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Cancer

Cover image for Vol. 119 Issue 13

01 July 2013

Volume 119, Issue 13

Pages 2359–2513

  1. Issue information

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Editorial
    5. Original Articles
    6. Correspondence
    7. Erratum
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      Issue information (pages i–viii)

      Version of Record online: 22 FEB 2016 | DOI: 10.1002/cncr.29916

  2. CancerScope

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Editorial
    5. Original Articles
    6. Correspondence
    7. Erratum
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    2. You have free access to this content
    3. You have free access to this content
  3. Editorial

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Editorial
    5. Original Articles
    6. Correspondence
    7. Erratum
    1. You have free access to this content
      Acupuncture: Could an ancient therapy be the latest advance in the treatment of lymphedema? (pages 2362–2365)

      Brian D. Lawenda and Frank A. Vicini

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28090

      Acupuncture, an ancient medical therapy, might be the latest treatment for breast cancer–related lymphedema (BCRL). In this review, you will learn about diagnostic assessments, risk factors, complete decongestive therapy, and the potential role of acupuncture for BCRL.

  4. Original Articles

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Editorial
    5. Original Articles
    6. Correspondence
    7. Erratum
    1. Disease Site

      Breast Disease
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      Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors (pages 2366–2374)

      Xingxing Chen, Xiaoli Yu, Jiayi Chen, Zhen Zhang, Jeffrey Tuan, Zhimin Shao, Xiaomao Guo and Yan Feng

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28085

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      Patients with triple-negative breast cancer reportedly have a high rate of locoregional recurrence (LRR), but data are limited on the patterns of recurrence and prognostic factors of LRR specific to early stage triple-negative breast cancer. In a retrospective analysis of a large series of patients who had triple-negative breast cancer with pathologic T1/T2 tumors and N0/N1 lymph node status who underwent modified radical mastectomy without postmastectomy radiotherapy, several risk factors are identified that correlate independently with LRR, which will aid decision making for locoregional therapy in this specific population.

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      Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort (pages 2375–2382)

      Liana D. Castel, Katherine E. Hartmann, Ingrid A. Mayer, Benjamin R. Saville, JoAnn Alvarez, Chad S. Boomershine, Vandana G. Abramson, A. Bapsi Chakravarthy, Debra L. Friedman and David F. Cella

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28016

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      In postmenopausal women initiating aromatase inhibitors (AI) for adjuvant hormonal treatment of early-stage breast cancer, arthralgia (joint pain) trajectories diverge in comparison with the background rate at 6 weeks following AI initiation, and arthralgia worsens over a year following the divergence. Menopausal symptom severity and existing joint conditions at AI initiation should be assessed in women initiating AI to identify patients at risk for later new or exacerbating arthralgia.

    3. Chest and Lung Disease
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      Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients (pages 2383–2390)

      Andrew J. Weickhardt, Robert C. Doebele, W. Thomas Purcell, Paul A. Bunn, Ana B. Oton, Micol S. Rothman, Margaret E. Wierman, Tony Mok, Sanjay Popat, Julie Bauman, Jorge Nieva, Silvia Novello, Sai-Hong Ignatius Ou and D. Ross Camidge

      Version of Record online: 12 APR 2013 | DOI: 10.1002/cncr.28089

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      Crizotinib therapy rapidly reduced total testosterone levels in 84% of men studied (27 of 32), reflecting decreases in both gonadotropins and in testosterone-binding proteins. Free testosterone was low in 76%, with the majority (84%) manifesting symptoms of androgen deficiency and more than half experiencing benefit from testosterone replacement.

    4. Gastrointestinal Disease
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      Squamous cell carcinoma antigen: A potentially useful prognostic marker in squamous cell carcinoma of the anal canal and margin (pages 2391–2398)

      Matt Williams, Angela Swampillai, Melanie Osborne, Suzannah Mawdsley, Rob Hughes, Mark Harrison, Richard Harvey, Rob Glynne-Jones and on behalf of the Mount Vernon Colorectal Cancer Network

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28055

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      The results from this retrospective analysis indicate that pretreatment squamous cell carcinoma antigen (SCCAg) levels in patients with squamous cell carcinoma of the anal canal and margin correlate with clinical tumor classification and lymph node status. In addition, elevated pretreatment levels of SCCAg are associated with a reduced chance of achieving a complete response and an increased chance of recurrence and death.

    5. Genitourinary Disease
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      Agent Orange as a risk factor for high-grade prostate cancer (pages 2399–2404)

      Nathan Ansbaugh, Jackilen Shannon, Motomi Mori, Paige E. Farris and Mark Garzotto

      Version of Record online: 13 MAY 2013 | DOI: 10.1002/cncr.27941

      It is unknown whether Agent Orange exposure increases the overall risk of developing prostate cancer or whether it specifically increases the risk of lethal prostate cancer. The objective of this study is to determine the association between Agent Orange exposure and the risk of detecting high-grade prostate cancer (Gleason score ≥7) on biopsy in a US veteran cohort.

