You have free access to this content

Cancer

Cover image for Vol. 117 Issue 7

1 April 2011

Volume 117, Issue 7

Pages 1331–1556

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    1. You have free access to this content
    2. You have free access to this content
    3. You have free access to this content
  2. Review Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    1. You have free access to this content
      Venous thromboembolism in the patient with cancer : Focus on burden of disease and benefits of thromboprophylaxis (pages 1334–1349)

      Gary H. Lyman

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25714

      • original image

      Venous thromboembolism (VTE) is a common complication of cancer and cancer treatment and is associated with considerable morbidity and mortality. Thromboprophylaxis may be considered in selected high-risk patients. Improved methods for the identification of these patients as well as the evaluation of new anticoagulants are important to improve outcomes for patients with cancer.

  3. Original Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    1. Disease Site

      Breast Disease
      You have free access to this content
      CK8/18 expression, the basal phenotype, and family history in identifying BRCA1-associated breast cancer in the Ontario site of the Breast Cancer Family Registry (pages 1350–1359)

      Anna Marie Mulligan, Dushanthi Pinnaduwage, Anita L. Bane, Shelley B. Bull, Frances P. O'Malley and Irene L. Andrulis

      Version of Record online: 2 NOV 2010 | DOI: 10.1002/cncr.25642

      Reduced CK8/18 expression was significantly associated with BRCA1 germline mutations. In conjunction with the basal-like phenotype and family history, this association may have helped streamline genetic testing.

    2. You have free access to this content
      Prognosis and pathology of screen-detected carcinomas : How different are they? (pages 1360–1368)

      Iris D. Nagtegaal, Prue C. Allgood, Stephen W. Duffy, Olive Kearins, E. O. Sullivan, Nancy Tappenden, Matthew Wallis and Gill Lawrence

      Version of Record online: 2 NOV 2010 | DOI: 10.1002/cncr.25613

      • original image
      • original image
      • original image

      Most of the survival advantage seen in women with screen-detected breast cancer compared with women diagnosed symptomatically can be accounted for by age and routinely measured histological factors. This leaves a small proportion to be explained by lead time and unmeasured biological features.

    3. You have free access to this content
      Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors (pages 1369–1376)

      Brent J. Small, Kerri Sharp Rawson, Erin Walsh, Heather S. L. Jim, Tiffany F. Hughes, Lindsay Iser, Michael A. Andrykowski and Paul B. Jacobsen

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25685

      The impact of cancer treatment on cognitive performance is an important quality-of-life outcome for cancer survivors. In this study, the authors demonstrated that breast cancer survivors who were treated with chemotherapy were at the greatest risk of cognitive impairment if they carried the catechol-O-methyltransferase Val gene.

    4. Endocrine Disease
      You have free access to this content
      Peptide receptor radioligand therapy is an effective treatment for the long-term stabilization of malignant gastrinomas (pages 1377–1385)

      Simona Grozinsky-Glasberg, Dganit Barak, Merav Fraenkel, Martin A. Walter, Jan Müeller-Brand, Joseph Eckstein, Liat Applebaum, Ilan Shimon and David J. Gross

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25646

      • original image
      • original image
      • original image

      PRRT seems to be a promising tool for the management of patients with inoperable or progressive metastatic gastrinomas. Early use of PRRT in these patients is recommended, before tumor progression and patient deterioration have occurred.

    5. You have free access to this content
      Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method (pages 1386–1398)

      Scott N. Pinchot, Renata Jaskula-Sztul, Li Ning, Noel R. Peters, Mackenzie R. Cook, Muthusamy Kunnimalaiyaan and Herbert Chen

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25652

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Notch activation has been shown to suppress growth and hormone production in carcinoid cells. The purpose of this study was to provide a process for identifying Notch activating compounds via high-throughput screening and to validate the effects of the strongest hit from the 7264 compounds analyzed: resveratrol.

    6. Gastrointestinal Disease
      You have free access to this content
      Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers (pages 1399–1408)

      Yoshifumi Baba, Katsuhiko Nosho, Kaori Shima, Marika Hayashi, Jeffrey A. Meyerhardt, Andrew T. Chan, Edward Giovannucci, Charles S. Fuchs and Shuji Ogino

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25630

      • original image
      • original image
      • original image

      p-AKT expression in colorectal cancer was associated with PIK3CA mutation, early stage, and good prognosis. p-AKT expression may have served as a tissue biomarker to identify patients with better prognosis and a possible therapeutic target.

    7. You have free access to this content
      A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus (pages 1409–1414)

      David H. Ilson, David Kelsen, Manish Shah, Gary Schwartz, Douglas A. Levine, Jeff Boyd, Marinela Capanu, Benjamin Miron and David Klimstra

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25602

      The authors evaluated an oral epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, for the treatment of patients who had previously treated esophageal cancer. Erlotinib had limited activity in esophageal cancer, with responses observed in patients who had squamous cell cancers. The current results indicated that further evaluation of erlotinib in patients with squamous cancers might be warranted.

