Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging (pages 5320–5330)
Jeffrey K. Mito, Jorge M. Ferrer, Brian E. Brigman, Chang-Lung Lee, Rebecca D. Dodd, William C. Eward, Lisa F. Marshall, Kyle C. Cuneo, Jessica E. Carter, Shalini Ramasunder, Yongbaek Kim, W. David Lee, Linda G. Griffith, Moungi G. Bawendi and David G. Kirsch
Article first published online: 21 MAR 2012 | DOI: 10.1002/cncr.27458
The presence of microscopic residual sarcoma left in the tumor bed of patients is associated with local failure, the development of distant metastases, and disease-specific survival. We use an imaging system targeting cathepsin proteases for real-time intraoperative imaging in mice to detect and remove microscopic residual sarcoma in vivo.