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Cancer

Cover image for Vol. 118 Issue 15

1 August 2012

Volume 118, Issue 15

Pages 3667–3877

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Original Articles
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    2. You have free access to this content
    3. You have free access to this content
  2. Original Articles

    1. Top of page
    2. CancerScope
    3. Original Articles
    1. Disease Site

      Breast Disease
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      The prognostic significance of lymphovascular invasion in invasive breast carcinoma (pages 3670–3680)

      Emad A. Rakha, Stewart Martin, Andrew H. S. Lee, David Morgan, Paul D. P. Pharoah, Zsolt Hodi, Douglas MacMillan and Ian O. Ellis

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26711

      In patients with lymph node-negative breast cancer, lymphovascular invasion (LVI) can be used as a high-risk criterion to indicate a survival disadvantage equivalent to that indicated by a positive pathologic lymph node status of pN0 or pN1 and a pathologic tumor classification of pT1 or pT2. The use of immunohistochemistry to identify an endothelial-specific marker can contribute to the significance of LVI when applied to routine cases that are LVI negative/possible.

    2. Genitourinary Disease
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      Hypofractionated stereotactic body radiotherapy in low-risk prostate adenocarcinoma : Preliminary results of a multi-institutional phase 1 feasibility trial (pages 3681–3690)

      Sean M. McBride, Douglas S. Wong, John J. Dombrowski, Bonnie Harkins, Patricia Tapella, Heather N. Hanscom, Sean P. Collins and Irving D. Kaplan

      Article first published online: 13 DEC 2011 | DOI: 10.1002/cncr.26699

      The authors report excellent tumor control with acceptable toxicity in a multi-institutional phase 1 trial of extreme hypofractionated stereotactic radiotherapy for low-risk prostate adenocarcinoma.

    3. Gynecologic Oncology
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      Krüppel-like factor 4 functions as a tumor suppressor in cervical carcinoma (pages 3691–3702)

      Wen-Ting Yang and Peng-Sheng Zheng

      Article first published online: 13 DEC 2011 | DOI: 10.1002/cncr.26698

      Krüppel-like factor 4 functions as a tumor suppressor in cervical carcinoma by inhibiting cell growth and tumor formation.

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      Improved survival for BRCA2-associated serous ovarian cancer compared with both BRCA-negative and BRCA1-associated serous ovarian cancer (pages 3703–3709)

      David M. Hyman, Qin Zhou, Alexia Iasonos, Rachel N. Grisham, Angela G. Arnold, Mary F. Phillips, Jasmine Bhatia, Douglas A. Levine, Carol Aghajanian, Kenneth Offit, Richard R. Barakat, David R. Spriggs and Noah D. Kauff

      Article first published online: 2 DEC 2011 | DOI: 10.1002/cncr.26655

      Breast cancer gene 2 (BRCA2) mutations confer an overall survival advantage compared with both being BRCA-negative or having a BRCA1 mutation in high-grade serous ovarian cancer. This finding may have important implications for clinical trial design.

    5. Head and Neck Disease
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      Quality of life of patients after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma (pages 3710–3718)

      Yu Wai Chan, Velda Ling Yu Chow and William Ignace Wei

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26719

      The quality of life of patients after salvage nasopharyngectomy is good. Attention must be paid to the factors that adversely affect quality of life after surgery, such as palliative resection, and complications like trismus, palatal fistula, and osteoradionecrosis.

    6. Hematologic Malignancies
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      Successful treatment of refractory metastatic histiocytic sarcoma with alemtuzumab (pages 3719–3724)

      Neerav Shukla, Rachel Kobos, Thomas Renaud, Julie Teruya-Feldstein, Anita Price, Linda McAllister-Lucas and Peter Steinherz

      Article first published online: 13 DEC 2011 | DOI: 10.1002/cncr.26712

      The authors report 2 patients who have long-term disease-free survival after receiving single-agent alemtuzumab therapy for refractory, metastatic histiocytic sarcoma. Patients with unresectable and metastatic histiocytic sarcoma should have tumor tissue tested for CD52 expression and should be considered for alemtuzumab therapy if they are CD52-positive.

    7. Melanoma
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      Behavioral determinants of successful early melanoma detection : Role of self and physician skin examination (pages 3725–3734)

      Susan M. Swetter, Ricardo A. Pollitt, Timothy M. Johnson, Daniel R. Brooks and Alan C. Geller

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26707

      Physician skin examination (PSE) in the year before melanoma diagnosis is strongly associated with thinner tumors in men aged >60 years. Improving rates of PSE in this high-risk group is likely to result in earlier detection of melanoma.

    8. Neuro-Oncology
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      Postoperative radiation therapy for low-grade glioma : Patterns of care between 1998 and 2006 (pages 3735–3742)

      Gita Suneja, Michelle Alonso-Basanta, Robert Lustig, John Y. K. Lee and Justin E. Bekelman

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26693

      The role of postoperative radiotherapy (PORT) in the management of low-grade glioma is controversial. In this study, the authors use the Surveillance, Epidemiology, and End Results database to examine practice patterns, and find that use of PORT declines over the study period for both low- and high-risk patients.

