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Cancer

Cover image for Cancer

15 April 2002

Volume 94, Issue 8

Pages 2119–2319

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. Disease Site

      Breast Disease
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      Adenoid cystic carcinoma of the breast : Molecular markers, treatment, and clinical outcome (pages 2119–2127)

      Grazia Arpino, Gary M. Clark, Syed Mohsin, Valerie J. Bardou and Richard M. Elledge

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10455

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      Adenoid cystic carcinomas of the breast have very favorable biologic characteristics, and, consistent with this, an excellent prognosis. Good local control can be achieved by lumpectomy with radiation or by simple mastectomy. Axillary lymph node dissection is not helpful in clinical management of this disease.

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      Male breast carcinoma in Israel : Higher incidence but possibly better prognosis in Ashkenazi Jews (pages 2128–2133)

      Baruch Brenner, Georgeta Fried, Pavel Levitzki, Erica Rakowsky, Hedwig Lurie, Efraim Idelevich, Avivit Neuman, Bella Kaufman, Jaqueline Sulkes and Aaron Sulkes

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10449

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      In accordance with findings for breast carcinoma in women among Jewish ethnic subpopulations, the analysis of two independent samples in Israel showed a higher incidence of male breast carcinoma in Ashkenazi Jews compared with the incidence in Sephardic Jews. However, outcome is apparently inferior in the latter group.

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      Breast ductal carcinoma in situ with microinvasion : A definition supported by a long-term study of 1248 serially sectioned ductal carcinomas (pages 2134–2142)

      Isabelle de Mascarel, Gaëtan MacGrogan, Simone Mathoulin-Pélissier, Isabelle Soubeyran, Véronique Picot and Jean-Michel Coindre

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10451

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      The authors defined ductal carcinoma in situ with microinvasion (DCIS-MI) as DCIS with infiltration of the periductal stroma by a few tumor cells, singly (type 1) or in clusters (type 2). The objective was to study the metastasis risk related to the microinvasive component of these types of cancer by comparing the clinical, histologic, and survival characteristics of 4 groups of patients with, respectively, DCIS (722 patients), DCIS-MI type 1 and type 2 (243 patients), and ductal carcinoma in situ with a predominant DCIS component greater than or equal to 80% of the tumor (IDC-DCIS, 283 patients).

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      Influence of delay to diagnosis on prognostic indicators of screen-detected breast carcinoma (pages 2143–2150)

      Ivo A. Olivotto, Asako Gomi, Christina Bancej, Jacques Brisson, Jon Tonita, Lisa Kan, Zeva Mah, Marion Harrison and Rene Shumak

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10453

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      Delays to diagnosis beyond 20 weeks after an abnormal breast screening examination are associated with a linear trend of increased tumor size and lymph node involvement among asymptomatic women who later receive a diagnosis of breast carcinoma.

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      Correlation between MIB-1 and other proliferation markers : Clinical implications of the MIB-1 cutoff value (pages 2151–2159)

      Frédérique Spyratos, Magali Ferrero-Poüs, Martine Trassard, Kamel Hacène, Edelmira Phillips, Michèle Tubiana-Hulin and Viviane Le Doussal

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10458

      The choice of MIB-1 cutoff depends on the following clinical objective: if MIB-1 is used to exclude patients with slowly proliferating tumors from chemotherapeutic protocols, a cutoff of 10% will help to avoid overtreatment. In contrast, if MIB-1 is used to identify patients sensitive to chemotherapy protocols, the cutoff should be set at 25%.

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      Increased mammography use and its impact on earlier breast cancer detection in Vermont, 1975–1999 (pages 2160–2168)

      Pamela M. Vacek, Berta M. Geller, Donald L. Weaver and Roger S. Foster Jr.

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10459

      Reductions in tumor size and axillary lymph node metastasis were due primarily to mammographic detection, although mammographic detection had a smaller effect on tumor size in women age < 50 years. Women age < 50 years had a greater risk of lymph node metastasis independent of the method of detection or the frequency of mammography.

