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Cancer

Cover image for Cancer

1 February 2002

Volume 94, Issue 3

Pages 585–871

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Disease Site

      Blood/Bone Marrow
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      Cisplatin, fludarabine, and cytarabine : A novel, pharmacologically designed salvage therapy for patients with refractory, histologically aggressive or mantle cell non-Hodgkin lymphoma (pages 585–593)

      John F. Seymour, Andrew P. Grigg, Jeff Szer and Richard M. Fox

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10240

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      The pharmacologically designed regimen of infusional cisplatin with timed-sequential fludarabine and cytarabine obtained a 48% response rate in patients with refractory, histologically aggressive non-Hodgkin lymphoma. Hematologic toxicity was significant, but promising activity was seen among a small number of patients with mantle cell histology.

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      Irinotecan hydrochloride for the treatment of recurrent and refractory non-Hodgkin lymphoma : A single institution experience (pages 594–600)

      Katsuki Sugiyama, Ken Omachi, Keiichi Fujiwara, Takashi Saotome, Nobuyuki Mizunuma, Shunji Takahashi, Yoshinori Ito, Keisuke Aiba and Noboru Horikoshi

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10266

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      The results of the current study suggested the activity of irinotecan as a single agent in the treatment of patients with recurrent and refractory non-Hodgkin lymphoma.

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      Results with chemotherapy comprised of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by radiotherapy with or without prechemotherapy surgical debulking for patients with bulky, aggressive lymphoma (pages 601–605)

      Richard B. Wilder, Jorge E. Romaguera, Susan L. Tucker, Chul S. Ha, Mark A. Hess, Fernando Cabanillas and James D. Cox

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10260

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      This case–control study led to the hypothesis that progression free survival is significantly better in patients who undergo surgical debulking for Stage I–II aggressive lymphomas measuring ≥ 7 cm in greatest dimension. Unfortunately, it is unlikely that a randomized trial will be conducted to test this hypothesis. The authors' current efforts are focused on escalation of the radiotherapy dose rather than debulking, because they believe that this is a less costly and less morbid approach toward improving progression free survival in patients with bulky, aggressive lymphoma.

    4. Breast Disease
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      Breast carcinoma in women age 25 years or less (pages 606–614)

      Ashutosh S. Kothari, Nicolas Beechey-Newman, Corrado D'Arrigo, Andrew M. Hanby, Ken Ryder, Hisham Hamed and Ian S. Fentiman

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10273

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      The presentation, tumor biology, behavior, and outcome of breast carcinoma in very young women age ≤ 25 years are summarized. The current article shows that young women as a whole have a worse prognosis due to factors relating to tumor differentiation, but in women ≤ 25 years of age the incidence of a positive family history, tumor characteristics, and survival are no different than in young women (≤ 35 years of age) in general.

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      Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women (pages 615–623)

      Indra Poola, Robert Clarke, Robert DeWitty and LaSelle D. Leffall

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10274

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      The protective estrogen receptor β (ERβ) isoform is decreased markedly, and the ERα exon 5Δ isoform that activates gene transcription in the absence of estrogen is highly elevated in the breast tumors of African-American women. Alterations in these two molecules may contribute in part to the aggressive breast tumor biology observed in this population.

    6. Chest
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      The World Health Organization histologic classification system reflects the oncologic behavior of thymoma : A clinical study of 273 patients (pages 624–632)

      Meinoshin Okumura, Mitsunori Ohta, Hisashi Tateyama, Katsuhiro Nakagawa, Akihide Matsumura, Hajime Maeda, Hiroto Tada, Tadaaki Eimoto, Hikaru Matsuda and Akira Masaoka

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10226

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      World Health Organization (WHO) histologic classification reflects the oncologic behavior of thymoma in terms of invasiveness, postoperative survival, and tumor recurrence. The WHO histologic classification system and the Masaoka staging system are significant independent prognostic factors for patients with thymoma.

    7. Diagnostic Imaging
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      Functional imaging of Langerhans cell histiocytosis by 111In-DTPA-D-Phe1-octreotide scintigraphy (pages 633–640)

      Secondo Lastoria, Liliana Montella, Lucio Catalano, Bruno Rotoli, Pietro Muto and Giovannella Palmieri

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10276

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      Somatostatin receptor scintigraphy can be useful in the evaluation of Langerhans cell histiocytosis. Somatostatin receptor scintigraphy provides functional information on the disease activity and shows in vivo the expression of somatostatin receptors in the sites of Langerhans cell histiocytosis.