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      Genetic markers associated with early cancer-specific mortality following prostatectomy (pages 2405–2412)

      Wennuan Liu, Chunmei C. Xie, Christopher Y. Thomas, Seong-Tae Kim, Johan Lindberg, Lars Egevad, Zhong Wang, Zheng Zhang, Jishan Sun, Jielin Sun, Patrick P. Koty, A. Karim Kader, Scott D. Cramer, G. Steven Bova, S. Lilly Zheng, Henrik Grönberg, William B. Isaacs and Jianfeng Xu

      Version of Record online: 22 APR 2013 | DOI: 10.1002/cncr.27954

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      Genome-wide analysis of prostate cancer reveals copy number alterations of multiple genetic loci associated with early cancer-specific mortality. These findings may allow for more accurate patient prognosis at the time of surgery or biopsy, and may help guide the selection of appropriate therapy.

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      Consideration of comorbidity in risk stratification prior to prostate biopsy (pages 2413–2418)

      Michael A. Liss, John Billimek, Kathryn Osann, Jane Cho, Ross Moskowitz, Adam Kaplan, Richard J. Szabo, Sherrie H. Kaplan, Sheldon Greenfield and Atreya Dash

      Version of Record online: 25 APR 2013 | DOI: 10.1002/cncr.28044

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      Organizations are recommending the use of life tables or comorbidity assessment in patients before prostate cancer screening or prostate biopsy to reduce overtreatment; however, they do not provide specific means for comorbidity analysis. In the current study, the authors present the Charlson Comorbidity Index and the patient-reported Total Illness Burden Index for Prostate Cancer (TIBI-CaP) as tools to predict acute hospital admission as a surrogate for poor overall health and those patients who should avoid prostate biopsy.

    8. Head and Neck Disease
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      Modifiable risk behaviors in patients with head and neck cancer (pages 2419–2426)

      Janani Sivasithamparam, Carly A. Visk, Ezra E. W. Cohen and Andrea C. King

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.27993

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      Cigarette smoking is associated with engagement in other modifiable risk factors in patients with head and neck cancer, yet self-report measures may not accurately depict true smoking status. Regular screening and targeted interventions for these behaviors are warranted.

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      Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma (pages 2427–2437)

      Sydney Ch'ng, Sophie Corbett-Burns, Norm Stanton, Kan Gao, Kerwin Shannon, Anthony Clifford, Ruta Gupta and Jonathan R. Clark

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28081

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      Close margins alone in the absence of additional adverse features do not warrant postoperative adjuvant radiotherapy for patients with oral squamous cell carcinoma. In this study, the local control rate among patients who undergo surgery alone is 91%.

    10. Hematologic Malignancies
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      Autologous retransplantation for patients with recurrent multiple myeloma: A single-center experience with 200 patients (pages 2438–2446)

      Leopold Sellner, Christiane Heiss, Axel Benner, Marc S. Raab, Jens Hillengass, Dirk Hose, Nicola Lehners, Gerlinde Egerer, Anthony D. Ho, Hartmut Goldschmidt and Kai Neben

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28104

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      Therapeutic options for patients with recurrent multiple myeloma after autologous stem cell transplantation (ASCT) include novel agents, conventional chemotherapy, or salvage ASCT with no standard of care. In the current study, the authors demonstrate that the use of lenalidomide and bortezomib for reinduction has improved the results after salvage ASCT in 200 patients, suggesting that novel agents and salvage ASCT are complementary rather than alternative treatment approaches

    11. Discipline

      Clinical Trials
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      Effect of body mass index on tumor characteristics and disease-free survival in patients from the HER2-positive adjuvant trastuzumab trial N9831 (pages 2447–2454)

      Jennifer A. Crozier, Alvaro Moreno-Aspitia, Karla V. Ballman, Amylou C. Dueck, Barbara A. Pockaj and Edith A. Perez

      Version of Record online: 12 APR 2013 | DOI: 10.1002/cncr.28051

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      In patients with resected, HER2-positive, early stage breast cancer, a baseline body mass index of ≥25 kg/m2 is associated with a lower 5-year disease-free survival. Adjuvant trastuzumab leads to an improvement in disease-free survival for all patients, regardless of their body mass index.

    12. Complementary Medicine
      You have full text access to this OnlineOpen article
      Acupuncture in the treatment of upper-limb lymphedema: Results of a pilot study (pages 2455–2461)

      Barrie R. Cassileth, Kimberly J. Van Zee, K. Simon Yeung, Marci I. Coleton, Sara Cohen, Yi H. Chan, Andrew J. Vickers, Daniel D. Sjoberg and Clifford A. Hudis

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28093

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      Acupuncture for breast cancer–related lymphedema appears safe and may reduce arm circumference. Although these results await confirmation in a randomized trial, acupuncture can be considered for women with no other options for sustained arm circumference reduction.

