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Cancer

Cover image for Vol. 120 Issue 17

September 1, 2014

Volume 120, Issue 17

Pages 2625–2780

  1. Issue information

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Issue information (pages i–vii)

      Version of Record online: 23 SEP 2015 | DOI: 10.1002/cncr.29718

  2. CancerScope

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Highlights from the AACR annual meeting (page 2627)

      Carrie Printz

      Version of Record online: 20 AUG 2014 | DOI: 10.1002/cncr.28944

  3. Review Articles

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Concept and viability of androgen annihilation for advanced prostate cancer (pages 2628–2637)

      James L. Mohler

      Version of Record online: 25 APR 2014 | DOI: 10.1002/cncr.28675

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      Prostate-specific antigen recurrence after radical prostatectomy signifies minimal residual disease. Early application of short-term more intensive androgen deprivation therapy (androgen annihilation) using newer agents may offer an opportunity for cure.

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      Surgical management of localized soft tissue tumors (pages 2638–2648)

      Alessandro Gronchi, Chiara Colombo and Chandrajit P. Raut

      Version of Record online: 17 APR 2014 | DOI: 10.1002/cncr.28715

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      The surgical approach to soft tissue tumors has undergone significant changes over the past 10 years. A better understanding of the natural history of the different histologic subtypes, the importance of tumor site, and the different sensitivity to available drugs has opened the way to advances in the individualized treatment of most of them.

  4. Original Articles

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. Disease Site

      Breast Disease
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      Reduction in late-stage breast cancer incidence in the mammography era: Implications for overdiagnosis of invasive cancer (pages 2649–2656)

      Mark A. Helvie, Joanne T. Chang, R. Edward Hendrick and Mousumi Banerjee

      Version of Record online: 19 MAY 2014 | DOI: 10.1002/cncr.28784

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      Data from the mammography era have demonstrated evidence of a substantial reduction in late-stage breast cancer when appropriate adjustments are made for prescreening temporal trends. At background annual percent change estimates of ≥ 1%, the incidence of total invasive breast cancer also was found to decrease.

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      Assessing the discordance rate between local and central HER2 testing in women with locally determined HER2-negative breast cancer (pages 2657–2664)

      Peter A. Kaufman, Kenneth J. Bloom, Howard Burris, Julie R. Gralow, Musa Mayer, Mark Pegram, Hope S. Rugo, Sandra M. Swain, Denise A. Yardley, Miu Chau, Deepa Lalla, Bongin Yoo, Melissa G. Brammer and Charles L. Vogel

      Version of Record online: 13 JUN 2014 | DOI: 10.1002/cncr.28710

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      Breast tumor samples from patients in the VIRGO observational cohort study originally determined to be negative for HER2 (human epidermal growth factor receptor 2) were retested using both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (n = 552); of these, 22 (4%) were found to be HER2-positive. Eighteen samples were initially assessed with a single test, and 15 of these were determined to be HER2-positive with the testing methodology (IHC or FISH) not performed initially. These results highlight the value of using multiple tests to assess HER2 status to ensure patients do not forgo potentially efficacious therapy.

    3. Gastrointestinal Disease
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      A randomized controlled trial of a multiple health behavior change intervention delivered to colorectal cancer survivors: Effects on sedentary behavior (pages 2665–2672)

      Brigid M. Lynch, Kerry S. Courneya, Parneet Sethi, Tania A. Patrao and Anna L. Hawkes

      Version of Record online: 9 MAY 2014 | DOI: 10.1002/cncr.28773

      The CanChange intervention (a telephone-delivered multiple health behavior change intervention) was found to have a potentially meaningful, but nonsignificant, effect on total sedentary time. Significant differences in some subgroup analyses were observed.