    8. Gastrointestinal Tract
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      CPT-11 plus cisplatin in patients with advanced, untreated gastric or gastroesophageal junction carcinoma : Results of a Phase II study (pages 641–646)

      Jaffer A. Ajani, Jackie Baker, Peter W. T. Pisters, Linus Ho, Paul F. Mansfield, Barry W. Feig and Chusilp Charnsangavej

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10279

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      The response rate and toxicity profile were evaluated in this Phase II study of the combination of CPT-11 and cisplatin administered weekly to patients with untreated, advanced adenocarcinoma of the stomach or the gastroesophageal junction. The results showed that the CPT-11/cisplatin combination was active against gastric or gastroesophageal adenocarcinoma, and further studies are warranted.

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      Relevance of biologic markers in colorectal carcinoma : A comparative study of a broad panel (pages 647–657)

      Chiara Barozzi, Matteo Ravaioli, Antonia D'Errico, Gian Luca Grazi, Gilberto Poggioli, Giulia Cavrini, Alighieri Mazziotti and Walter Franco Grigioni

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10278

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      A comparison of the main biologic markers for colorectal carcinoma suggests that transforming growth factor-α, matrix metalloproteinase 2, and insulin-like growth factor II are suitable candidates for a selective panel of markers designed to provide relevant additional information with respect to the current pathologic staging system that may help implement novel therapeutic strategies for patients with colorectal carcinoma.

    10. Genitourinary Disease
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      Prognostic importance of tumor size for localized conventional (clear cell) renal cell carcinoma : Assessment of TNM T1 and T2 tumor categories and comparison with other prognostic parameters (pages 658–664)

      Brett Delahunt, John M. Kittelson, Margaret R. E. McCredie, Anthony E. Reeve, John H. Stewart and A. Michael Bilous

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10255

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      Analysis of 116 cases of organ-confined clear cell renal cell carcinoma showed a linear relation between tumor size and survival. On multivariate testing that included tumor grade and growth kinetic parameters (AgNORs and Ki-67), only tumor size retained a significant association with survival.

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      Higher doses of mitoxantrone among men with hormone-refractory prostate carcinoma : A Cancer and Leukemia Group B study (pages 665–672)

      Ellis G. Levine, Susan Halabi, John D. Roberts, Ellen B. Kaplan, Randall Rago, James N. Atkins and Nicholas J. Vogelzang

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10217

      A regimen including higher doses of mitoxantrone has activity comparable to many estramustine regimens and is well tolerated. However, the regimen cannot be recommended for Phase III testing, because the frequency of thrombocytopenia was higher than anticipated.

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      Sialosyl-Lex expression defines invasive and metastatic properties of bladder carcinoma (pages 673–685)

      Kenji Numahata, Makoto Satoh, Kazuko Handa, Seiichi Saito, Chikara Ohyama, Akihiro Ito, Toshiko Takahashi, Senji Hoshi, Seiichi Orikasa and Sen-itiroh Hakomori

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10268

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      Two types of transitional bladder carcinoma have been distinguished: type A (papillary) and type B (nodular). However, to date, no specific marker has been identified for patients with early-stage type B tumors that can predict the risk of developing invasive and metastatic disease. In this study, the authors found that antisialosyl Lex, as defined by the monoclonal antibody SNH3, was capable of predicting invasive and metastatic outcome for patients with type B (nodular) bladder carcinoma.

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      Rapid rise of serum prostate specific antigen levels after discontinuation of the herbal therapy PC-SPES in patients with advanced prostate carcinoma : Report of four cases (pages 686–689)

      William K. Oh, Daniel J. George and Philip W. Kantoff

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10269

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      Discontinuing the herbal combination therapy PC-SPES in androgen-independent prostate carcinoma patients can lead to a rapid and higher-than-expected rise in serum prostate-specific antigen. Four patient cases are described.

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      Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence (pages 690–699)

      Alfredo Velasco, Stephen M. Hewitt, Paul S. Albert, M. Hossein Saboorian, Helmar Rosenberg, Carlos Martinez, Arthur I. Sagalowsky, John D. McConnell, W. Marston Linehan and Fredrick S. Leach

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10247

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      Differential expression of the human mismatch repair gene, hMSH2, occurs in benign and malignant prostate tissue. Reduced or absent hMSH2 expression correlated with microsatellite instability and a favorable clinical outcome with respect to prostate specific antigen recurrence after radical prostatectomy.

    15. Gynecologic Oncology
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      Clinical usefulness of color doppler ultrasound in patients with endometrial hyperplasia and carcinoma (pages 700–706)

      Makoto Emoto, Riko Tamura, Kyoko Shirota, Toru Hachisuga and Tatsuhiko Kawarabayashi

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10208

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      Transvaginal color Doppler ultrasound may be more useful in differentiating between endometrial hyperplasia and carcinoma than measuring the endometrial thickness by transvaginal gray-scale sonography.

