Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women (pages 488–494)
Theresa Schwartz, Azadeh Stark, Judy Pang, Baffour Awuah, Celina G. Kleer, Solomon Quayson, Stephanie Kingman, Francis Aitpillah, Francis Abantanga, Evelyn Jiagge, Joseph K. Oppong, Ernest Osei-Bonsu, Iman Martin, Xiaowei Yan, Kathy Toy, Ernest Adjei, Max Wicha and Lisa A. Newman
Version of Record online: 28 AUG 2012 | DOI: 10.1002/cncr.27737
Mammary stem cells, as identified by cells expressing the marker aldehyde dehydrogenase 1 (ALDH1), appear to be correlated with malignant transformation and progression of breast tissue into biologically aggressive phenotypes. This study reveals increased expression of ALDH1 in benign and malignant tissue of women from the western sub-Saharan African nation of Ghana, a population known to have higher frequency of triple-negative breast cancer, and ALDH1 expression in the malignant specimens was found to be associated with risk of triple-negative breast cancer.