    8. You have free access to this content
      Perineural invasion in pT3N0 rectal cancer : The incidence and its prognostic effect (pages 1415–1421)

      Junjie Peng, Weiqi Sheng, Dan Huang, Alan P. Venook, Ye Xu, Zuqing Guan and Sanjun Cai

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25620

      • original image
      • original image
      • original image

      Perineural invasion is a common pathologic feature in rectal cancer. Rectal cancer patients with positive perineural invasion are at higher risk of local recurrence and should be considered for more intensive treatment.

    9. You have free access to this content
      Second-line chemotherapy with fluorouracil, leucovorin, and irinotecan (FOLFIRI regimen) in patients with advanced small bowel adenocarcinoma after failure of first-line platinum-based chemotherapy : A multicenter AGEO study (pages 1422–1428)

      Aziz Zaanan, Mélanie Gauthier, David Malka, Christophe Locher, Jean-Marc Gornet, Anne Thirot-Bidault, David Tougeron, Julien Taïeb, Franck Bonnetain, Thomas Aparicio and for the Association des Gastro Entérologues Oncologues

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25614

      • original image

      Second-line chemotherapy with FOLFIRI produced disease control in half of patients with advanced small bowel adenocarcinoma after failure with first-line platinum-based chemotherapy. Median PFS and OS were 3.2 and 10.5 months, respectively.

    10. Genitourinary Disease
      You have free access to this content
      Ten-year outcomes of high-dose, intensity-modulated radiotherapy for localized prostate cancer (pages 1429–1437)

      Zumre A. Alicikus, Yoshiya Yamada, Zhigang Zhang, Xin Pei, Margie Hunt, Marisa Kollmeier, Brett Cox and Michael J. Zelefsky

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25467

      • original image
      • original image
      • original image
      • original image
      • original image

      The authors investigated long-term tumor-control and toxicity outcomes after high-dose, intensity-modulated radiation therapy (IMRT) in patients with clinically localized prostate cancer. High-dose IMRT was well tolerated and was associated with excellent long-term tumor-control outcomes in these patients.

    11. Gynecologic Oncology
      You have free access to this content
      Expectant management versus immediate treatment for low-grade cervical intraepithelial neoplasia : A randomized trial in Canada and Brazil (pages 1438–1445)

      Laurie Elit, Mark N. Levine, Jim A. Julian, John W. Sellors, Alice Lytwyn, Sylvia Chong, James B. Mahony, ChuShu Gu, Terri Finch and Luiz C. Zeferino

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25635

      • original image

      Our objective was to compare the effectiveness of regular colposcopic follow-up and treatment of progressive disease only versus immediate treatment. In this randomized trial of noninferiority design, we showed that the risk of progression to CIN grade 2 or 3, or cancer over 18 months, was similar in the 2 treatment groups.

    12. You have free access to this content
      DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma (pages 1446–1453)

      Israel Zighelboim, Andrew J. Reinhart, Feng Gao, Amy P. Schmidt, David G. Mutch, Premal H. Thaker and Paul J. Goodfellow

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25665

      • original image
      • original image

      Lower expression levels of DICER1 transcripts were correlated with worse outcomes in patients with endometrioid endometrial cancer. The factors that influence DICER1 transcript levels in primary endometrial tumors remain unknown.

    13. Head and Neck Disease
      You have free access to this content
      MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck (pages 1454–1462)

      Scott M. Langevin, Roslyn A. Stone, Clareann H. Bunker, Maureen A. Lyons-Weiler, William A. LaFramboise, Lori Kelly, Raja R. Seethala, Jennifer R. Grandis, Robert W. Sobol and Emanuela Taioli

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25689

      • original image
      • original image

      MicroRNA-137 promoter methylation was detected in squamous cell carcinoma of the head and neck across all sites. Methylation-positive tumor tissue was associated with poorer overall survival.

    14. Hematologic Malignancies
      You have free access to this content
      Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome (pages 1463–1469)

      Celeste Bello, Daohai Yu, Rami S. Komrokji, Weiwei Zhu, Gene A. Wetzstein, Alan F. List and Jeffrey E. Lancet

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25598

      • original image
      • original image

      Prognostic factors in secondary acute myeloid leukemia have not been clearly defined. This study demonstrated that the type of prior treatment for an antecedent myelodysplastic syndrome/myeloproliferative neoplasm and the duration of the disorder negatively affect a patient's response to induction therapy.

    15. You have free access to this content
      Timeliness and quality of diagnostic care for medicare recipients with chronic lymphocytic leukemia (pages 1470–1477)

      Christopher R. Friese, Craig C. Earle, Lysa S. Magazu, Jennifer R. Brown, Bridget A. Neville, Nathanael D. Hevelone, Lisa C. Richardson and Gregory A. Abel

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25655

      • original image

      The authors used SEER-Medicare data to investigate delays in diagnosis and use of baseline flow cytometry for patients with chronic lymphocytic leukemia. Delays in diagnosis did not affect mortality, but use of flow cytometry at diagnosis was associated with improved survival.

