Pleomorphic liposarcoma : Clinical observations and molecular variables (pages 5359–5369)
Markus P. Ghadimi, Ping Liu, Tingsheng Peng, Svetlana Bolshakov, Eric D. Young, Keila E. Torres, Chiara Colombo, Aviad Hoffman, Dominique Broccoli, Jason L. Hornick, Alexander J. Lazar, Peter Pisters, Raphael E. Pollock and Dina Lev
Article first published online: 19 MAY 2011 | DOI: 10.1002/cncr.26195
Pleomorphic liposarcoma (PLS) is an aggressive, commonly metastasizing sarcoma, and identifying the ubiquitous molecular events underlying PLS progression is crucial for progress in patient management and outcomes. In this study, the authors investigated the natural history and clinical outcome of a large PLS cohort treated at a single institution, seeking to identify disease-specific survival prognosticators and to identify commonly deregulated molecular processes/biomarkers using human PLS specimens assembled in a tissue microarray.