Clinical and molecular features of papillary thyroid cancer in adolescents and young adults (pages 259–267)
Menno R. Vriens, Willieford Moses, Julie Weng, Miao Peng, Ann Griffin, Archie Bleyer, Brad H Pollock, Daniel J. Indelicato, Jimmy Hwang and Electron Kebebew
Article first published online: 7 SEP 2010 | DOI: 10.1002/cncr.25369
The extent of disease at presentation and survival among adolescents and young adults with papillary thyroid carcinoma differed from that among older patients. The current results indicated that this difference may be caused by candidate genes (extracellular matrix protein 1 [ECM1], v-erb-2 erythroblastic leukemia viral oncogene homolog 2 [ERBB2], urinary plasminogen activator [UPA], 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [PFKFB2], meis homeobox 2 [MEIS2], and carbonic anhydrase II [CA2]) that are expressed differentially and may play important roles in tumor cell biology.