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Cancer

Cover image for Cancer

15 May 2002

Volume 94, Issue 10

Pages 2519–2800

  1. In memoriam

    1. Top of page
    2. In memoriam
    3. Original Articles
    4. Communication
    5. Correspondence
    6. Erratum
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      William E. Powers, M.D. : In Memoriam 2001 (pages 2519–2520)

      Carlos A. Perez

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10534

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  2. Original Articles

    1. Top of page
    2. In memoriam
    3. Original Articles
    4. Communication
    5. Correspondence
    6. Erratum
    1. Disease Site

      Blood/Bone Marrow
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      The clinical use of bone resorption markers in patients with malignant bone disease (pages 2521–2533)

      Robert E. Coleman

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10522

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      The unique breakdown products of Type I collagen, N-telopeptide, and C- telopeptide have been identified as the most sensitive and specific biochemical markers for diagnosing bone metastases, assessing disease progression and response to treatment, and predicting the rate of bone loss and the potential for fracture. Suppression of bone resorption markers in response to bisphosphonate therapy appears to correlate with clinical outcome in patients with both osteolytic and blastic bone lesions.

    2. Breast Disease
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      Patient and provider characteristics that affect the use of axillary dissection in older women with Stage I–II breast carcinoma (pages 2534–2541)

      Stephen B. Edge, Karen Gold, Christine D. Berg, Neal J. Meropol, Theodore N. Tsangaris, Luther Gray, Bert M. Petersen Jr., Yi-ting Hwang, Jeanne S. Mandelblatt and Outcomes and Preferences for Treatment in Older Women Nationwide Study Research Team

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10540

      The omission of axillary dissection in women age > 67 years was correlated independently with advancing age, functional status, and treatment by a surgeon with training in surgical oncology. These findings suggest that the omission of axillary dissection in older women may be appropriate, underscoring the complexity of treatment decisions for the elderly and their physicians.

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      Proceedings of the Consensus Conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19–22, 2001, Philadelphia, Pennsylvania (pages 2542–2551)

      Gordon F. Schwartz, Armando E. Giuliano, Umberto Veronesi and Consensus Conference Committee

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10539

      A consensus conference on the role of sentinel node biopsy in breast carcinoma was held in Philadelphia, April 19-22, 2001. The current report summarizes the deliberations of the group and advances its current guidelines for the integration of this new technique into contemporary clinical practice.

    4. Gastrointestinal Tract
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      Fas (CD95/APO-1) and Fas ligand expression in normal pancreas and pancreatic tumors : Implications for immune privilege and immune escape (pages 2552–2560)

      Wolfram V. Bernstorff, Jonathan N. Glickman, Robert D. Odze, Francis A. Farraye, Hong G. Joo, Peter S. Goedegebuure and Timothy J. Eberlein

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10549

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      The results of the current study implicate the Fas pathway in the regulation of physiologic cell turnover and immune privilege in the normal pancreas and indicate that loss of Fas expression is correlated with malignant transformation and biologic aggressiveness in pancreatic adenocarcinomas. This may represent a mechanism by which pancreatic tumor cells become resistant to apoptosis and escape immune surveillance in vivo.

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      Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia : Evidence for a founder effect (pages 2561–2568)

      Paul Rozen, Tova Naiman, Hana Strul, Philipp Taussky, Nataly Karminsky, Ruth Shomrat, Ziona Samuel, Yuval Yaron and Avi Orr-Urtreger

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10529

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      The I1307K adenomatous polyposis coli (APC) gene variant found in Jews is of ancient origin and probably antedates their dispersion to the Ashkenazi, Sephardi, and Oriental population streams. Its clinical relevance is equivalent to obtaining a family history of sporadic colorectal neoplasia and, at an early age, entering a screening protocol for those at slightly increased risk.

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      Adherence to repeat screening flexible sigmoidoscopy in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial (pages 2569–2576)

      Joel L. Weissfeld, Bruce S. Ling, Robert E. Schoen, Robert S. Bresalier, Thomas Riley, Philip C. Prorok and PLCO Project Team

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10538

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      Acceptance of screening flexible sigmoidoscopy has been poor, in part because of providers' concerns regarding the acceptability of the procedure. Gender and past experiences with sigmoidoscopy may impact adherence to repeat screening. In the current study, the authors used adherence to repeat testing to assess the acceptability of screening flexible sigmoidoscopy.