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      Pemetrexed in the treatment of relapsed/refractory primary central nervous system lymphoma (pages 3743–3748)

      Jeffrey J. Raizer, Alfred Rademaker, Andrew M. Evens, Laurie Rice, Margaret Schwartz, James P. Chandler, Christopher C. Getch, Claudia Tellez and Sean A. Grimm

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26709

      Pemetrexed has single-agent activity in relapsed/refractory primary central nervous system lymphoma (PCNSL). This is the first report of a newer generation antifolate in PCSNL.

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      Predicting survival in women with breast cancer and brain metastasis : A nomogram outperforms current survival prediction models (pages 3749–3757)

      Nicholas F. Marko, Zhiyuan Xu, Tianming Gao, Michael W. Kattan and Robert J. Weil

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26716

      A survival nomogram based on a Cox regression model outperforms current strategies for survival prediction in breast cancer patients with brain metastases. We believe this represents a potentially valuable alternative to current models of survival prediction in this patient population.

    11. Soft Tissue and Bone Sarcoma
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      Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas (pages 3758–3765)

      John T. Mullen, Wendy Kobayashi, Jing Jing Wang, David C. Harmon, Edwin Choy, Francis J. Hornicek, Andrew E. Rosenberg, Yen-Lin Chen, Ira J. Spiro and Thomas F. DeLaney

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26696

      For patients with high-risk, extremity soft tissue sarcoma, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery are sustained even with long-term follow-up, despite the fact that sarcoma-related deaths continue to occur well beyond 5 years.

    12. Discipline

      Clinical Trials
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      Yoga for persistent fatigue in breast cancer survivors : A randomized controlled trial (pages 3766–3775)

      Julienne E. Bower, Deborah Garet, Beth Sternlieb, Patricia A. Ganz, Michael R. Irwin, Richard Olmstead and Gail Greendale

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26702

      An Iyengar-based yoga intervention leads to significant improvements in fatigue and vigor among breast cancer survivors with persistent post-treatment fatigue in this randomized controlled trial.

    13. Diagnostic Imaging
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      Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival in pediatric patients with osteosarcoma (pages 3776–3785)

      Junyu Guo, Wilburn E. Reddick, John O. Glass, Qing Ji, Catherine A. Billups, Jianrong Wu, Fredric A. Hoffer, Sue C. Kaste, Jesse J. Jenkins, Ximena C. Ortega Flores, Juan Quintana, Milena Villarroel and Najat C. Daw

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26701

      A multi-institutional phase 2 trial for pediatric patients with newly diagnosed, nonmetastatic osteosarcoma demonstrates that some dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters assessed during neoadjuvant therapy are indicative of histologic response, and some DCE-MRI parameters assessed before treatment are prognostic of event-free and overall survival.

    14. Epidemiology
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      Increasing incidence of enteropathy-associated T-cell lymphoma in the United States, 1973-2008 (pages 3786–3792)

      Reem Z. Sharaiha, Ben Lebwohl, Laura Reimers, Govind Bhagat, Peter H. Green and Alfred I. Neugut

      Article first published online: 13 DEC 2011 | DOI: 10.1002/cncr.26700

      The incidence of enteropathy-associated T-cell lymphoma (EATL) is rising in the United States and may continue to rise given the large ratio of undiagnosed-to-diagnosed individuals with celiac disease. The survival of patients with EATL remains poor, and efforts should be made to diagnose and treat this disease early.

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      Temporal and geographic variations of Waldenstrom macroglobulinemia incidence : A large population-based study (pages 3793–3800)

      Haijun Wang, Yiming Chen, Fanglin Li, Kay Delasalle, Jialei Wang, Raymond Alexanian, Larry Kwak, Luis Rustveld, Xianglin L. Du and Michael Wang

      Article first published online: 2 DEC 2011 | DOI: 10.1002/cncr.26627

      Twenty-year data from the Surveillance, Epidemiology, and End Results program is used for this study. Although the overall incidence of Waldenstrom macroglobulinemia remains steady over time, significant increases in incidence are seen over the past 20 years in whites, in those aged 70 to 79 years, and in 3 geographic registry areas.

    16. Pathology
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      Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation (pages 3801–3811)

      Jiansheng Wang, Jeannelyn S. Estrella, Lan Peng, Asif Rashid, Gauri R. Varadhachary, Hua Wang, Jeffrey E. Lee, Peter W. T. Pisters, Jean-Nicolas Vauthey, Matthew H. Katz, Henry F. Gomez, Douglas B. Evans, James L. Abbruzzese, Jason B. Fleming and Huamin Wang

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26717

      The authors demonstrate that histologic tumor involvement of the resected superior mesenteric vein (SMV)/portal vein (PV) is associated with larger tumor size, higher rates of positive margin, and local/distant recurrence, and is an independent predictor of both disease-free survival and overall survival by multivariate analysis. Complete histologic evaluation of the resected SMV/PV is important for the prognosis in patients with pancreatic adenocarcinoma treated with neoadjuvant therapy and pancreaticoduodenectomy.

