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Cancer

Cover image for Vol. 117 Issue 23

1 December 2011

Volume 117, Issue 23

Pages 5247–5431

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
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    2. You have free access to this content
    3. You have free access to this content
  2. Review Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    1. You have full text access to this OnlineOpen article
      Risk factors for radiation-induced hypothyroidism : A literature-based meta-analysis (pages 5250–5260)

      Ivan R. Vogelius, Søren M. Bentzen, Maja V. Maraldo, Peter M. Petersen and Lena Specht

      Article first published online: 12 MAY 2011 | DOI: 10.1002/cncr.26186

      A systematic overview and meta-analysis of studies reporting data on hypothyroidism (HT) after radiation therapy was conducted to identify risk factors for development of HT.

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      Early cytogenetic and molecular response during first-line treatment of chronic myeloid leukemia in chronic phase : Long-term implications (pages 5261–5270)

      Alfonso Quintás-Cardama, Jorgé E. Cortes and Hagop M. Kantarjian

      Article first published online: 19 MAY 2011 | DOI: 10.1002/cncr.26196

      In patients with chronic myeloid leukemia in chronic phase, several studies have shown that early response to imatinib is associated with optimal long-term outcomes. These findings highlight the significance of emerging data from randomized trials showing that compared with imatinib, both dasatinib and nilotinib are associated with higher response rates at early time points and more rapid responses.

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      A review of body size and breast cancer risk in Hispanic and African American women (pages 5271–5281)

      Krystal R. Sexton, Luisa Franzini, R. Sue Day, Abenaa Brewster, Sally W. Vernon and Melissa L. Bondy

      Article first published online: 19 MAY 2011 | DOI: 10.1002/cncr.26217

      It has been demonstrated that obesity reduces the risk of premenopausal breast cancer but increases the risk of postmenopausal disease in studies comprised mostly of non-Hispanic white women. In this review, the authors summarized the studies of obesity and breast cancer in both Hispanic women and African American women and identified gaps in the literature in these minority populations.

  3. Original Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    1. Disease Site

      Gastrointestinal Disease
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      Cyclic 3′,5′-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia (pages 5282–5293)

      In-Kiu Kwon, Rui Wang, Nikhil Prakash, Renee Bozard, Troy A. Baudino, Kebin Liu, Muthusamy Thangaraju, Zheng Dong and Darren D. Browning

      Article first published online: 11 MAY 2011 | DOI: 10.1002/cncr.26192

      Ectopic cyclic 3′,5′-guanosine monophosphate-dependent protein kinase (PKG) expression in colon cancer cells inhibited response to hypoxia, including up-regulation of vascular endothelial growth factor and glycolytic enzymes, and caused necrotic cell death in hypoxic conditions. The effect of PKG on hypoxia was at the level of hypoxia inducible factor activity, but it did not affect protein levels or nuclear translocation.

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      Interactive effects of fatty acid and butyrate-induced mitochondrial Ca2+ loading and apoptosis in colonocytes (pages 5294–5303)

      Satya Kolar, Rola Barhoumi, Chris K. Jones, Joshua Wesley, Joanne R. Lupton, Yang-Yi Fan and Robert S. Chapkin

      Article first published online: 11 MAY 2011 | DOI: 10.1002/cncr.26205

      The current study demonstrated that the pleiotropic bioactive components generated by fermentable fiber (butyrate) and fish oil (docosahexaenoic acid but not eicosapentaenoic acid) worked in a coordinated fashion to trigger a Ca2+-dependent, intrinsic mitochondrial-mediated, apoptotic pathway in colonocytes.

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      Fibroblast growth factor receptor 4 regulates proliferation and antiapoptosis during gastric cancer progression (pages 5304–5313)

      Yan Wei Ye, Ye Zhou, Lin Yuan, Chun Meng Wang, Chun Yan Du, Xiao Yan Zhou, Bi Qiang Zheng, Xi Cao, Meng Hong Sun, Hong Fu and Ying Qiang Shi

      Article first published online: 12 MAY 2011 | DOI: 10.1002/cncr.26207

      Fibroblast growth factor receptor 4 (FGFR4) expression in gastric cancer tissue was extremely high. The current results revealed that FGFR4 may contribute to gastric cancer progression by regulating proliferation and antiapoptosis, indicating a potential, novel drug target against gastric cancer.

