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Cancer

Cover image for Cancer

1 December 2002

Volume 95, Issue 11

Pages 2257–2444

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. General Topic

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      Disparities in breast carcinoma treatment in Asian/Pacific Islander women : A challenge to the provider (pages 2257–2259)

      Stephen Y. Chui and H. Kim Lyerly

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10964

      A comprehensive epidemiologic survey raises issues as to why differences occur between Asian/Pacific Islander and non-Hispanic white women in the treatment of localized breast carcinoma.

      See also pages 2268-75, this issue.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. Disease Site

      Breast Disease
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      Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema : A randomized, prospective study of a role for adjunctive intermittent pneumatic compression (pages 2260–2267)

      Andrzej Szuba, Radha Achalu and Stanley G. Rockson

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10976

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      There is no cure for breast carcinoma-associated lymphedema, a common and important sequela of the successful treatment of patients with breast carcinoma. Edema can be controlled, and complications can be minimized, through the aggressive use of physiotherapy. In this study, the authors prospectively document their finding that adjunctive intermittent pneumatic compression adds significant therapeutic advantage: The therapy is well tolerated without demonstrable adverse effects.

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      Differences in treatment patterns for localized breast carcinoma among Asian/Pacific islander women (pages 2268–2275)

      Angela W. Prehn, Barbara Topol, Susan Stewart, Sally L. Glaser, Lilia O'Connor and Dee W. West

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10965

      Treatment patterns for localized breast carcinoma differed among Chinese, Japanese, Filipino, and white women. These differences were not explained by demographic, medical, or socioeconomic characteristics, supporting the idea that cultural factors may play a role in breast carcinoma treatment choices.

      See also pages 2257–9, this issue.

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      Identification of distinct protein expression patterns in bilateral matched pair breast ductal fluid specimens from women with unilateral invasive breast carcinoma : High-throughput biomarker discovery (pages 2276–2282)

      Henry M. Kuerer, Ira L. Goldknopf, Herbert Fritsche, Savitri Krishnamurthy, Essam A. Sheta and Kelly K. Hunt

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10974

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      Systematic comparisons of breast ductal fluid samples obtained by nipple aspiration from women with unilateral breast carcinoma revealed significant differences in ductal fluid protein expression between the breast with cancer and the breast without cancer in each patient. The current study showed that breast ductal fluid contains over 1000 separate protein species and suggests that ductal fluids from breast carcinoma patients may be useful for high-throughput biomarker discovery.

    4. Gastrointestinal Tract
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      Combination of neoadjuvant chemotherapy with cryotherapy and surgical resection for the treatment of unresectable liver metastases from colorectal carcinoma : Long-term results (pages 2283–2292)

      Michel Rivoire, Franco De Cian, Pierre Meeus, Sylvie Négrier, Henri Sebban and Pierre Kaemmerlen

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10973

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      Use of neoadjuvant chemotherapy combined with cryotherapy and liver resection was found to be effective in controlling advanced unresectable metastatic disease to the liver.

    5. Genitourinary Disease
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      Nitric oxide pathways in human bladder carcinoma : The distribution of nitric oxide synthases, soluble guanylyl cyclase, cyclic guanosine monophosphate, and nitrotyrosine (pages 2293–2301)

      Amgad Ehsan, Frank Sommer, Annette Schmidt, Theodor Klotz, Jolanta Koslowski, Sandra Niggemann, Georg Jacobs, Udo Engelmann, Klaus Addicks and Wilhelm Bloch

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10942

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      The current paper described two different nitric oxide pathways in normal and malignant human vesical tissues. The distribution of these pathway components as soluble guanylate cyclase, cyclic guanosine monophosphate (cGMP), and nitrotyrosine were also described. The induced physiologic and pathologic effects of NO were classified into cGMP-mediated and non-cGMP-mediated effects.