    7. Genitourinary Disease
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      Prostate specific antigen progression after radical prostatectomy in African-American men versus White men (pages 2577–2583)

      Mousumi Banerjee, Isaac J. Powell, Julie George, Debjit Biswas, Fernando Bianco and Richard K. Severson

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10535

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      The current study examines ethnic differences in prostate specific antigen (PSA) progression rates after radical prostatectomy for clinically localized prostate carcinoma. Results of analyses based on longitudinal modeling of serial PSA profiles indicate that African-American men and white men have similar rates of PSA progression.

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      HER-2/neu is overexpressed infrequently in patients with prostate carcinoma : Results from the California Cancer Consortium screening trial (pages 2584–2589)

      Primo N. Lara Jr., Frederick J. Meyers, Carl R. Gray, Regina Gandour Edwards, Paul H. Gumerlock, Caren Kauderer, Garrett Tichauer, Przemyslaw Twardowski, James H. Doroshow and David R. Gandara

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10526

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      The results of HER-2 screening from a Phase II trial of chemotherapy with trastuzumab and docetaxel in patients with HER-2overexpressing prostate carcinoma showed that HER-2 expression was infrequent in archival tumor specimens from patients with disease that progressed to hormone-refractory prostate carcinoma (HRPC). These findings are important in considering the role of trastuzumab as a single agent or in combination chemotherapy for the treatment of patients with HRPC.

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      Prognostic value of nuclear grading in patients with intracapsular (pT1-pT2) renal cell carcinoma : Long-term analysis in 213 patients (pages 2590–2595)

      Andrea Minervini, Leon Lilas, Riccardo Minervini and Cesare Selli

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10510

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      Within intracapsular tumors that measure > 7.0 cm in greatest dimension (pT2), nuclear grade is an important morphologic variable for predicting long-term survival. Identification of patients with nuclear Grade 3–4 tumors is important prognostically to determine the metastatic potential of pT2 tumors.

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      Estramustine phosphate combined with orchidectomy as first-line therapy in patients with prostate carcinoma : Effect of age on survival (pages 2596–2601)

      Rob C. M. Pelger, Guus a. B. Lycklama À Nijeholt, Aeilko H. Zwinderman and Neveen A. T. Hamdy

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10558

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      The results of this retrospective study showed that, although combining orchidectomy with estramustine phosphate in the treatment of patients with prostate carcinoma appeared to be beneficial in younger patients, using this relatively more aggressive therapeutic approach as first-line therapy in older patients (age ≥ 80 years) may shorten their survival.

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      A Phase II trial of intravenous gemcitabine and 5-fluorouracil with subcutaneous interleukin-2 and interferon-α in patients with metastatic renal cell carcinoma (pages 2602–2609)

      Christopher W. Ryan, Nicholas J. Vogelzang and Walter M. Stadler

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10528

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      This report details the results of a combined immunotherapy and chemotherapy regimen for patients with metastatic renal cell carcinoma. Activity was observed, but toxicity was significant.

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      Prostate carcinoma with testicular or penile metastases : Clinical, pathologic, and immunohistochemical features (pages 2610–2617)

      Shi-Ming Tu, Adriana Reyes, April Maa, Deb Bhowmick, Louis L. Pisters, Curtis A. Pettaway, Sue-Hwa Lin, Patricia Troncoso and Christopher J. Logothetis

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10546

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      The results of the current study of patients with prostate carcinoma and testicular or penile metastases suggests the existence of a unique subtype of prostate carcinoma with distinct clinical characteristics and pathologic features. The findings imply that there are alternative ways of understanding the biology and improving the diagnosis of prostate carcinoma.

    13. Gynecologic Oncology
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      Serum activin A and inhibin A : New clinical markers for hydatidiform mole (pages 2618–2622)

      Pasquale Florio, Filiberto M. Severi, Luigi Cobellis, Secondo Danero, Alice Bomè, Stefano Luisi and Felice Petraglia

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10524

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      High serum levels of activin A and inhibin A represent potential new markers in diagnosis and followup of molar pregnancies.

