Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations (pages 1812–1818)
Louise Bordeleau, Lorraine Lipscombe, Jan Lubinski, Parviz Ghadirian, William D. Foulkes, Susan Neuhausen, Peter Ainsworth, Michael Pollak, Ping Sun, Steven A. Narod and the Hereditary Breast Cancer Clinical Study Group
Version of Record online: 10 NOV 2010 | DOI: 10.1002/cncr.25595
The risk of new onset diabetes was doubled among BRCA carriers in the 15-year period after the diagnosis of breast cancer (relative risk, 2.0; 95% confidence interval [CI], 1.4-2.8; P = .0001), compared with carriers without cancer. The risk was particularly high for women with a body mass index >25.0 kg/m2 (odds ratio, 5.8; 95% CI, 4.0-8.6; P = .0001).