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      Circulating tumor cells in the peripheral blood and bone marrow of patients with ovarian carcinoma do not predict prognosis (pages 707–712)

      Christian Marth, Jelena Kisic, Janne Kærn, Claes Tropé and Øystein Fodstad

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10250

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      In 21% of ovarian carcinoma patients, tumor cells were observable in bone marrow aspirates. However, detection of these cells in bone marrow or blood was not associated with poor prognosis.

    17. Head and Neck Disease
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      p53 and Ki-67 as markers of radioresistance in head and neck carcinoma (pages 713–722)

      Christian Couture, Hélène Raybaud-Diogène, Bernard Têtu, Isabelle Bairati, Danielle Murry, Josée Allard and André Fortin

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10232

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      In a retrospective study of patients who were treated uniformly with radical radiotherapy only, p53 overexpression determined by immunohistochemistry was associated strongly with local treatment failure, suggesting that it may predict radioresistance. Furthermore, p53 overexpression, when it was associated with low Ki-67 expression, identified a subgroup of patients with an even worse response to radiotherapy.

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      Detection of cell free Epstein–Barr virus DNA in sera from patients with nasopharyngeal carcinoma (pages 723–729)

      Jenn-Ren Hsiao, Yin-Tai Jin and Sen-Tien Tsai

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10251

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      Detection of cell free Epstein–Barr virus genomes in circulation by using polymerase chain reaction-based approaches may be a valuable tool for monitoring patients with nasopharyngeal carcinoma.

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      National Cancer Data Base report on malignant paragangliomas of the head and neck (pages 730–737)

      John H. Lee, Frank Barich, Lucy Hynds Karnell, Robert A. Robinson, Weining K. Zhen, Bruce J. Gantz, Henry T. Hoffman and American College of Surgeons Commission on Cancer and the American Cancer Society

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10252

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      The 59 cases of malignant paraganglioma of the head and neck that were extracted from the National Cancer Data Base for the current study provide insight into this rare disease. The 5-year relative survival rate was 59.5%, and adjuvant irradiation to treat regional metastasis (which appeared to increase across the years of the current study) appeared to increase survival.

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      Angiogenesis in patients with craniopharyngiomas : Correlation with treatment and outcome (pages 738–745)

      Sergio Vidal, Kalman Kovacs, Ricardo V. Lloyd, Frederic B. Meyer and Bernd W. Scheithauer

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10281

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      The current study demonstrated that angiogenesis seemed to be a prognostic indicator of recurrence in patients with craniopharyngiomas. The expression of vascular endothelial growth factor receptor 2 mRNA in endothelial cells as well as in the neoplastic epithelium raises the possibility that craniopharyngiomas may be responsive to antiangiogenic therapy.

    21. Hepatobiliary Tract
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      Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma (pages 746–751)

      Noriyoshi Kusano, Kiwamu Okita, Hitoshi Shirahashi, Tomohiko Harada, Kei Shiraishi, Atsunori Oga, Shigeto Kawauchi, Tomoko Furuya and Kohsuke Sasaki

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10254

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      The decrease in DNA copy number at 8p and 13q and amplification at 11q13 were significantly associated with unfavorable outcome of patients (P = 0.017, P = 0.012, and P = 0.00081, respectively). The number of DNA copy number aberrations was significantly different between favorable and poor prognosis patients with hepatocellular carcinoma (HCC); 5.78 ± 2.7 versus 11.13 ± 4.8 (P = 0.004), and it was an independent prognostic marker in HCCs.

    22. Lung Disease
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      Increased expression of β-catenin predicts better prognosis in nonsmall cell lung carcinomas (pages 752–758)

      Fumihiro Hommura, Keiji Furuuchi, Koichi Yamazaki, Shigeaki Ogura, Ichiro Kinoshita, Michio Shimizu, Tetsuya Moriuchi, Hiroyuki Katoh, Masaharu Nishimura and Hirotoshi Dosaka-Akita

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10213

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      Increased expression of β-catenin can predict favorable prognosis of patients with resected nonsmall cell lung carcinomas. This suggests that accumulation of β-catenin has no or little oncogenic effect by activation of the Wnt pathway in nonsmall cell lung carcinomas, unlike in colon carcinomas or hepatomas.

