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Cancer

Cover image for Vol. 117 Issue 9

1 May 2011

Volume 117, Issue 9

Pages 1785–2016

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
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    2. You have free access to this content
    3. You have free access to this content
  2. Review Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
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      Metabolic surgery and cancer : Protective effects of bariatric procedures (pages 1788–1799)

      Hutan Ashrafian, Kamran Ahmed, Simon P. Rowland, Vanash M. Patel, Nigel J. Gooderham, Elaine Holmes, Ara Darzi and Thanos Athanasiou

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25738

      Metabolic operations demonstrate a significant reduction of mortality and incidence of cancer. The cancer protective role of metabolic surgery is strongest for obesity-related cancers in females. This may allude to the beneficial association of surgery for sex-steroid–related cancers.

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      Practical advice for determining the role of BCR-ABL mutations in guiding tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia (pages 1800–1811)

      Elias Jabbour, Susan Branford, Giuseppe Saglio, Dan Jones, Jorge E. Cortes and Hagop M. Kantarjian

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25717

      For patients with chronic myeloid leukemia (CML), in vitro 50% inhibitory concentration data alone in the absence of clinical data are insufficient to guide the choice of tyrosine kinase inhibitor (TKI) therapy in the presence of a mutant breakpoint cluster region-v-abl Abelson murine leukemia viral oncogene homolog (BCR-ABL) clone. Results from this review indicated that the choice of second-line TKI therapy should involve examination of patient comorbidities, safety profile, and BCR-ABL mutations in the minority of patients who have mutations that have been associated with less favorable responses to second-generation TKIs.

      Corrected by:

      Erratum: Erratum

      Vol. 117, Issue 15, 3535, Article first published online: 10 JAN 2011

  3. Original Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    1. Disease Site

      Breast Disease
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      Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations (pages 1812–1818)

      Louise Bordeleau, Lorraine Lipscombe, Jan Lubinski, Parviz Ghadirian, William D. Foulkes, Susan Neuhausen, Peter Ainsworth, Michael Pollak, Ping Sun, Steven A. Narod and the Hereditary Breast Cancer Clinical Study Group

      Article first published online: 10 NOV 2010 | DOI: 10.1002/cncr.25595

      The risk of new onset diabetes was doubled among BRCA carriers in the 15-year period after the diagnosis of breast cancer (relative risk, 2.0; 95% confidence interval [CI], 1.4-2.8; P = .0001), compared with carriers without cancer. The risk was particularly high for women with a body mass index >25.0 kg/m2 (odds ratio, 5.8; 95% CI, 4.0-8.6; P = .0001).

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      Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early : A large population-based study (pages 1819–1826)

      Shaheenah Dawood, Naoto T. Ueno, Vicente Valero, Wendy A. Woodward, Thomas A. Buchholz, Gabriel N. Hortobagyi, Ana Maria Gonzalez-Angulo and Massimo Cristofanilli

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25682

      In the era of multidisciplinary management and anthracycline-based and taxane-based polychemotherapy regimens, women with inflammatory breast cancer (IBC) continue to have worse survival outcomes compared with those with non-IBC locally advanced breast cancer, with differences in survival appearing early.

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      Correlates of worry about recurrence in a multiethnic population-based sample of women with breast cancer (pages 1827–1836)

      Nancy K. Janz, Sarah T. Hawley, Mahasin S. Mujahid, Jennifer J. Griggs, Amy Alderman, Ann S. Hamilton, John J. Graff, Reshma Jagsi and Steven J. Katz

      Article first published online: 28 MAR 2011 | DOI: 10.1002/cncr.25740

      Less worry about recurrence was associated with greater ease of understanding information, better symptom management, and more coordinated care. Less acculturated Latina breast cancer patients are vulnerable to high levels of worry.

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      Multifactorial central nervous system recurrence susceptibility in patients with HER2-positive breast cancer : Epidemiological and clinical data from a population-based cancer registry study (pages 1837–1846)

      Antonino Musolino, Laura Ciccolallo, Michele Panebianco, Elisa Fontana, Daniele Zanoni, Cecilia Bozzetti, Maria Michiara, Enrico Maria Silini and Andrea Ardizzoni

      Article first published online: 10 NOV 2010 | DOI: 10.1002/cncr.25771

      This cancer registry study provides evidence that patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer have a significantly high incidence of central nervous system (CNS) metastasis after treatment with trastuzumab. The putative increase in CNS disease in women with HER2-positive breast cancer appears to be multifactorial, and can include both inherent biological factors and treatment-related factors.

