Neutrophilic-chronic myeloid leukemia : Low levels of p230 BCR/ABL mRNA and undetectable p230 BCR/ABL protein may predict an indolent course (pages 2416–2425)
Srdan Verstovsek, Hui Lin, Hagop Kantarjian, Giuseppe Saglio, Daniela De Micheli, Fabrizio Pane, Guillermo Garcia-Manero, Mariano Intrieri, Bruno Rotoli, Francesco Salvatore, Jie Q. Guo, Moshe Talpaz, Giorgina Specchia, Gianni Pizzolo, Anna Marina Liberati, Jorge Cortes, Robert C. Quackenbush and Ralph B. Arlinghaus
Article first published online: 25 APR 2002 | DOI: 10.1002/cncr.10490
Neutrophilic-chronic myeloid leukemia (CML-N) has been described as a CML variant associated with translocation (9;22) that results in the transcription of an e19/a2 type BCR/ABL mRNA encoding for a 230-kD protein. The great majority of patients with CML-N have a minimal number of molecules of BCR/ABL transcripts/total RNA and undetectable p230 protein. This may explain the milder leukemic phenotype in most patients with CML-N.