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Cancer

Cover image for Cancer

15 March 2002

Volume 94, Issue 6

Pages 1619–1905

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. Disease Site

      Breast
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      Incidence of the superficial fascia and its relevance in skin-sparing mastectomy (pages 1619–1625)

      Gertrude M. Beer, Zsuzsanna Varga, Srecko Budi, Burkhardt Seifert and Viktor E. Meyer

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10429

      There is an ongoing debate about how thin skin flaps must to be to accomplish the successful, complete removal of breast tissue while leaving viable skin flaps in patients who undergo skin-sparing mastectomies. Several authors have recommended the dissection of skin flaps superficial to the superficial fascia of the breast, a layer that functions as the interface between breast tissue and subcutaneous fat. In this histologic study of 31 women, the fascia was absent in 44% of breasts. When it was present, the distance between the superficial fascia and the overlying dermis was as small as 0.2 mm, and it was < 1.1 mm in 50% of women. Thus, the superficial fascia is of only limited use as a guide during breast resection without compromising skin-flap circulation.

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      The association between breast carcinoma and meningioma in women (pages 1626–1635)

      Brian S. Custer, Thomas D. Koepsell and Beth A. Mueller

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10410

      Although clinical case reports of the association between breast carcinoma and meningioma are not uncommon in the literature, few analytic studies have examined the possible association. The results of this population-based, retrospective cohort study suggest that the risk of the occurrence of either tumor among women who have previously experienced the other tumor is quite modest.

    3. Gastrointestinal Tract
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      Expression of tumor rejection antigens in colorectal carcinomas (pages 1636–1641)

      Teruo Sasatomi, Yuichi Suefuji, Kazuko Matsunaga, Hideaki Yamana, Yoshiaki Miyagi, Yasumi Araki, Yutaka Ogata, Kyogo Itoh and Kazuo Shirouzu

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10421

      The possible use of SART3 antigen as a target molecule for specific immuno therapy for colorectal carcinoma patients was investigated.

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      Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastases (pages 1642–1647)

      Naoyuki Yokoyama, Yoshio Shirai, Yoich Ajioka, Shigenori Nagakura, Takeyasu Suda and Katsuyoshi Hatakeyama

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10422

      Immunohistochemical detection of hepatic micrometastases is feasible in patients with colorectal carcinoma liver metastases. Hepatic micrometastasis indicates widespread hepatic involvement and thus predicts an increased risk of intrahepatic recurrence after hepatic resection and a poorer patient prognosis.

    5. Genitourinary Disease
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      Seminal vesicle involvement in patients with D1 disease predicts early prostate specific antigen recurrence and metastasis after radical prostatectomy and early androgen ablation (pages 1648–1653)

      Thomas E. Ahlering, Douglas W. Skarecky, Christine E. McLaren and Alan C. Weinberg

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10378

      The results of the current study demonstrate that D1 radical prostatectomy patients who develop disease progression after early androgen ablation and who have seminal vesicle involvement will have significantly poorer survival outcomes.

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      A multiinstitutional, concurrent chemoradiation trial of strontium-89, estramustine, and vinblastine for hormone refractory prostate carcinoma involving bone (pages 1654–1660)

      Wallace Akerley, James Butera, Terek Wehbe, Richard Noto, Barry Stein, Howard Safran, Frank Cummings, Sundaresan Sambandam, John Maynard, Gregory Di Rienzo and Louis Leone

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10437

      Strontium-89, estramustine, and vinblastine are effective as concurrent chemoradiation therapy for hormone refractory prostate carcinoma.

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      Prospective study of cancer detection in black and white men with normal digital rectal examination but prostate specific antigen equal or greater than 4.0 ng/mL (pages 1661–1667)

      Jackson E. Fowler Jr., Steven A. Bigler and Paul B. Farabaugh

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10446

      The authors assessed prostate carcinoma detection with 1 biopsy procedure in 451 black and 480 white men with a normal DRE and a serum prostate specific antigen (PSA) greater than or equal to 4.0 ng/mL. When adjusted for PSA, carcinoma detection was not significantly different in men of the two races (P = 0.06), but Gleason score 7–10 cancer detection was 1.7 times greater in the black than the white men (P = 0.008).