    5. Gastrointestinal Disease
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      DNA methylation predicts recurrence from resected stage III proximal colon cancer (pages 1847–1854)

      Joong Bae Ahn, Woon Bok Chung, Osamu Maeda, Sang Joon Shin, Hyun Soo Kim, Hyun Chul Chung, Nam Kyu Kim and Jean-Pierre J. Issa

      Article first published online: 18 NOV 2010 | DOI: 10.1002/cncr.25737

      CIMP1 and low LINE1 methylation were independent prognostic factors for disease-free survival (DFS) in proximal colorectal cancer (CRC). DNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC.

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      A novel tumor-node-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database (pages 1855–1863)

      Tristan D. Yan, Marcello Deraco, Dominique Elias, Olivier Glehen, Edward A. Levine, Brendan J. Moran, David L. Morris, Terence C. Chua, Pompiliu Piso, Paul H. Sugarbaker and Peritoneal Surface Oncology Group

      Article first published online: 18 NOV 2010 | DOI: 10.1002/cncr.25640

      The proposed TNM staging system for diffuse malignant peritoneal mesothelioma emphasizes the prognostic importance of Peritoneal Cancer Index, lymph node involvement, and extra-abdominal metastasis. The staging system results in significant stratification of survival by stage when applied to current multi-institutional registry data.

    7. Head and Neck Disease
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      Nuclear localization of Nm23-H1 in head and neck squamous cell carcinoma is associated with radiation resistance (pages 1864–1873)

      Haeng Ran Park, Se-Heon Kim, Sei Young Lee, Ji Min Sung, Ae Ran Park, Suki Kang, Baek Gil Kim, Yoon Pyo Choi, Yong-Bae Kim and Nam Hoon Cho

      Article first published online: 18 NOV 2010 | DOI: 10.1002/cncr.25760

      Overexpression of Nm23-H1, specifically its nuclear translocation, may be a powerful predictor of radiation resistance in head and neck squamous cell carcinoma.

      Corrected by:

      Erratum: Erratum: Nuclear Localization of Nm23-H1 in Head and Neck Squamous Cell Carcinoma Is Associated With Radiation Resistance

      Vol. 117, Issue 12, 2825, Article first published online: 29 DEC 2010

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      Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy : Long-term results of a phase 2 study (pages 1874–1883)

      Wei-Wei Xiao, Shao-Min Huang, Fei Han, Shao-Xiong Wu, Li-Xia Lu, Cheng-Guang Lin, Xiao-Wu Deng, Tai-Xiang Lu, Nian-Ji Cui and Chong Zhao

      Article first published online: 16 NOV 2010 | DOI: 10.1002/cncr.25754

      The SMART boost scheme to protect normal tissue, with acceptable toxicity through its superior dose distribution, and to enhance biologically effective dose to nasopharynx gross target volume to improve long-term local control rates and survival, is feasible in patients with locally advanced nasopharyngeal carcinoma. Long-term results showed excellent local control with acceptable mild late toxicities.

    9. Hematologic Malignancies
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      The efficacy and safety of bortezomib and dexamethasone as a maintenance therapy in patients with advanced multiple myeloma who are responsive to salvage bortezomib-containing regimens (pages 1884–1890)

      Giulia Benevolo, Alessandra Larocca, Massimo Gentile, Patrizia Pregno, Francesca Gay, Barbara Botto, Chiara Frairia, Andrea Evangelista, Fortunato Morabito, Mario Boccadoro, Umberto Vitolo and Antonio Palumbo

      Article first published online: 18 NOV 2010 | DOI: 10.1002/cncr.25743

      This is the first study that evaluated the efficacy and safety of bortezomib and dexamethasone combination as maintenance therapy in refractory/relapsed myeloma patients responding to salvage therapies containing bortezomib. We performed a prospective analysis and showed that the combination VD is effective and well tolerated. The maintenance therapy improves the quality of responses obtained with salvage therapy and determine a PFS at 1 years of 61% that was significantly high in this subgroups of patients.

