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Cancer

Cover image for Cancer

1 May 2002

Volume 94, Issue 9

Pages 2321–2517

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Communication
    4. Erratum
    1. Disease Site

      Breast Disease
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      Phase I study of eniluracil and oral 5-fluorouracil in combination with docetaxel in the treatment of patients with metastatic breast carcinoma (pages 2321–2326)

      Edgardo Rivera, Vicente Valero, Massimo Cristofanilli, Debra K. Frye, Daniel J. Booser, Marguerite M. Rosales and Gabriel N. Hortobagyi

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10488

      The authors determined that the combination of oral eniluracil/5-fluorouracil and intravenous docetaxel is a safe and well tolerated regimen for patients with metastatic breast carcinoma. Significant antitumor activity is associated with this combination.

    2. Colorectal Disease
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      Colorectal carcinoma in poor blacks (pages 2327–2332)

      Harold P. Freeman and Tarek A. Alshafie

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10486

      Five-year survival of colorectal carcinoma patients was very low at an inner-city hospital serving an African-American population. This was primarily because of advanced stage at presentation.

    3. Endocrine Disorders
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      A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma : Continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist (pages 2333–2343)

      Jame Abraham, Susan Bakke, Ann Rutt, Beverly Meadows, Maria Merino, Richard Alexander, David Schrump, David Bartlett, Peter Choyke, Rob Robey, Elizabeth Hung, Seth M. Steinberg, Susan Bates and Tito Fojo

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10487

      A Phase II trial was conducted using three natural products known to be P-glycoprotein substrates, in combination with mitotane. The study design was based on in vitro data demonstrating that mitotane could reverse P-glycoprotein-mediated drug resistance, and the knowledge that all adrenocortical tumors express high levels of P-glycoprotein.

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      A prospective pancreatographic study of the prevalence of pancreatic carcinoma in patients with diabetes mellitus (pages 2344–2349)

      Yoshiaki Ogawa, Masao Tanaka, Ken Inoue, Koji Yamaguchi, Kazuo Chijiiwa, Kazuhiro Mizumoto, Nobutaka Tsutsu and Yoshihiro Nakamura

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10493

      Endoscopic retrograde pancreatography revealed pancreatic carcinoma at an extremely high rate of 7.0% (6 of 86 patients) in patients with diabetes mellitus who were selected prospectively by the authors' original criteria. The prevalence of pancreatic carcinoma was significantly greater in patients with recent onset diabetes (13.9%; 5 of 36 patients) compared with patients > 3 years after the onset of diabetes (2.0%; 1 of 50 patients; P = 0.0442).

    5. Genitourinary Disease
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      The prevalence of high-grade prostatic intraepithelial neoplasia in surgical resection specimens : An Indian experience (pages 2350–2352)

      Sangeeta B. Desai and Anita M. Borges

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10495

      To the authors' knowledge, there is scant literature available regarding the prevalence of high-grade prostatic intraepithelial neoplasia (HGPIN) in a low-risk Indian population. The current study documents the prevalence of HGPIN in patients who visited the study institution. HGPIN was found to be associated closely with invasive prostate carcinoma; however, it was found to be absent in patients with benign prostates.

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      Prospective comparison of [18F]fluorodeoxyglucose positron emission tomography with conventional assessment by computed tomography scans and serum tumor markers for the evaluation of residual masses in patients with nonseminomatous germ cell carcinoma (pages 2353–2362)

      Christian Kollmannsberger, Karin Oechsle, Bernhard M. Dohmen, Anna Pfannenberg, Roland Bares, Claus D. Claussen, Lothar Kanz and Carsten Bokemeyer

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10494

      18Fluorodeoxyglucose positron emission tomography imaging performed in conjunction with conventional staging methods offers additional information for the prediction of residual mass histology in patients with nonseminomatous germ cell tumors, particularly for those with multiple residual masses and those with marker negative disease.

