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Cancer

Cover image for Vol. 118 Issue 10

15 May 2012

Volume 118, Issue 10

Pages 2563–2776

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Erratum
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    2. You have free access to this content
  2. Editorials

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Erratum
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      Selective detection of aggressive prostate cancer (pages 2568–2570)

      Fritz H. Schröder and Monique J. Roobol

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/cncr.26385

      Selectively identifying aggressive prostate cancer will reduce unnecessary testing and overdiagnosis. Multivariate models can be of assistance but require proper validation, and users must be aware of the setting from which the models were derived.

  3. Review Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Erratum
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      Ensuring quality cancer care : A follow-up review of the Institute of Medicine's 10 recommendations for improving the quality of cancer care in America (pages 2571–2582)

      Tracy Spinks, Heidi W. Albright, Thomas W. Feeley, Ron Walters, Thomas W. Burke, Thomas Aloia, Eduardo Bruera, Aman Buzdar, Lewis Foxhall, David Hui, Barbara Summers, Alma Rodriguez, Raymond DuBois and Kenneth I. Shine

      Version of Record online: 1 NOV 2011 | DOI: 10.1002/cncr.26536

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      In 1999, the Institute of Medicine outlined 10 recommendations to optimize cancer care for all Americans. Limited progress has been made in implementing these recommendations, and additional efforts are needed to ensure the quality of cancer care in the United States.

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      Castration-resistant prostate cancer: Many treatments, many options, many challenges ahead (pages 2583–2593)

      Jorge A. Garcia and Brian I. Rini

      Version of Record online: 28 OCT 2011 | DOI: 10.1002/cncr.26582

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      New chemotherapeutic approaches have demonstrated clinical benefit in the management of castration-resistant prostate cancer (CRPC), with novel adrenal androgen inhibitors also exhibiting antitumor activity. This review summarizes the current management of CRPC and discusses future directions.

  4. Original Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Erratum
    1. Disease Site

      Breast Disease
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      Clinical trial results of the HER-2/neu (E75) vaccine to prevent breast cancer recurrence in high-risk patients : From US Military Cancer Institute Clinical Trials Group Study I-01 and I-02 (pages 2594–2602)

      Elizabeth A. Mittendorf, Guy T. Clifton, Jarrod P. Holmes, Kevin S. Clive, Ritesh Patil, Linda C. Benavides, Jeremy D. Gates, Alan K. Sears, Alexander Stojadinovic, Sathibalan Ponniah and George E. Peoples

      Version of Record online: 11 OCT 2011 | DOI: 10.1002/cncr.26574

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      A phase 1-2 clinical trial vaccinating human leukocyte antigen A2/A3+ breast cancer patients with the human epidermal growth receptor 2 (HER2)-derived E75 vaccine in the adjuvant setting has been completed. The vaccine has clinical efficacy that is more prominent in certain patients, including those with lymph node-positive, HER2 immunohistochemistry 1+ or 2+, or grade 1 or 2 disease who received the optimal vaccine dose.

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      Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients (pages 2603–2614)

      Eun-Jung Jung, Libero Santarpia, Juyeon Kim, Francisco J. Esteva, Erica Moretti, Aman U. Buzdar, Angelo Di Leo, Xiao-Feng Le, Robert C. Bast Jr, Soon-Tae Park, Lajos Pusztai and George A. Calin

      Version of Record online: 5 OCT 2011 | DOI: 10.1002/cncr.26565

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      Circulating levels of microRNA 210 correlate with trastuzumab sensitivity, tumor presence, and lymph node metastasis. Plasma microRNA 210 may be used to predict and perhaps monitor response to therapies that contain trastuzumab.

    3. Endocrine Disease
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      Association between tamoxifen treatment and diabetes : A population-based study (pages 2615–2622)

      Lorraine L. Lipscombe, Hadas D. Fischer, Lingsong Yun, Andrea Gruneir, Peter Austin, Lawrence Paszat, Geoff M. Anderson and Paula A. Rochon

      Version of Record online: 20 SEP 2011 | DOI: 10.1002/cncr.26559

      There is evidence that estrogen deficiency may increase the risk of diabetes, which has implications for breast cancer patients being treated with adjuvant hormonal therapy. This population-based nested case-control study from Ontario, Canada, of 14,360 breast cancer survivors aged 66 years or older finds that current tamoxifen treatment is associated with a significant increase in the incidence of diabetes compared with no tamoxifen treatment (adjusted odds ratio, 1.24; 95% confidence interval, 1.08-1.42; P = .002).