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      Metastatic nonseminomatous germ cell tumors of the testis : Results of elective and salvage surgery for patients with residual retroperitoneal masses (pages 1668–1676)

      William F. Hendry, Andrew R. Norman, David P. Dearnaley, Cyril Fisher, Judy Nicholls, Robert A. Huddart and Alan Horwich

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10440

      Retroperitoneal lymph node dissection is an important component of therapy for men with residual masses after initial or salvage chemotherapy for metastatic testicular teratoma. In this retrospective review of 442 men who underwent surgery over a 24-year period, features related to outcome have been analyzed.

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      Multivariate analysis of survival, recurrence, progression and development of mestastasis in T1 and T2a transitional cell bladder carcinoma (pages 1677–1684)

      Andrés Rodríguez-Alonso, Salvador Pita-Fernández, Joaquín González-Carreró and José Luis Nogueira-March

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10376

      Age and expression of p53 constitute the independent variables for survival in classification T1 and T2a bladder carcinoma. The independent variables determining recurrence are T classification, tumor multifocality, tumor size, carcinoma in situ in random bladder biopsy, and expression of Ki-67. Independent variables for progression may be listed as age, T classification, and expression of p53. The p53 expression is the only variable that offers an independent prediction for the development of metastasis.

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      Prostate specific antigen complexed to α-1-antichymotrypsin in patients with intermediate prostate specific antigen levels (pages 1685–1691)

      Takashi Saika, Tomoyasu Tsushima, Yasutomo Nasu, Nobuyuki Kusaka, Yoshiyuki Miyaji, Hitoshi Takamoto, Katsuji Takeda, Satoru Uno, Hiromi Kumon and for the Okayama Urological Cancer Collaborating Group

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10377

      This prospective study suggests that serum prostate specific antigen (PSA) complexed to α-1 antichymotrypsin may serve as a single assay replacement for the measurement of total PSA in the early detection of prostate carcinoma, and its density may be a good indicator of prostate carcinoma for patients with intermediate PSA levels.

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      The dynamics of prostate specific antigen during watchful waiting of prostate carcinoma : A study of 94 Japanese men (pages 1692–1698)

      Robin T. Vollmer, Shin Egawa, Sadahito Kuwao and Shiro Baba

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10443

      During expectant management for prostate carcinoma, serial values of prostate specific antigen can be accurately fit by a log-linear model yielding two important parameters, the amplitude and the relative velocity. Both appear to relate to clinical outcomes.

    12. Gynecologic Oncology
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      Direct visual inspection for cervical cancer screening : An analysis of factors influencing test performance (pages 1699–1707)

      Lynette Denny, Louise Kuhn, Amy Pollack and Thomas C. Wright Jr.

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10381

      Direct visual inspection of the cervix after the application of 5% acetic acid detects over two-thirds of high-grade cervical carcinoma precursors and cervical carcinoma in a screened population. This low-technology test offers an attractive alternative to cervical cytology in low-resource settings.

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      The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma (pages 1708–1712)

      Isis Dove-Edwin, Dominique Boks, Sheila Goff, Gemma G. Kenter, Robert Carpenter, Hans F. A. Vasen and Huw J. W. Thomas

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10380

      Endometrial carcinoma surveillance by ultrasound scanning was offered to women from hereditary nonpolyposis colorectal carcinoma syndrome (HNPCC) and HNPCC-like families. The cases of endometrial carcinoma which occurred presented with symptoms and were not detected by surveillance.

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      Transcervical needle biopsy for the differential diagnosis between uterine sarcoma and leiomyoma (pages 1713–1720)

      Naoki Kawamura, Tomoyuki Ichimura, Fumihiro Ito, Sachiko Shibata, Kumiyo Takahashi, Akemi Tsujimura, Osamu Ishiko, Tomoko Haba, Kenichi Wakasa and Sachio Ogita

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10382

      Transcervical core needle biopsy is a reliable diagnostic test for the differential diagnosis between uterine sarcoma and leiomyoma. This diagnostic method, combined with magnetic resonance imaging, could reduce the number of patients currently undergoing unnecessary surgery.