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      High-risk human papillomavirus infection associated with telomere elongation in patients with esophageal squamous cell carcinoma with poor prognosis (pages 2673–2683)

      Dong-Hong Zhang, Jiong-Yu Chen, Chao-Qun Hong, De-Qing Yi, Fei Wang and Wei Cui

      Version of Record online: 19 MAY 2014 | DOI: 10.1002/cncr.28797

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      A previous study from the authors indicated that infection with high-risk human papillomavirus types 16, 18, and 58 was a risk factor for esophageal squamous cell carcinoma in the Shantou region of China. In the current study, the authors found that high-risk human papillomavirus infection and integration related to long telomere length and DNA methylation may be a potential biomarker of prognosis in patients with esophageal squamous cell carcinoma.

    5. Genitourinary Disease
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      A randomized phase 2 trial of gemcitabine/cisplatin with or without cetuximab in patients with advanced urothelial carcinoma (pages 2684–2693)

      Maha Hussain, Stephanie Daignault, Neeraj Agarwal, Petros D. Grivas, Arlene O. Siefker-Radtke, Igor Puzanov, Gary R. MacVicar, Ellis Glenn Levine, Sandy Srinivas, Przemyslaw Twardowski, Mario A. Eisenberger, David I. Quinn, Ulka N. Vaishampayan, Evan Y. Yu, Scott Dawsey, Kathleen C. Day, Mark L. Day, Mahmoud Al-Hawary and David C. Smith

      Version of Record online: 6 MAY 2014 | DOI: 10.1002/cncr.28767

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      The combination of cetuximab and gemcitabine/cisplatin is feasible. The combination does not appear to improve response rates in patients with advanced urothelial carcinoma.

    6. Head and Neck Disease
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      Treatment of advanced thyroid cancer with axitinib: Phase 2 study with pharmacokinetic/pharmacodynamic and quality-of-life assessments (pages 2694–2703)

      Laura D. Locati, Lisa Licitra, Laura Agate, Sai-Hong I. Ou, Andree Boucher, Barbara Jarzab, Shukui Qin, Madeleine A. Kane, Lori J. Wirth, Connie Chen, Sinil Kim, Antonella Ingrosso, Yazdi K. Pithavala, Paul Bycott and Ezra E. W. Cohen

      Version of Record online: 20 MAY 2014 | DOI: 10.1002/cncr.28766

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      This phase 2 trial confirms the clinical activity and favorable safety profile of axitinib in patients with advanced thyroid cancer. Pharmacokinetic/pharmacodynamic analyses suggest that patients with greater axitinib exposure may have longer progression-free survival, and an assessment of patient-reported outcomes indicates that quality of life is maintained during axitinib therapy.

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      Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma (pages 2704–2712)

      Anna E. Arthur, Karen E. Peterson, Jincheng Shen, Zora Djuric, Jeremy M. G. Taylor, James R. Hebert, Sonia A. Duffy, Lisa A. Peterson, Emily L. Bellile, Joel R. Whitfield, Douglas B. Chepeha, Matthew J. Schipper, Gregory T. Wolf and Laura S. Rozek

      Version of Record online: 15 MAY 2014 | DOI: 10.1002/cncr.28778

      Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with head and neck cancer.

    8. Neuro-Oncology
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      Patterns of presentation and failure in patients with gliomatosis cerebri treated with partial-brain radiation therapy (pages 2713–2720)

      Shravan Kandula, Amit M. Saindane, Roshan S. Prabhu, Sheela Hanasoge, Kirtesh R. Patel, Hui-Kuo Shu, Walter J. Curran and Ian R. Crocker

      Version of Record online: 20 MAY 2014 | DOI: 10.1002/cncr.28785

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      In patients with gliomatosis cerebri who were treated with partial-brain radiation therapy, nearly all recurrences were infield and clinical outcomes were similar to historical series, thereby suggesting that whole-brain radiation therapy is not necessary for this patient population. A greater number of involved lobes also did not appear to correlate with inferior outcomes.

    9. Discipline

      Disparities Research
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      Decisional conflict in economically disadvantaged men with newly diagnosed prostate cancer: Baseline results from a shared decision-making trial (pages 2721–2727)

      Alan L. Kaplan, Catherine M. Crespi, Josemanuel D. Saucedo, Sarah E. Connor, Mark S. Litwin and Christopher S. Saigal

      Version of Record online: 9 MAY 2014 | DOI: 10.1002/cncr.28755

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      In economically disadvantaged men with newly diagnosed prostate cancer, a poor understanding of the disease is associated with personal conflict surrounding the treatment decision. Targeted educational interventions may mitigate the decisional burden.