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      Factors affecting recurrence rates after prostatectomy or radiotherapy in localized prostate carcinoma patients with biopsy Gleason score 8 or above (pages 2302–2307)

      Patrick A. Kupelian, Jeffrey C. Buchsbaum, Mohamed Elshaikh, Chandana A. Reddy, Craig Zippe and Eric A. Klein

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10977

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      Patients with localized prostate carcinoma with a biopsy Gleason score 8 or less have lower recurrence rates if pretreatment prostate specific antigen (PSA) levels are 10 or less. Biochemical control rates are encouraging for patients with biopsy Gleason score 8 or above, clinical stage T1–T2, and pretreatment PSA levels less than or equal to 10 ng/mL treated with adjuvant androgen deprivation given only for 6 months or less.

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      Initial treatment for prostate carcinoma in relation to comorbidity and symptoms (pages 2308–2315)

      H. Irene Hall, William A. Satariano, Trevor Thompson, Kathleen E. Ragland, Stephen K. Van Den Eeden and Steve Selvin

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10926

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      Specific symptoms and comorbidities appear to influence decision making about treatment for prostate carcinoma.

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      Risk factors for urinary bladder carcinoma in postmenopausal women : The Iowa Women's Health Study (pages 2316–2323)

      Apeksha Tripathi, Aaron R. Folsom and Kristin E. Anderson

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10975

      In a prospective study of older women, we confirmed that cigarette smoking is an important risk factor for bladder carcinoma. Women who had quit smoking had a reduction of risk. We also identified diabetes as a potential risk factor, which may invite more research on its role in the development of urinary bladder carcinoma.

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      Subcutaneous interleukin-2 and interferon α in the treatment of patients with metastatic renal cell carcinoma—Less efficacy compared with intravenous interleukin-2 and interferon α : Results of a multicenter Phase II trial from the Groupe Français d'Immunothérapie (pages 2324–2330)

      Alain Ravaud, Rémy Delva, Fréderic Gomez, Christine Chevreau, Jean-Yves Douillard, Jean Peny, Bruno Coudert and Sylvie Négrier

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10968

      Subcutaneous interleukin-2 and interferon α did not reproduce the results from a previous, similar trial (the CRECY trial) with intravenous interleukin-2 and subcutaneous interferon α in patients with metastatic renal cell carcinoma.

    10. Gynecologic Oncology
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      Vulvar carcinoma : The price of less radical surgery (pages 2331–2338)

      Joanne A. de Hullu, Harry Hollema, Sietske Lolkema, Marike Boezen, Henk Boonstra, Matthe P. M. Burger, Jan G. Aalders, Marian J. E. Mourits and Ate G. J. van der Zee

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10969

      The standard radical treatment of patients with early-stage vulvar carcinoma has changed to wide local excision and inguinofemoral lymphadenectomy through separate incisions, leading to an increased number of fatal recurrences in either the groin or the skin bridge. Histologic margins of the wide local excision measuring ≤ 8 mm resulted in a high risk on local recurrences. Therefore, the authors recommend obtaining surgical margins of 2 cm for the local treatment of patients with vulvar carcinoma.

    11. Hematologic Malignancies
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      Autologous stem cell transplantation for patients with chronic myeloid leukemia : The Argentine Group of Bone Marrow Transplantation (GATMO) experience (pages 2339–2345)

      Benjamín Koziner, Cristina Dengra, Graciela Lucero, Graciela Klein, Carlos Cánepa, Vera Milovic, Gustavo Milone, Anibal Robinson, Ider Cerutti, Graciela Saporito, Gustavo Kusminsky, Jorge Milone, Javier Bordone and Francisco Lastiri

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10931

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      The objective of this analysis was to evaluate the role of autologous stem cell transplantation in prolonging disease free survival (DFS) and overall survival (OS) in patients with chronic myeloid leukemia who received autografts of Philadelphia chromosome (Ph) positive or Ph negative cell harvests. Although DFS at 36 months was significantly longer after the infusion of Ph negative cell products (54% vs. 14%; P ≤ 0.005), the differences in OS between patients who received Ph negative cells and patients who received Ph positive cells (68% vs. 53%; P ≤ 0.134) were not significant.