    23. Neuro-Oncology
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      Brain metastases from esophageal carcinoma : Natural history, prognostic factors, and outcome (pages 759–764)

      Kazuhiko Ogawa, Takafumi Toita, Hiroo Sueyama, Nobukazu Fuwa, Yasumasa Kakinohana, Minoru Kamata, Genki Adachi, Atsushi Saito, Yoshihiko Yoshii and Sadayuki Murayama

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10271

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      Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, and possible prognostic factors in these patients is limited. In the current study, the authors analyzed their experience of 36 patients with brain metastases from esophageal carcinoma and review the previous case reports.

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      Stromelysin-3 is expressed by aggressive meningiomas (pages 765–772)

      Anne Gentil Perret, Robert Duthel, Marie-Jeanette Fotso, Jacques Brunon and Jean-François Mosnier

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10270

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      Expression of the metalloproteinase stromelysin-3 (ST3) by neoplastic cells is a frequent event in atypical meningiomas. In meningiomas, there is a correlation between the invasion of bone muscle or brain as well as the recurrence and the ST3 expression.

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      Central nervous system relapse in adults with acute lymphoblastic leukemia (pages 773–779)

      Usha R. Surapaneni, Jorge E. Cortes, Deborah Thomas, Susan O'Brien, Francis J. Giles, Charles Koller, Stefan Faderl and Hagop Kantarjian

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10265

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      The outcome of adult patients with acute lymphoblastic leukemia ALL and a central nervous system recurrence was analyzed. Although the response to intrathecal chemotherapy was good, most patients died of systemic disease. Better treatment strategies are needed for patients with this complication.

    26. Skin
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      Impaired platelet aggregation in melanoma patients treated with interferon-α-2b adjuvant therapy (pages 780–785)

      Haim Gutman, Jacob Schachter, Ella Stopel, Roee Gutman and Judith Lahav

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10261

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      High-dose interferon (INF) treatment is associated with impairment of platelet aggregation. This effect has important implications in the event of accidental injury or elective surgery. The antiaggregation activity may be the mechanism whereby INF delays, reduces, or prevents the formation of melanoma metastases.

    27. Soft Tissue
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      Chemotherapy, irradiation, and surgery for function-preserving therapy of primary extremity soft tissue sarcomas : Initial treatment with ifosfamide, mitomycin, doxorubicin, and cisplatin plus granulocyte macrophage–colony-stimulating factor (pages 786–792)

      John H. Edmonson, Ivy A. Petersen, Thomas C. Shives, Michelle R. Mahoney, Michael G. Rock, Michael G. Haddock, Franklin H. Sim, William J. Maples, Mary I. O'Connor, Leonard L. Gunderson, May L. Foo, Douglas J. Pritchard, Jan C. Buckner and Scott L. Stafford

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10259

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      Ifosfamide, mitomycin, doxorubicin, and cisplatin (IMAP) plus granulocyte macrophage–colony-stimulating factor given in two monthly cycles preceding preoperative irradiation is satisfactory as initial treatment for primary high-grade extremity soft tissue sarcomas. Although the outcome of patients treated on this regimen has been favorable, the metastasis problem has not been eliminated.

    28. Discipline

      Pathology
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      Loss of heterozygosity on chromosome arms 3p and 6q in microdissected adenocarcinomas of the uterine cervix and adenocarcinoma in situ (pages 793–802)

      Claudia M. Acevedo, Marcela Henríquez, Michael R. Emmert-Buck and Rodrigo F. Chuaqui

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10275

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      Allelic deletions were analyzed in precisely microdissected samples from 40 patients with adenocarcinoma of the uterine cervix and adenocarcinoma in situ. Deletions were frequent on chromosomes 3p and 6q, suggesting that inactivation of tumor suppressor genes at these loci are important events in the pathogenesis of glandular tumors of the uterine cervix.

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      Immunologic quantitation of the carcinoma specific human carcinoma antigen in clinical samples (pages 803–813)

      John F. Codington, Svein Haavik, Najmosama Nikrui, Irene Kuter, Christina Vassileva, Hui Zhang, Samantha Matson, Xiaomei Chen and Zibin Wu

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10124

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      The successful determination of the human carcinoma antigen (HCA) concentration, found to be proportional to the stage of breast carcinoma, by a radioimmunoassay using rabbit antiepiglycanin polyclonal antiserum, was followed by the preparation of two idiotype generations of immunoglobulin (Ig) G monoclonal antibodies (Ab-2, which simulates epiglycanin/HCA, and Ab-3, which simulates AE3) from spleen cells of mice immunized with 1) the antiepiglycanin/HCA antibody AE3 (Ab-1), an IgM, and 2) Ab-2, respectively. The results suggest that the use of Ab-2 for epiglycanin and Ab-3 for AE3 in a competitive binding assay will increase the specificity, sensitivity, and consistency of the assay, thereby improving this novel and important tool for detecting carcinomas.