    10. Epidemiology
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      Increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States (pages 2728–2734)

      Franklin L. Chien, Stephen M. Schwartz and Rebecca H. Johnson

      Version of Record online: 14 JUL 2014 | DOI: 10.1002/cncr.28684

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      There has been a recent, substantial increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States. Similar trends are not observed in non-Hispanic whites.

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      Risk of second primary tumors in men diagnosed with prostate cancer: A population-based cohort study (pages 2735–2741)

      Elizabeth J. Davis, Jennifer L. Beebe-Dimmer, Cecilia L. Yee and Kathleen A. Cooney

      Version of Record online: 19 MAY 2014 | DOI: 10.1002/cncr.28769

      Men diagnosed with prostate cancer have a high 10-year relative survival rate, which raises questions about the need for surveillance for secondary cancers. Although the overall risk for secondary malignancies in this cohort is lower than that in the US general population, these patients have a greater likelihood of being diagnosed with bladder, kidney, and soft tissue cancers.

    12. Outcomes Research
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      Lifestyle and metabolic syndrome in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study (pages 2742–2750)

      Webb A. Smith, Chenghong Li, Kerri A. Nottage, Daniel A. Mulrooney, Gregory T. Armstrong, Jennifer Q. Lanctot, Wassim Chemaitilly, Joseph H. Laver, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson and Kirsten K. Ness

      Version of Record online: 28 JUL 2014 | DOI: 10.1002/cncr.28670

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      Survivors of childhood cancer are at an increased risk of developing metabolic syndrome, which may be reduced with lifestyle modifications. Adherence to a heart-healthy lifestyle is associated with a lower risk of metabolic syndrome among survivors of childhood cancer.

    13. Pediatric Oncology
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      Inferior survival among Aboriginal children with cancer in Ontario (pages 2751–2759)

      Stacey Marjerrison, Jason D. Pole and Lillian Sung

      Version of Record online: 13 MAY 2014 | DOI: 10.1002/cncr.28762

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      In the first study to report Canadian Aboriginal childhood cancer outcomes, approximately 15% lower survival is demonstrated among Aboriginal versus non-Aboriginal children in Ontario. Because baseline characteristics, the times to diagnosis and treatment, the presence of metastasis, nutritional status, and treatment approach do not differ according to Aboriginal ethnicity, socioeconomic disparity does not appear to be driving the outcome discrepancy, as commonly postulated in the literature.

    14. Radiation Oncology
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      Extreme heterogeneity of myeloablative total body irradiation techniques in clinical practice: A survey of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (pages 2760–2765)

      Sebastian Giebel, Leszek Miszczyk, Krzysztof Slosarek, Leila Moukhtari, Fabio Ciceri, Jordi Esteve, Norbert-Claude Gorin, Myriam Labopin, Arnon Nagler, Christoph Schmid and Mohamad Mohty

      Version of Record online: 7 MAY 2014 | DOI: 10.1002/cncr.28768

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      Results of the current survey analysis indicate that total body irradiation is an extremely heterogeneous treatment modality. The differences between treatment centers may influence both the efficacy and toxicity of the procedure.

    15. Translational Research
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      Coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma (pages 2766–2777)

      Ya-Chin Hou, Ying-Jui Chao, Hui-Ling Tung, Hao-Chen Wang and Yan-Shen Shan

      Version of Record online: 19 MAY 2014 | DOI: 10.1002/cncr.28774

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      The clinical significance of pancreatic cancer stem cells and tumor-associated macrophages is explored in patients with pancreatic ductal adenocarcinoma. The results clearly demonstrate that coexpression of 2 cancer stem cell markers (CD44 and CD133) and a tumor-associated macrophage marker (CD204) is a useful prognostic factor for predicting the survival of patients with pancreatic ductal adenocarcinoma after surgery.

  5. Correspondence

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. You have free access to this content
    2. You have free access to this content

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