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Cancer

Cover image for Vol. 119 Issue 10

15 May 2013

Volume 119, Issue 10

Pages 1765–1923

  1. Issue information

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
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      Issue information (pages i–viii)

      Version of Record online: 22 FEB 2016 | DOI: 10.1002/cncr.29942

  2. CancerScope

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
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    2. You have free access to this content
    3. You have free access to this content
  3. Review Articles

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
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      Modulation of c-Met signaling and cellular sensitivity to radiation : Potential implications for therapy (pages 1768–1775)

      Vikas Bhardwaj, Tina Cascone, Maria Angelica Cortez, Arya Amini, Jaden Evans, Ritsuko U. Komaki, John V. Heymach and James W. Welsh

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/cncr.27965

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      c-Met signaling is correlated with poor prognosis and therapy resistance in various cancer types. This review presents the authors' current understanding of the interplay between c-Met and radiation-induced effects on cancer cells as well as potential targeting strategies.

  4. Original Articles

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
    1. Disease Site

      Breast Disease
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      Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer : Translational Breast Cancer Research Consortium trial 017 (pages 1776–1783)

      Jennifer F. De Los Santos, Alan Cantor, Keith D. Amos, Andres Forero, Mehra Golshan, Janet K. Horton, Clifford A. Hudis, Nola M. Hylton, Kandace McGuire, Funda Meric-Bernstam, Ingrid M. Meszoely, Rita Nanda and E. Shelley Hwang

      Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.27995

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      In this study, the overall accuracy of magnetic resonance imaging for predicting a pathologic complete response in 746 patients with invasive breast cancer receiving neoadjuvant chemotherapy is 74%. Magnetic resonance performance differs among subtypes, possibly influenced by absolute differences in pathologic complete response rates.

    2. Chest and Lung Disease
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      Coregistered whole body magnetic resonance imaging-positron emission tomography (MRI-PET) versus PET-computed tomography plus brain MRI in staging resectable lung cancer : Comparisons of clinical effectiveness in a randomized trial (pages 1784–1791)

      Chin A Yi, Kyung Soo Lee, Ho Yun Lee, Seonwoo Kim, O Jung Kwon, Hojoong Kim, Joon Young Choi, Byung-Tae Kim, Hye Sun Hwang and Young Mog Shim

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/cncr.28000

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      Coregistered magnetic resonance imaging-positron emission tomography (MRI-PET) allows greater than 20% correct upstaging compared with conventional staging methods in patients with nonsmall cell lung cancer, but it does not appear to help identify significantly more correctly upstaged patients than positron emission tomography-computed tomography plus brain MRI. Coregistered MRI-PET may be helpful for guiding appropriate treatment and for predicting prognosis by reducing under staged lung cancer.

    3. Endocrine Disease
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      RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics (pages 1792–1799)

      Rebecca J. Leeman-Neill, Alina V. Brenner, Mark P. Little, Tetiana I. Bogdanova, Maureen Hatch, Liudmyla Y. Zurnadzy, Kiyohiko Mabuchi, Mykola D. Tronko and Yuri E. Nikiforov

      Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.27893

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      This study of papillary thyroid carcinomas in populations exposed to the 1986 accident in Chernobyl, Ukraine, provides the first documentation of PAX8/PPARγ rearrangements in post-Chernobyl thyroid cancer; demonstrates a link between chromosomal rearrangements, but not point mutations, and individual iodine-131 dose received; and points to a possible role of iodine deficiency in generation of RET/PTC rearrangements in these patients.

    4. Gastrointestinal Disease
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      Use of colonoscopy for polyp surveillance in Medicare beneficiaries (pages 1800–1807)

      Gregory S. Cooper, Tzuyung D. Kou, Jill S. Barnholtz Sloan, Siran M. Koroukian and Mark D. Schluchter

      Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.27990

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      In this population-based study of elderly Medicare beneficiaries who underwent previous colorectal polypectomy, the authors observe a frequency <50% for repeat colonoscopy within 5 years. Moreover, the frequency decreases over time, suggesting discordance from practice guidelines.

    5. Genitourinary Disease
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      Death from high-risk prostate cancer versus cardiovascular mortality with hormonal therapy : A decision analysis (pages 1808–1815)

      Nataniel H. Lester-Coll, Samuel Z. Goldhaber, David J. Sher and Anthony V. D'Amico

      Version of Record online: 7 FEB 2013 | DOI: 10.1002/cncr.27980

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      Men with a history of myocardial infarction who receive radiation therapy experience net harm when they receive hormonal therapy. Men without a history of myocardial infarction gain a quality-adjusted life-expectancy benefit from hormonal therapy; therefore, the optimal duration of hormonal therapy is a function of patient age and the number of cardiac risk factors.