    4. Genitourinary Disease
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      The Karakiewicz nomogram is the most useful clinical predictor for survival outcomes in patients with localized renal cell carcinoma (pages 5314–5324)

      Min-Han Tan, Huihua Li, Caroline Victoria Choong, Kee Seng Chia, Chee Keong Toh, Tiffany Tang, Puay Hoon Tan, Chin Fong Wong, Weber Lau and Christopher Cheng

      Article first published online: 12 MAY 2011 | DOI: 10.1002/cncr.26193

      The Karakiewicz nomogram was found to be the most useful clinical predictor of survival outcomes in localized renal cell carcinoma compared with the Kattan nomogram, the Sorbellini nomogram, and the Leibovich model in terms of accuracy, calibration, and clinical net benefit. Exploratory comparison of a discretized Karakiewicz nomogram and the current SORCE trial recruitment criteria favored the discretized Karakiewicz nomogram.

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      A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder : Epidemiology, prognostic variables, and treatment trends (pages 5325–5333)

      Eugene J. Koay, Bin S. Teh, Arnold C. Paulino and E. Brian Butler

      Article first published online: 12 MAY 2011 | DOI: 10.1002/cncr.26197

      In this study, the authors delineated the patient population for small cell carcinoma of the bladder, described several independent prognostic variables, and demonstrated clear treatment trends. The data suggested that a simpler staging system (ie, limited stage vs extensive stage) may be appropriate for this disease.

    6. Gynecologic Oncology
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      Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians : A vignette-based study (pages 5334–5343)

      Katrina F. Trivers, Laura-Mae Baldwin, Jacqueline W. Miller, Barbara Matthews, C. Holly A. Andrilla, Denise M. Lishner and Barbara A. Goff

      Article first published online: 25 JUL 2011 | DOI: 10.1002/cncr.26166

      Physicians self-report they would refer many women at average risk for developing ovarian cancer for genetic counseling/testing, for whom counseling and testing is not recommended. Too few physicians report referring high-risk women, for whom counseling/testing is recommended.

    7. Lung Disease
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      An E3 ubiquitin ligase: c-Cbl : A new therapeutic target of lung cancer (pages 5344–5350)

      Fang-Yi Lo, Yi-Hung Carol Tan, Hung-Chi Cheng, Ravi Salgia and Yi-Ching Wang

      Article first published online: 23 MAY 2011 | DOI: 10.1002/cncr.26153

      The results of the current study provide compelling evidence that overexpression of an E3 ubiquitin ligase Casitas B-lineage lymphoma protein, c-Cbl, inhibits tumor growth and tumor metastasis in lung cancer xenograft models. Ectopic expression of c-Cbl protein could be a therapeutic strategy for patients with lung cancer.

    8. Neuro-Oncology
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      Phase 2 study of carboplatin, irinotecan, and bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy (pages 5351–5358)

      David A. Reardon, Annick Desjardins, Katherine B. Peters, James J. Vredenburgh, Sridharan Gururangan, John H. Sampson, Roger E. McLendon, James E. Herndon II, April Coan, Stevie Threatt, Allan H. Friedman and Henry S. Friedman

      Article first published online: 16 MAY 2011 | DOI: 10.1002/cncr.26188

      Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor, was shown to improve outcome for recurrent glioblastoma (GBM) patients; however, no effective therapy has been identified for patients who progress on bevacizumab therapy. This phase 2 study demonstrated that carboplatin, irinotecan, and bevacizumab had modest activity and an adequate safety profile among recurrent GBM patients who progressed previously on bevacizumab.

    9. Sarcoma
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      Pleomorphic liposarcoma : Clinical observations and molecular variables (pages 5359–5369)

      Markus P. Ghadimi, Ping Liu, Tingsheng Peng, Svetlana Bolshakov, Eric D. Young, Keila E. Torres, Chiara Colombo, Aviad Hoffman, Dominique Broccoli, Jason L. Hornick, Alexander J. Lazar, Peter Pisters, Raphael E. Pollock and Dina Lev

      Article first published online: 19 MAY 2011 | DOI: 10.1002/cncr.26195

      Pleomorphic liposarcoma (PLS) is an aggressive, commonly metastasizing sarcoma, and identifying the ubiquitous molecular events underlying PLS progression is crucial for progress in patient management and outcomes. In this study, the authors investigated the natural history and clinical outcome of a large PLS cohort treated at a single institution, seeking to identify disease-specific survival prognosticators and to identify commonly deregulated molecular processes/biomarkers using human PLS specimens assembled in a tissue microarray.