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      HER2 status in patients with breast carcinoma is not modified selectively by preoperative chemotherapy and is stable during the metastatic process (pages 2169–2173)

      Anne Vincent-Salomon, Michel Jouve, Pascal Genin, Paul Fréneaux, Brigitte Sigal-Zafrani, Martial Caly, Philippe Beuzeboc, Pierre Pouillart and Xavier Sastre-Garau

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10456

      The sequential assessment of HER2 expression in two different series of breast carcinomas showed that HER2 status remained unchanged after patients received anthracycline-based chemotherapy and during the metastatic process. Thus, the absence of an effect of anti-HER2 therapy probably is not related to the loss of HER2 overexpression in persistent or metastatic tumor cells.

    8. Gastrointestinal Tract
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      Phase II trial of irinotecan in combination with amifostine in patients with advanced colorectal carcinoma (pages 2174–2179)

      Maria L. Delioukina, Diane Prager, Mandy Parson, J. Randolph Hecht, Peter Rosen and Lee S. Rosen

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10432

      In the current study, the authors tested the combination of irinotecan and amifostine in patients with previously treated metastatic colorectal carcinoma. The results demonstrate that amifostine did not conclusively decrease the neutropenia or diarrhea caused by irinotecan. However, the current study did provided an additional experience with an every-2-weeks irinotecan regimen as efficacious, safe, and a reasonable alternative in this disease setting.

    9. Genitourinary Tract
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      pT1 clear cell renal cell carcinoma : A study of the association between MIB-1 proliferative activity and pathologic features and cancer specific survival (pages 2180–2184)

      John C. Cheville, Horst Zincke, Christine M. Lohse, Thomas J. Sebo, Darren Riehle, Amy L. Weaver and Michael L. Blute

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10433

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      Several studies have identified MIB-1 proliferative activity as an independent predictor of outcome in patients with renal cell carcinoma (RCC). The current study found that MIB-1 proliferative activity was not an independent predictor of cancer specific survival in a large cohort of patients with pT1 clear cell RCC who were treated uniformly with radical nephrectomy. If a clear cell RCC is measured adequately, graded appropriately, and assessed for necrosis, MIB-1 proliferative activity appears to provide no additional prognostic information.

    10. Gynecologic Oncology
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      Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma (pages 2185–2191)

      Helga B. Salvesen, Ingunn Stefansson, May Britt Kalvenes, Soma Das and Lars A. Akslen

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10434

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      In a population-based series of patients with endometrial carcinoma, the loss of PTEN expression was seen in 20% of patients and was associated significantly with metastatic disease.

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      Fertility-preserving treatment in young patients with endometrial adenocarcinoma (pages 2192–2198)

      Chen-Bin Wang, Chin-Jung Wang, Huei-Jean Huang, Swei Hsueh, Hung-Hsueh Chou, Yung-Kuei Soong and Chyong-Huey Lai

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10435

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      A cohort study of nulliparous young women with clinically diagnosed Stage IA, Grade 1 endometrial adenocarcinoma undergoing fertility-preserving treatment by using combinations of megestrol, tamoxifen, and leuprolide is presented.

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      Quantitation of human papillomavirus 16 E6 and E7 DNA and RNA in residual material from ThinPrep Papanicolaou tests using real-time polymerase chain reaction analysis (pages 2199–2210)

      Feng Wang-Johanning, Danielle W. Lu, Yueying Wang, Martin R. Johnson and Gary L. Johanning

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10439

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      Detection of human papillomavirus 16 (HPV-16) E6 and E7 expression by real-time reverse transcriptase-polymerase chain reaction analysis or polymerase chain reaction analysis in ThinPrep cervical cytologic specimens may serve as a quick, reliable, and sensitive tool to identify a subset of patients who express HPV-16 oncoproteins.