      Corrected by:

      Errata: Errata: Death from high-risk prostate cancer versus cardiovascular mortality with hormonal therapy

      Vol. 119, Issue 12, 2358, Version of Record online: 2 APR 2013

    6. Gynecologic Oncology
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      External validation of a prognostic nomogram for overall survival in women with uterine leiomyosarcoma (pages 1816–1822)

      Alexia Iasonos, Emily Z. Keung, Oliver Zivanovic, Rosanna Mancari, Michele Peiretti, Marisa Nucci, Suzanne George, Nicoletta Colombo, Silvestro Carinelli, Martee L. Hensley and Chandrajit P. Raut

      Version of Record online: 1 MAR 2013 | DOI: 10.1002/cncr.27971

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      By using an independent, pooled, multi-institutional, international patient cohort, the authors validated a recently proposed prognostic nomogram for overall survival in women with uterine leiomyosarcoma.

    7. Head and Neck Disease
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      A phase 1 study of everolimus plus docetaxel plus cisplatin as induction chemotherapy for patients with locally and/or regionally advanced head and neck cancer (pages 1823–1831)

      Matthew G. Fury, Eric Sherman, Alan L. Ho, Han Xiao, Frank Tsai, Oby Nwankwo, Camelia Sima, Adrian Heguy, Nora Katabi, Sofia Haque and David G. Pfister

      Version of Record online: 13 FEB 2013 | DOI: 10.1002/cncr.27986

      This phase 1 study establishes the safety and tolerability of everolimus added to docetaxel/taxotere and cisplatin as induction chemotherapy for head and neck cancer. Everolimus dose levels that are known to be therapeutic are achieved.

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      Synchronous cancers in patients with head and neck cancer : Risks in the era of human papillomavirus-associated oropharyngeal cancer (pages 1832–1837)

      Kunal S. Jain, Andrew G. Sikora, Shrujal S. Baxi and Luc G. T. Morris

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/cncr.27988

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      This population-based cohort study, which was performed using Surveillance, Epidemiology, and End Results (SEER) data, demonstrates the various risks of synchronous second cancers among patients with head and neck cancer and the dramatic decrease in risk among patients with oropharyngeal cancer since the 1990s. These data are consistent with the etiologic shift of oropharyngeal squamous cell carcinoma from a primarily tobacco-based malignancy to a disease caused by oncogenic human papillomavirus.

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      Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program (pages 1838–1844)

      K. C. Allen Chan, Emily C. W. Hung, John K. S. Woo, Paul K. S. Chan, Sing-Fai Leung, Franco P. T. Lai, Anita S. M. Cheng, Sze Wan Yeung, Yin Wah Chan, Teresa K. C. Tsui, Jeffrey S. S. Kwok, Ann D. King, Anthony T. C. Chan, Andrew C. van Hasselt and Y. M. Dennis Lo

      Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.28001

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      This prospective study demonstrates that plasma Epstein-Barr virus DNA is detectable in patients who have early stage nasopharyngeal carcinoma. The results indicate that it is feasible to use plasma Epstein-Barr virus DNA as surveillance for nasopharyngeal carcinoma in asymptomatic individuals.

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      Hospital volume is associated with survival but not multimodality therapy in Medicare patients with advanced head and neck cancer (pages 1845–1852)

      Arun Sharma, Stephen M. Schwartz and Eduardo Méndez

      Version of Record online: 1 MAR 2013 | DOI: 10.1002/cncr.27976

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      Patients with advanced head and neck squamous cell carcinoma treated at high-volume hospitals had better survival, but were not more likely to receive National Comprehensive Cancer Network (NCCN) guideline therapy, when compared with patients treated at low-volume hospitals. These results suggest that features of high-volume hospitals, other than delivery of NCCN guideline therapy, influence survival.

    11. Hematologic Malignancies
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      Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis : A study of 176 patients with prognostic implications (pages 1853–1859)

      Tamar Tadmor, Lev Shvidel, Ariel Aviv, Rosa Ruchlemer, Osnat Bairey, Mona Yuklea, Yair Herishanu, Andre Braester, Naomi Levene, Fiona Vernea, Jonathan Ben-Ezra, Jacob Bejar, Aaron Polliack and on behalf of the Israeli CLL Study Group

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/cncr.27930

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      This study demonstrates a significant correlation between the grade of reticulin fibrosis of the bone marrow and poor overall survival and outcome in patients with chronic lymphocytic leukemia (CLL). This easy staining procedure can readily be added routinely when examining bone marrow biopsies in CLL, because results have prognostic implications for patients with CLL.

    12. Skin
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      Ultrathin primary is a marker for worse prognosis in lymph node–positive cutaneous melanoma (pages 1860–1867)

      Sanjay P. Bagaria, Partha S. Ray, Richard W. Joseph, Michael G. Heckman, Bhupendra Rawal, Richard J. Gray, Barbara Pockaj and Nabil Wasif

      Version of Record online: 13 FEB 2013 | DOI: 10.1002/cncr.27985

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      Patients with ultrathin melanomas (≤0.50 mm) who present with concurrent lymph node metastasis have poor survival. This phenomenon likely represents aggressive tumor biology.

