Disease Site Breast Disease You have free access to this content Intraoperative molecular assay for sentinel lymph node metastases in early stage breast cancer : A comparative analysis between one-step nucleic acid amplification whole node assay and routine frozen section histology (pages 4365–4374)
Tomo Osako, Takuji Iwase, Kiyomi Kimura, Kyoko Yamashita, Rie Horii, Akio Yanagisawa and Futoshi Akiyama
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26060
Intraoperative one-step nucleic acid amplification (OSNA) assay using a whole lymph node detects more sentinel lymph node metastases, particularly micrometastases, than routine frozen section histology using a 2 mm-sectioned lymph node. The OSNA assay can also detect more metastases in elderly patients or from less progressive primary tumors than the frozen section histology.
You have free access to this content A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells (pages 4375–4380)
Nachman Mazurek, James C. Byrd, Yunjie Sun, Suguru Ueno and Robert S. Bresalier
Version of Record online: 28 MAR 2011 | DOI: 10.1002/cncr.26078
A common galectin-3 polymorphism, rs4644, is known to influence the susceptibility of galectin-3 to cleavage by matrix metalloproteinases and is associated with breast cancer incidence. The results of the current study demonstrated that this naturally occurring Pro64His mutation in galectin-3 increases sensitivity to death receptor-mediated apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Endocrine Disease You have free access to this content Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion : The University of Texas MD Anderson Cancer Center Experience (pages 4381–4389)
Shamim Ejaz, Rena Vassilopoulou-Sellin, Naifa L. Busaidy, Mimi I. Hu, Steven G. Waguespack, Camilo Jimenez, Anita K. Ying, Maria Cabanillas, Maher Abbara and Mouhammed Amir Habra
Version of Record online: 15 MAR 2011 | DOI: 10.1002/cncr.26029
In patients with Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion (CS-EAS) who attended a comprehensive cancer center, tumors originating in the chest cavity were the leading tumors associated with this syndrome. The authors suspect that CS-EAS is underreported, and they suggest a careful evaluation of patients with neuroendocrine tumors to avoid missing coexisting CS-EAS.
You have free access to this content Higher rate of BRAF mutation in papillary thyroid cancer over time : A single-institution study (pages 4390–4395)
Aarti Mathur, Willeford Moses, Reza Rahbari, Elham Khanafshar, Quan-Yang Duh, Orlo Clark and Electron Kebebew
Version of Record online: 15 MAR 2011 | DOI: 10.1002/cncr.26072
The authors found that the rate of
BRAF V600E mutation increased significantly over a 15-year period at their institution. This finding suggests that a higher rate of BRAF V600E mutation may contribute to the increasing incidence of thyroid cancer. You have free access to this content Steroid receptor expression in thymomas and thymic carcinomas (pages 4396–4405)
Takahiro Mimae, Koji Tsuta, Fumiaki Takahashi, Akihiko Yoshida, Tadashi Kondo, Yoshinori Murakami, Morihito Okada, Masahiro Takeuchi, Hisao Asamura and Hitoshi Tsuda
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26061
The results of the current study indicate that glucocorticoid receptor (GR) and estrogen receptor β were frequently expressed in thymoma and thymic carcinoma. GR protein expression was found to be correlated with a better prognosis for the patient with thymic epithelial tumors.
Genitourinary Disease You have free access to this content Impact of androgen deprivation on physical well-being in patients with prostate cancer : Analysis from the CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) registry (pages 4406–4413)
Natalia Sadetsky, Kirsten Greene, Matthew R. Cooperberg, Alan Hubbard, Peter R. Carroll and William Satariano
Version of Record online: 15 MAR 2011 | DOI: 10.1002/cncr.26064
As androgen deprivation therapy (ADT) becomes a standard of treatment for men with recurrent or metastatic prostate cancer, evaluation of adverse effects associated with this treatment is needed. In this study, exposure to ADT was associated with worse physical well-being in prostate cancer survivors.