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      B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia (pages 1891–1900)

      Mascha Binder, Fabian Müller, Antje Jackst, Barbara Léchenne, Milena Pantic, Ulrike Bacher, Christine zu Eulenburg, Hendrik Veelken, Roland Mertelsmann, Renata Pasqualini, Wadih Arap and Martin Trepel

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25755

      A novel system for modeling epitope reactivity revealed that the epitope recognition pattern of B-cell receptors in chronic lymphocytic leukemia is surprisingly uniform and that a polyreactive pattern may be a determinant of an aggressive clinical course.

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      Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma (pages 1901–1910)

      Sascha Dietrich, Blanca Tielesch, Michael Rieger, Maike Nickelsen, Christiane Pott, Mathias Witzens-Harig, Michael Kneba, Norbert Schmitz, Antony D. Ho and Peter Dreger

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25756

      The current results indicated that, although the outcome of patients with mantle cell lymphoma who relapse remains poor, allogeneic stem cell transplantation may offer the possibility of long-term remissions.

    12. Neuro-Oncology
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      Treatment of epidural spinal cord involvement from germ cell tumors with chemotherapy (pages 1911–1916)

      Christian Grommes, George J. Bosl and Lisa M. DeAngelis

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25693

      Chemotherapy alone is effective in treating epidural spinal cord compression caused by germ cell tumors, with excellent clinical outcomes.

    13. Discipline

      Clinical Trials
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      Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy (pages 1917–1927)

      Gary H. Lyman, Nicole M. Kuderer, Jeffrey Crawford, Debra A. Wolff, Eva Culakova, Marek S. Poniewierski and David C. Dale

      Article first published online: 29 NOV 2010 | DOI: 10.1002/cncr.25691

      A prospective cohort study was undertaken to develop and validate a risk model for neutropenic complications in cancer patients receiving chemotherapy. After adjustment for cancer type and age, major independent risk factors in multivariate analysis included: prior chemotherapy, abnormal hepatic and renal function, low white blood count, chemotherapy and planned delivery ≥85%. Model risk discrimination for neutropenic events was excellent. With further validation, this application may guide the effective and cost-effective use of available supportive care.

    14. Diagnostic Imaging
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      Laparoscopic extraperitoneal para-aortic lymphadenectomy in locally advanced cervical cancer : A prospective correlation of surgical findings with positron emission tomography/computed tomography findings (pages 1928–1934)

      Pedro T. Ramirez, Anuja Jhingran, Homer A. Macapinlac, Elizabeth D. Euscher, Mark F. Munsell, Robert L. Coleman, Pamela T. Soliman, Kathleen M. Schmeler, Michael Frumovitz and Lois M. Ramondetta

      Article first published online: 16 NOV 2010 | DOI: 10.1002/cncr.25739

      Laparoscopic extraperitoneal para-aortic staging is safe and feasible and should be considered before radiation therapy in patients with locally advanced cervical cancer. The correlation of positron emission tomography/computed tomography findings with histopathologic results is limited.

    15. Disparities Research
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      Head and neck cancer-specific survival based on socioeconomic status in Asians and Pacific Islanders (pages 1935–1945)

      Karen P. Chu, Sarah Shema, Simon Wu, Scarlett L. Gomez, Ellen T. Chang and Quynh-Thu Le

      Article first published online: 10 NOV 2010 | DOI: 10.1002/cncr.25723

      Neighborhood socioeconomic status was associated with longer disease-specific survival and overall survival in Asians and Pacific Islanders with head and neck cancer. The effect of socioeconomic status on head and neck cancer survival should be considered in future studies, and particular attention should be paid to clinical care of head and neck cancer patients of lower socioeconomic status.

    16. Epidemiology
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      Late age at first full term birth is strongly associated with lobular breast cancer (pages 1946–1956)

      Polly A. Newcomb, Amy Trentham-Dietz, John M. Hampton, Kathleen M. Egan, Linda Titus-Ernstoff, Shaneda Warren Andersen, E. Robert Greenberg and Walter C. Willett MD, DrPH

      Article first published online: 10 NOV 2010 | DOI: 10.1002/cncr.25728

      Stronger associations observed for late age at first birth and nulliparity suggest that these factors preferentially stimulate growth of lobular breast carcinomas. Recent temporal changes in reproductive patterns and rates of obesity may impact the histological presentation of breast cancer.