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      Expression of CD95 (Fas) in sun-exposed human skin and cutaneous carcinomas (pages 814–819)

      Ewa Filipowicz, P. Adegboyega, R. L. Sanchez and Zoran Gatalica

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10277

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      CD95 (Fas) is up-regulated in chronically sun-exposed human skin (solar elastosis). Dysplastic skin (actinic keratosis) and squamous cell carcinoma showed marked reduction in the expression of CD95, possibly contributing to the progression of the disease.

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      Cytokeratin expression patterns in noncardia, intestinal metaplasia-associated gastric adenocarcinoma : Implication for the evaluation of intestinal metaplasia and tumors at the esophagogastric junction (pages 820–831)

      Bo Shen, Adrian H. Ormsby, Chen Shen, John A. Dumot, Yun-Wei Shao, Charles L. Bevins and Terry L. Gramlich

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10215

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      The cytokeratin 7/cytokeratin 20 expression pattern was evaluated in noncardia, intestinal metaplasia (IM)-associated gastric adenocarcinoma in 50 Chinese patients who were at low risk for Barrett esophagus (BE) and esophageal adenocarcinoma and at high risk for Helicobacter pylori infection and gastric carcinoma. The results support the hypothesis that, despite the presence of intestinalized mucosa in both disorders, BE/Barrett adenocarcinoma and gastric IM/adenocarcinoma are two distinct clinical entities with unique demographic, clinical, and cytokeratin immunophenotypic findings.

    32. Pain and Symptom Control
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      Episodic (breakthrough) pain : Consensus conference of an expert working group of the European Association for Palliative Care (pages 832–839)

      Sebastiano Mercadante, Lukas Radbruch, Augusto Caraceni, Nathan Cherny, Stein Kaasa, Friedemann Nauck, Carla Ripamonti, Franco De Conno and Steering Committee of the European Association for Palliative Care (EAPC) Research Network

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10249

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      Episodic pain is associated with a reduced likelihood for adequate pain control and has been treated with drugs commonly used for cancer pain, including opioids, anticonvulsants, antidepressants, and nonsteroidal antiinflammatory drugs. However, transmucosal fentanyl is actually the only therapeutic option that has been demonstrated to be effective in controlled randomized studies in these specific settings.

    33. Medical Oncology
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      Alternative bimonthly cycles of doxorubicin, cyclophosphamide, and etoposide, cisplatin with hematopoietic growth factor support in patients with carcinoma of unknown primary site (pages 840–846)

      Stéphane Culine, Michel Fabbro, Marc Ychou, Gilles Romieu, Didier Cupissol and Frédéric Pinguet

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10264

      A median survival of 10 months was observed in 82 patients with carcinomas of unknown primary origin who were treated with alternative bimonthly cycles of doxorubicin/cyclophosphamide and etoposide/cisplatin with granulocyte-macrophage–colony stimulating factor support.

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      Severe interstitial pneumonitis associated with docetaxel administration (pages 847–853)

      William L. Read, Joanne E. Mortimer and Joel Picus

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10263

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      Pneumonitis associated with docetaxel administration has been reported but not described. Docetaxel-associated pneumonitis is remarkable for its severity and protracted course. Clinical and pathologic findings in four patients who developed severe pneumonitis after docetaxel treatment are presented, followed by a review of the literature.

    35. Pediatric Oncology
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      Proliferation marker KI-S5 discriminates between favorable and adverse prognosis in advanced stages of neuroblastoma with and without MYCN amplification (pages 854–861)

      Matthias Krams, Barbara Hero, Frank Berthold, Reza Parwaresch, Dieter Harms and Pierre Rudolph

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10256

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      Although International Neuroblastoma Staging System (INSS) stage and MYCN status are highly significant prognostic indicators for neuroblastoma, proliferation measurements using monoclonal antibody Ki-S5 allowed a further risk stratification in subgroups defined by these two parameters. By multivariate analysis, the proliferation index emerged as the second most significant predictor of prognosis next to INSS stage in this study.

    36. Integrated Medicine
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      The association of treatment-related symptoms with quality-of-life outcomes for localized prostate carcinoma patients (pages 862–871)

      Constance G. Bacon, Edward Giovannucci, Marcia Testa, Thomas A. Glass and Ichiro Kawachi

      Article first published online: 31 JAN 2002 | DOI: 10.1002/cncr.10248

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      Common symptoms of localized prostate carcinoma—sexual, urinary, and bowel problems—are associated with physical as well as mental domains of general quality of life. As a result, patients and health care providers should consider these associations when making decisions about treatment and follow-up care.

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