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Cancer

Cover image for Vol. 118 Issue 3

1 February 2012

Volume 118, Issue 3

Pages 579–865

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    5. Correspondence
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  2. Review Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    5. Correspondence
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      Urinary symptoms in breast cancer : A systematic review (pages 582–593)

      Kristine A. Donovan, Alice R. Boyington, Roohi Ismail-Khan and Jean F. Wyman

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26324

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      A systematic review of studies published between 1990 and 2010 was conducted to describe the prevalence and severity of urinary symptoms in breast cancer survivors. The results indicated that urinary symptoms are prevalent among women who are diagnosed and treated for breast cancer and tend to be mild to moderate in severity.

  3. Original Articles

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    5. Correspondence
    1. Disease Site

      Breast Disease
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      SNP–SNP interactions between DNA repair genes were associated with breast cancer risk in a Korean population (pages 594–602)

      Wonshik Han, Kyoung-Yeon Kim, Song-Ju Yang, Dong-Young Noh, Daehee Kang and KyuBum Kwack

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26220

      We analyzed the association between single nucleotide polymorphisms (SNPs) in DNA repair pathway–related genes and breast cancer risk in a case-control study of a Korean population. Our findings suggested that SNPs in DNA repair genes may increase susceptibility to breast cancer and could potentially be used as prognostic genetic markers for breast cancer.

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      Radiation therapy for ductal carcinoma in situ : A decision analysis (pages 603–611)

      Rinaa S. Punglia, Harold J. Burstein and Jane C. Weeks

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/cncr.26293

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      The authors developed a Markov decision model and observed that radiation therapy for ductal carcinoma in situ (DCIS) was associated with slight improvements in invasive disease-free and overall survival but decreased the chance of having both breasts intact over a woman's lifetime. The results indicated that patient age and preferences should be considered when making the decision to add or forgo radiation for DCIS.

    3. Endocrine Disease
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      Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors : Clinical experience with a rare entity (pages 612–619)

      Alexander Gorshtein, David J. Gross, Dganit Barak, Yulia Strenov, Yael Refaeli, Ilan Shimon and Simona Grozinsky-Glasberg

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26200

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      The association of lung neuroendocrine tumors with multiple nodules in women, together with complaints of chronic cough and wheezing, should raise suspicion of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. The current results indicate that, whenever possible, these patients should undergo surgical excision to resect the dominant lesion, whereas somatostatin analogs may be considered for symptomatic or tumor control in patients with progressive disease.

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      Medullary thyroid microcarcinoma : A population-level analysis of 310 patients (pages 620–627)

      Hadiza S. Kazaure, Sanziana A. Roman and Julie A. Sosa

      Version of Record online: 29 JUN 2011 | DOI: 10.1002/cncr.26283

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      Medullary thyroid microcarcinomas have significant rates of poor prognostic features known to impact the survival of patients with medullary thyroid carcinoma. The results from this study indicate that these microcarcinomas are an important clinical entity that requires comprehensive evaluation and surgical management.

    5. Gastrointestinal Disease
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      Intramural and extramural vascular invasion in colorectal cancer : Prognostic significance and quality of pathology reporting (pages 628–638)

      Johannes Betge, Marion J. Pollheimer, Richard A. Lindtner, Peter Kornprat, Andrea Schlemmer, Peter Rehak, Michael Vieth, Gerald Hoefler and Cord Langner

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26310

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      The detection of vascular invasion in colorectal cancer and consequent risk stratification of affected patients was related to the quality of pathology workup, ie, the number of examined tissue blocks. In this study, marked differences between review and routine pathology diagnoses illustrated the need for high-quality pathology reporting.

