloquent locations is safe and may be favored given the potential for long-term radiation-induced neurocognitive effects.

    21. Translational Research
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      A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers (pages 4080–4091)

      Duk-Hwan Kim, Seong-Eun Park, Minseung Kim, Yong Ick Ji, Mi Yeon Kang, Eun Hyun Jung, Eunkyung Ko, Yujin Kim, Sung Kim, Young Mog Shim and Joobae Park

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/cncr.25930

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      Single nucleotide polymorphisms (SNPs) are the most common types of genetic variation in humans and are related to the risk of a variety of cancers. Several SNPs at the promoter or exon of cyclins that are involved in cell cycle progression have been reported, but their correlation with the risk of human cancer has not been studied extensively. Results from the current study suggested that an SNP (reference SNP 769236) at the transcription start site of cyclin A2 may be associated significantly with an increased risk of colon, liver, and lung cancers.

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      Formation of solid tumors by a single multinucleated cancer cell (pages 4092–4099)

      Zhang Weihua, Qingtang Lin, Asa J. Ramoth, Dominic Fan and Isaiah J. Fidler

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/cncr.26021

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      Large multinucleated cells (MNCs) that were identified in cancer cell lines were able to form a tumor from a single cell. The findings indicated that investigation of the molecular features of MNCs can provide valuable information that may enhance current understanding of tumor formation by cancer cell lines and that MNCs may be important therapeutic targets.

  5. Correspondence

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Reply to treatment of pituitary neoplasms with temozolomide : A review (page 4102)

      Luis V. Syro, Kalman Kovacs and Bernd W. Scheithauer

      Version of Record online: 8 MAR 2011 | DOI: 10.1002/cncr.25998

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