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Cancer

Cover image for Cancer

15 June 2002

Volume 94, Issue 12

Pages 3073–3312

  1. Original Article

    1. Top of page
    2. Original Article
    3. Original Articles
    4. Original Article
    5. Original Articles
    1. Disease Site

      Blood/Bone Marrow
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      Polymerase chain reaction-based diagnosis of bone marrow involvement in 170 cases of non-Hodgkin lymphoma (pages 3073–3082)

      Yoon Hee Kang, Chan Jeoung Park, Eul Joo Seo, Jooryung Huh, Sung Bae Kim, Yoon-Koo Kang and Hyun Sook Chi

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10584

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      In the current study evaluating bone marrow (BM) involvement in non-Hodgkin lymphoma, the results of polymerase chain reaction (PCR) compared with morphology showed a low positive concordance rate. Furthermore, PCR-based clonality did not show significant impact on survival. The results of this large study confirm that morphology remains the gold standard in the evaluation of BM involvement in non-Hodgkin lymphoma.

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      International prognostic index-based outcomes for diffuse large B-cell lymphomas (pages 3083–3088)

      Richard B. Wilder, Maria A. Rodriguez, L. Jeffrey Medeiros, Susan L. Tucker, Chul S. Ha, Jorge E. Romaguera, Barbara Pro, Mark A. Hess, Fernando Cabanillas and James D. Cox

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10583

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      We analyzed outcomes in 224 patients with Stage I–IV diffuse large B-cell lymphoma (DLBCL). Patients participated in two Phase II clinical trials, which included chemotherapy with a median of six cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without involved-field radiotherapy. Five-year progression-free, cause-specific, and overall survival rates for patients with an international prognostic index (IPI) of 0–2 were 73%, 84%, and 82%, respectively, versus only 37%, 33%, and 32% for patients with an IPI of 3–4. To improve our results, we are currently conducting clinical trials with young DLBCL patients and patients older than 60 years old. The young DLBCL patients, who have more than two adverse prognostic features, are being treated with high-dose chemotherapy and autologous stem cell rescue. The patients older than 60 years, regardless of IPI, are being treated with rituximab immunotherapy and liposomal CHOP chemotherapy with or without involved-field radiotherapy.

    3. Breast Disease
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      A problem-solving approach to stress reduction among younger women with breast carcinoma : A randomized controlled trial (pages 3089–3100)

      Susan M. Allen, Ann C. Shah, Arthur M. Nezu, Christine Maguth Nezu, Desirée Ciambrone, Joseph Hogan and Vincent Mor

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10586

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      A problem-solving training intervention specifically designed for younger women with breast carcinoma significantly decreased the difficulties experienced by women who had average or good problem-solving skills before the intervention. However, it was not effective in alleviating or resolving the problems encountered by women with poor problem-solving skills, relative to the control group. The results underscore the importance of targeting interventions to the population subgroups most likely to benefit from them.

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      Significance of secondary ultrasonographic endometrial thickening in postmenopausal tamoxifen-treated women (pages 3101–3106)

      Ilan Cohen, Ron Azaria, Jeremiah Shapira, Dror Yigael and Ron Tepper

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10587

      A significant increase (> 50%) in secondary endometrial thickening, measured ultrasonographically, in postmenopausal tamoxifen-treated patients is associated with a high rate of endometrial pathologies, including endometrial cancer.

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      Assessment of histologic features and expression of biomarkers in predicting pathologic response to anthracycline-based neoadjuvant chemotherapy in patients with breast carcinoma (pages 3107–3114)

      Jianzhou Wang, Thomas A. Buchholz, Lavinia P. Middleton, D. Craig Allred, Susan L. Tucker, Henry M. Kuerer, Francisco J. Esteva, Gabriel N. Hortobagyi and Aysegul A. Sahin

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10585

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      The roles of tumor nuclear grade, mitotic activity, and biomarker expression profiles were investigated in predicting the pathologic response of patients with breast carcinoma to preoperative chemotherapy. The results suggest that nuclear grade and proliferative activity are not only indicators of tumor biologic behavior but also may serve as important predictors of tumor response to doxorubicin-based neoadjuvant chemotherapy.

    6. Chest
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      Treatment and prognosis of thymic carcinoma : A retrospective analysis of 40 cases (pages 3115–3119)

      Kazuhiko Ogawa, Takafumi Toita, Takashi Uno, Nobukazu Fuwa, Yasumasa Kakinohana, Minoru Kamata, Kageharu Koja, Takao Kinjo, Genki Adachi and Sadayuki Murayama

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10588

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      Thymic carcinomas are rare neoplasms and to the authors' knowledge information regarding the results of treatment and possible prognostic factors in patients with these tumors is limited. In the current study, the authors analyze their experience of 40 patients with thymic carcinomas and indicate a possible curative treatment for these tumors.