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      Identification and assessment of new biomarkers for colorectal cancer with serum N-glycan profiling (pages 639–650)

      Yun-Peng Zhao, Can-Ping Ruan, Hao Wang, Zhi-Qian Hu, Meng Fang, Xing Gu, Jun Ji, Jin-Yan Zhao and Chun-Fang Gao

      Version of Record online: 18 AUG 2011 | DOI: 10.1002/cncr.26342

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      The authors constructed 2 colorectal cancer N-glycan marker-based diagnostic models. The sensitivity and specificity of both models were at least 11% higher than the sensitivity and specificity of carcinoembryonic antigen, and the results were validated in retrospective, prospective, and follow-up studies.

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      Management of malignant colonic polyps: A population-based analysis of colonoscopic polypectomy versus surgery (pages 651–659)

      Gregory S. Cooper, Fang Xu, Jill S. Barnholtz Sloan, Siran M. Koroukian and Mark D. Schluchter

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26340

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      Malignant colonic polyps can be managed with colonoscopic polypectomy or surgical resection, but population-based data comparing outcomes are lacking. We observed favorable postprocedure outcomes and long-term survival in patients treated with polypectomy alone.

    8. Gynecologic Oncology
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      A nomogram to predict postresection 5-year overall survival for patients with uterine leiomyosarcoma (pages 660–669)

      Oliver Zivanovic, Lindsay M. Jacks, Alexia Iasonos, Mario M. Leitao Jr., Robert A. Soslow, Emanuela Veras, Dennis S. Chi, Nadeem R. Abu-Rustum, Richard R. Barakat, Murray F. Brennan and Martee L. Hensley

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26333

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      The authors developed a uterine leiomyosarcoma-specific nomogram to predict 5-year overall survival. This novel, individualized prognostic model outperformed the existing, traditionally used staging systems.

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      Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers (pages 670–680)

      Anna Klukovits, Andrew V. Schally, Luca Szalontay, Irving Vidaurre, Andrea Papadia, Marta Zarandi, Jozsef L. Varga, Norman L. Block and Gabor Halmos

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26291

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      In this study, new, potent antagonists of growth hormone-releasing hormone (GHRH) receptors inhibited the growth of human experimental ovarian cancers, and some even reduced tumor vascularization, without affecting vascular endothelial growth factor (VEGF) signaling in the terminal ileum. This novel therapeutic approach based on GHRH antagonists may offer therapeutic alternatives for patients with advanced ovarian cancer who do not tolerate conventional anti-VEGF therapy.

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      Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries (pages 681–688)

      Paul Ryan, Anna Marie Mulligan, Melyssa Aronson, Sarah E. Ferguson, Bharati Bapat, Kara Semotiuk, Spring Holter, Janice Kwon, Steve E. Kalloger, C. Blake Gilks, Steven Gallinger, Aaron Pollett and Blaise A. Clarke

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/cncr.26323

      Examination of Lynch syndrome screening was performed in 76 patients with mutation-proven endometrial cancer using clinical schemas, microsatellite instability (MSI) and mismatch repair (MMR) immunohistochemistry, and tumor morphology. Recently published Society of Gynecologic Oncologists (SGO) schemas are more effective than colon cancer-centered schemas (Amsterdam II criteria, revised Bethesda guidelines), and tumor morphology in identifying Lynch syndrome. In this study, using detailed family pedigrees, the SGO schema identified up to 93% of cases, but their specificity and robustness in practice is unknown.

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      Xeroderma pigmentosum complementation group C single-nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression-free survival in advanced ovarian cancer (pages 689–697)

      Nicole D. Fleming, Hasmik Agadjanian, Hoorig Nassanian, Carl W. Miller, Sandra Orsulic, Beth Y. Karlan and Christine S. Walsh

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26329

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      Xeroderma pigmentosum complementation group C (XPC) is a key component of the nucleotide excision repair pathway that participates in platinum-induced DNA damage recognition and repair. In this study, single-nucleotide polymorphisms in XPC were associated with improved platinum response in patients with advanced epithelial ovarian cancer.