    4. Gastrointestinal Disease
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      Stool DNA testing for the detection of pancreatic cancer : Assessment of methylation marker candidates (pages 2623–2631)

      John B. Kisiel, Tracy C. Yab, William R. Taylor, Suresh T. Chari, Gloria M. Petersen, Douglas W. Mahoney and David A. Ahlquist

      Version of Record online: 22 SEP 2011 | DOI: 10.1002/cncr.26558

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      Aberrant methylation of gene promoters discriminates pancreatic cancer from controls when assayed from tissue specimens. This study reports the first known noninvasive molecular detection of pancreatic cancer using stool DNA assay of methylated bone morphogenic protein 3, alone and in combination with mutant KRAS.

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      Failure patterns in patients with esophageal cancer treated with definitive chemoradiation (pages 2632–2640)

      James Welsh, Stephen H. Settle, Arya Amini, Lianchun Xiao, Akihiro Suzuki, Yuki Hayashi, Wayne Hofstetter, Ritsuko Komaki, Zhongxing Liao and Jaffer A. Ajani

      Version of Record online: 5 OCT 2011 | DOI: 10.1002/cncr.26586

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      Most local failures after definitive chemoradiation for unresectable esophageal cancer occur within the gross tumor volume. Future therapeutic strategies should focus on enhancing local control.

    6. Genitourinary Disease
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      The impact of biomarkers in multivariate algorithms for bladder cancer diagnosis in patients with hematuria (pages 2641–2650)

      Funso Abogunrin, Hugh F. O'Kane, Mark W. Ruddock, Michael Stevenson, Cherith N. Reid, Joe M. O'Sullivan, Neil H. Anderson, Declan O'Rourke, Brian Duggan, John V. Lamont, Ruth E. Boyd, Peter Hamilton, Thiagarajan Nambirajan and Kate E. Williamson

      Version of Record online: 14 SEP 2011 | DOI: 10.1002/cncr.26544

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      We appraised 23 biomarkers representing diverse carcinogenic pathways and created a multivariate algorithm that significantly improved on the ROC statistic based on demographics. This algorithm once translated into a biochip format could be used to inform risk stratification of hematuria patients.

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      Selective detection of histologically aggressive prostate cancer : An Early Detection Research Network Prediction model to reduce unnecessary prostate biopsies with validation in the Prostate Cancer Prevention Trial (pages 2651–2658)

      Stephen B. Williams, Simpa Salami, Meredith M. Regan, Donna P. Ankerst, John T. Wei, Mark A. Rubin, Ian M. Thompson and Martin G. Sanda

      Version of Record online: 17 OCT 2011 | DOI: 10.1002/cncr.26396

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      A predictive model incorporating age, family history, obesity, prostate-specific antigen density, and digital rectal examination has been proposed in detecting aggressive prostate cancer. Using these criteria, ¼ of prostate biopsies can be avoided.

    8. Hematologic Malignancies
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      Validation of the MD Anderson Prognostic Risk Model for patients with myelodysplastic syndrome (pages 2659–2664)

      Rami S. Komrokji, Maria Corrales-Yepez, Najla Al Ali, Mohammad Kharfan-Dabaja, Eric Padron, Teresa Fields, Jeffrey E. Lancet and Alan F. List

      Version of Record online: 28 SEP 2011 | DOI: 10.1002/cncr.26567

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      We validated the new proposed MD Anderson Risk Model for MDS in a cohort of 755 patients. This is the first study to externally validate this proposed risk model, demonstrating that it is complementary to International Prognostic Scoring System (IPSS) and refines the precision.