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      Randomized study of single early instillation of (2″R)-4′-O-tetrahydropyranyl-doxorubicin for a single superficial bladder carcinoma (pages 2363–2368)

      Kikuo Okamura, Yoshinari Ono, Tsunero Kinukawa, Osamu Matsuura, Shin Yamada, Tadashi Ando, Toshiaki Fukatsu, Yoshiyuki Ohno and Shinichi Ohshima

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10496

      The authors' data indicate that a single (2″R)-4′-O-tetrahydropyranyl-doxorubicin instillation immediately after transurethral resection reduces the recurrence of superficial bladder carcinoma.

    8. Gynecologic Oncology
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      Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis (pages 2369–2379)

      Anjila Koul, Roger Willén, Pär-Ola Bendahl, Mef Nilbert and Åke Borg

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10498

      Sporadic endometrial tumors were analyzed for mutations in various genes, and the results correlated with presence/absence of complex atypical hyperplasia and microsatellite instability in these tumors.

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      Molecular events associated with dysplastic morphologic transformation and initiation of ovarian tumorigenicity (pages 2380–2392)

      Dong-Hua Yang, Elizabeth R. Smith, Cynthia Cohen, Hong Wu, Christos Patriotis, Andrew K. Godwin, Thomas C. Hamilton and Xiang-Xi Xu

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10497

      Disabled-2 (Dab2), a candidate tumor suppressor of ovarian carcinoma, loses its expression in ovarian tumors with about 80% frequency. The authors immunohistochemically analyzed the correlation among Dab2 expression, basement membrane presence, surface epithelial cell morphologic alteration, and the expression of the mitotic index marker Mib-1 in 50 archived ovarian tumors.

    10. Head and Neck Disease
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      Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis (pages 2393–2400)

      Jatin K. Nagpal, Rajakishore Mishra and Bibhu R. Das

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10499

      STAT-3 expression and activation in various stages of tobacco chewing-mediated squamous cell carcinoma of the head and neck was compared with the normal and premalignant cases. An early and specific activation of STAT-3 was observed in head and neck solid tumors with total absence of STAT-3 in noncancer controls. Antiapoptotic role of STAT-3 in solid head and neck tumors was not observed.

    11. Hematologic Malignancies
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      CD56+ TdT+ blastic natural killer cell tumor of the skin : A primitive systemic malignancy related to myelomonocytic leukemia (pages 2401–2408)

      Joseph D. Khoury, L. Jeffrey Medeiros, John T. Manning, Laura E. Sulak, Carlos Bueso-Ramos and Dan Jones

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10489

      CD56+ terminal deoxynucleotidyl transferase+ cutaneous tumors are aggressive systemic malignancies that can progress to myelomonocytic leukemia. The current study supports a primitive origin, possibly myeloid, for this characteristic tumor type.

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      Allogeneic blood stem cell transplantation after a reduced-intensity, preparative regimen : A pilot study in patients with refractory malignancies (pages 2409–2415)

      Paolo Pedrazzoli, Gian Antonio Da Prada, Giovanna Giorgiani, Roberta Schiavo, Alberto Zambelli, Eugenia Giraldi, Giuseppe Landonio, Franco Locatelli, Salvatore Siena and Gioacchino Robustelli Della Cuna

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10491

      This study explored the feasibility of allogeneic hematopoietic stem cell transplantation after patients underwent a reduced-intensity, preparative regimen for the treatment of refractory malignancies, including solid tumors. The procedure is associated with the occurrence of lethal, treatment-related complications, mostly in patients with poor performance status and large tumor load. Allogeneic transplantation results in tumor regression in a proportion of patients.

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      Neutrophilic-chronic myeloid leukemia : Low levels of p230 BCR/ABL mRNA and undetectable p230 BCR/ABL protein may predict an indolent course (pages 2416–2425)

      Srdan Verstovsek, Hui Lin, Hagop Kantarjian, Giuseppe Saglio, Daniela De Micheli, Fabrizio Pane, Guillermo Garcia-Manero, Mariano Intrieri, Bruno Rotoli, Francesco Salvatore, Jie Q. Guo, Moshe Talpaz, Giorgina Specchia, Gianni Pizzolo, Anna Marina Liberati, Jorge Cortes, Robert C. Quackenbush and Ralph B. Arlinghaus

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10490

      Neutrophilic-chronic myeloid leukemia (CML-N) has been described as a CML variant associated with translocation (9;22) that results in the transcription of an e19/a2 type BCR/ABL mRNA encoding for a 230-kD protein. The great majority of patients with CML-N have a minimal number of molecules of BCR/ABL transcripts/total RNA and undetectable p230 protein. This may explain the milder leukemic phenotype in most patients with CML-N.