    12. Head and Neck Disease
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      Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs (pages 698–710)

      Alissa Michelle Go Wong, Kar Lok Kong, Janice Wing Hang Tsang, Dora Lai Wan Kwong and Xin-Yuan Guan

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/cncr.26309

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      The distinct presence of Epstein-Barr virus (EBV) BART microRNAs in nasopharyngeal carcinoma (NPC) tumors and serum reveals potential screening markers for endemic populations. EBV microRNAs could also extensively deregulate pathways associated with NPC tumorigenesis.

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      Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status (pages 711–721)

      Vlad C. Sandulache, Heath D. Skinner, Thomas J. Ow, Aijun Zhang, Xuefeng Xia, James M. Luchak, Lee-Jun C. Wong, Curtis R. Pickering, Ge Zhou and Jeffrey N. Myers

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/cncr.26321

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      The current results indicate that loss of p53 function in head and neck squamous cell carcinoma triggers a metabolic switch away from mitochondrial respiration toward glycolysis. The authors observed that the resulting decreased metabolic flexibility can be exploited using pharmacologic agents that inhibit glycolysis to potentiate the antitumor effects of radiation.

    14. Hematologic Malignancies
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      A randomized study of 2 dose levels of intravenous clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome (pages 722–728)

      Stefan Faderl, Guillermo Garcia-Manero, Elias Jabbour, Farhad Ravandi, Gautam Borthakur, Zeev Estrov, Varsha Gandhi, Anna L. Byrd, Monica Kwari, Jorge Cortes and Hagop M. Kantarjian

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26327

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      Intravenous clofarabine was used at 2 different dose levels in patients with higher-risk myelodysplastic syndrome. Responses were comparable, but the lower dose level was less toxic. Activity has been noted in patients with and without prior exposure to DNA methyltransferase inhibitors.

    15. Lung Disease
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      Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement (pages 729–739)

      Hye Ryun Kim, Hyo Sup Shim, Jin-Haeng Chung, Young Joo Lee, Yun Kyoung Hong, Sun Young Rha, Se Hoon Kim, Sang-Jun Ha, Se Kyu Kim, Kyung Young Chung, Ross Soo, Joo Hang Kim and Byoung Chul Cho

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/cncr.26311

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      This was a comprehensive analysis of alterations in 3 major oncogenes (EGFR mutations, KRAS mutations, and ALK rearrangements) in the largest cohort to date of East Asian never-smokers with nonsmall cell lung cancer. Because survival outcomes differ for different genotypes and drugs are available that can target specific mutations, the authors concluded that genetic profiling should be performed to identify genotype-specific subsets to allow treatment with appropriate kinase inhibitors.

    16. Sarcoma
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      Cell surface receptor expression patterns in osteosarcoma (pages 740–749)

      Sheref E. Hassan, Mikhail Bekarev, Mimi Y. Kim, Juan Lin, Sajida Piperdi, Richard Gorlick and David S. Geller

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26339

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      Insulin growth factor 2 receptor may play a more central role in osteosarcoma tumorigenesis than previously thought. In addition, the application of multiple targeted treatment approaches within a subset of tumors may have relevance.

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      Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth (pages 750–760)

      Gatien Moriceau, Anke J. Roelofs, Régis Brion, Françoise Redini, Frank H. Ebetion, Michael J. Rogers and Dominique Heymann

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26336

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      Osteosarcoma is the most frequent malignant primary bone tumor that occurs mainly in the young, with an incidence peak observed at age 18 years. Both apomine and lovastatin have antitumor activity in a variety of cancer cell lines. The results from this study reveal that combination therapy with apomine and lovastatin may be a novel treatment strategy for osteosarcoma.

