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Cancer

Cover image for Cancer

1 July 2002

Volume 95, Issue 1

Pages 1–208

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Commentary
    4. Original Articles
    1. Disease Site

      Breast Disease
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      Paget disease of the nipple : A multifocal manifestation of higher-risk disease (pages 1–7)

      Ashutosh S. Kothari, Nicolas Beechey-Newman, Hisham Hamed, Ian S. Fentiman, Corrado D'Arrigo, Andrew M. Hanby and Ken Ryder

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10638

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      The characteristics of 70 women with Paget disease were reviewed to determine whether a cone excision would have provided effective surgical clearance of the underlying malignancy. In 43% of cases the disease was underestimated by mammography and in 75% of cases it was multicentric precluding cone excision. In addition, 96.5% of cases of ductal carcinoma in situ and 100% of cases of invasive carcinomas were of high cytonuclear grade. Survival of patients with Paget disease was significantly worse than that of age-matched controls. This was largely attributable to the preponderance of c-erb-B2 overexpression, which was demonstrated in 83% of cases.

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      Carcinoma detection at the breast examination center of Harlem (pages 8–14)

      Laura Liberman, Harold P. Freeman, Sukanya Chandra, Amanda L. Stein, Colin Mccord, Diana Godfrey and D. David Dershaw

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10640

      A breast carcinoma screening and diagnostic program has been established in Harlem, an underserved area that has the highest mortality rates and worst life expectancy in New York City. Early and curable cancers were detected but outreach remains a challenge, particularly for the uninsured.

  2. Commentary

    1. Top of page
    2. Original Articles
    3. Commentary
    4. Original Articles
    1. Disease Site

      Breast Disease
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      Sentinel lymph node biopsy in patients with ductal carcinoma in situ : A proposal (pages 15–20)

      Kelly M. McMasters, Celia Chao, Sandra L. Wong, Robert C. G. Martin III and Michael J. Edwards

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10641

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      Sentinel lymph node (SLN) biopsy for the treatment of ductal carcinoma in situ (DCIS) is not necessary and generally should be limited to those patients with a core needle biopsy diagnosis of DCIS who are undergoing mastectomy. Used in this way, SLN biopsy will spare the majority of patients with occult invasive tumor the need for axillary lymph node dissection.

  3. Original Articles

    1. Top of page
    2. Original Articles
    3. Commentary
    4. Original Articles
    1. Disease Site

      Breast Disease
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      Ethnicity related differences in the survival of young breast carcinoma patients (pages 21–27)

      Lisa A. Newman, Scott Bunner, Kathryn Carolin, David Bouwman, Mary Ann Kosir, Michael White and Ann Schwartz

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10639

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      African-American women face an increased risk of early-onset breast carcinoma compared to white American women, and breast carcinoma has been reported to be biologically more aggressive in premenopausal women compared to women of older age. The current study of breast carcinoma in women under the age of 40 years showed that African-American ethnicity was associated with increased mortality risk at all stages of disease.

    2. Central Nervous System
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      GLI3 is not mutated commonly in sporadic medulloblastomas (pages 28–31)

      Ayelet Erez, Tsafra Ilan, Ninette Amariglio, Inna Muler, Frida Brok-Simoni, Gideon Rechavi and Shai Izraeli

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10642

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      Mutational activation of the sonic hedgehog pathway causes medulloblastoma. Although medulloblastomas were observed in two patients with the extremely rare Greig syndrome, Gli3 is not mutated commonly in sporadic tumors.

    3. Gastrointestinal Tract
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      Association of prediagnosis endoscopy with stage and survival in adenocarcinoma of the esophagus and gastric cardia (pages 32–38)

      Gregory S. Cooper, Zhong Yuan, Amitabh Chak and Alfred A. Rimm

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10646

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      In this population-based study, receipt of upper gastrointestinal endoscopy 1 year or more before diagnosis of carcinoma was associated with an earlier stage at presentation and improved survival in patients with adenocarcinoma of the esophagus. The findings suggest the potential benefits of screening and surveillance in patients with the premalignant condition, Barrett esophagus.