    17. Pediatric Oncology
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      Clinicopathologic prognostic factors in childhood atypical teratoid and rhabdoid tumor of the central nervous system : A multicenter study (pages 3812–3821)

      Christelle Dufour, Annick Beaugrand, Marie Cécile Le Deley, Franck Bourdeaut, Nicolas André, Pierre Leblond, Anne-Isabelle Bertozzi, Didier Frappaz, Xavier Rialland, Fanny Fouyssac, Christine Edan, Jacques Grill, Marion Quidot and Pascale Varlet

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26684

      The objective of this research is to describe the clinical and pathologic features and to identify prognostic factors in patients with atypical teratoid/rhabdoid tumors of the central nervous system. In children, these tumors carry a dismal prognosis. Age <2 years, metastasis at diagnosis, and strong claudin-6 positivity appear to be independent prognostic factors for outcome.

    18. Psychosocial Oncology
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      Randomized trial of therapeutic group by teleconference : African American women with breast cancer (pages 3822–3832)

      Sue P. Heiney, Sandra Millon Underwood, Abbas Tavakoli, Swann Arp Adams, Linda M. Wells and Lisa H. Bryant

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26676

      In this randomized controlled trial, a therapeutic group by teleconference for African American women with breast cancer significantly improves social connection and decreases fatalism in the intervention group compared with the control group. The study documents the benefits of a therapeutic group by teleconference, a novel way to provide support to African American women with breast cancer, especially those in rural communities.

    19. Quality of Life
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      Prolonged impact of chemotherapy on fatigue in breast cancer survivors : A longitudinal comparison with radiotherapy-treated breast cancer survivors and noncancer controls (pages 3833–3841)

      Martine M. Goedendorp, Michael A. Andrykowski, Kristine A. Donovan, Heather S. Jim, Kristin M. Phillips, Brent J. Small, Christine Laronga and Paul B. Jacobsen

      Article first published online: 15 NOV 2011 | DOI: 10.1002/cncr.26226

      The results from this study indicate that, over a 36-month period after the completion of adjuvant therapy, fatigue severity worsened in patients with breast cancer who received chemotherapy relative to patients who received radiotherapy and women who had no history of cancer. These findings have important implications for patient education and for fatigue monitoring during follow-up.

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      How does health literacy affect quality of life among men with newly diagnosed clinically localized prostate cancer? : Findings from the North Carolina-Louisiana Prostate Cancer Project (PCaP) (pages 3842–3851)

      Lixin Song, Merle Mishel, Jeannette T. Bensen, Ronald C. Chen, George J. Knafl, Bonny Blackard, Laura Farnan, Elizabeth Fontham, L. Joseph Su, Christine S. Brennan, James L. Mohler and Paul A. Godley

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26713

      In this population-based study of men with newly diagnosed localized prostate cancer, the mental well-being of the research subjects varies by their health literacy levels, whereas their physical well-being is no different. These findings suggest that health literacy may be important for patients coping with prostate cancer diagnosis and treatment effects.

    21. Radiation Oncology
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      Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis (pages 3852–3859)

      Dirk Rades, Annika Panzner, Liesa Dziggel, Tiina Haatanen, Radka Lohynska and Steven E. Schild

      Article first published online: 13 DEC 2011 | DOI: 10.1002/cncr.26680

      Data from 109 patients with a favorable survival prognosis receiving whole-brain radiotherapy at a dose of 30 grays (Gy) in 10 fractions are compared with 75 patients receiving 40 Gy in 20 fractions for local (intracerebral) control and overall survival. Escalation of the whole-brain radiotherapy dose beyond 30 Gy results in better local control and overall survival, particularly in patients with less radiosensitive tumors.

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      Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury (pages 3860–3868)

      Neil B. Hampson, James R. Holm, Claude E. Wreford-Brown and John Feldmeier

      Article first published online: 2 DEC 2011 | DOI: 10.1002/cncr.26637

      In this large clinical series from a single institution, the authors demonstrate that hyperbaric oxygen therapy is beneficial treatment for a variety of sites of chronic radiation tissue injury.

    23. Symptom Control and Palliative Care
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      Achievement of personalized pain goal in cancer patients referred to a supportive care clinic at a comprehensive cancer center (pages 3869–3877)

      Shalini Dalal, David Hui, Linh Nguyen, Ray Chacko, Cheryl Scott, Lynn Roberts and Eduardo Bruera

      Article first published online: 16 DEC 2011 | DOI: 10.1002/cncr.26694

      Cancer pain initiatives recommend tailoring pain treatments to patient's personalized pain goals for pain relief. Obtaining patient's personalized pain goal is feasible and represents a novel target for pain response.

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