    10. Discipline

      Epidemiology
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      Nicotine dependence phenotype and lung cancer risk (pages 5370–5376)

      Joshua E. Muscat, Kwangmi Ahn, John P. Richie Jr and Steven D. Stellman

      Article first published online: 8 AUG 2011 | DOI: 10.1002/cncr.26236

      The time to first cigarette after waking is a nicotine dependence behavior associated with nicotine uptake. The results of the current study indicate that it is a significant predictor of lung cancer risk.

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      Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer (pages 5377–5382)

      Joshua E. Muscat, Kwangmi Ahn, John P. Richie Jr and Steven D. Stellman

      Article first published online: 8 AUG 2011 | DOI: 10.1002/cncr.26235

      The time to first cigarette after waking is a nicotine dependence behavior associated with nicotine uptake. The results of the current study demonstrate that it is a significant predictor of head and neck cancer risk.

    12. Outcomes Research
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      Support of cancer patients' spiritual needs and associations with medical care costs at the end of life (pages 5383–5391)

      Tracy Balboni, Michael Balboni, M. Elizabeth Paulk, Andrea Phelps, Alexi Wright, John Peteet, Susan Block, Chris Lathan, Tyler VanderWeele and Holly Prigerson

      Article first published online: 11 MAY 2011 | DOI: 10.1002/cncr.26221

      Cancer patients whose spiritual needs are not well supported by the health care team have higher end of life costs, particularly minorities and high religious copers.

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      Compliance with guidelines for patients with bladder cancer : Variation in the delivery of care (pages 5392–5401)

      Karim Chamie, Christopher S. Saigal, Julie Lai, Jan M. Hanley, Claude M. Setodji, Badrinath R. Konety, Mark S. Litwin and The Urologic Diseases in America Project

      Article first published online: 11 JUL 2011 | DOI: 10.1002/cncr.26198

      Of 4545 eligible cases of high-grade non–muscle-invasive bladder cancer, only 1 received all guideline-recommended measures. Using mixed-effects analysis, the authors demonstrated a significant percentage of this low compliance rate to be provider-driven.

    14. Pediatric Oncology
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      Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood (pages 5402–5411)

      Donald J. Mabbott, Eric Monsalves, Brenda J. Spiegler, Ute Bartels, Laura Janzen, Sharon Guger, Normand Laperriere, Nicole Andrews and Eric Bouffet

      Article first published online: 11 MAY 2011 | DOI: 10.1002/cncr.26127

      General cognitive abilities appeared stable and intact after treatment for most children with central nervous system germ cell tumors (CNS GCT), but a significant decline over time in working memory, processing speed, and visual memory was evident. Tumor location appeared to be important in understanding the trajectory of stability and decline in CNS GCT patients, as did radiation field.

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      Perifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo (pages 5412–5422)

      Zhijie Li, Doo-Yi Oh, Katsuya Nakamura and Carol J. Thiele

      Article first published online: 16 MAY 2011 | DOI: 10.1002/cncr.26133

      High expression of brain-derived neurotrophic factor (BDNF)/TrkB or activated Akt is associated with decreased event-free or overall survival in patients with neuroblastoma. The Akt inhibitor perifosine attenuated BDNF/TrkB-induced resistance to the chemotherapeutic drug etoposide both in vitro and in vivo in an isogenic TrkB-expressing neuroblastoma model.

    16. Radiation Oncology
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      Thoracic radiation therapy improves the overall survival of patients with extensive-stage small cell lung cancer with distant metastasis (pages 5423–5431)

      Hui Zhu, Zongmei Zhou, Yan Wang, Nan Bi, Qinfu Feng, Junling Li, Jima Lv, Dongfu Chen, Yuankai Shi and Luhua Wang

      Article first published online: 11 MAY 2011 | DOI: 10.1002/cncr.26206

      The addition of thoracic radiation therapy (TRT) to chemotherapy (ChT) improved the overall survival (OS) of patients with extensive-stage small cell lung cancer. The receipt of ≥4 cycles of ChT and/or TRT was an independent, favorable prognostic factor for OS.

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