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      Socioeconomic and demographic disparities in treatment for carcinomas of the colon and rectum (pages 39–46)

      Juliet VanEenwyk, Joseph S. Campo and Eric M. Ossiander

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10645

      The current study examined the relationship between socioeconomic and demographic factors and type of treatment for carcinomas of the colon and rectum. The findings suggest disparities in the provision of recommended medical procedures related to socioeconomic and demographic factors.

    5. Genitourinary Disease
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      Vascular endothelial growth factor overexpression is correlated with von Hippel-Lindau tumor suppressor gene inactivation in patients with sporadic renal cell carcinoma (pages 47–53)

      Hiroshi Igarashi, Mariko Esumi, Hajime Ishida and Kiyoki Okada

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10635

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      In the current study, the authors found a correlation between vascular endothelial growth factor (VEGF) overexpression and both biallelic and monoallelic von Hippel-Lindau (VHL) gene inactivation in patients with sporadic renal cell carcinoma (RCC). Alteration of the VHL gene is believed to cause angiogenesis in RCC through overexpression of VEGF.

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      Mental health in men treated for early stage prostate carcinoma : A posttreatment, longitudinal quality of life analysis from the cancer of the prostate strategic urologic research endeavor™ (pages 54–60)

      Mark S. Litwin, Deborah P. Lubeck, G. Mark Spitalny, James M. Henning and Peter R. Carroll

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10651

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      In the current study, the mental health profiles differed for men undergoing surgery, radiation, or watchful waiting for early stage prostate carcinoma. Men with more serious disease, as evidenced by higher prostate specific antigen levels or more aggressive histology, tended to worry more about it. Older men performed better, while sicker men performed worse, even though the older men tended to be sicker.

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      Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid–hyaluronidase and BTA-Stat tests (pages 61–72)

      Vinata B. Lokeshwar, Grethchen L. Schroeder, Marie G. Selzer, Stefan H. Hautmann, J. Timothy Posey, Robert C. Duncan, Roger Watson, Lyndon Rose, Steven Markowitz and Mark S. Soloway

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10652

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      The hyaluronic acid–hyaluronidase (HA-HAase) urine test, with over 85% accuracy, was superior to the Food and Drug Administration approved BTA-Stat test in detecting bladder carcinoma recurrence, and a false positive HA-HAase test had a 4- to 10-fold risk of tumor recurrence within 4.7 months. Noninvasive tests with a low false-positive rates may be helpful in bladder carcinoma screening in high-risk populations (i.e., smokers or those with occupational exposure to bladder carcinogens).

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      Fas/Fas ligand system and apoptosis induction in testicular carcinoma (pages 73–81)

      Hans U. Schmelz, Michael Abend, Klaus Kraft, Ekkehard W. Hauck, Wolfgang Weidner, Dirk van Beuningen and Christoph Sparwasser

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10649

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      In this study, the authors postulated that the interaction between tumor-infiltrating lymphocytes and tumor cells in terms of apoptosis induction is mediated by the Fas/Fas ligand (FasL) system in many types of tumors. No correlation between the level of Fas or FasL expression and the apoptotic index (either in lymphocytes or in tumor cells) was found in tissue sections from patients with testicular nonseminomatous tumors.

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      Complications from treatment for prostate carcinoma among men in the Detroit area (pages 82–89)

      Kendra Schwartz, Scott Bunner, Ryan Bearer and Richard K. Severson

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10650

      Detroit area men with localized prostate carcinoma were interviewed regarding pretreatment and post-treatment urinary, bowel, and sexual function. Both men who underwent radical prostatectomy and men who received radiotherapy reported a significant increase in urinary and bowel incontinence and impotence; however, men who underwent radical prostatectomy were at least 3.0 times more likely to report incontinence and impotence, whereas men who received radiotherapy were 3.6 times more likely to report bowel incontinence.

    10. Head and Neck Disease
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      Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx (pages 90–97)

      Antonella De Stefani, Guido Forni, Riccardo Ragona, Giovanni Cavallo, Mario Bussi, Antonio Usai, Fausto Badellino and Giorgio Cortesina

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10654

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      In patients with resectable squamous cell carcinoma (SCC) of the oral cavity or oropharynx (T2–T4,N0–N3,M0), the perilymphatic administration of low, nontoxic doses of recombinant interleukin 2 (rIL-2) significantly lengthened disease free survival, resulting in longer overall survival. The regimen of low-dose rIL-2 is a simple and manageable way to delay recurrences of oral SCC.