Gynecologic Oncology You have free access to this content How are symptoms of ovarian cancer managed? : A study of primary care physicians (pages 4414–4423)
Barbara A. Goff, Barbara Matthews, C. Holly A. Andrilla, Jacqueline W. Miller, Katrina F. Trivers, Donna Berry, Denise M. Lishner and Laura-Mae Baldwin
Version of Record online: 16 MAR 2011 | DOI: 10.1002/cncr.26035
The majority of primary care physicians, when asked about a patient with symptoms suggestive of ovarian cancer, recommended diagnostic tests that would likely lead to a correct diagnosis. Ovarian cancer testing was more commonly recommended by gynecologists, those involved with clinical teaching, and those in group practices.
You have free access to this content Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy (pages 4424–4438)
Min-Yu Chen, Warren S.-L. Liao, Zhen Lu, William G. Bornmann, Violeta Hennessey, Michele N. Washington, Gary L. Rosner, Yinhua Yu, Ahmed Ashour Ahmed and Robert C. Bast Jr.
Version of Record online: 16 MAR 2011 | DOI: 10.1002/cncr.26073
A demethylating agent, 5-aza-2′-deoxycytidine, and a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), inhibited the growth of ovarian cancer cell lines and xenografts while inducing the expression of imprinted tumor suppressor genes (guanosine triphosphate-binding Di-RAS-like 3 [
ARHI] and paternally expressed 3 [ PEG3]), G2/M arrest, and/or autophagy. Head and Neck Disease You have free access to this content Rising incidence of second cancers in patients with low-risk (T1N0) thyroid cancer who receive radioactive iodine therapy (pages 4439–4446)
N. Gopalakrishna Iyer, Luc G. T. Morris, R. Michael Tuttle, Ashok R. Shaha and Ian Ganly
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26070
Despite the lack of evidence for any benefit from radioactive iodine (RAI) ablation in patients with low-risk (T1N0), differentiated thyroid cancer, statistics from the Surveillance, Epidemiology, and End Results database indicate that its use has increased from 3.3% to 38.1% in the last 3 decades. The use of RAI is associated with a significantly higher incidence of second primary malignancies, providing a strong rationale for limiting its use in this patient population.
You have free access to this content Examination of laryngoesophageal dysfunction-free survival as an endpoint in nonsurgical treatment of squamous cell carcinomas of the larynx and hypopharynx (pages 4447–4451)
Jimmy J. Caudell, William R. Carroll, Sharon A. Spencer and James A. Bonner
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26066
Laryngoesophageal dysfunction-free survival (LEDFS) is a new endpoint recommended for future clinical trials for laryngeal and hypopharyngeal cancer. In this retrospective analysis, LEDFS was superior for patients who received concurrent chemoradiation over radiation alone.
You have free access to this content Plasma Epstein-Barr virus DNA screening followed by 18F-fluoro-2-deoxy-D-glucose positron emission tomography in detecting posttreatment failures of nasopharyngeal carcinoma (pages 4452–4459)
Wen-Yi Wang, Chih-Wen Twu, Wan-Yu Lin, Rong-San Jiang, Kai-Li Liang, Kuan-Wen Chen, Ching-Te Wu, Yi-Ting Shih and Jin-Ching Lin
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26069
Applying the strategy of Epstein-Barr virus DNA screening followed by positron emission tomography as a diagnostic modality for the clinical follow-up of patients with nasopharyngeal carcinoma (NPC) not only accurately predicted NPC relapse but also appropriately guided further treatment planning in a cost-effective manner.
You have free access to this content The prognostic and staging implications of bone invasion in oral squamous cell carcinoma (pages 4460–4467)
Ardalan Ebrahimi, Rajmohan Murali, Kan Gao, Michael S. Elliott and Jonathan R. Clark
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26032
This retrospective study demonstrated that medullary bone invasion is an independent predictor of reduced survival in patients with oral squamous cell carcinoma, and this appears to result from an increased risk of distant metastatic failure. However, within the subset of patients with medullary invasion, survival differs significantly based on tumor size, limiting the prognostic utility of designating all such tumors as T4. We propose a revision of the American Joint Committee on Cancer T staging system based on our results.