    16. You have free access to this content
      Breast implant-associated, ALK-negative, T-cell, anaplastic, large-cell lymphoma: Establishment and characterization of a model cell line (TLBR-1) for this newly emerging clinical entity (pages 1478–1489)

      Melissa G. Lechner, Stephen Lade, Daniel J. Liebertz, H. Miles Prince, Garry S. Brody, Howard R. Webster and Alan L. Epstein

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25654

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Recent evidence suggests an increased incidence of anaplastic large-cell kinase (ALK)-negative, T-cell, non-Hodgkin Lymphoma arising in association with salt-withdrawal textured breast implants. TLBR-1, a novel T-cell, anaplastic, large-cell lymphoma, has been established and characterized from a surgical biopsy and represents an important tool for studying this newly recognized disease entity.

    17. You have free access to this content
      Efficacy and safety of clofarabine in relapsed and/or refractory non-hodgkin lymphoma, including rituximab-refractory patients (pages 1490–1497)

      Chadi Nabhan, Nancy Davis, Jacob D. Bitran, Angel Galvez, Walter Fried, Kathy Tolzien, Susan Foss, Wendy M. Dewey and Parameswaran Venugopal

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25603

      • original image
      • original image

      The results from this study indicated that intravenous clofarabine is safe and active in patients with refractory non-Hodgkin lymphoma, including those who are rituximab-refractory.

    18. Hepatobiliary Disease
      You have free access to this content
      Chemoembolization of intrahepatic cholangiocarcinoma with cisplatinum, doxorubicin, mitomycin C, ethiodol, and polyvinyl alcohol : A 2-center study (pages 1498–1505)

      Matthew V. Kiefer, Marissa Albert, Madeline McNally, Mary Robertson, Weijing Sun, Douglas Fraker, Kim Olthoff, Kathleen Christians, Sam Pappas, William Rilling and Michael C. Soulen

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25625

      • original image
      • original image
      • original image
      • original image
      • original image

      Chemoembolization of intrahepatic cholangiocarcinoma and adenocarcinoma of unknown primary (AUP) provided disease control in 76% with median survival of 20 months in the setting of multidisciplinary care, with the best result among those receiving integrated liver-directed and systemic therapy. Outcome was identical for cholangiocarcinoma and AUP, supporting the hypothesis that these represent a histologic continuum.

    19. Lung Disease
      You have free access to this content
      Racial disparities in the use of hospice services according to geographic residence and socioeconomic status in an elderly cohort with nonsmall cell lung cancer (pages 1506–1515)

      Dale Hardy, Wenyaw Chan, Chih-Chin Liu, Janice N. Cormier, Rui Xia, Eduardo Bruera and Xianglin L. Du

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25669

      • original image
      • original image

      There were substantial disparities in the receipt of hospice services among ethnic minorities within urban and rural areas and within socioeconomic status levels. The results from this study indicated that efforts are needed to identify barriers, enhance support, and educate patients on the benefits of hospice services.

    20. You have free access to this content
      Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27 (pages 1516–1528)

      Han-Shui Hsu, Jiun-Han Lin, Wen-Chien Huang, Tien-Wei Hsu, Kelly Su, Shih-Hwa Chiou, Yo-Ting Tsai and Shih-Chieh Hung

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25599

      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image
      • original image

      Lung cancer stem cells have elevated levels of activated Hsp27 upon treatment with superoxide and traditional chemotherapy. When combined with chemotoxic agents, blockage of Hsp27 decreased the survival of lung cancer stem cells, which otherwise were resistant to traditional chemotherapy.

    21. Sarcoma
      You have free access to this content
      Malignant sarcoma of the pelvic bones : Treatment outcomes and prognostic factors vary by histopathology (pages 1529–1541)

      Muhammad Umar Jawad, Abdul Ahad Haleem and Sean P. Scully

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25684

      • original image
      • original image
      • original image

      Survival and prognostics among patients with pelvic bone sarcomas varied with histopathological diagnoses. Although surgical resection was associated with superior outcomes for osteosarcoma and chondrosarcoma, there was no significant difference in outcomes of patients with Ewing sarcoma treated with surgery and/or radiotherapy.

    22. Discipline

      Disparities Research
      You have free access to this content
      Socioeconomic status and survival after an invasive breast cancer diagnosis (pages 1542–1551)

      Brian L. Sprague, Amy Trentham-Dietz, Ronald E. Gangnon, Ritesh Ramchandani, John M. Hampton, Stephanie A. Robert, Patrick L. Remington and Polly A. Newcomb

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25589

      The authors of this report examined both individual-level and community-level socioeconomic status in relation to breast cancer survival in a population-based cohort. The results indicated that early detection with mammography may account for most of the substantial disparity in survival according to income; however, disparities by education level could not be explained fully by variation in early detection and lifestyle factors.

    23. Epidemiology
      You have free access to this content
      Diabetes and risk of bladder cancer : Evidence from a case-control study in New England (pages 1552–1556)

      Todd MacKenzie, Michael S. Zens, Assiamira Ferrara, Alan Schned and Margaret R. Karagas

      Version of Record online: 8 NOV 2010 | DOI: 10.1002/cncr.25641

      In this population-based case-control study, risk of bladder cancer was elevated among those patients with a history of diabetes, in particular those taking oral hypoglycemics or insulin.

SEARCH

SEARCH BY CITATION