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      Prognostic significance of alterations in IDH enzyme isoforms in patients with AML treated with high-dose cytarabine and idarubicin (pages 2665–2673)

      Farhad Ravandi, Keyur Patel, Rajyalakshmi Luthra, Stefan Faderl, Marina Konopleva, Tapan Kadia, Mark Brandt, Sherry Pierce, Steven Kornblau, Michael Andreeff, Xuemei Wang, Guillermo Garcia-Manero, Jorge Cortes and Hagop Kantarjian

      Version of Record online: 21 OCT 2011 | DOI: 10.1002/cncr.26580

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      IDH mutations have been identified in patients with acute myeloid leukemia. Their prognostic impact, particularly among patients with diploid cytogenetics, is evaluated.

    10. Hepatobiliary Disease
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      Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent (pages 2674–2681)

      Skye C. Mayo, Hari Nathan, John L. Cameron, Kelly Olino, Barish H. Edil, Joseph M. Herman, Kenzo Hirose, Richard D. Schulick, Michael A. Choti, Christopher L. Wolfgang and Timothy M. Pawlik

      Version of Record online: 20 SEP 2011 | DOI: 10.1002/cncr.26553

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      Conditional survival is a useful adjunct to help counsel patients with resected pancreatic cancer because it accounts for survival time already accrued.

    11. Soft Tissue and Bone Sarcoma
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      The clinical and functional outcome for patients with radiation-induced soft tissue sarcoma (pages 2682–2692)

      Soha Riad, David Biau, Ginger E. Holt, Joel Werier, Robert E. Turcotte, Peter C. Ferguson, Anthony M. Griffin, Colleen I. Dickie, Peter W. Chung, Charles N. Catton, Brian O'sullivan and Jay S. Wunder

      Version of Record online: 11 OCT 2011 | DOI: 10.1002/cncr.26543

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      Despite aggressive surgical treatment, patients who have radiation-induced soft tissue sarcoma remain at higher risk of both local and systemic recurrence compared with patients who have sporadic soft tissue sarcoma but can anticipate similar functional outcomes. Reirradiation can be relatively safe and effective if used properly.

    12. Discipline

      Disparities Research
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      Racial disparities in breast cancer mortality in a multiethnic cohort in the Southeast (pages 2693–2699)

      Swann Arp Adams, William M. Butler, Jeanette Fulton, Sue P. Heiney, Edith M. Williams, Alexandria F. Delage, Leepao Khang and James R. Hebert

      Version of Record online: 27 SEP 2011 | DOI: 10.1002/cncr.26570

      African American women residing in rural South Carolina have poorer 3-year and 5-year breast cancer survival compared with European Americans. A possible biological processing basis may contribute to some of the breast cancer mortality disparities seen in South Carolina.

    13. Epidemiology
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      Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma (pages 2700–2707)

      Euphemia Mu, Julie R. Lange and John J. Strouse

      Version of Record online: 5 OCT 2011 | DOI: 10.1002/cncr.26578

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      The results from this study indicate that thickness and ulceration are strong predictors of sentinel lymph node (SLN) biopsy use and SLN metastases in pediatric and young adult patients with melanoma. Children and young adults have similar rates of SLN biopsy use, but children are more likely to have SLN metastases.

    14. Medical Oncology
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      HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection (pages 2708–2717)

      Yi-Ming Zhao, Jia-Min Zhou, Long-Rong Wang, Hong-Wei He, Xi-Long Wang, Zhong-Hua Tao, Hui-Chuan Sun, Wei-Zhong Wu, Jia Fan, Zhao-You Tang and Lu Wang

      Version of Record online: 11 OCT 2011 | DOI: 10.1002/cncr.26524

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      HIWI may be a useful prognostic factor for hepatocellular carcinoma (HCC)—particularly with well-differentiated HCC—after curative resection and may be involved in tumor proliferation and metastasis.

    15. Pediatric Oncology
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      A prospective protocol for nasopharyngeal carcinoma in children and adolescents : The Italian Rare Tumors in Pediatric Age (TREP) project (pages 2718–2725)

      Michela Casanova, Gianni Bisogno, Lorenza Gandola, Giovanni Cecchetto, Andrea Di Cataldo, Eleonora Basso, Paolo Indolfi, Paolo D'Angelo, Francesca Favini, Paola Collini, Paolo Potepan, Andrea Ferrari and on behalf of the Rare Tumors in Pediatric Age Group

      Version of Record online: 14 SEP 2011 | DOI: 10.1002/cncr.26528

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      The current results indicate the feasibility and efficacy of a prospective chemoradiotherapy protocol for patients with pediatric nasopharyngeal carcinoma that was developed between 2000 and 2009 within the framework of the Italian Rare Tumors in Pediatric Age (TREP) project.