Hematologic Malignancies You have free access to this content Solitary plasmacytomas : Outcome and prognostic factors after definitive radiation therapy (pages 4468–4474)
Valerie Reed, Jatin Shah, L. Jeffery Medeiros, Chul S. Ha, Ali Mazloom, Donna M. Weber, Isidora Y. Arzu, Robert Z. Orlowski, Sheeba K. Thomas, Ferial Shihadeh, Raymond Alexanian and Bouthaina S. Dabaja
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26031
In this retrospective analysis, the authors evaluated the outcome of patients with solitary plasmacytoma who received definitive radiation therapy and investigated the impact of size, location, and the presence of serum paraprotein at diagnosis on the risk of developing multiple myeloma.
Hepatobiliary Disease You have free access to this content Hepatocellular carcinoma with extrahepatic metastasis : Clinical features and prognostic factors (pages 4475–4483)
Koji Uchino, Ryosuke Tateishi, Shuichiro Shiina, Miho Kanda, Ryota Masuzaki, Yuji Kondo, Tadashi Goto, Masao Omata, Haruhiko Yoshida and Kazuhiko Koike
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.25960
The major cause of death in patients with hepatocellular carcinoma (HCC) who had extrahepatic metastases was the progression of intrahepatic HCC lesions. The current results indicate that the ability to control intrahepatic lesions and performance status are important prognostic factors in these patients.
You have free access to this content Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? (pages 4484–4492)
Antoine Brouquet, Michael J. Overman, Scott Kopetz, Dipen M. Maru, Evelyne M. Loyer, Andreas Andreou, Amanda Cooper, Steven A. Curley, Christopher R. Garrett, Eddie K. Abdalla and Jean-Nicolas Vauthey
Version of Record online: 28 MAR 2011 | DOI: 10.1002/cncr.26036
Resection of colorectal liver metastases (CLM) after second-line chemotherapy regimen was found to be safe and was associated with a modest hope for definitive cure. This approach represents a viable option in patients with advanced CLM.
Lung Disease You have free access to this content Neutrophil interactions with sialyl Lewis X on human nonsmall cell lung carcinoma cells regulate invasive behavior (pages 4493–4505)
Catherine A. St. Hill, Katherine Krieser and Mariya Farooqui
Version of Record online: 22 MAR 2011 | DOI: 10.1002/cncr.26059
A human nonsmall cell lung carcinoma (NSCLC) cell line that expressed the transfected α(1,3/1,4) fucosyltransferase (
FucT-III) gene produced cell membrane sialyl Lewis X (sLeX), released neutrophil chemoattractants, and demonstrated increased invasiveness compared with the NSCLC cell line that lacked sLeX. Because exposure of transfected lung cancer cells to neutrophil-derived tumor necrosis factor-α further enhanced these properties, the authors concluded that FucT-III activity and sLeX expression in lung carcinomas may recruit neutrophils in the tumor microenvironment that subsequently enhance the invasive and metastatic potential of lung cancer cells. Neuro-Oncology You have free access to this content Pulmonary metastases in patients with recurrent, treatment-resistant meningioma : Prognosis and identification by 111indium-octreotide imaging (pages 4506–4511)
Daniela Alexandru, Michael J. Glantz, Lyndon Kim, Marc C. Chamberlain and Daniela A. Bota
Version of Record online: 28 MAR 2011 | DOI: 10.1002/cncr.26065
The presence of pulmonary metastases appears to negatively predict for survival in patients with recurrent meningioma. The utility of
111indium ( 111In)-octreotide scintigraphy should be considered in staging patients with recurrent meningioma who are being considered for further treatment. You have free access to this content High frequency of neurolymphomatosis as a relapse disease of intravascular large B-cell lymphoma (pages 4512–4521)
Kosei Matsue, Brian Y. Hayama, Kan-Ichi Iwama, Takafumi Koyama, Hideaki Fujiwara, Masayuki Yamakura, Masami Takeuchi and Toshihiro O'uchi
Version of Record online: 29 MAR 2011 | DOI: 10.1002/cncr.26090
Over the past 4 years, the authors identified 4 patients with neurolymphomatosis (NL) among 11 patients who had intravascular large B-cell lymphoma (IVL) at their institution. Considering the rarity of IVL and NL, the current observations indicate that IVL may have a predilection not only for the vessels but also both the central and peripheral nervous systems.