    15. Hematologic Malignancies
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      The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease (pages 1721–1730)

      Francesco DiRaimondo, Maher Albitar, Yang Huh, Susan O'Brien, Marco Montillo, Alessandra Tedeschi, Hagop Kantarjian, Susan Lerner, Rosario Giustolisi and Michael Keating

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10401

      Surface expression of CD23 in chronic lymphoproliferative disease is helpful in distinguishing chronic lymphocytic leukemia (CLL) from mantle cell leukemia. Rare cases of CLL could be negative for CD23.

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      European Organization for Research and Treatment of Cancer and Groupe d'Etude des Lymphomes de l'Adulte very favorable and favorable, lymphocyte-predominant Hodgkin disease (pages 1731–1738)

      Richard B. Wilder, Pamela J. Schlembach, Dan Jones, Gregory M. Chronowski, Chul S. Ha, Anas Younes, Fredrick B. Hagemeister, Ibrahim Barista, Fernando Cabanillas and James D. Cox

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10404

      Recurrence free survival for patients with Stage I–II, lymphocyte-predominant Hodgkin disease categorized as very favorable or favorable, according to the criteria of the European Organization for Research and Treatment of Cancer and the Groupe d'Etude des Lymphomes de l'Adulte, was similar for patients who received radiotherapy alone and patients who received chemotherapy followed by radiotherapy, although the statistical power was limited. Overall survival also was similar for the two treatment groups. Clinical trials are underway to help clarify the role of a watch-and-wait strategy or systemic therapy, including anthracycline, bleomycin, and vinblastine-based chemotherapy or antibody-based approaches, in patients with favorable, lymphocyte-predominant Hodgkin disease.

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      Comparison in treatments of nonleukemic granulocytic sarcoma : Report of two cases and a review of 72 cases in the literature (pages 1739–1746)

      Kunihiko Yamauchi and Masami Yasuda

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10399

      To reduce the risk of subsequent acute nonlymphoblastic leukemia (ANLL) in patients with isolated cases of granulocytic sarcoma (GS), it is important that an accurate histologic diagnosis is initially established for GS and that intensive systemic chemotherapy similar to that used to treat ANLL is begun during the nonleukemic period as soon as possible.

    18. Hepatobiliary Tract
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      A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma (pages 1747–1752)

      Annie O. Chan, Man-Fung Yuen, Chee-Kin Hui, Wai-Kuen Tso and Ching-Lung Lai

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10407

      Hepatocellular carcinoma (HCC) is a common cause of cancer death throughout the world. Transcatheter intraarterial lipiodol chemoembolization (TACE) has been reported to be one of the most effective palliative measures for HCC. However, the severe side effects of TACE continue to make it controversial. In the current study, the authors prospectively studied 197 sessions of TACE performed in 59 patients with HCC.

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      Echogenicity of liver metastases from colorectal carcinoma is an independent prognostic factor in patients treated with regional chemotherapy (pages 1753–1759)

      Thomas Gruenberger, Jing Zhao, Julie King, TengTeng Chung, Phil R. Clingan and David L. Morris

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10386

      The effect of the echogenic appearance of unresectable colorectal liver metastases on overall survival in patients treated with regional chemotherapy was evaluated. Ultrasonic echogenicity was found to be highly prognostic for survival in this patient group.

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      Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system : A study based on 926 patients (pages 1760–1769)

      Thomas W. T. Leung, Amanda M. Y. Tang, Benny Zee, W. Y. Lau, Paul B. S. Lai, K. L. Leung, Joseph T. F. Lau, Simon C. H. Yu and Philip J. Johnson

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10384

      A new prognostic index, the Chinese University Prognostic Index (CUPI), was derived from 926 patients with hepatocellular carcinoma. The results showed that the CUPI was more discriminant for survival of different groups than existing prognostic indices.