    13. Head and Neck Disease
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      Expression of estrogen receptor, progesterone receptor, and insulin-like growth factor receptor-1 and of MIB-1 in patients with recurrent pleomorphic adenoma of the parotid gland (pages 2211–2216)

      Afina S. Glas, Harry Hollema, Raoul E. Nap and John T. Plukker

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10445

      The prognostic value of endocrine receptors and of the expression of MIB-1 and insulin-like growth factor-1 in 52 patients with recurrent pleomorphic adenoma of the parotid gland was investigated. Expression of progesterone was higher in the patients with recurrent disease, suggesting a possible role for hormonal intervention.

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      A prospective, randomized trial comparing neoadjuvant chemotherapy with radiotherapy alone in patients with advanced nasopharyngeal carcinoma (pages 2217–2223)

      Masato Hareyama, Koh-ichi Sakata, Hiroki Shirato, Takeshi Nishioka, Masamichi Nishio, Keishiro Suzuki, Akio Saitoh, Atsushi Oouchi, Satoshi Fukuda and Tetsuo Himi

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10473

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      The use of combined chemotherapy with cisplatin and 5-fluorouracil prior to radiotherapy in patients with nasopharyngeal carcinoma did not result in a significant improvement in disease free survival or overall survival. However, there was a tendency in favor of the chemoradiotherapy arm toward an improvement in the distant metastasis free survival rate, although there was no improvement in the locoregional recurrence free survival rate.

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      Phase II study of methotrexate, vinblastine, doxorubicin, and cisplatin in patients with squamous cell carcinoma of the upper respiratory or alimentary passages of the head and neck (pages 2224–2231)

      Scott H. Okuno, James A. Mailliard, Vera J. Suman, John H. Edmonson, Edward T. Creagan, Suresh Nair, Ralph Levitt and John W. Kugler

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10442

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      This Phase II trial of methotrexate, vinblastine, doxorubicin, and cisplatin demonstrates significant activity in patients with recurrent and metastatic head and neck carcinoma.

    16. Hematologic Malignancies
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      Clinical significance of telomerase activity in multiple myeloma (pages 2232–2238)

      Motoaki Shiratsuchi, Koichiro Muta, Yasunobu Abe, Seiichi Motomura, Fumihiro Taguchi, Hiroshi Takatsuki, Naokuni Uike, Tsukuru Umemura, Hajime Nawata and Junji Nishimura

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10472

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      The clinical course of patients with multiple myeloma varies, and therefore it is important to evaluate the disease state. The measurement of the telomerase activity in myeloma cells was found to be a reliable marker for the proliferating capacity and tumor mass in myeloma patients.

    17. Lung Disease
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      Topoisomerase IIα gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients (pages 2239–2247)

      Dage Liu, Cheng-long Huang, Kotaro Kameyama, Eiichi Hayashi, Akira Yamauchi, Shinichi Sumitomo and Hiroyasu Yokomise

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10450

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      Topoisomerase IIα gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients. Topoisomerase IIα gene expression in tumors reflects biologic behavior, such as tumor differentiation.

    18. Melanoma
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      Multiple primary melanoma revisited (pages 2248–2255)

      M. Anne Blackwood, Robin Holmes, Marie Synnestvedt, Megan Young, Cicily George, Hannah Yang, David E. Elder, Lynn M. Schuchter, DuPont Guerry and Arupa Ganguly

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10454

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      Incidence of multiple primary melanoma is associated with a limited but substantial incidence of a family history of melanoma, dysplastic nevi (DN), or basal cell carcinoma (BCC) and a small association with CDKN2A mutations. The family members of multiple primary melanoma patients can benefit from screening and regular surveillance for melanoma, DN, and BCC.

    19. Sarcoma
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      Soft tissue sarcoma of the upper extremity : A 5-year experience at two institutions emphasizing the role of soft tissue flap reconstruction (pages 2256–2264)

      Robert F. Lohman, Ayman S. Nabawi, Gregory P. Reece, Raphael E. Pollock and Gregory R. D. Evans

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10419

      Soft tissue reconstruction allows for resection of sarcomas from the upper limb with few complications but may be associated with greater blood loss and longer hospital stay. Patients who underwent soft tissue reconstruction had larger margins compared with patients who had primary closure, but this did not influence survival or tumor recurrence.