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      An exploration of the pretreatment coping strategies of patients with carcinoma of the head and neck (pages 98–104)

      Marcy A. List, Judith Lee Rutherford, John Stracks, Daniel Haraf, Merrill S. Kies and Everett E. Vokes

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10653

      Patients with carcinoma of the head and neck demonstrated the use of diverse coping strategies, with social seeking behavior representing the largest proportion of overall coping effort. Although it was employed least frequently, avoidant coping was associated with poorer quality of life.

    12. Hepatobiliary Tract
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      Prognostic significance of intrahepatic lymphatic invasion in patients with hepatic resection due to metastases from colorectal carcinoma (pages 105–111)

      Atsushi Sasaki, Masanori Aramaki, Katsunori Kawano, Kazuhiro Yasuda, Masafumi Inomata and Seigo Kitano

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10655

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      To investigate the clinical significance of the intrahepatic spread of metastatic colorectal carcinoma, the authors statistically evaluated 14 clinicopathologic factors and patient survival rates after hepatectomy for liver metastasis from primary colorectal carcinoma. Intrahepatic lymphatic invasion was shown to be an independent risk factor for recurrence and death after hepatectomy.

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      Serum tissue polypeptide specific antigen as a noninvasive prognostic indicator for early recurrence of hepatocellular carcinoma after curative resection (pages 112–118)

      Wei-Jen Yao, Shan-Tair Wang, Nan-Haw Chow, Ting-Tsung Chang, Pin-Wen Lin and Dom-Gene Tu

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10626

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      Serum tissue polypeptide specific antigen (TPS) is a significant independent predictor of tumor recurrence after curative resection of hepatocellular carcinoma. Patients with high serum TPS levels warrant more aggressive treatment and close follow-up after they undergo tumor resection.

    14. Lung Disease
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      The clinical course of nonsmall cell lung carcinoma in survivors of Hodgkin disease (pages 119–126)

      Scott A. Laurie, Mark G. Kris, Carol S. Portlock, Kenneth E. Rosenzweig, Vincent A. Miller, Lee M. Krug and Valerie W. Rusch

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10628

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      The outcome after the development of lung carcinoma for patients who survive Hodgkin disease is poor. Steps must be taken to reduce this long-term complication of treatment for Hodgkin disease and to improve early detection of second lung malignancies in survivors of Hodgkin disease.

    15. Melanoma
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      Phase I trial of subcutaneous recombinant human interleukin-2 in patients with metastatic melanoma (pages 127–134)

      Omar Eton, Michael G. Rosenblum, Sewa S. Legha, Wehei Zhang, Mary Jo East, Agop Bedikian, Nicholas Papadopoulos, Antonio Buzaid and Robert S. Benjamin

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10631

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      Interleukin-2 (IL-2) has activity in metastatic melanoma only at the higher doses studied. This study shows that IL-2 can be self-administered at home by the subcutaneous route daily 5 days per week at a maximum tolerated dose of 12 MIU/m2. This regimen can be incorporated in multiagent clinical trials, such as biochemotherapy.

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      Predictors of skin self-examination performance (pages 135–146)

      June K. Robinson, Susan G. Fisher and Robert J. Turrisi

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10637

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      The strongest predictors of skin self-examination (SSE) performance in a population who were at high risk of developing melanoma or nonmelanoma skin malignancy were attitude, having dermatology visits with skin biopsies and at least one skin carcinoma in the previous 3 years, and confidence in performance. Other predictors of SSE performance were perceived risk, knowledge, and younger age.

    17. Sarcoma
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      Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma (pages 147–154)

      Anil Tulpule, Jerome Groopman, M. Wayne Saville, William Harrington Jr., Alvin Friedman-Kien, Byron M. Espina, Carlos Garces, Lily Mantelle, Karl Mettinger, David T. Scadden and Parkash S. Gill

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10634

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      Paclitaxel induces major tumor regression in the majority of patients with advanced Kaposi sarcoma who failed to respond to systemic chemotherapy. It is associated with significant improvement in quality of life with acceptable toxicity.