    12. Hepatobiliary Tract
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      Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma : A broad survey using high-throughput tissue microarray (pages 2346–2352)

      Yi Wang, Meng-Chao Wu, Jonathan S. T. Sham, Weigou Zhang, Wei-Qing Wu and Xin-Yuan Guan

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10963

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      The current study demonstrates that amplification of the c-myc and AIB1 oncogenes is a late genetic alteration in the progression of hepatocellular carcinoma (HCC) and is associated with a poor prognosis. Therefore, the c-myc and AIB1 oncogenes can be used as prognostic markers and factors for the therapeutic evaluation of patients with HCC.

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      Percutaneous radiofrequency ablation therapy for patients with hepatocellular carcinoma during occlusion of hepatic blood flow : Comparison with standard percutaneous radiofrequency ablation therapy (pages 2353–2360)

      Takahiro Yamasaki, Fumie Kurokawa, Hitoshi Shirahashi, Noriyoshi Kusano, Kouji Hironaka and Kiwamu Okita

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10966

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      This study reports a novel treatment for hepatocellular carcinoma (HCC) using percutaneous radiofrequency ablation (RFA) with balloon occlusion of the hepatic artery (balloon-occluded RFA). The area of coagulation necrosis with balloon-occluded RFA was significantly larger than that with standard RFA. Balloon-occluded RFA is a safe and effective technique for treatment of HCC.

    14. Lung Disease
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      Pathologic review of the Mayo Lung Project : Is there a case for misdiagnosis or overdiagnosis of lung carcinoma in the screened group? (pages 2361–2365)

      Thomas V. Colby, Henry D. Tazelaar, William D. Travis, Erik J. Bergstralh and James R. Jett

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10930

      Pathologic review of the Mayo Lung Cancer Screening Trial indicates that misdiagnosis of lung carcinoma did not occur. Overrepresentation of in situ carcinoma in the screened group, however, may account for some instances of lung carcinoma overdiagnosis (diagnosis of carcinomas that would not result in the death of the patient). The relative absence of carcinoma in situ detected in the control group (except for a single patient) may account in part for the fewer patients with lung carcinoma in that group compared with the screened group, but this difference does not entirely explain the difference in observed mortality in the two groups.

    15. Melanoma
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      Chemoimmunotherapy with bleomycin, vincristine, lomustine, dacarbazine (BOLD), and human leukocyte interferon for metastatic uveal melanoma (pages 2366–2372)

      Seppo Pyrhönen, Marjo Hahka-Kemppinen, Timo Muhonen, Väinämö Nikkanen, Sebastian Eskelin, Paula Summanen, Ahti Tarkkanen and Tero Kivelä

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10996

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      Systemic dacarbazine-based combination chemotherapy was administered with human leukocyte interferon to patients with metastatic uveal melanoma. This regimen gave a modest 15% objective response rate and a median overall survival of 17 and 11 months, respectively, among patients with a favorable and less favorable prognosis, respectively, based on pretreatment characteristics. It is useful to report survival according to prognostic categories to aid assessing lead time bias in nonrandomized trials of rare cancers.

    16. Sarcoma
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      Response of extraabdominal desmoid tumors to therapy with imatinib mesylate (pages 2373–2379)

      Joseph Mace, J. Sybil Biermann, Vernon Sondak, Cornelius McGinn, Curtis Hayes, Dafydd Thomas and Laurence Baker

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.11029

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      Imatinib mesylate has been reported to have activity against desmoid tumors, most likely on the basis of c-Kit and platelet-derived growth factor receptor tyrosine kinase (PDGFR RTK) activity inhibition, and therefore warrants further study. The relative novelty of this agent and the lack of long-term toxicity data should prompt its use only in the salvage setting in which established local and systemic approaches fail to control disease. In addition, the use of imatinib mesylate in the treatment of this neoplasm preferably should occur within the context of a formal prospective clinical trial.

    17. Discipline

      Epidemiology
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      Incidence patterns of invasive and borderline ovarian tumors among white women and black women in the United States : Results from the SEER Program, 1978–1998 (pages 2380–2389)

      Pamela J. Mink, Mark E. Sherman and Susan S. Devesa

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10935

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      Analysis of SEER data for approximately 38,000 invasive and borderline ovarian tumors that were diagnosed between 1978 and 1998 revealed that, whereas rates varied by histopathologic type, overall carcinoma incidence rates remained relatively constant, with higher rates for all major histopathologic types among white women compared with black women.