    18. Discipline

      Clinical Trials
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      AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia : A report from the Children's Oncology Group (pages 761–769)

      Todd M. Cooper, Janet Franklin, Robert B. Gerbing, Todd A. Alonzo, Craig Hurwitz, Susana C. Raimondi, Betsy Hirsch, Franklin O. Smith, Prasad Mathew, Robert J. Arceci, James Feusner, Robert Iannone, Robert S. Lavey, Soheil Meshinchi and Alan Gamis

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/cncr.26190

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      Children's Oncology Group Study AAML03P1 determined the safety and efficacy of gemtuzumab in combination with intensive chemotherapy. The survival rates compare favorably with the recently published results of pediatric acute myeloid leukemia clinical trials worldwide.

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      Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas (pages 770–776)

      Margaret von Mehren, Cathryn Rankin, John R. Goldblum, George D. Demetri, Vivien Bramwell, Christopher W. Ryan and Ernest Borden

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26334

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      A phase 2 multicenter trial of sorafenib in patients with advanced soft tissue sarcoma indicated that the drug was tolerated at the doses tested. No responses according to Response Evaluation Criteria in Solid Tumors were observed in patients with liposarcoma, leiomyosarcoma, or vascular sarcomas.

    20. Complementary Medicine
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      Complementary medicine for fatigue and cortisol variability in breast cancer survivors : A randomized controlled trial (pages 777–787)

      Shamini Jain, Desiree Pavlik, Janet Distefan, Reverend Rosalyn L. Bruyere, Julia Acer, Rosalie Garcia, Ian Coulter, John Ives, Scott C. Roesch, Wayne Jonas and Paul J. Mills

      Version of Record online: 5 AUG 2011 | DOI: 10.1002/cncr.26345

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      Results from this study suggest that biofield and mock healing reduce fatigue, and that biofield healing alone increases cortisol variability in fatigued breast cancer survivors. Belief in receiving healing significantly predicts improvements in quality of life (but not fatigue or cortisol variability) in response to touch-based interventions.

    21. Disparities Research
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      21-Gene recurrence scores : Racial differences in testing, scores, treatment, and outcome (pages 788–796)

      Mary Jo Lund, Marina Mosunjac, Kelly M. Davis, Sheryl Gabram-Mendola, Monica Rizzo, Harvey L. Bumpers, Sherita Hearn, Amelia Zelnak, Toncred Styblo and Ruth M. O'Regan

      Version of Record online: 30 JUN 2011 | DOI: 10.1002/cncr.26180

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      African American women who were diagnosed with breast cancer were half as likely as white women to receive American Society of Clinical Oncology-recommended 21-gene recurrence score (RS) testing; however, if they were tested, then they were 2-fold more likely to be included in the group with the greatest risk of recurrence. The current data suggest that testing guidelines are not applied equivalently, that testing bias may attenuate racial differences in RS, and that disparate outcomes may be explained in part by differences in RS, although compliance and pharmacogenomics also may play a role.

    22. Epidemiology
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      Statin use and the risk of renal cell carcinoma in 2 prospective US cohorts (pages 797–803)

      Wei Liu, Toni K. Choueiri and Eunyoung Cho

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26338

      The current study indicates that statin use may be associated with a lower risk of renal cell carcinoma. However, these results need to be investigated further.

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      Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: A case-only study (pages 804–811)

      Rihong Zhai, Yang Zhao, Geoffrey Liu, Monica Ter-Minassian, I.-Chen Wu, Zhaoxi Wang, Li Su, Kofi Asomaning, Feng Chen, Matthew H. Kulke, Xihong Lin, Rebecca S. Heist, John C. Wain and David C. Christiani

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26325

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      Genetic variations in the angiogenesis pathway genes may contribute to esophageal adenocarcinoma risk through interactions with environmental factors in a single nucleotide polymorphism dose-response manner.

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      Racial variation in breast cancer treatment among Department of Defense beneficiaries (pages 812–820)

      Lindsey Enewold, Jing Zhou, Katherine A. McGlynn, William F. Anderson, Craig D. Shriver, John F. Potter, Shelia H. Zahm and Kangmin Zhu

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/cncr.26346

      Even within an equal access health care system, stage-related racial variations in breast cancer treatment were evident.