    14. Head and Neck Disease
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      Neuroendocrine tumors of the sinonasal tract : Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy (pages 2623–2634)

      Markus M. Fitzek, Allan F. Thornton, Marc Varvares, Marek Ancukiewicz, James Mcintyre, Judy Adams, Stanley Rosenthal, Michael Joseph and Philip Amrein

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10537

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      Combined modality treatment of patients with neuroendocrine carcinoma of the sinonasal tract with chemotherapy, proton-photon radiotherapy, and conservative surgery led to a 5-year survival rate of 74% and a local control rate of 88% in this prospective Phase I–II study. Despite the selection for patients with advanced disease, visual preservation was achieved in all patients.

    15. Hematologic Malignancies
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      Low incidence of BCL-6 gene alterations for diffuse large B-cell lymphomas in Taiwan Chinese (pages 2635–2644)

      Po-Min Chen, Muh-Hwa Yang, I-Ting Yu, Jen-Tsun Lin, Yu-Chen Lin, Frank S. Fan, Wei-Shu Wang, Chueh-Chuan Yen, Tzeon-Jye Chiou and Jin-Hwang Liu

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10545

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      The incidence of BCL-6 alterations in patients with diffuse large B-cell lymphoma (DLBCL) is lower in the Taiwanese population compared with the incidence in Western populations. This study found no association between BCL-6 alteration and clinical characteristics and found no prognostic significance of the BCL-6 gene alteration in Taiwanese patients with DLBCL.

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      Liposomal daunorubicin (DaunoXome) plus dexamethasone for patients with multiple myeloma : A Phase II International Oncology Study Group study (pages 2645–2652)

      Ann F. Mohrbacher, Stephanie A. Gregory, Don A. Gabriel, Jason M. Rusk and Francis J. Giles

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10561

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      Liposomal daunorubicin, which has been proven effective in treating patients with Kaposi sarcoma and hematologic malignancies, shows activity and survival similar to other salvage treatment options in patients with advanced multiple myeloma who fail standard, front-line regimens. Further studies with this agent in combination regimens are warranted.

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      In vitro effects of STI 571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells (pages 2653–2662)

      Barbara Scappini, Francesco Onida, Hagop M. Kantarjian, Li Dong, Srdan Verstovsek, Michael J. Keating and Miloslav Beran

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10543

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      The authors investigated the in vitro effect of STI571/cytarabine and STI571/homoharringtonine combinations on the growth of two BCR-ABL positive cell lines and on mononuclear white blood cells derived from patients affected by chronic myelogenous leukemia in chronic phase. Using a software based-analysis, the authors showed an additive-synergistic inhibitory effect of these combinations on both cell line proliferation and patient-derived colony growth, providing support for clinical trials.

    18. Hepatobiliary Tract
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      Viral load is a significant prognostic factor for hepatitis B virus-associated hepatocellular carcinoma (pages 2663–2668)

      Kazuaki Ohkubo, Yuji Kato, Tatsuki Ichikawa, Yuji Kajiya, Yoshio Takeda, Shinnichirou Higashi, Keisuke Hamasaki, Kazuhiko Nakao, Keisuke Nakata and Katsumi Eguchi

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10557

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      Hepatitis B viral load is a potentially useful prognostic marker in patients with hepatocellular carcinoma and those with a less favorable course appear either to clear the virus poorly or to have a higher level of virus production.

    19. Lung Disease
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      HER-2/neu overexpression in patients with radically resected nonsmall cell lung carcinoma : Impact on long-term survival (pages 2669–2674)

      Giovanni Selvaggi, Giorgio V. Scagliotti, Valter Torri, Silvia Novello, Eugenio Leonardo, Susanna Cappia, Claudio Mossetti, Francesco Ardissone, Paolo Lausi and Piero Borasio

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10531

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      In the current study, the negative impact of HER-2/neu overexpression on survival was maintained in the long-term follow-up of nonsmall cell lung carcinoma patients who underwent radical resection. HER-2/neu may be a valuable prognostic factor as well as a potential target for biologic therapies.

    20. Neuro-Oncology
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      A Phase II trial of intra-cerebrospinal fluid alpha interferon in the treatment of neoplastic meningitis (pages 2675–2680)

      Marc C. Chamberlain

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10547

      Intra-cerebrospinal fluid alpha interferon has activity in patients with neoplastic meningitis. However, treatment related toxicity (chronic fatigue) may limit alpha interferon applicability in the treatment of neoplastic meningitis.