    16. Psychosocial Oncology
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      Preferences for colorectal cancer screening tests and screening test use in a large multispecialty primary care practice (pages 2726–2734)

      Sarah T. Hawley, Amy McQueen, L. Kay Bartholomew, Anthony J. Greisinger, Sharon P. Coan, Ronald Myers and Sally W. Vernon

      Version of Record online: 21 SEP 2011 | DOI: 10.1002/cncr.26551

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      Lack of concordance between patient preference and test completed suggests that patients' preferences are not well incorporated into screening discussions and test decisions, which may hinder screening completion. Physicians should acknowledge patients' preferences when discussing test options and making recommendations, which may increase patients' receptivity to screening.

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      Is screening effective in detecting untreated psychiatric disorders among newly diagnosed breast cancer patients? (pages 2735–2743)

      Steven C. Palmer, Alison Taggi, Angela DeMichele and James C. Coyne

      Version of Record online: 11 OCT 2011 | DOI: 10.1002/cncr.26603

      Screening is widely advocated as a means of identifying individuals in need of evaluation and treatment for psychiatric disorders. However, the present data indicate that most psychiatric disorders among recently diagnosed cancer patients are already being treated. Surveillance of response to ongoing or recent treatment may be more efficient than initiation of treatment based on screening for untreated disorders.

    18. Radiation Oncology
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      Predicting the need for palliative thoracic radiation after first-line chemotherapy for advanced nonsmall cell lung carcinoma (pages 2744–2751)

      Daniel S. Higginson, Ronald C. Chen, David E. Morris, Jan Halle, Julian G. Rosenman, Mark A. Socinski and Lawrence B. Marks

      Version of Record online: 20 SEP 2011 | DOI: 10.1002/cncr.26495

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      Hilar disease that measures >3 cm in greatest single dimension and a history of pneumonia at diagnosis predict the need for palliative thoracic radiotherapy after first-line, platinum-based chemotherapy for incurable stage IIIB/IV nonsmall cell carcinoma.

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      Change in treatment strategy for intracranial germinoma: Long-term follow-up experience at a single institute (pages 2752–2762)

      Yi-Wei Chen, Pin-I Huang, Donald Ming-Tak Ho, Yu-Wen Hu, Kai-Ping Chang, Shih-Hwa Chiou, Wan-Yuo Guo, Feng-Chi Chang, Muh-Lii Liang, Yi-Yen Lee, Hsin-Hung Chen, Ting-Rong Hsu, Shih-Chieh Lin, Tai-Tong Wong and Sang-Hue Yen

      Version of Record online: 11 OCT 2011 | DOI: 10.1002/cncr.26564

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      Adjustment of radiation volume to whole ventricular irradiation with lower radiation dose provides long-term control and reduced toxicity for patients with intracranial germinoma. Large-field irradiation with chemotherapy is only suitable for patients with initial dissemination or after multisite relapse.

    20. Translational Research
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      The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms (pages 2763–2775)

      Simon Schimmack, Ben Lawrence, Bernhard Svejda, Daniele Alaimo, Hubertus Schmitz-Winnenthal, Lars Fischer, Markus W. Büchler, Mark Kidd and Irvin Modlin

      Version of Record online: 11 OCT 2011 | DOI: 10.1002/cncr.26592

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      The neurofilament internexin alpha (INA), which is a strong positive prognostic marker in oligodendrogliomas, and the other 3 class IV intermediate filaments are highly expressed at both the messenger RNA level and the protein level in gastroenteropancreatic neuroendocrine neoplasms. INA is linked to the mitogen-activated protein kinase pathway and plays an important role in tumor proliferation, invasion, and metastasis.

  5. Erratum

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Erratum
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      Erratum: Stereotactic body radiotherapy for colorectal liver metastases (page 2776)

      Version of Record online: 20 SEP 2011 | DOI: 10.1002/cncr.26583

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      This article corrects:

      Stereotactic body radiotherapy for colorectal liver metastases1

      Vol. 117, Issue 17, 4060–4069, Version of Record online: 22 MAR 2011

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