    14. Lung Disease
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      Paclitaxel, carboplatin, and topotecan in the treatment of patients with small cell lung carcinoma : A Phase II trial of the Minnie Pearl Cancer Research Network (pages 2426–2433)

      John D. Hainsworth, Lisa H. Morrissey, Daniel C. Scullin Jr., Gerry Ann Houston, Edgar F. Prasthofer, James R. Gray, Howard A. Burris III and F. Anthony Greco

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10508

      The efficacy of combined chemotherapy with paclitaxel, carboplatin, and topotecan followed by oral etoposide was evaluated in the treatment of patients with small cell lung carcinoma. Although it was active in these patients, this three-drug regimen was more toxic than standard regimens with platinum and etoposide and provided no apparent improvement.

    15. Neuro-Oncology
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      Lhermitte sign and urinary retention : Atypical presentation of oxaliplatin neurotoxicity in four patients (pages 2434–2440)

      Sarah Taieb, Véronique Trillet-Lenoir, Loïc Rambaud, Louis Descos and Gilles Freyer

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10500

      Oxaliplatin-induced neurotoxicity typically consists of two distinct clusters of symptoms. Cold-induced distal paresthesiae occur during or shortly after infusion in most patients, and are usually transient and mild. A persistent sensory peripheral neuropathy may develop with prolonged treatment, eventually causing superficial and deep sensory loss, sensory ataxia and functional impairment. The authors report on four patients presenting with atypical oxaliplatin neurotoxicity: Lhermitte sign and urinary retention. The physiopathology of these symptoms is discussed in view of the current knowledge of the neurotoxicity of platinum compounds.

    16. Sarcoma
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      Tumor volume as a prognostic factor for sarcomatosis (pages 2441–2446)

      Malcolm M. Bilimoria, Daniel J. Holtz, Nadeem Q. Mirza, Barry W. Feig, Peter W. T. Pisters, Shreyaskumar Patel, Raphael E. Pollock, Robert S. Benjamin, Nicholas E. Papadopoulos, Carl Plager, Anne Murphy, Janet R. Griffin, Michael A. Burgess and Kelly K. Hunt

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10504

      The influence of patient and clinicopathologic features on survival rates was examined in 51 patients diagnosed with sarcomatosis. The two and four year survival rates of patients with low tumor volume were significantly higher than those of patients with high tumor volume.

    17. Translational Research
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      Tumor vaccine for ovarian carcinoma targeting sperm protein 17 (pages 2447–2453)

      Maurizio Chiriva-Internati, Zhiqing Wang, Emanuela Salati, Patrick Timmins and Seah H. Lim

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10506

      The authors of the current study identified the expression of sperm protein 17 (Sp17) in ovarian carcinoma patients and were able to generate successfully Sp17 specific human leukocyte antigen class I-restricted cytotoxic T-lymphocytes that were capable of lysing autologous tumor cells from these patients, suggesting the potential use of Sp17 as a target for tumor vaccine in patients with ovarian carcinoma.

    18. You have free access to this content
      High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas : Relation to E-Cadherin alterations, proliferative activity, and ploidy of the tumors (pages 2454–2465)

      Maria Kouvaraki, Vassilis G. Gorgoulis, George Z. Rassidakis, Petros Liodis, Christos Markopoulos, John Gogas and Christos Kittas

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10505

      High expression levels of p27 are detected in a subset of advanced invasive breast carcinomas and associated with metastasis to axillary lymph nodes, suggesting that other mechanisms may override the impact of p27 on cell cycle arrest. p27 levels in breast carcinoma do not correlate with E-cadherin expression and alterations of its gene locus in vivo.