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      Clinical trial participation among patients enrolled in the Glioma Outcomes Project (pages 2681–2687)

      Susan M. Chang, Fred G. Barker II, Meic H. Schmidt, Andrew E. Sloan, Rachel Kasper, Leslie Phillips, Karen Shih, Subramanian Hariharan, Mitchel S. Berger and The Glioma Outcomes Investigators

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10536

      Among 708 patients with malignant glioma who were enrolled in the Glioma Outcomes Project, 21.3% participated in a clinical trial. Younger age and glioblastoma histology were factors that predicted trial participation in multivariate analysis.

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      Molecular markers of prognosis in astrocytic tumors (pages 2688–2697)

      Ahmed Rasheed, James E. Herndon, Timothy T. Stenzel, Jacqueline G. M. Raetz, Jason Kendelhardt, Henry S. Friedman, Allan H. Friedman, Darell D. Bigner, Sandra H. Bigner and Roger E. McLendon

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10544

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      Alterations in CDKN2A, PTEN, and linked allelic losses on 9p and 10q are associated with high-grade astrocytomas and are predictors of a poor prognosis. TP53 mutations are more common in patients age < 45 year, but do not have prognostic significance.

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      Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma (pages 2698–2705)

      Leo J. Schouten, Joost Rutten, Hans A. M. Huveneers and Albert Twijnstra

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10541

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      The incidence of brain metastases was studied in a cohort of patients who had one of the five specified solid tumors: carcinoma of the breast, colon, kidney, and lung and melanoma. Compared with what generally is assumed, there was no evidence of an increasing incidence of this serious complication of malignant disease.

    24. Sarcoma
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      Soft tissue sarcoma brain metastases : Prevalence in a cohort of 3829 patients (pages 2706–2711)

      N. Joseph Espat, Mark Bilsky, Jonathan J. Lewis, Denis Leung and Murray F. Brennan

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10554

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      Brain metastases from soft tissue sarcoma are uncommon, but vigilance is warranted. Symptomatic patients should be examined neurologically and investigated thoroughly for metastases. Although surgical resection may be an appropriate treatment for selected patients, survival after metastasis is dismal.

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      Survival analysis with p27 expression and apoptosis appears to estimate the prognosis of patients with synovial sarcoma more accurately (pages 2712–2718)

      Shigeto Kawauchi, Yoshinari Goto, Koichiro Ihara, Tomoko Furuya, Atsunori Oga, Masazumi Tsuneyoshi, Shinya Kawai and Kohsuke Sasaki

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10556

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      A significant inverse correlation between p27 expression and apoptosis was demonstrated in patients with synovial sarcoma. A combination of p27 expression and apoptosis allowed more accurate estimation of the prognosis of patients with synovial sarcoma than either parameter alone.

    26. Integrated Medicine
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      Depression and functional status as predictors of death among cancer patients (pages 2719–2727)

      Manfred Stommel, Barbara A. Given and Charles W. Given

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10533

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      Among newly diagnosed cancer patients, patients with prior functional limitations and emotional problems have worse survival chances than would be expected on the basis of their cancer diagnosis alone. Depressive symptoms and functional limitations are common short-run responses to initial diagnosis and treatment, but patients with no prior history of such problems appear to be resilient.

    27. Medical Oncology
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      Adjuvant chemohormonal therapy of high risk prostate carcinoma : Ten year results (pages 2728–2732)

      Charles M. Bagley Jr., Robert F. Lane, John C. Blasko, Peter D. Grimm, Haakon Ragde, Oliver E. Cobb and Ronald K. Rowbotham

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10527

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      Twenty five patients with T3 and/or N1 prostate carcinoma received chemotherapy, radiation, and permanent hormonal therapy resulting in 73% of patients having continuously undetectable prostate specific antigen levels ten years later. Randomized trials of the addition of chemotherapy to adjuvant hormonal therapy would be valuable.

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      Physician factors in the timing of cancer patient referral to hospice palliative care (pages 2733–2737)

      Elizabeth B. Lamont and Nicholas A. Christakis

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10530

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      In the current study, the authors found physician factors to be associated with the length of survival in terminally ill cancer patients after referral to hospice. The prognostic ability of the physician, a specialty of general internal medicine/ geriatrics, and prior experience with hospice patients each were found to be associated with longer patient survival in hospice and thus most likely an earlier referral to hospice.