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      Correlation between expression of MUC1 core protein and outcome after surgery in mass-forming intrahepatic cholangiocarcinoma (pages 1770–1776)

      Naoki Matsumura, Masakazu Yamamoto, Atsushi Aruga, Ken Takasaki and Masayuki Nakano

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10398

      Immunohistochemically, the location of MUC1 expression correlated with poor surgical outcomes in mass-forming intrahepatic cholangiocarcinoma (m-ICC). The evaluation of MUC1 expression may be very useful in predicting the surgical outcome in m-ICC.

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      Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis (pages 1777–1786)

      Yo Sasaki, Hisako Yamamura, Yuriko Kawakami, Terumasa Yamada, Masahiro Hiratsuka, Masao Kameyama, Hiroaki Ohigashi, Osamu Ishikawa, Shingi Imaoka, Shingo Ishiguro and Katsuhito Takahashi

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10402

      Immunohistochemical examination of the calponin expression in tumor vessels is a new and useful means to predict the prognosis of patients with hepatocellular carcinoma after hepatic resection.

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      Close association between high serum alanine aminotransferase levels and multicentric hepatocarcinogenesis in patients with hepatitis C virus-associated cirrhosis (pages 1787–1795)

      Kazuo Tarao, Yasushi Rino, Shinichi Ohkawa, Setsuo Tamai, Kaoru Miyakawa, Hideki Takakura, Osamu Endo, Michiyasu Yoshitsugu, Norihito Watanabe and Shohei Matsuzaki

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10391

      A close association between multicentric hepatocarcinogenesis and sustained necroinflammation of the liver was confirmed in patients with hepatitis C virus-associated cirrhosis.

    24. Lung Disease
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      99mTC-tetrofosmin scintigraphy in lung carcinoma staging and follow-up evaluations (pages 1796–1807)

      Gianfranco Buccheri, Alberto Biggi, Domenico Ferrigno and Antonella Francini

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10394

      Scanning with 99mTC-tetrofosmin is an accurate method for lung carcinoma pretreatment staging evaluation. However, current data exclude substantially increased yields of this technique, whose precise clinical value remains to be defined

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      Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin (pages 1808–1814)

      Bernd Kinzel, Jonathan Hall, Francois Natt, Jan Weiler and Dalia Cohen

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10383

      Specific inhibition of Hus1 by antisense oligonucleotides enhances the sensitivity of human H1299 lung carcinoma cells to cisplatin. Directly targeting Hus1 could offer a checkpoint-based strategy to selectively enhance the cytotoxicity of DNA damaging agents for cancer therapy.

    26. Neuro-Oncology
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      Cerebrospinal fluid concentrations of vincristine after bolus intravenous dosing : A surrogate marker of brain penetration (pages 1815–1820)

      Stewart J. Kellie, Draga Barbaric, Pauline Koopmans, John Earl, Deborah J. Carr and Siebold S. N. de Graaf

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10397

      Cerebrospinal fluid (CSF) concentrations of chemotherapy agents may be used as surrogate markers of brain penetration. Detectable CSF concentrations of vincristine using a highly sensitive high-performance liquid chromatography assay were not achieved after the administration of intravenous bolus doses of vincristine in children with an intact blood-brain barrier.

    27. Discipline

      Translational Research
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      Understanding cancer metastasis : An urgent need for using differential gene expression analysis (pages 1821–1829)

      Murali D. Bashyam

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10362

      The article presents a review of different pathways involved in the generation and maintenance of metastatic spread of cancer and the use of various differential gene expression techniques to study cancer.

    28. Pediatric Oncology
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      A population-based study of pediatric anaplastic large cell lymphoma (pages 1830–1835)

      Angela J. Alessandri, Sheila L. Pritchard, Kirk R. Schultz and Bonnie G. Massing

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10396

      The average annual incidence of anaplastic large cell lymphoma in children younger than 15 years of age in British Columbia is 1.2 per million. The authors report a high incidence of central nervous system involvement at diagnosis and an overrepresentation of patients of East and Southeast Asian ethnic origin.

