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Cancer

Cover image for Vol. 118 Issue 7

1 April 2012

Volume 118, Issue 7

Pages 1741–1958

  1. CancerScope

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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    3. You have free access to this content
  2. Editorials

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Combination of targeted agents in metastatic renal cell carcinoma : A path forward or a dead-end street? (pages 1744–1746)

      M. Dror Michaelson

      Article first published online: 6 SEP 2011 | DOI: 10.1002/cncr.26427

      Targeted therapy has favorably changed the standard of care for patients with advanced renal cell carcinoma. However, combinations of targeted therapy have been characterized by excessive toxicity, as exemplified in the report by Molina et al in this issue.

  3. Review Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Flow cytometry as a diagnostic tool in lymphomatous or leukemic meningitis : Ready for prime time? (pages 1747–1753)

      Manmeet S. Ahluwalia, Paul K. Wallace and David M. Peereboom

      Article first published online: 24 OCT 2011 | DOI: 10.1002/cncr.26335

      The current study examines flow cytometry detection of malignant lymphocytes in cerebrospinal fluid (CSF) samples with very low cell counts or ambiguous cytological findings. Flow cytometry enables the detection of these cells before the onset of clinical symptoms and CSF pleocytosis and therefore may allow for more effective treatment.

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      The volume-outcome relation in the surgical treatment of esophageal cancer : A systematic review and meta-analysis (pages 1754–1763)

      Michel W. J. M. Wouters, Gea A. Gooiker, Johanna W. van Sandick and Rob A. E. M. Tollenaar

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26383

      The evidence for hospital volume as an important determinant of outcome in esophageal cancer surgery is strong, especially in studies originating from the United States.

  4. Original Articles

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. Disease Site

      Endocrine Disease
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      The association of the BRAFV600E mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer : A meta-analysis (pages 1764–1773)

      Tae Hyuk Kim, Young Joo Park, Jung Ah Lim, Hwa Young Ahn, Eun Kyung Lee, You Jin Lee, Kyung Won Kim, Seo Kyung Hahn, Yeo Kyu Youn, Kwang Hyun Kim, Bo Youn Cho and Do Joon Park

      Article first published online: 31 AUG 2011 | DOI: 10.1002/cncr.26500

      The meta-analysis confirms that the BRAFV600E mutation is related to high-risk clinicopathological factors and poor clinical outcome of papillary thyroid cancer.

    2. Gastrointestinal Disease
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      Insulin resistance, central obesity, and risk of colorectal adenomas (pages 1774–1781)

      Ana Patricia Ortiz, Cheryl L. Thompson, Amitabh Chak, Nathan A. Berger and Li Li

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26454

      Central obesity (waist to hip ratio) is found to be an independent risk factor for colorectal adenomas among both men and women. Stratified analyses show that the homeostasis model assessment-insulin resistance and colorectal adenoma association is largely limited to men (P-interaction = .04). The results support the notion that central obesity and insulin resistance, particularly in men, are risk factors for the development of early colorectal neoplasia.

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      Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo (pages 1782–1794)

      Feng Fang, Ruimin Chang and Lianyue Yang

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26482

      Heat shock factor 1 (HSF1) is elevated predominantly in hepatocellular carcinoma (HCC) and is significantly correlated with metastatic potential and with the prognosis of patients with HCC after hepatic resection. In addition, HSF1 is capable of promoting HCC cell migration and invasion in vitro and in vivo by facilitating the expression and phosphorylation of heat shock protein 27, suggesting that HSF1 may serve as a novel prognostic marker and therapeutic target for HCC.

    4. Genitourinary Disease
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      Smoking negatively impacts renal cell carcinoma overall and cancer-specific survival (pages 1795–1802)

      Nils Kroeger, Tobias Klatte, Frédéric D. Birkhäuser, Edward N. Rampersaud, David B. Seligson, Nazy Zomorodian, Fairooz F. Kabbinavar, Arie S. Belldegrun and Allan J. Pantuck

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26453

      This retrospective study of 802 patients with renal cell carcinoma demonstrates an association between smoking and worse clinicopathologic features, a dose-dependent relation with survival outcome, and an increased risk of p53 mutation. Further investigations of the molecular and genetic mechanisms underlying these findings are indicated.