    7. Gastrointestinal Tract
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      Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma (pages 3120–3126)

      Rudolf Pihusch, Gudrun Danzl, Michael Scholz, Detlev Harich, Markus Pihusch, Peter Lohse and Erhard Hiller

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10590

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      Heterozygosity for the thrombophilic mutation factor V Leiden proved to be a significant risk factor for tumor-associated thrombosis. Most thrombotic events occurred during the first few months after tumor diagnosis and in close correlation to the onset of chemotherapy, indicating that diagnostic and therapeutic procedures might play an additional role in the pathogenesis of thrombosis. Results also suggest that the prothrombin G20210A mutation might be a significant cofactor in cancer pathogenesis.

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      Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma (pages 3127–3134)

      Nanami Itoh, Shuho Semba, Masafumi Ito, Hiroaki Takeda, Sumio Kawata and Mitsunori Yamakawa

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10591

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      The authors investigated the expression of phosphorylated Akt (Ser473) in colon carcinoma cell lines and tissue samples and found close associations with cell growth, resistance to apoptosis, and clinicopathologic parameters. These findings indicate that activation of Akt/protein kinase B (PKB) plays an important role in the progression of colorectal carcinomas implicating the usefulness of an Akt/PKB inactivating agent in colon carcinoma treatment.

  2. Original Articles

    1. Top of page
    2. Original Article
    3. Original Articles
    4. Original Article
    5. Original Articles
    1. Disease Site

      Gastrointestinal Tract
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      7-hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors (pages 3135–3140)

      Diego J. Walther, Jens-Uwe Peter and Michael Bader

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10592

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      Conventional chemotherapeutic agents that target tumor cells directly have produced disappointing results in the treatment of patients with serotonin-producing tumors in the advanced stage. The data from this study suggest that 7-hydroxytryptophan may be a highly specific chemotherapeutic compound against such tumors.

  3. Original Article

    1. Top of page
    2. Original Article
    3. Original Articles
    4. Original Article
    5. Original Articles
    1. Disease Site

      Genitourinary Disease
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      Prediction of pelvic lymph node metastasis by the ratio of cathepsin B to stefin A in patients with prostate carcinoma (pages 3141–3149)

      Akhouri A. Sinha, Barry J. Quast, Michael J. Wilson, Eduardo T. Fernandes, Pratap K. Reddy, Stephen L. Ewing and Donald F. Gleason

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10604

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      Prostate carcinoma (PC) with an aggressive clone can be identified when the ratio of cathepsin B (CB) is greater than that of stefin A. Less aggressive clones are identified when the ratio of CB is less than that of stefin A or when the ratio of CB is equal to that of stefin A. The ratios of CB to stefin A can be used in the differential diagnosis and treatment of patients with PC.

  4. Original Articles

    1. Top of page
    2. Original Article
    3. Original Articles
    4. Original Article
    5. Original Articles
    1. Disease Site

      Genitourinary Disease
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      Prognostic impact of extensive parenchymal invasion pattern in pT3 renal pelvic transitional cell carcinoma (pages 3150–3156)

      Koji Yoshimura, Yoichi Arai, Hiroyuki Fujimoto, Hiroyuki Nishiyama, Keiji Ogura, Takeshi Okino and Osamu Ogawa

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10609

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      The authors reviewed the prognostic impact of three patterns of invasion of pT3 renal pelvic transitional cell carcinoma. Multivariate analysis revealed that extensive parenchymal invasion was the most powerful predictor of prognosis among the variables tested.

    2. Gynecologic Oncology
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      Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma (pages 3157–3168)

      Paola Baldinu, Antonio Cossu, Antonella Manca, Maria P. Satta, Marina Pisano, Milena Casula, Salvatore Dessole, Adriana Pintus, Francesco Tanda and Giuseppe Palmieri

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10606

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      Microsatellite analysis of Sardinian patients with endometrial carcinoma revealed that about one-third of primary tumors exhibited genetic instability. This was associated with lack of expression of DNA mismatch-repair genes but not with disease-causing mutations of candidate genes (hMLH1/hMSH2 and PTEN). In patients with endometrial carcinoma, microsatellite instability does not seem to be associated significantly with a different clinical outcome.

    3. Head and Neck Disease
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      Multimodal intensification therapy for previously untreated advanced resectable squamous cell carcinoma of the oral cavity, oropharynx, or hypopharynx (pages 3169–3178)

      David E. Schuller, John C. Grecula, Amit Agrawal, Chris A. Rhoades, Debra A. Orr, Donn C. Young, James P. Malone and Meredith Merz

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10571

      In this Phase II clinical trial for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, and hypopharynx, a multimodal regimen involving surgery, intraoperative radiation therapy, and pre- and postoperative chemoradiotherapy showed improved locoregional and distant disease control. The regimen maintained a low rate of patient noncompliance and acceptable toxicities.

