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Cancer

Cover image for Vol. 120 Issue 9

1 May 2014

Volume 120, Issue 9

Pages 1287–1442

  1. Issue information

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Commentary
    5. Editorial
    6. Original Articles
    7. Correspondence
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      Issue information (pages i–viii)

      Version of Record online: 25 SEP 2015 | DOI: 10.1002/cncr.29627

  2. CancerScope

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Commentary
    5. Editorial
    6. Original Articles
    7. Correspondence
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      Diabetes associated with increased risk of liver cancer (page 1288)

      Carrie Printz

      Version of Record online: 22 APR 2014 | DOI: 10.1002/cncr.28718

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      Cancer mutation tied to scleroderma (page 1289)

      Carrie Printz

      Version of Record online: 22 APR 2014 | DOI: 10.1002/cncr.28719

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  3. Commentary

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Commentary
    5. Editorial
    6. Original Articles
    7. Correspondence
    1. You have full text access to this OnlineOpen article
      Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer (pages 1290–1314)

      Brenda K. Edwards, Anne-Michelle Noone, Angela B. Mariotto, Edgar P. Simard, Francis P. Boscoe, S. Jane Henley, Ahmedin Jemal, Hyunsoon Cho, Robert N. Anderson, Betsy A. Kohler, Christie R. Eheman and Elizabeth M. Ward

      Version of Record online: 16 DEC 2013 | DOI: 10.1002/cncr.28509

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      Cancer death rates in the United States continue to decline. Estimates of survival that include the probability of dying of cancer and other causes stratified by comorbidity level, age, and stage can provide important information to facilitate treatment decisions.

  4. Editorial

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Commentary
    5. Editorial
    6. Original Articles
    7. Correspondence
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      Increased clarity on the use of radiotherapy in the management of desmoplastic melanoma (pages 1315–1318)

      Roy B. Tishler

      Version of Record online: 20 FEB 2014 | DOI: 10.1002/cncr.28613

      Desmoplastic melanoma is a rare type of cutaneous melanoma with a distinct clinical behavior characterized by a propensity for local recurrence. The 2 articles in this issue of Cancer present significant information clarifying the role of adjuvant radiotherapy in the treatment of patients with desmoplastic melanoma.

  5. Original Articles

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Commentary
    5. Editorial
    6. Original Articles
    7. Correspondence
    1. Disease Site

      Breast Disease
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      Primary tumor resection as a component of multimodality treatment may improve local control and survival in patients with stage IV inflammatory breast cancer (pages 1319–1328)

      Catherine L. Akay, Naoto T. Ueno, Gary B. Chisholm, Gabriel N. Hortobagyi, Wendy A. Woodward, Ricardo H. Alvarez, Isabelle Bedrosian, Henry M. Kuerer, Kelly K. Hunt, Lei Huo and Gildy V. Babiera

      Version of Record online: 7 FEB 2014 | DOI: 10.1002/cncr.28550

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      Multimodality treatment that includes primary tumor resection may result in better overall survival, distant progression-free survival, and local control for patients with stage IV inflammatory breast cancer. Primary tumor resection is associated with better overall and distant progression-free survival for responders as well as nonresponders to induction chemotherapy.

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      GATA3 mutations define a unique subtype of luminal-like breast cancer with improved survival (pages 1329–1337)

      Yi-Zhou Jiang, Ke-Da Yu, Wen-Jia Zuo, Wen-Ting Peng and Zhi-Ming Shao

      Version of Record online: 29 JAN 2014 | DOI: 10.1002/cncr.28566

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      GATA3 (GATA-binding protein 3) mutations mainly occur in luminal-like breast cancer, are mostly mutually exclusive to PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) and TP53 (tumor protein p53) mutations, and are associated with a favorable prognosis. GATA3 mutations define a subgroup of patients with luminal-like breast cancer in whom limited therapy may be appropriate.

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      Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study (pages 1338–1344)

      Yuan-Wen Lee, Ta-Liang Chen, Yu-Ru Vernon Shih, Chu-Lin Tsai, Chuen-Chau Chang, Hung-Hua Liang, Sung-Hui Tseng, Shu-Chen Chien and Ching-Chiung Wang

      Version of Record online: 3 FEB 2014 | DOI: 10.1002/cncr.28579

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      Traditional Chinese medicine is one of the most common complementary and alternative medicines used in the treatment of patients with breast cancer. This population-based cohort study provides evidence that adjunctive therapy with traditional Chinese medicine improves the survival of patients with advanced breast cancer.

    4. Endocrine Disease
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      Annual financial impact of well-differentiated thyroid cancer care in the United States (pages 1345–1352)

      Carrie C. Lubitz, Chung Y. Kong, Pamela M. McMahon, Gilbert H. Daniels, Yufei Chen, Konstantinos P. Economopoulos, G. Scott Gazelle and Milton C. Weinstein

      Version of Record online: 30 JAN 2014 | DOI: 10.1002/cncr.28562

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      The incidence and prevalence of thyroid cancer is increasing. This analysis of the US cost of well-differentiated thyroid cancer care estimates the toll to be more than US $1.6 billion in 2013, and, unlike other cancers where the cost is mostly attributable to the last year of care, initial treatment and surveillance of thyroid cancer survivors makes up 78% of this annual cost.