    25. Pediatric Oncology
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      Rhabdomyosarcoma in adolescents : A report from the AIEOP Soft Tissue Sarcoma Committee (pages 821–827)

      Gianni Bisogno, Alessia Compostella, Andrea Ferrari, Guido Pastore, Giovanni Cecchetto, Alberto Garaventa, Paolo Indolfi, Luigi De Sio and Modesto Carli

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26355

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      To investigate the prognosis for adolescents with rhabdomyosarcoma, the authors analyzed 643 cases enrolled for the protocols coordinated by the Italian Soft Tissue Sarcoma Committee. The survival rates appeared to be satisfactory, although not as good as those noted in younger children because of a higher prevalence of unfavorable characteristics in adolescents.

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      Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia : Associations with physical performance and chemotherapy doses (pages 828–838)

      Kirsten K. Ness, Melissa M. Hudson, Ching-Hon Pui, Daniel M. Green, Kevin R. Krull, Tseng T. Huang, Leslie L. Robison and E. Brannon Morris

      Version of Record online: 15 JUL 2011 | DOI: 10.1002/cncr.26337

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      Neuromuscular impairments are prevalent in survivors of childhood acute lymphoblastic leukemia and interfere with physical performance. In this study, higher cumulative doses of vincristine and/or intrathecal methotrexate were associated with long-term neuromuscular impairments, which have implications on future function as these survivors age.

    27. Radiation Oncology
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      Outcomes after prostate brachytherapy are even better than predicted (pages 839–847)

      Steven J. Frank, Lawrence B. Levy, Marco van Vulpen, Juanita Crook, John Sylvester, Peter Grimm, Thomas J. Pugh and David A. Swanson

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26307

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      The objective of this study was to evaluate a commonly used prostate-specific antigen failure definition in a multinational, multi-institutional study after monotherapy with prostate brachytherapy. The results indicated that outcomes after brachytherapy for prostate cancer were even better than predicted largely because a nomogram (nicknamed the “prostogram”) could not distinguish between benign prostate-specific antigen bounces and biochemical failures.

    28. Symptom Control and Palliative Care
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      Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma : Results of a randomized clinical trial (pages 848–855)

      Maria E. Cabanillas, Hagop Kantarjian, Deborah A. Thomas, Gloria N. Mattiuzzi, Michael E. Rytting, Eduardo Bruera, Lianchun Xiao, B. Nebiyou Bekele, Maria C. Foudray and Jorge E. Cortes

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26341

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      Anemia is an expected consequence of intensive chemotherapy regimens administered to patients with acute leukemia. The authors of this report studied the effect of epoetin alpha on packed erythrocyte transfusions, remission rates, and quality of life. Epoetin alpha decreased the number of erythrocyte transfusions, had no effect on remission rates, and may have had a positive effect on quality of life.

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      Early referral to supportive care specialists for symptom burden in lung cancer patients : A Comparison of Non-Hispanic Whites, Hispanics, and Non-Hispanic Blacks (pages 856–863)

      Cielito C. Reyes-Gibby, Karen O. Anderson, Sanjay Shete, Eduardo Bruera and Sriram Yennurajalingam

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26312

      Whereas the timing of referral to supportive care services did not vary by race or ethnicity, disparities in symptom burden outcomes persisted. The proportion of non-Hispanic white patients reporting severe pain, depressed mood, and fatigue significantly decreased after referral to the supportive care services. Among Hispanics, improvement was only observed for depressed mood. No improvement in any of these symptoms was observed for non-Hispanic blacks.

  4. Correspondence

    1. Top of page
    2. CancerScope
    3. Review Articles
    4. Original Articles
    5. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Reply to receipt of adjuvant breast cancer therapy in minority women (page 865)

      Rachel A. Freedman and Nancy L. Keating

      Version of Record online: 12 JUL 2011 | DOI: 10.1002/cncr.26322

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