    4. Hepatobiliary Tract
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      High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation (pages 3179–3185)

      Kok-Lung Chan, Joyce Man-Fong Lee, Xin-Yuan Guan, Sheung-Tat Fan and Irene Oi-Lin Ng

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10612

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      Allelic losses on 8p are frequent in patients with hepatocellular carcinoma (HCC). Association of allelic losses at specific loci on 8p with a more aggressive tumor behavior suggests that loss/inactivation of putative tumor suppressor gene(s) located at these regions may confer a tumor growth advantage and contribute to the progression of HCC.

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      A phase II trial of gemcitabine in patients with advanced hepatocellular carcinoma (pages 3186–3191)

      Charles S. Fuchs, Jeffrey W. Clark, David P. Ryan, Mathew H. Kulke, Haesook Kim, Craig C. Earle, Michele Vincitore, Robert J. Mayer and Keith E. Stuart

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10607

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      A recent trial reported moderate activity for gemcitabine among Asian patients with advanced hepatocellular carcinoma; however, this trial observed no responses for gemcitabine in a population of U.S. patients.

    6. Melanoma
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      A natural history of melanomas and dysplastic nevi : An atlas of lesions in melanoma-prone families (pages 3192–3209)

      Margaret A. Tucker, Mary C. Fraser, Alisa M. Goldstein, Jeffery P. Struewing, Mary A. King, John T. Crawford, Ellen A. Chiazze, Deborah P. Zametkin, Laura S. Fontaine and Wallace H. Clark Jr.

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10605

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      Clinical photographs and photomicrographs of melanomas and dysplastic nevi from members of melanoma-prone families who were followed for up to 24 years are presented. The lesions do not appear to vary substantially by type of germline mutation found in the families.

    7. Neuro-Oncology
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      Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma (pages 3210–3218)

      Oscar Arrieta, Esperanza Garcia, Patricia Guevara, Roberto Garcia-Navarrete, Rodolfo Ondarza, Daniel Rembao and Julio Sotelo

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10594

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      In the current study, the intratumoral concentration of hepatocyte growth factor (HGF) in human intracranial neoplasms was measured and correlated with prognosis, tumor recurrence, vasogenic edema, cell proliferation index, and vascular density. The findings suggest that the routine measurement of HGF may be used as a predictive factor for planning therapeutic strategies in both malignant gliomas and meningiomas.

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      High-grade gliomas in patients with prior systemic malignancies (pages 3219–3224)

      Fernando C. Maluf, Lisa M. DeAngelis, Jeffrey J. Raizer and Lauren E. Abrey

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10595

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      A glioma may occur secondary to inherited genetic disorders, prior treatments, or as a sporadic event. In the current study, the authors describe 21 patients with a malignant glioma that was diagnosed subsequent to a prior malignancy.

    9. Sarcoma
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      Phase II trial of gemcitabine in advanced sarcomas (pages 3225–3229)

      Scott Okuno, John Edmonson, Michelle Mahoney, Jan C. Buckner, Stephen Frytak and Evanthia Galanis

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10602

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      In the current experiment, the use of gemcitabine in patients with advanced sarcomas was well tolerated but had limited activity.

    10. Medical Oncology
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      Antifungal prophylaxis for severely neutropenic chemotherapy recipients : A meta-analysis of randomized-controlled clinical trials (pages 3230–3246)

      Eric J. Bow, Michel Laverdière, Nathalie Lussier, Coleman Rotstein, Mary S. Cheang and Stratis Ioannou

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10610

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      A meta-analysis of 38 randomized-controlled clinical trials of antifungal prophylaxis in 7014 patients with severe neutropenia demonstrated treatment effects for a number of outcomes, including reductions in the use of empiric parenteral antifungal therapy, superficial and proven invasive fungal infection, and fungal infection-related mortality. In addition, a metaregression analysis identified additional treatment-related reductions in overall mortality for patients who had prolonged neutropenia and patients who underwent hematopoietic stem cell transplantation.

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      Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients (pages 3247–3251)

      Elena M. V. de Cavanagh, Alba E. Honegger, Erica Hofer, Raul H. Bordenave, Eduardo O. Bullorsky, Norma A. Chasseing and Cesar Fraga

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10611

      Oxidative stress in peripheral blood plasma and bone marrow plasma was higher in advanced lung and breast carcinoma patients than in healthy controls. The levels of both lipid oxidation and lipid-soluble antioxidants in peripheral blood plasma correlate positively with those in bone marrow plasma. Peripheral blood plasma and bone marrow plasma lipid oxidation is inversely related to lipid-soluble antioxidant levels.