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      Morbidity and mortality of radical prostatectomy differs by insurance status (pages 1803–1810)

      Quoc-Dien Trinh, Jan Schmitges, Maxine Sun, Jesse Sammon, Shahrokh F. Shariat, Kevin Zorn, Shyam Sukumar, Marco Bianchi, Paul Perrotte, Markus Graefen, Craig G. Rogers, James O. Peabody, Mani Menon and Pierre I. Karakiewicz

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26475

      Within the Health Care Utilization Project Nationwide Inpatient Sample, we focused on radical prostatectomies performed within the 5 most contemporary years (2003-2007). Even after adjusting for confounding factors, patients with private insurance status have better outcomes than their counterparts with nonprivate insurance status.

    6. Head and Neck Disease
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      Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer : An analysis of the TAX 324 trial (pages 1811–1817)

      Yin Wu, Marshall R. Posner, Lisa M. Schumaker, Nikolaos Nikitakis, Olga Goloubeva, Ming Tan, Changwan Lu, Sana Iqbal, Jochen Lorch, Nicholas J. Sarlis, Robert I. Haddad and Kevin J. Cullen

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26485

      The authors define a molecular data set that readily differentiates between 2 distinct groups of patients with locally advanced, human papillomavirus-negative oropharyngeal cancer. This risk stratification strategy may serve as a guide for treatment selection.

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      Gene amplification and protein overexpression of EGFR and ERBB2 in sinonasal squamous cell carcinoma (pages 1818–1826)

      Fernando López, José Luis Llorente, Carlos Martín Oviedo, Blanca Vivanco, César Álvarez Marcos, Cristina García-Inclán, Bartolomé Scola and Mario A. Hermsen

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26451

      Alterations in epidermal growth factor receptor (EGFR) or in v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2) are observed in 46% of sinonasal squamous cell carcinoma, whereas mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) are absent. These findings indicate that therapies targeting these molecules may be promising additions to the therapeutic possibilities for these tumors.

    8. Hematologic Malignancies
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      Hematologist/oncologist disease-specific expertise and survival: Lessons from chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) (pages 1827–1837)

      Tait D. Shanafelt, Neil E. Kay, Kari G. Rabe, David J. Inwards, Clive S. Zent, Jose F. Leis, Susan M. Schwager, Carrie A. Thompson, Deborah A. Bowen, Thomas E. Witzig, Susan L. Slager and Timothy G. Call

      Article first published online: 26 AUG 2011 | DOI: 10.1002/cncr.26474

      Among 1309 newly diagnosed patients with chronic lymphocytic leukemia (CLL) cared for at a single academic center, patients surivival was superior for patients cared for by CLL hematologists (10.5 years vs 8.4 years; P = .001). Physicians' disease-specific expertise remained an independent predictor of overall survival after adjusting for age, sex, stage, and lymphocyte count.

    9. Hepatobiliary Disease
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      National trends in surgical procedures for hepatocellular carcinoma: 1998-2008 (pages 1838–1844)

      Hari Nathan, Dorry L. Segev, Skye C. Mayo, Michael A. Choti, Andrew M. Cameron, Christopher L. Wolfgang, Kenzo Hirose, Barish H. Edil, Richard D. Schulick and Timothy M. Pawlik

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26501

      The use of surgical therapy for hepatocellular carcinoma has increased dramatically over the last decade, with a relative shift away from liver resection and toward liver transplantation. At the same time, inpatient mortality has decreased, despite increasing age and comorbidity burden.

    10. Sarcoma
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      Cancer-testis antigens expressed in osteosarcoma identified by gene microarray correlate with a poor patient prognosis (pages 1845–1855)

      Changye Zou, Jingnan Shen, Qinglian Tang, Zheng Yang, Junqiang Yin, Zhibin Li, Xianbiao Xie, Gang Huang, Dina Lev and Jin Wang

      Article first published online: 26 AUG 2011 | DOI: 10.1002/cncr.26486

      A comparison of expression profiles in osteosarcoma cell lines and normal human osteoblasts with results from a oligonucleotide microarray identifies cancer-testis antigens as the most significantly increased genes in osteosarcoma. Among them, the melanoma antigen family A (MAGEA) genes are the most prevalently expressed genes, and their expression predicts a high risk of metastasis and poor clinical outcome for patients with osteosarcoma.