    17. Outcomes Research
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      A comparison of charlson and elixhauser comorbidity measures to predict colorectal cancer survival using administrative health data (pages 1957–1965)

      Jessica R. Lieffers, Vickie E. Baracos, Marcy Winget and Konrad Fassbender

      Article first published online: 22 DEC 2010 | DOI: 10.1002/cncr.25653

      This study was the first to directly compare survival determination by the Charlson and Elixhauser comorbidity measures in colorectal cancer patients. The finding that Elixhauser is a superior comorbidity risk-adjustment method is significant because most studies use the Charlson method.

    18. Pediatric Oncology
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      Impact of insurance type on survivor-focused and general preventive health care utilization in adult survivors of childhood cancer : The Childhood Cancer Survivor Study (CCSS) (pages 1966–1975)

      Jacqueline Casillas, Sharon M. Castellino, Melissa M. Hudson, Ann C. Mertens, Isac S. F. Lima, Qi Liu, Lonnie K. Zeltzer, Yutaka Yasui, Leslie L. Robison and Kevin C. Oeffinger

      Article first published online: 10 NOV 2010 | DOI: 10.1002/cncr.25688

      The influence of insurance type (private, public, none) on survivor-focused and general preventive health care in adult survivors of childhood cancer was examined. Publicly insured survivors utilized survivor-focused health care at rates at least as high as survivors with private insurance; however, health care utilization was significantly lower for the uninsured.

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      Successful nontransplant resection of POST-TEXT III and IV hepatoblastoma (pages 1976–1983)

      Timothy B. Lautz, Tamar Ben-Ami, Niramol Tantemsapya, Yasmin Gosiengfiao and Riccardo A. Superina

      Article first published online: 16 NOV 2010 | DOI: 10.1002/cncr.25722

      Excellent survival (93%) was possible with aggressive resection in children with POST-TEXT III and IV hepatoblastoma. Patients with large residual tumors after neoadjuvant chemotherapy did not all require liver transplantation.

    20. Psychosocial Oncology
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      Marital status and stage at diagnosis of cutaneous melanoma : Results from the Surveillance Epidemiology and End Results (SEER) program, 1973-2006 (pages 1984–1993)

      John M. McLaughlin, James L. Fisher and Electra D. Paskett

      Article first published online: 10 NOV 2010 | DOI: 10.1002/cncr.25726

      An analysis of 192,014 cutaneous melanoma patients from SEER, 1976-2006 showed that unmarried patients had higher risk of being diagnosed at late stage among males and females, and that the magnitude of the effect varied by gender. Results from this study are important and may be used by clinicians and public health practitioners interested in increasing the proportion of melanoma patients diagnosed at early stage through screening, perhaps by specifically targeting unmarried individuals in addition to broad-based skin cancer prevention programs.

    21. Symptom Control and Palliative Care
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      Cancer-related chronic pain : Examining quality of life in diverse cancer survivors (pages 1994–2003)

      Carmen R. Green, Tamera Hart-Johnson and Deena R. Loeffler

      Article first published online: 18 NOV 2010 | DOI: 10.1002/cncr.25761

      This survey study examining cancer-related chronic pain and its impact on quality of life (QOL) in cancer survivors found that 20% were experiencing current pain and 43% had experienced pain since their diagnosis. Pain was related to poorer QOL and was more frequently experienced by women; blacks experienced greater pain severity.

    22. Translational Research
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      Considering temozolomide as a novel potential treatment for esophageal cancer (pages 2004–2016)

      Céline Bruyère, Caroline Lonez, Anaelle Duray, Stéphanie Cludts, Jean-Marie Ruysschaert, Sven Saussez, Paul Yeaton, Robert Kiss and Tatjana Mijatovic

      Article first published online: 8 NOV 2010 | DOI: 10.1002/cncr.25687

      The current results emphasized the role of proangiogenic chemokines in esophageal cancer biology and suggested a novel proposal for therapy involving C-X-C chemokine ligand (CXCL) inhibition to improve clinical outcomes. In vivo data demonstrated that were therapeutic benefits from temozolomide (TMZ) in an experimental esophageal cancer model that affected both cancer cell proliferation and CXCL-dependent, vascular endothelial growth factor-independent angiogenesis The results indicated that TMZ is a potential new therapeutic strategy for esophageal cancer.

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