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      Food groups and the risk of colorectal carcinoma in an Asian population (pages 2390–2396)

      Adeline Seow, Stella R. Quah, Denis Nyam, Paulin T. Straughan, Terrence Chua and Tar-Choon Aw

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10971

      Among Chinese in Singapore, a population that is undergoing rapid transition toward high rates of chronic degenerative diseases, high dietary intake of red meat and low intake of total vegetables predispose to a higher risk of colorectal carcinoma. The results of this study also showed a positive (albeit nonsignificant) association with foods that are high in simple sugars.

    19. Integrated Medicine
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      The use of treatments for erectile dysfunction among survivors of prostate carcinoma (pages 2397–2407)

      Leslie R. Schover, Rachel T. Fouladi, Carla L. Warneke, Leah Neese, Eric A. Klein, Craig Zippe and Patrick A. Kupelian

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10970

      Although 85% of long-term survivors of treatment for localized prostate carcinoma experienced chronic erectile dysfunction (ED), only 38% found a therapy for ED that was at least somewhat helpful in improving their sex lives, and 30% were still using a therapy for ED at long-term follow-up.

    20. Medical Oncology
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      Response predicting factors to recombinant human erythropoietin in cancer patients undergoing platinum-based chemotherapy (pages 2408–2413)

      Manolo González-Barón, Amdio Ordóñez, Rosa Franquesa, Manuel Constenla, Joaquin Montalar, Frederic Gili, Carlos Camps, José Felix Sancho and Pedro Pérez-Cachot

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10980

      The change in hemoglobin (Hb) values after 4 weeks of treatment proved to be the prognostic factor that best explained the response to human recombinant erythropoietin in cancer patients receiving platinum chemotherapy. The response algorithm can be summarized as follows: the power to predict response to treatment (when the rise in Hb ≥ 0.5 g/dL) is 89.1% and the power to predict nonresponse (when the rise in Hb is < 0.5 g/dL) is 71%.

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      Ethical communication in clinical trials : Issues faced by data managers in obtaining informed consent (pages 2414–2421)

      Winnie Y. Loh, Phyllis N. Butow, Richard F. Brown and Frances Boyle

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10994

      The authors explored the perceptions of data managers about their role in obtaining ethical informed consent from participants in clinical trials This study identifies three distinct roles for data managers, apart from the role of clinician, in obtaining consent and provides information about the training needs of data managers within the context of multidisciplinary teams that have important implications for the successful conduct of clinical trials.

    22. Pathology
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      Antibody-based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing (pages 2422–2430)

      Mariann Christensen, Niels Katballe, Friedrik Wikman, Hanne Primdahl, Flemming B. Sørensen, Søren Laurberg and Torben F. Ørntoft

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10979

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      Immunohistochemistry and microsatellite analysis in combination can be used to prescreen patients suspected to have hereditary nonpolyposis colorectal carcinoma. These patients should be further identified by sequencing the mismatch repair genes, MSH2 and MLH1.

    23. Pediatric Oncology
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      Pulmonary complications in survivors of childhood and adolescent cancer : A report from the Childhood Cancer Survivor Study (pages 2431–2441)

      Ann C. Mertens, Yutaka Yasui, Yan Liu, Marilyn Stovall, Ray Hutchinson, Jill Ginsberg, Charles Sklar and Leslie L. Robison

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10978

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      The Childhood Cancer Survivor Study is a resource that was designed to investigate long-term effects among 5-year survivors of childhood and adolescent malignancies. Pulmonary conditions continue to manifest more than 5 years after diagnosis, and treatment-related factors are important determinants of risk.

  3. Correspondence

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
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    2. You have free access to this content
      Author reply (pages 2443–2444)

      Jacques Bonneterre, Aman Buzdar, Jean-Marc Nabholtz, John Robertson, Beat Thürlimann, Mikael von Euler, Tarek Sahmoud, Mark Steinberg and Alan Webster

      Version of Record online: 15 NOV 2002 | DOI: 10.1002/cncr.10959

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