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      Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma : A pilot study (pages 1856–1867)

      Rachael E. Windsor, Sandra J. Strauss, Constantinos Kallis, Nicholas E. Wood and Jeremy S. Whelan

      Article first published online: 1 SEP 2011 | DOI: 10.1002/cncr.26472

      This pilot study represents the most comprehensive study to date examining the role of genetic polymorphisms in osteosarcoma. A number of polymorphisms appear to significantly influence toxicity and clinical outcome and deserve prospective validation.

    12. Discipline

      Clinical Trials
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      Phase 1 trial of everolimus plus sunitinib in patients with metastatic renal cell carcinoma (pages 1868–1876)

      Ana M. Molina, Darren R. Feldman, Martin H. Voss, Michelle S. Ginsberg, Michael S. Baum, Dion R. Brocks, Patricia M. Fischer, Michael J. Trinos, Sujata Patil and Robert J. Motzer

      Article first published online: 6 SEP 2011 | DOI: 10.1002/cncr.26429

      In this dose-finding study of everolimus and sunitinib in advanced renal cell carcinoma, significant toxicity necessitates dose attenuation of both drugs. Responses are seen in clear cell and nonclear cell type tumors.

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      “Entering a clinical trial: Is it right for you?” : A randomized study of the clinical trials video and its impact on the informed consent process (pages 1877–1883)

      Brianna Hoffner, Susan Bauer-Wu, Suzanne Hitchcock-Bryan, Mark Powell, Andrew Wolanski and Steven Joffe

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26438

      Informed consent in clinical trials continues to be an area of concern for oncology providers. This study assesses the effect of an educational video on patients' understanding and perceptions of clinical trials, its impact on decision making and patient-provider communication, and patients' satisfacation with the video.

    14. Diagnostic Imaging
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      Noninvasive and real-time monitoring of the therapeutic response of tumors in vivo with an optimized hTERT promoter (pages 1884–1893)

      Song-Tao Yu, Chuan Li, Mu-Han Lü, Guang-Ping Liang, Ning Li, Xu-Dong Tang, Yu-Yun Wu, Chun-Meng Shi, Ling Chen, Chang-Zhu Li, Ya-Ling Cao, Dian-Chun Fang and Shi-Ming Yang

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26476

      Gene therapy has emerged as a new and promising strategy for the treatment of tumors. However, the inability to track gene expression adequately in target tissue remains a major problem in clinical trials. The success of gene therapy protocols depends primarily on the specific and adequate delivery of therapeutic genes to target tissue as well as temporal and spatial distribution and regulation of therapeutic gene expression. In this study, we provide a valuable, noninvasive method of evaluating the real-time therapeutic response of tumors in vivo based on optimized human telomerase reverse transcriptase promoter.

    15. Disparities Research
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      Improvement of racial disparities with respect to the utilization of minimally invasive radical prostatectomy in the United States (pages 1894–1900)

      Quoc-Dien Trinh, Jan Schmitges, Maxine Sun, Shyam Sukumar, Jesse Sammon, Shahrokh F. Shariat, Claudio Jeldres, Marco Bianchi, Zhe Tian, Paul Perrotte, Craig G. Rogers, Markus Graefen, James O. Peabody, Mani Menon and Pierre I. Karakiewicz

      Article first published online: 6 SEP 2011 | DOI: 10.1002/cncr.26527

      In a population-based analysis of 65,148 radical prostatectomies (RP) recorded in the Healthcare Cost and Utilization Project Nationwide Inpatient Sample between 2001 and 2007, the authors demonstrate that racial discrepancies in the rate of minimally invasive RP utilization are gradually improving.