    5. Head and Neck Disease
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      Evaluation of plasma Epstein-Barr virus DNA load to distinguish nasopharyngeal carcinoma patients from healthy high-risk populations in Southern China (pages 1353–1360)

      Ming-Fang Ji, Qi-Hong Huang, Xia Yu, Zhiwei Liu, Xinghua Li, Li-Fang Zhang, Panpan Wang, Shang-Hang Xie, Hui-Lan Rao, Fang Fang, Xiang Guo, Qing Liu, Ming-Huang Hong, Weimin Ye, Yi-Xin Zeng and Su-Mei Cao

      Version of Record online: 29 JAN 2014 | DOI: 10.1002/cncr.28564

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      This study is the first to prospectively evaluate whether plasma Epstein-Barr virus (EBV) DNA load may serve as a complementary screening tool to distinguish nasopharyngeal carcinoma (NPC) patients from the individuals who are positive for anti-EBV antibodies in a population-based NPC screening trial in endemic areas. The results provide high-grade evidence that EBV DNA could be useful in clinical diagnosis of NPC but has limited value in screening for early stage NPC or predicting NPC development.

    6. Melanoma
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      The role of adjuvant radiotherapy in the local management of desmoplastic melanoma (pages 1361–1368)

      B. Ashleigh Guadagnolo, Victor Prieto, Randal Weber, Merrick I. Ross and Gunar K. Zagars

      Version of Record online: 18 OCT 2013 | DOI: 10.1002/cncr.28415

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      The authors performed a retrospective review of 130 consecutive patients presenting for definitive treatment of nonmetastatic desmoplastic melanoma. It was observed that patients treated with surgery followed by postoperative radiotherapy had superior local control compared with patients treated with surgery alone.

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      Radiotherapy influences local control in patients with desmoplastic melanoma (pages 1369–1378)

      Tobin Strom, Jimmy J. Caudell, Dale Han, Jonathan S. Zager, Daohai Yu, C. Wayne Cruse, Suroosh S. Marzban, Jane L. Messina, Andy M. Trotti, Vernon K. Sondak and Nikhil G. Rao

      Version of Record online: 18 OCT 2013 | DOI: 10.1002/cncr.28412

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      Radiotherapy for desmoplastic melanoma was found to be independently associated with improved local control. Patients with positive resection margins or deeper tumors appeared to benefit the most from radiotherapy, whereas selected low-risk patients, including those with negative resection margins and a Breslow depth of 4 mm or less and either no perineural invasion present or a non-head and neck tumor location, can safely omit radiotherapy.

    8. Discipline

      Clinical Trials
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      A randomized phase 2 trial of erlotinib versus pemetrexed as second-line therapy in the treatment of patients with advanced EGFR wild-type and EGFR FISH-positive lung adenocarcinoma (pages 1379–1386)

      Ning Li, Wei Ou, Hua Yang, Qian-Wen Liu, Song-Liang Zhang, Bao-Xiao Wang and Si-Yu Wang

      Version of Record online: 30 JAN 2014 | DOI: 10.1002/cncr.28591

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      The results of the current randomized phase 2 trial demonstrate that there are no significant differences in efficacy between erlotinib and pemetrexed in the second-line setting for patients with advanced epidermal growth factor receptor wild-type and epidermal growth factor receptor fluorescence in situ hybridization-positive lung adenocarcinoma, and both regimens are effective treatment options in the second-line setting for these patients.

    9. Disparities Research
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      Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants (pages 1387–1393)

      Marianna Sarkissyan, Yanyuan Wu, Zujian Chen, Dhruva K. Mishra, Suren Sarkissyan, Ioannis Giannikopoulos and Jaydutt V. Vadgama

      Version of Record online: 7 FEB 2014 | DOI: 10.1002/cncr.28565

      Vitamin D receptor Fokl polymorphisms are associated with colorectal cancer in African American study participants. Vitamin D receptor polymorphisms may modulate vitamin D activity and affect risk.

    10. Epidemiology
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      Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer (pages 1394–1400)

      Hyunseok Kang, Theresa W. Gillespie, Michael Goodman, Seth A. Brodie, Mina Brandes, Maria Ribeiro, Suresh S. Ramalingam, Dong M. Shin, Fadlo R. Khuri and Johann Christoph Brandes

      Version of Record online: 24 MAR 2014 | DOI: 10.1002/cncr.28479

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      Because epigenetic changes are early events in smoking-induced carcinogenesis, the authors investigated the incidence of smoking-related cancers in patients with long-term use of the histone deacetylase inhibitor valproic acid. Use of valproic acid was associated with a significant reduction in the risk of head and neck cancer (hazards ratio, 0.66; 95% confidence interval, 0.48-0.92).