Sarcoma You have free access to this content Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma (pages 4522–4530)
I. Frank Ciernik, Andrzej Niemierko, David C. Harmon, Wendy Kobayashi, Yen-Lin Chen, Torunn I. Yock, David H. Ebb, Edwin Choy, Kevin A. Raskin, Norbert Liebsch, Francis J. Hornicek and Thomas F. DeLaney
Version of Record online: 29 MAR 2011 | DOI: 10.1002/cncr.26037
The cohort of Massachusetts General Hospital patients with inoperable or incompletely resectable osteosarcoma treated with proton or combined photon/proton therapy was reviewed. Local control could be achieved in >70% of cases with acceptable toxicity in most patients.
Discipline Disparities Research You have free access to this content Persistent disparities in liver transplantation for patients with hepatocellular carcinoma in the United States, 1998 through 2007 (pages 4531–4539)
Anthony S. Robbins, Derrick D. Cox, Lynt B. Johnson and Elizabeth M. Ward
Version of Record online: 29 MAR 2011 | DOI: 10.1002/cncr.26063
Between 1998 and 2007, there were large and persistent racial/ethnic disparities in the receipt of liver transplantation among patients with hepatocellular carcinoma. These disparities were not explained by socioeconomic or clinical factors.
Pediatric Oncology You have free access to this content Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder (pages 4540–4550)
Jennifer Picarsic, Ronald Jaffe, George Mazariegos, Steve A. Webber, Demetrius Ellis, Michael D. Green and Miguel Reyes-Múgica
Version of Record online: 28 MAR 2011 | DOI: 10.1002/cncr.26001
Burkitt lymphoma as a post-transplant lymphoproliferative disorder appears to be distinct and monomorphic with a more aggressive course; thus, there is a need for immediate antineoplastic therapy. Burkitt lymphoma post-transplant lymphoproliferative disorder has a more prevalent Epstein-Barr virus expression than that seen in sporadic and immunodeficient Burkitt lymphoma and represents a distinct entity.
Psychosocial Oncology You have free access to this content Undocumented alcoholism and its correlation with tobacco and illegal drug use in advanced cancer patients (pages 4551–4556)
Rony Dev, Henrique A. Parsons, Shana Palla, J. Lynn Palmer, Egidio Del Fabbro and Eduardo Bruera
Version of Record online: 28 MAR 2011 | DOI: 10.1002/cncr.26082
The objectives of the current study were to determine the frequency of undiagnosed alcoholism among patients with advanced cancer and to explore its correlation with alcoholism, tobacco abuse, and the use of illegal drugs. The findings suggested that alcoholism is highly prevalent and frequently underdiagnosed in patients with advanced cancer. Patients who scored positive on a screening survey that was designed to identify alcoholism were more likely to have a history of, or to actively engage in, smoking and illegal recreational drug use, placing them at risk for unnecessary opioid escalation.
Radiation Oncology You have free access to this content Three-dimensional external beam radiotherapy for prostate cancer increases the risk of hip fracture (pages 4557–4565)
Sean P. Elliott, Stephanie L. Jarosek, Shaheen R. Alanee, Badrinath R. Konety, Kathryn E. Dusenbery and Beth A. Virnig
Version of Record online: 16 MAR 2011 | DOI: 10.1002/cncr.25994
In a SEER-Medicare dataset of men treated for prostate cancer, external beam radiotherapy was associated with a 76% increased risk of hip fracture without any increased risk of fall-related fractures outside the radiation field (ie, forearm fractures).
You have free access to this content A survey of stereotactic body radiotherapy use in the United States (pages 4566–4572)
Hubert Pan, Daniel R. Simpson, Loren K. Mell, Arno J. Mundt and Joshua D. Lawson
Version of Record online: 15 MAR 2011 | DOI: 10.1002/cncr.26067
Stereotactic body radiotherapy (SBRT) has rapidly become a widely adopted treatment approach among radiation oncologists in the United States. SBRT use appears to be increasing, and further research is needed to determine its benefits and risks.