    19. Pediatric Oncology
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      Motor nervous system impairment persists in long-term survivors of childhood acute lymphoblastic leukemia (pages 2466–2473)

      Satu S. Lehtinen, Usko E. Huuskonen, Arja H. Harila-Saari, Uolevi Tolonen, Leena K. Vainionpää and B. Marjatta Lanning

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10503

      Five years after the cessation of therapy for acute lymphoblastic leukemia, neurologic signs were found to presist in approximately 33% of patients in the form of fine or gross motor difficulties and dysdiadochokinesia, and motor-evoked potential latencies in the peripheral nerve tracts were reported to be delayed proximally but not within the central nervous system.

    20. You have free access to this content
      Outcome of suprarenal localized masses diagnosed during the perinatal period : A retrospective multicenter study (pages 2474–2480)

      Frederique Sauvat, Sabine Sarnacki, Herve Brisse, Jacques Medioni, Herve Rubie, Yves Aigrain, Frederic Gauthier, Georges Audry, Pierre Helardot, Paul Landais, Jean Michon, Olivier Hartmann and Claire Nihoul-Fékété

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10502

      The growing use of abdominal ultrasonography during pregnancy and in the postnatal period is leading to the discovery of an increasing number of suprarenal masses. The authors reviewed files of patients with suprarenal masses detected prenatally or during the first 3 months of life. They found that 58% of the suprarenal masses were localized neuroblastoma with a favorable outcome. All other cases either regressed or were benign.

    21. Integrated Medicine
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      Clinical relevance of fatigue levels in cancer patients at a Veterans Administration Medical Center (pages 2481–2489)

      Shirley S. Hwang, Victor T. Chang, Janet Cogswell and Basil S. Kasimis

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10507

      Clinically relevant fatigue levels can be defined based on their correlation with functional interference items, symptom distress, and quality of life.

    22. Epidemiology
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      The American Cancer Society Cancer Prevention Study II Nutrition Cohort : Rationale, study design, and baseline characteristics (pages 2490–2501)

      Eugenia E. Calle, Carmen Rodriguez, Eric J. Jacobs, M. Lyn Almon, Ann Chao, Marjorie L. McCullough, Heather S. Feigelson and Michael J. Thun

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.101970

      The authors describe the rationale, design, implementation, and baseline characteristics of a new, large-scale, prospective cohort that includes over 84,000 men and 97,000 women who were enrolled in 1992. This cohort is followed actively for new cases of cancer and for all causes of death and has banked blood and buccal cell samples for a subgroup of cohort participants.

    23. Pathology
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      High frequency of microsatellite instability and loss of mismatch-repair protein expression in patients with double primary tumors of the endometrium and colorectum (pages 2502–2510)

      Maria Planck, Eva Rambech, Gabriela Möslein, Wolfram Müller, Håkan Olsson and Mef Nilbert

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10501

      Endometrial carcinoma and colorectal carcinoma are the two most common tumor types in patients with hereditary nonpolyposis colorectal carcinoma (HNPCC). The objective of this study was to estimate the proportion of patients with double primary endometrial and colorectal carcinoma at a young age who display tumor characteristics compatible with HNPCC. The authors found a high frequency of microsatellite instability and loss of mismatch repair protein expression and concluded that double primary malignancies of the colorectum and endometrium should make the clinician suspect HNPCC.

  2. Communication

    1. Top of page
    2. Original Articles
    3. Communication
    4. Erratum
    1. Disease Site

      UICC TNM Prognostic Factors Project Committee and the AJCC TNM Process Subcommittee
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      TNM residual tumor classification revisited (pages 2511–2516)

      Christian Wittekind, Carolyn C. Compton, Frederick L. Greene and Leslie H. Sobin

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10492

      This communication addresses the importance of the TNM residual tumor (R) classification, clarifies its definition, and offers guidelines for its appropriate application.

  3. Erratum

    1. Top of page
    2. Original Articles
    3. Communication
    4. Erratum
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      Erratum (page 2517)

      Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10624

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