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      The bleeding risk index : A clinical prediction rule to guide the prophylactic use of platelet transfusions in patients with lymphoma or solid tumors (pages 3252–3262)

      Linda S. Elting, Charles G. Martin, Danna J. Kurtin, Scott B. Cantor, Edward B. Rubenstein, Saul Rodriguez, Krishnakumari Kanesan, Saroj Vadhan-Raj and Robert S. Benjamin

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10603

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      The bleeding risk index identifies patients with solid tumors who are at high risk of bleeding during chemotherapy-induced thrombocytopenia by using information that is readily available on Day 1 of a chemotherapy cycle. This individualized approach to bleeding prophylaxis is more sensitive and specific compared with platelet threshold-based strategies as a guide for the use of prophylactic platelet transfusions.

    13. Pediatric Oncology
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      Vinorelbine in previously treated advanced childhood sarcomas : Evidence of activity in rhadbomyosarcoma (pages 3263–3268)

      Michela Casanova, Andrea Ferrari, Filippo Spreafico, Monica Terenziani, Maura Massimino, Roberto Luksch, Graziella Cefalo, Daniela Polastri, Ilaria Marcon and Franca Fossati Bellani

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10600

      This article shows that vinorelbine as a single agent is feasible and potentially effective in already heavily treated pediatric patients with recurrent sarcomas. In particular, it appears to have a significant clinical effect in patients with alveolar rhabdomyosarcoma.

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      Clear cell sarcoma of tendons and aponeuroses in pediatric patients : A report from the Italian and German Soft Tissue Sarcoma Cooperative Group (pages 3269–3276)

      Andrea Ferrari, Michela Casanova, Gianni Bisogno, Adrian Mattke, Cristina Meazza, Lorenza Gandola, Guido Sotti, Giovanni Cecchetto, Dieter Harms, Eva Koscielniak, Jorn Treuner and Modesto Carli

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10597

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      This article describes the clinical management and outcome of 28 pediatric patients with clear cell sarcoma of tendons and aponeuroses. This pediatric series confirms that clear cell sarcoma behaves like a high-grade soft tissue sarcoma. Surgery is the mainstay of treatment, whereas chemotherapy is ineffective.

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      Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography (pages 3277–3284)

      Douglas S. Hawkins, Joseph G. Rajendran, Ernest U. Conrad III, James D. Bruckner and Janet F. Eary

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10599

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      Neoadjuvant chemotherapy for pediatric bone sarcomas results in significant changes in [F-18]-fluorodeoxy-D-glucose (FDG) metabolism quantified by positron emission tomography (PET). In our study, FDG PET correlates with histopathologic response to chemotherapy in surgically excised pediatric bone sarcomas.

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      Radiation-induced cavernous hemangiomas of the brain : A late effect predominantly in children (pages 3285–3291)

      Stefan Heckl, Alfred Aschoff and Stefan Kunze

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10596

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      In the current study evidence was found to support the assumption that cavernomas are induced by radiation.

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      Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia (pages 3292–3298)

      Der-Cherng Liang, Lee-Yung Shih, Iou-Jih Hung, Chao-Ping Yang, Shu-Huey Chen, Tang-Her Jaing, Hsi-Che Liu and Wan-Hui Chang

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10598

      In the current study, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 11.3% of children with acute myeloid leukemia and was frequently associated with PML/RARα, particularly the S-form. The authors did not confirm the previous finding that FLT3/ITD predicted a poor outcome, but they found that a high mutant/wild type ratio of FLT3 may serve as a potential predictor for a poor outcome.

    18. Psychosocial Oncology
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      Psychic vulnerability and the associated risk for cancer (pages 3299–3306)

      Ina R. Schapiro, Lene F. Nielsen, Torben Jørgensen, Ellen H. Boesen and Christoffer Johansen

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10601

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      This large, prospective, population-based study provided no support for the hypothesis that personality, as measured by the Test of Psychic Vulnerability, is an independent risk factor for cancer. If an association between personality and risk for cancer does exist, then it is likely that personality influences health practices.

    19. Epidemiology
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      Primary malignant neoplasms of the appendix : A population-based study from the surveillance, epidemiology and end-results program, 1973–1998 (pages 3307–3312)

      Margaret E. McCusker, Timothy R. Coté, Limin X. Clegg and Leslie H. Sobin

      Version of Record online: 12 JUN 2002 | DOI: 10.1002/cncr.10589

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      Population-based data were used to compare the incidence, demographics, and survival of malignant tumors of the appendix by histologic types.

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