    13. Disparities Research
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      Trends in immediate breast reconstruction across insurance groups after enactment of breast cancer legislation (pages 2462–2468)

      Rachel L. Yang, Andrew S. Newman, Ines C. Lin, Caroline E. Reinke, Giorgos C. Karakousis, Brian J. Czerniecki, Liza C. Wu and Rachel R. Kelz

      Version of Record online: 12 APR 2013 | DOI: 10.1002/cncr.28050

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      After the enactment of policies designed to improve access to breast reconstruction, overall rates of postmastectomy immediate breast reconstruction increased. Medicaid and Medicare patients saw the greatest relative rise in rates of immediate breast reconstruction, yet their likelihood of undergoing immediate breast reconstruction still remains low compared with privately insured patients.

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      Analyzing excess mortality from cancer among individuals with mental illness (pages 2469–2476)

      Jackson S. Musuuza, Marion E. Sherman, Kraig J. Knudsen, Helen Anne Sweeney, Carl V. Tyler and Siran M. Koroukian

      Version of Record online: 12 APR 2013 | DOI: 10.1002/cncr.28091

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      Compared with the general population in Ohio, individuals with mental illness experienced excess mortality from cancers, possibly explained by a higher prevalence of smoking, substance abuse, and chronic hepatitis B or C infections in individuals with mental illness, but also by hindered access to care.

    15. Epidemiology
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      The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk (pages 2477–2485)

      Andrea Y. Angstadt, Arthur Berg, Junjia Zhu, Paige Miller, Terryl J. Hartman, Samuel M. Lesko, Joshua E. Muscat, Philip Lazarus and Carla J. Gallagher

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28009

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      UGT2B17 and UGT2B28 are 2 of the most commonly deleted genes in the human genome and are metabolizers of environmental and endogenous compounds. This study found that the UGT2B17 gene deletion is associated with decreased colorectal cancer risk, suggesting a protective function for the UGT2B17 gene, because individuals without the gene may have higher circulating levels of flavonoids and nonsteroidal anti-inflammatory drugs.

    16. Outcomes Research
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      Racial differences in time from prostate cancer diagnosis to treatment initiation : A Population-Based Study (pages 2486–2493)

      William A. Stokes, Laura H. Hendrix, Trevor J. Royce, Ian M. Allen, Paul A. Godley, Andrew Z. Wang and Ronald C. Chen

      Version of Record online: 28 MAY 2013 | DOI: 10.1002/cncr.27975

      In an analysis of SEER-Medicare data, African Americans experience longer intervals than Caucasians from diagnosis to treatment for localized prostate cancer. Although small, these differences help inform our understanding of racial disparities in this disease.

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      Cost-effectiveness of full coverage of aromatase inhibitors for Medicare beneficiaries with early breast cancer (pages 2494–2502)

      Kouta Ito, Elena Elkin, Victoria Blinder, Nancy Keating and Niteesh Choudhry

      Version of Record online: 23 APR 2013 | DOI: 10.1002/cncr.28084

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      Rates of nonadherence to aromatase inhibitors among Medicare beneficiaries with hormone receptor-positive early breast cancer are high. The elimination of copayments for aromatase inhibitors for these Medicare beneficiaries would be cost saving to society.

    18. Psychosocial Oncology
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      Cumulative family risk predicts sibling adjustment to childhood cancer (pages 2503–2510)

      Kristin A. Long, Anna L. Marsland and Melissa A. Alderfer

      Version of Record online: 10 APR 2013 | DOI: 10.1002/cncr.28077

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      Among 209 siblings of children with cancer, higher distress is associated with more family functioning problems, higher parental psychological control, and lower parenting acceptance. When family risk factors are considered in combination, the results support a quadratic model in which associations between family risk and sibling distress are stronger at higher levels of risk.

  5. Correspondence

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Editorial
    5. Original Articles
    6. Correspondence
    7. Erratum
    1. You have free access to this content
      Monitoring of seminoma patients with serum markers (page 2511)

      Kristina Hotakainen, Anna Lempiäinen and Ulf-Håkan Stenman

      Version of Record online: 12 APR 2013 | DOI: 10.1002/cncr.28008

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      Reply to monitoring of seminoma patients with serum markers (pages 2511–2512)

      Danny Vesprini, Padraig Warde and Peter Chung

      Version of Record online: 12 APR 2013 | DOI: 10.1002/cncr.28005

  6. Erratum

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Editorial
    5. Original Articles
    6. Correspondence
    7. Erratum
    1. You have free access to this content

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