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      Immigration factors and prostate cancer survival among Hispanic men in California: Does neighborhood matter? (pages 1401–1408)

      Clayton W. Schupp, David J. Press and Scarlett Lin Gomez

      Version of Record online: 29 JAN 2014 | DOI: 10.1002/cncr.28587

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      Despite the tendency toward a later stage of prostate cancer at the time of diagnosis and a greater likelihood of living in neighborhoods of lower socioeconomic status and Hispanic ethnic enclaves, foreign-born Hispanics had better survival after prostate cancer than US-born Hispanics. Further research is needed to examine the reasons for the observed paradox because identifying factors that facilitate this survival advantage in Hispanic immigrants may improve survival for all men with prostate cancer.

    12. Outcomes Research
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      Sharpening the focus on causes and timing of readmission after radical cystectomy for bladder cancer (pages 1409–1416)

      Michael Hu, Bruce L. Jacobs, Jeffrey S. Montgomery, Chang He, Jun Ye, Yun Zhang, Julien Brathwaite, Todd M. Morgan, Khaled S. Hafez, Alon Z. Weizer, Scott M. Gilbert, Cheryl T. Lee, Mariel S. Lavieri, Jonathan E. Helm, Brent K. Hollenbeck and Ted A. Skolarus

      Version of Record online: 29 JAN 2014 | DOI: 10.1002/cncr.28586

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      Readmissions after radical cystectomy are common and time-dependent. Interventions to prevent and reduce the readmission burden after cystectomy likely need to focus on the first 2 weeks after discharge, take into consideration the spectrum of reasons for readmission, and target high-risk individuals.

    13. Pediatric Oncology
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      A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group (pages 1417–1425)

      Regina M. Myers, Lyn Balsamo, Xiaomin Lu, Meenakshi Devidas, Stephen P. Hunger, William L. Carroll, Naomi J. Winick, Kelly W. Maloney and Nina S. Kadan-Lottick

      Version of Record online: 28 JAN 2014 | DOI: 10.1002/cncr.28578

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      In this prospective study of the psychological adjustment of children receiving active therapy for standard-risk acute lymphoblastic leukemia, the authors found that a significant subpopulation of children displayed symptoms of anxiety and depression that merit intervention. Particularly vulnerable were children of Hispanic descent or those with unhealthy family functioning.

    14. Radiation Oncology
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      Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation (pages 1426–1432)

      Jennifer Tseng, Deborah E. Citrin, Meryl Waldman, Donald E. White, Steven A. Rosenberg and James C. Yang

      Version of Record online: 28 JAN 2014 | DOI: 10.1002/cncr.28547

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      T-cell transfer therapy for patients with melanoma which incorporates preparative total body irradiation induces thrombotic microangiopathy in approximately a third of patients. Diagnosis and treatment of this entity can prevent renal failure and allow the safe administration of a potentially curative regimen for metastatic melanoma.

    15. Symptom Control and Palliative Care
      You have full text access to this OnlineOpen article
      Multi-institutional, randomized, double-blind, placebo-controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck (pages 1433–1440)

      Ron R. Allison, Aaron A. Ambrad, Youssef Arshoun, Richard J. Carmel, Doug F. Ciuba, Elizabeth Feldman, Steven E. Finkelstein, Ranjini Gandhavadi, Dwight E. Heron, Steven C. Lane, John M. Longo, Charles Meakin, Dimitrios Papadopoulos, David E. Pruitt, Lynn M. Steinbrenner, Michael A. Taylor, William M. Wisbeck, Grace E. Yuh, David P. Nowotnik and Stephen T. Sonis

      Version of Record online: 11 FEB 2014 | DOI: 10.1002/cncr.28553

      In a randomized, double-blind, placebo-controlled trial, the mucoadhesive hydrogel MuGard proved to be superior to saline-bicarbonate rinse in mitigating oral mucositis (OM) symptoms and delaying OM progression. MuGard was safe and well-tolerated, and favorably affected the rate and incidence of ulcerative lesions, consistent with the patient-reported outcomes.

  6. Correspondence

    1. Top of page
    2. Issue information
    3. CancerScope
    4. Commentary
    5. Editorial
    6. Original Articles
    7. Correspondence
    1. You have free access to this content
      Quality control of bone marrow aspirates: Additional steps toward a safer and more efficient procedure (pages 1441–1442)

      Gustavo Loureiro, Edgar G. Rizzatti, Alex F. Sandes and Maria de Lourdes Chauffaille

      Version of Record online: 30 JAN 2014 | DOI: 10.1002/cncr.28602

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      Reply to quality control of bone marrow aspirates: Additional steps toward a safer and more efficient procedure (page 1442)

      Oreofe O. Odejide, Joseph O. Jacobson and Gregory A. Abel

      Version of Record online: 30 JAN 2014 | DOI: 10.1002/cncr.28603

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