    29. Radiation Oncology
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      The role of local radiation therapy for mediastinal disease in adults with T-cell lymphoblastic lymphoma (pages 2738–2744)

      Bouthaina S. Dabaja, Chul S. Ha, Deborah A. Thomas, Richard B. Wilder, Ramesh Gopal, Jorge Cortes, Carlos Bueso-Ramos, Mark A. Hess, James D. Cox and Hagop M. Kantarjian

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10552

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      Mediastinal radiation therapy appears to benefit patients with mediastinal T-cell lymphoblastic lymphoma after a complete response to chemotherapy, especially with modern intensive chemotherapy regimens.

    30. Translational Research
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      Hypoxia upregulates Bcl-2 expression and suppresses interferon-γ induced antiangiogenic activity in human tumor derived endothelial cells (pages 2745–2755)

      Jiang Huai Wang, Qiong Di Wu, David Bouchier-Hayes and H. Paul Redmond

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10520

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      Under aerobic culture conditions human tumor-derived endothelial cells (HTDEC) freshly isolated from colorectal tumors were more susceptible to IFN-γ treatment, when compared to normal human macro-vascular and micro-vascular endothelial cells. However, under hypoxic culture conditions HTDEC became resistant to IFN-γ -induced cell apoptosis and anti-angiogenic activity, which correlated with hypoxia-induced upregulation of Bcl-2 expression. These data indicate that improvement of tumor oxygenation may be significant in targeting the inhibition of tumor angiogenesis.

    31. Pediatric Oncology
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      Evolving significance of prognostic markers associated with treatment improvement in patients with Stage 4 neuroblastoma (pages 2756–2765)

      Jaume Mora, William L. Gerald, Jing Qin and Nai-Kong V. Cheung

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10548

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      Because the survival of patients improves with more effective therapy, traditional prognostic markers, such as age, MYCN amplification, and serum lactate dehydrogenase levels, have become less important for patients with Stage 4 neuroblastoma.

  3. Communication

    1. Top of page
    2. In memoriam
    3. Original Articles
    4. Communication
    5. Correspondence
    6. Erratum
    1. Disease Site

      Pediatric Oncology
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      Annual Report to the Nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden (pages 2766–2792)

      Brenda K. Edwards, Holly L. Howe, Lynn A. G. Ries, Michael J. Thun, Harry M. Rosenberg, Rosemary Yancik, Phyllis A. Wingo, Ahmedin Jemal and Ellen G. Feigal

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10593

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      Across all ages, overall cancer death rates decreased in men and women from 1993 through 1999, while cancer incidence rates stabilized from 1995 through 1999. Age-specific trends varied by site, sex, and race. Despite the continuing decrease in cancer death rates and the stabilization of cancer incidence rates, the overall growth and aging of the U.S. population can be expected to increase the burden of cancer in our nation.

  4. Correspondence

    1. Top of page
    2. In memoriam
    3. Original Articles
    4. Communication
    5. Correspondence
    6. Erratum
    1. You have free access to this content
      The Ovarian Tumor Index predicts risk for malignancy (page 2793)

      Diane M. Twickler

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10511

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      Anemia as an independent prognostic factor for survival in patients with cancer (pages 2793–2796)

      Joseph Watine and Nordine Bouarioua

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10523

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      Author reply (pages 2796–2797)

      J. Jaime Caro, Maribel Salas, Alexandra Ward and Glenwood Goss

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10517

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      Sequential combination chemotherapy in patients with advanced nonsmall cell lung carcinoma : Carboplatin and gemcitabine followed by paclitaxel (pages 2797–2798)

      Javier De Castro, Jamie Feliu, Enrique Casado, Amalio Ordonñez and Manuel González Barón

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10514

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      Author reply (pages 2798–2799)

      Martin J. Edelman, David R. Gandara, Primo Lara and Derek H. Lau

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10513

  5. Erratum

    1. Top of page
    2. In memoriam
    3. Original Articles
    4. Communication
    5. Correspondence
    6. Erratum
    1. You have free access to this content
      Erratum (page 2800)

      Version of Record online: 14 MAY 2002 | DOI: 10.1002/cncr.10625

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