Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer (pages 1228–1236)
Xianhan Jiang, Xun Li, Hai Huang, Funeng Jiang, Zhuoyuan Lin, Huichan He, Yanru Chen, Fei Yue, Jing Zou, Yongzhong He, Pan You, Wenwei Wang, Weiqing Yang, Haibo Zhao, Yiming Lai, Fen Wang, Weide Zhong and Leyuan Liu
Article first published online: 3 JAN 2014 | DOI: 10.1002/cncr.28551
Leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) is a mitochondrion-associated autophagy inhibitor that protects mitochondria from degradation. To the authors' knowledge, the current study is the first to demonstrate that high levels of LRPPRC are associated with poor prognosis in patients with late-stage prostate cancer.