    16. Epidemiology
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      Body mass index, long-term weight change, and esophageal squamous cell carcinoma : Is the inverse association modified by smoking status? (pages 1901–1909)

      Petra H. Lahmann, Nirmala Pandeya, Penelope M. Webb, Adèle C. Green, David C. Whiteman and for the Australian Cancer Study

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26455

      In this study, the inverse associations between body mass index, long-term weight gain, and other body measures and esophageal squamous cell carcinoma appears to be robust and cannot be explained by smoking status or potential confounding factors. Future risk-prediction models for esophageal squamous cell carcinoma may incorporate measures of body mass in addition to levels of exposure to known carcinogens (tobacco and alcohol).

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      Racial and regional disparities in lung cancer incidence (pages 1910–1918)

      J. Michael Underwood, Julie S. Townsend, Eric Tai, Shane P. Davis, Sherri L. Stewart, Arica White, Behnoosh Momin and Temeika L. Fairley

      Article first published online: 14 SEP 2011 | DOI: 10.1002/cncr.26479

      This study illustrates the current lung cancer burden by providing incidence rates within the United States (US). We report racial, ethnic, and regional disparities in lung cancer incidence, using data from the largest population-based cancer registry in the nation, the US Cancer Statistics.

    18. Pediatric Oncology
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      Pretreatment and routine echocardiogram monitoring during chemotherapy for anthracycline-induced cardiotoxicity rarely identifies significant cardiac dysfunction or alters treatment decisions : A 5-year review at a single pediatric oncology center (pages 1919–1924)

      Raymond G. Watts, McKenzie George and Walter H. Johnson Jr.

      Article first published online: 31 AUG 2011 | DOI: 10.1002/cncr.26481

      The routine use of echocardiograms to screen for anthracycline-induced cardiac damage pretreatment and during chemotherapy rarely identifies significant cardiac damage to impact treatment decisions.

    19. Psychosocial Oncology
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      Cognitive functioning after cancer treatment : A 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls (pages 1925–1932)

      Kristin M. Phillips, Heather S. Jim, Brent J. Small, Christine Laronga, Michael A. Andrykowski and Paul B. Jacobsen

      Article first published online: 12 DEC 2011 | DOI: 10.1002/cncr.26432

      Results indicate that, from 6 to 36 months following completion of adjuvant therapy, breast cancer survivors who received chemotherapy plus radiotherapy and survivors who received radiotherapy without chemotherapy perform worse in the domains of processing speed and executive functioning than participants with no history of cancer. These findings highlight the importance of including a radiotherapy comparison group.

    20. Quality of Life
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      Acute ovarian failure underestimates age-specific reproductive impairment for young women undergoing chemotherapy for cancer (pages 1933–1939)

      Joseph M. Letourneau, Erin E. Ebbel, Patricia P. Katz, Kutluk H. Oktay, Charles E. McCulloch, Wei Z. Ai, A. Jo Chien, Michelle E. Melisko, Marcelle I. Cedars and Mitchell P. Rosen

      Article first published online: 17 AUG 2011 | DOI: 10.1002/cncr.26403

      The authors demonstrate that rates of acute ovarian failure alone underestimate the effect of chemotherapy on reproductive function in women of reproductive age. To give patients appropriate, age-specific counseling, it is critical that they understand the increased risk of infertility and early menopause beyond that of acute ovarian failure.

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      Impact of androgen deprivation therapy on depressive symptoms in men with nonmetastatic prostate cancer (pages 1940–1945)

      Narhari Timilshina, Henriette Breunis and Shabbir Alibhai

      Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26477

      We prospectively examined the impact of androgen deprivation therapy (ADT) use on depression in men with nonmetastatic prostate cancer compared with men who had prostate cancer but who were not taking ADT and with healthy controls. We found no increase in depressive symptoms, incident depression, or worsening of prevalent depression in ADT users compared with controls.

    22. Translational Research
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      Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib (pages 1946–1954)

      Jenny J. Kim, Susan A.J. Vaziri, Brian I. Rini, Paul Elson, Jorge A. Garcia, Robert Wirka, Robert Dreicer, Mahrukh K. Ganapathi and Ram Ganapathi

      Article first published online: 31 AUG 2011 | DOI: 10.1002/cncr.26491

      VEGF genotype is associated with prevalence and duration of sunitinib-induced hypertension.

  5. Correspondence

    1. Top of page
    2. CancerScope
    3. Editorials
    4. Review Articles
    5. Original Articles
    6. Correspondence
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