    18. Discipline

      Medical Oncology
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      Changing patient perceptions of the side effects of cancer chemotherapy (pages 155–163)

      Nadége Carelle, Estelle Piotto, Agnés Bellanger, Jerome Germanaud, Alain Thuillier and David Khayat

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10630

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      Seventeen years after the original study of patient perceptions of the side effects of cancer chemotherapy by Coates et al., the authors performed a similar survey of 100 patients with malignant disease. Current patient concerns focused on fatigue and psychosocial quality-of-life issues, compared with nausea, emesis, and negative reactions to the treatment visit that predominated in 1983.

    19. Radiation Oncology
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      Patterns of Care Study quantitative evaluation of the quality of radiotherapy in Japan (pages 164–171)

      Kazuaki Tanisada, Teruki Teshima, Yuko Ohno, Toshihiko Inoue, Mitsuyuki Abe, Hiroshi Ikeda, Jean B. Owen, Gerald E. Hanks, Kouji Masuda, Yoshifumi Honke and the Japanese Patterns of Care Study 1992–1994 Working Group

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10633

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      A quantitative evaluation method for the Patterns of Care Study was developed to assess the quality of radiotherapy at the institutional and national levels. This method should be useful for nationwide quality assurance projects in the field of radiation oncology as well as for other medical specialties.

    20. Pediatric Oncology
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      Pretreatment prognostic factors and treatment results in children with hepatoblastoma : A Report from the German Cooperative Pediatric Liver Tumor Study HB 94 (pages 172–182)

      Jörg Fuchs, Jana Rydzynski, Dietrich Von Schweinitz, Udo Bode, Hartmut Hecker, Peter Weinel, Dietrich Bürger, Dieter Harms, Rudolf Erttmann, Karl Oldhafer, Hermann Mildenberger and the Study Committee of the Cooperative Pediatric Liver Tumor Study Hb 94 for the German Society for the Pediatric Oncology and Hematology

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10632

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      The results of this study by the German Society for Pediatric Oncology and Hematology (Study HB 94) underline the necessity of preoperative chemotherapy in all children with hepatoblastoma (HB), as also shown in a subsequent study (Study HB 99). Complete resection of HB is one of the main prognostic factors. New surgical strategies and preoperative chemotherapy may improve the outcome of these children.

    21. Integrated Medicine
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      Cognitive functioning and quality of life in long-term adult survivors of bone marrow transplantation (pages 183–192)

      Helena Harder, Jan J. Cornelissen, Arthur R. Van Gool, Hugo J. Duivenvoorden, Wil M. H. Eijkenboom and Martin J. van den Bent

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10627

      Cognitive functioning and quality of life were investigated in a cohort of long-term adult survivors of bone marrow transplantation 2 years or more after their treatment. Mild cognitive deficits were found in the majority of patients and 12.5% of survivors showed moderate to severe cognitive performance in comparison to normative data.

    22. Epidemiology
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      Decreasing incidence rates of primary central nervous system lymphoma (pages 193–202)

      Nina S. Kadan-Lottick, Maria C. Skluzacek and James G. Gurney

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10643

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      Contrary to previous reports and prevailing opinion, the authors of the current study found that incidence rates of primary central nervous system lymphoma in the U.S. have decreased substantially since 1995, with the exception of individuals age ≥ 60 years, for whom rates have been steady since 1994.

    23. Symptom Control and Palliative Care
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      Rapid titration with intravenous morphine for severe cancer pain and immediate oral conversion (pages 203–208)

      Sebastiano Mercadante, Patrizia Villari, Patrizia Ferrera, Alessandra Casuccio and Fabio Fulfaro

      Version of Record online: 28 JUN 2002 | DOI: 10.1002/cncr.10636

      Cancer pain emergencies can be treated rapidly in the majority of cancer patients with intravenous morphine escalation and immediate oral conversion. The intravenous administration of morphine is safe, with an acceptable level of adverse effects, but requires initial close supervision and continuity of medical care.

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