    29. Integrated Medicine
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      The panorama of opioid-related cognitive dysfunction in patients with cancer : A critical literature appraisal (pages 1836–1853)

      Peter G. Lawlor

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10389

      Opioid-related cognitive effects are usually subtle in the early stages of disease but more dramatic in advanced disease, in the form of delirium. Objective monitoring of cognition can facilitate optimal opioid management through early recognition of opioid-related delirium and therefore prompt intervention, primarily in the form of dose reduction or change of opioid.

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      Helping patients with localized prostate carcinoma manage uncertainty and treatment side effects : Nurse-delivered psychoeducational intervention over the telephone (pages 1854–1866)

      Merle H. Mishel, Michael Belyea, Barbara B. Germino, Janet L. Stewart, Donald E. Bailey Jr., Cary Robertson and James Mohler

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10390

      A psychoeducational intervention directed at helping men with localized prostate carcinoma manage the uncertainties of their disease and treatment was effective in improving cognitive reframing and problem-solving skills, decreasing the overall number of symptoms experienced, and improving control over urinary incontinence and sexual satisfaction. The sample of 239 men included nearly 50% African-American men, allowing for the examination of ethnic differences in intervention effectiveness.

    31. Epidemiology
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      An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation (pages 1867–1875)

      William B. Grant

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10427

      The relation between solar ultraviolet (UV)-B exposure in July and cancer mortality rates for state economic areas in the U.S. between 1970–1994 was determined using regression analysis. Inverse correlations were found to exist between solar UV-B radiation and 13 types of cancer. Lack of sufficient solar UV-B radiation may account for 23,600 premature cancer deaths each year.

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      Utilization of BRCA1/2 genetic testing in the clinical setting : Report from a single institution (pages 1876–1885)

      Soo-Chin Lee, Barbara A. Bernhardt and Kathy J. Helzlsouer

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10420

      Of 258 high-risk patients eligible for BRCA1/2 genetic testing who were counseled in a cancer risk assessment clinic, only 26% undertook genetic testing, a proportion much lower than has been reported previously in hypothetical and research situations. Factors associated with testing include access to free testing, Ashkenazi Jewish heritage, and personal history of breast or ovarian carcinoma.

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      Ethnic differences in survival among women with ovarian carcinoma (pages 1886–1893)

      Jill S. Barnholtz-Sloan, Michael A. Tainsky, Judith Abrams, Richard K. Severson, Faisal Qureshi, Suzanne M. Jacques, Nancy Levin and Ann G. Schwartz

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10415

      A population of 13,083 patients (12,285 Caucasian women and 798 African-American women) who were diagnosed with primary ovarian carcinoma from the population-based Surveillance, Epidemiology and End Results Program was used to examine ethnic differences in survival after diagnosis. The crude median survival for African-American women was nearly 1 year less than for Caucasian women (22 months vs. 32 months, respectively; P < 0.0001), and African-American women who were diagnosed with ovarian carcinoma are at a 30% increased risk of death from any cause when adjusting for all other prognostic variables that differ between the two ethnic groups.

    34. Pathology
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      Cytoplasmic expression of laminin γ2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma (pages 1894–1901)

      Shinichiro Takahashi, Takahiro Hasebe, Tatsuya Oda, Satoshi Sasaki, Taira Kinoshita, Masaru Konishi, Takenori Ochiai and Atsushi Ochiai

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10395

      Laminin γ2 chain expression was examined immunohistochemically in 48 patients with pancreatic ductal adenocarcinoma. The cytoplasmic expression of the laminin γ2 chain was correlated with distant metastasis, especially hepatic metastasis, and with a poorer prognosis in patients with pancreatic ductal adenocarcinoma.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. You have free access to this content
      Time trends of cutaneous melanoma in Queensland, Australia and Central Europe (pages 1902–1903)

      Mathieu Boniol, Judith Sallin and Jean-François Doré

      Article first published online: 15 MAR 2002 | DOI: 10.1002/cncr.10408

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