    13. Soft Tissue and Bone Sarcoma
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      Localized and metastatic myxoid/round cell liposarcoma : Clinical and molecular observations (pages 1868–1877)

      Aviad Hoffman, Markus P. H. Ghadimi, Elizabeth G. Demicco, Chad J. Creighton, Keila Torres, Chiara Colombo, Tingsheng Peng, Kristelle Lusby, Davis Ingram, Jason L. Hornick, Wei-Lie Wang, Vinod Ravi, Alexander J. Lazar, Dina Lev and Raphael E. Pollock

      Version of Record online: 7 FEB 2013 | DOI: 10.1002/cncr.27847

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      Myxoid/round cell liposarcoma (MLPS) is a disease of relatively young adults that harbors the potential for local recurrence and metastasis. The authors have identified clinical and molecular outcome prognosticators as well as several potential therapeutic targets for patients with MLPS.

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      Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma (pages 1878–1884)

      Brian O'Sullivan, Anthony M. Griffin, Colleen I. Dickie, Michael B. Sharpe, Peter W. M. Chung, Charles N. Catton, Peter C. Ferguson, Jay S. Wunder, Benjamin M. Deheshi, Lawrence M. White, Rita A. Kandel, David A. Jaffray and Robert S. Bell

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/cncr.27951

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      The results of this prospective trial indicate that image-guided intensity-modulated radiotherapy appears to reduce the risk and severity of wound complications by reducing dose to tissues required for wound closure following soft tissue sarcoma resection. Moreover, the dose to bone and unaffected musculature is also apparently reduced, leading to improved limb function measures with no bone fractures.

    15. Discipline

      Epidemiology
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      Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma (pages 1885–1891)

      Hui Xie, Xifeng Wu, Shui Wang, David Chang, Raphael E. Pollock, Dina Lev and Jian Gu

      Version of Record online: 13 FEB 2013 | DOI: 10.1002/cncr.27984

      This is the first epidemiological study to evaluate constitutive telomere length with the risk of soft tissue sarcoma (STS). The results indicate that longer telomere length in peripheral blood lymphocytes is associated with an increased risk of STS with a significant dose-response effect, suggesting differential roles of telomere dysfunction in sarcoma and epithelial tumor development.

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      Birth rates among female cancer survivors : A population-based cohort study in Sweden (pages 1892–1899)

      Mikael Hartman, Jenny Liu, Kamila Czene, Hui Miao, Kee Seng Chia, Agus Salim and Helena M. Verkooijen

      Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.27929

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      Female cancer survivors are less likely to give birth as compared to the background population. This study suggests that large variations in the birth patterns among female cancer survivors were attributed to parity status at diagnosis, age at onset, and cancer site.

    17. Outcomes Research
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      Assessing the utility of cancer-registry–processed cause of death in calculating cancer-specific survival (pages 1900–1907)

      Chung-Yuan Hu, Yan Xing, Janice. N. Cormier and George J. Chang

      Version of Record online: 13 FEB 2013 | DOI: 10.1002/cncr.27968

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      Cancer-specific survival is considered an acceptable surrogate for relative survival in most circumstances, justifying the use of cancer-specific survival in outcome research that can be readily performed using commonly available statistical programs.

    18. Quality of Life
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      Health-related quality of life of patients with advanced breast cancer treated with everolimus plus exemestane versus placebo plus exemestane in the phase 3, randomized, controlled, BOLERO-2 trial (pages 1908–1915)

      Howard A. Burris III, Fabienne Lebrun, Hope S. Rugo, J. Thaddeus Beck, Martine Piccart, Patrick Neven, Jose Baselga, Katarina Petrakova, Gabriel N. Hortobagyi, Anna Komorowski, Edmond Chouinard, Robyn Young, Michael Gnant, Kathleen I. Pritchard, Lee Bennett, Jean-Francois Ricci, Hounayda Bauly, Tetiana Taran, Tarek Sahmoud and Shinzaburo Noguchi

      Version of Record online: 15 MAR 2013 | DOI: 10.1002/cncr.28010

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      In the randomized, controlled BOLERO-2 (Breast Cancer Trials of Oral Everolimus) trial, postmenopausal women with hormone receptor-positive advanced breast cancer who developed disease progression while receiving letrozole or anastrozole and who then received treatment with everolimus plus exemestane (EVE + EXE) experienced a longer time to definitive deterioration in global health-related quality of life (HRQOL) than those treated with placebo and EXE. Combined with significant improvements in clinical efficacy, these HRQOL findings provide added support for the benefit of EVE + EXE in this patient population.

    19. Supportive Care
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      Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States (pages 1916–1923)

      Marko Kavcic, Brian T. Fisher, Yimei Li, Alix E. Seif, Kari Torp, Dana M. Walker, Yuan-Shung Huang, Grace E. Lee, Sarah K. Tasian, Marijana Vujkovic, Rochelle Bagatell and Richard Aplenc

      Version of Record online: 21 FEB 2013 | DOI: 10.1002/cncr.27957

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      This study is the first comprehensive analysis of national trends in pediatric acute myeloid leukemia induction mortality and resource utilization. Using resource utilization data as a proxy for adverse events, adverse event rates reported on clinical trials substantially underestimated the clinical toxicities of all pediatric acute myeloid leukemia induction regimens.

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