    20. Discipline

      Radiation Oncology
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      Survival by radiation therapy oncology group recursive partitioning analysis class and treatment modality in patients with brain metastases from malignant melanoma : A retrospective study (pages 2265–2272)

      Jeffrey C. Buchsbaum, John H. Suh, Shih-Yuan Lee, Mark A. Chidel, John F. Greskovich and Gene H. Barnett

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10426

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      Previous recursive partitioning analyses for patients with brain metastases reviewed large patient series that included varied, common tumor histologies dominated by lung carcinoma. For the first time, the current study evaluated the survival of patients with brain metastases from melanoma according to treatment modality to confirm the usefulness of the Radiation Therapy Oncology Group recursive partitioning schema to predict the survival of patients with brain metastases in this population.

    21. Pathology
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      Prognostic relevance of cell biologic and biochemical features in conventional chondrosarcomas (pages 2273–2281)

      Thomas Aigner, Susanna Müller, Daniel Neureiter, Duane M. Illstrup, Thomas Kirchner and Johannes Björnsson

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10461

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      This study indicates that molecular markers are the biologic basis of the conventional tumor grading and can provide additional prognostic markers in certain circumstances. Further understanding of chondrocytic phenotypes will be a promising way to provide new tumor markers for better understanding, diagnosis, and treatment of chondroid neoplasms.

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      Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years : Is there evidence for systematic upgrading? (pages 2282–2287)

      Emily B. Smith, Henry F. Frierson Jr., Stacey E. Mills, James C. Boyd and Dan Theodorescu

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10457

      Over the past 10 years, a downward stage migration has been observed in prostate carcinoma. In contrast, tumor grade has shifted in the opposite direction. The authors' data suggest that such changes in biopsy grade in part may be because of a trend among pathologists to upgrade similar specimens over time. Therefore, outcome studies including biopsy Gleason scores from older specimens have a significant chance of being vulnerable to this phenomenon and should undergo pathological rereview.

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      Malignant placental site trophoblastic tumor : A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization (pages 2288–2294)

      Wei-Cheng Xue, Xin-Yuan Guan, Hextan Y. S. Ngan, Dan-Hua Shen, Ui-Soon Khoo and Annie N. Y. Cheung

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10424

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      Cytogenetic study of two cases of metastatic placental site trophoblastic tumors by comparative genomic hybridization and chromosome in situ hybridization analysis indicated that both cases had balanced diploid karyotype.

    24. Integrated Medicine
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      Cancer pain management among underserved minority outpatients : Perceived needs and barriers to optimal control (pages 2295–2304)

      Karen O. Anderson, Stephen P. Richman, Judith Hurley, Guadalupe Palos, Vicente Valero, Tito R. Mendoza, Ibrahima Gning and Charles S. Cleeland

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10414

      Socioeconomically disadvantaged African-American and Hispanic patients with cancer who had disease-related pain reported multiple barriers to optimal pain management. Concerns about opioid medications and difficulty communicating with health care providers were frequent impediments.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
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      A high number of tumor free axillary lymph nodes from patients with lymph node negative breast carcinoma is associated with poor outcome (pages 2307–2309)

      Rosemary R. Millis, Robert J. Springall, Andrew M. Hanby, Kenneth Ryder and Ian S. Fentiman

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10469

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      Author reply (pages 2311–2312)

      Peter A. Humphrey

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10467

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      Author reply (pages 2314–2316)

      Eric J. Suba and Stephen S. Raab

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10465

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      Author reply to previously published correspondence (pages 2316–2317)

      Radboud W. Koot, Mohammad Maarouf, Maarten C. C. M. Hulshof, Jürgen Voges, Harald Treuer, Cees Koedooder, Volker Sturm and Andries D. Bosch

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10470

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      Author reply (pages 2318–2319)

      Peter Birner, Brigitte Gatterbauer, Georg Oberhuber, Monika Schindl, Karl Rössler, Axel Prodinger, Herbert Budka and Johannnes A. Hainfellner

      Article first published online: 15 APR 2002 | DOI: 10.1002/cncr.10463

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