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Cancer

Cover image for Cancer

1 August 2002

Volume 95, Issue 3

Pages 451–674

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. General Topic

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      Effect of service screening mammography on population mortality from breast carcinoma (pages 451–457)

      Stephen A. Feig

      Article first published online: 22 JUL 2002 | DOI: 10.1002/cncr.10764

      Breast cancer deaths have been reduced as much as 44% in Swedish counties that offer service screening mammography. In the United States, death rates from breast cancer are now approximately 39 percent lower than expected given the increased incidence of invasive carcinoma. This estimated reduction may be attributed to heightened awareness of breast cancer, increased utilization of screening mammography, and improved treatment. See also pages 458–69.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    1. Disease Site

      Breast Disease
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      The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties : A collaborative evaluation (pages 458–469)

      Stephen W. Duffy, Laszlo Tabár, Hsiu-Hsi Chen, Marit Holmqvist, Ming-Fang Yen, Shahim Abdsalah, Birgitta Epstein, Ewa Frodis, Eva Ljungberg, Christina Hedborg-Melander, Ann Sundbom, Maria Tholin, Mika Wiege, Anders Åkerlund, Hui-Min Wu, Tao-Shin Tung, Yueh-Hsia Chiu, Chen-Pu Chiu, Chih-Chung Huang, Robert A. Smith, Måns Rosén, Magnus Stenbeck and Lars Holmberg

      Article first published online: 22 JUL 2002 | DOI: 10.1002/cncr.10765

      The evaluation of organized mammographic service screening programs is a major challenge in public health. In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in seven Swedish counties. A 44% reduction in breast carcinoma mortality was observed in women who were actually screened in the screening epoch. See also pages 451–7.

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      Detection method and breast carcinoma histology (pages 470–477)

      Laura M. Newcomer, Polly A. Newcomb, Amy Trentham-Dietz, Barry E. Storer, Yutaka Yasui, Janet R. Daling and John D. Potter

      Article first published online: 22 JUL 2002 | DOI: 10.1002/cncr.10695

      Among women age ≥ 50 years, self-reported methods of breast cancer detection by mammography, self detection, and clinical breast examination varied according to breast carcinoma histopathology. In addition, for some histologic types of breast carcinoma, the pattern varied further by body mass index and postmenopausal hormone use.

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      Optimal use of sentinel lymph node biopsy versus axillary lymph node dissection in patients with breast carcinoma : A decision analysis (pages 478–487)

      Sandra L. Wong, Troy D. Abell, Celia Chao, Michael J. Edwards and Kelly M. McMasters

      Article first published online: 22 JUL 2002 | DOI: 10.1002/cncr.10696

      Sentinel lymph node (SLN) biopsy was compared with axillary lymph node dissection (ALND) to quantify the relative value of these two procedures in the management of patients with breast carcinoma. The results suggest that SLN biopsy is preferred over ALND for patients with breast tumors that are 4 cm or smaller. Patients should be aware of the potential for false-negative results in SLN biopsy, but this risk is outweighed by the decreased morbidity associated with the procedure itself.

    4. Endocrine Disorders
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      Follicular thyroid carcinoma : Prognostic factors and the role of radioiodine (pages 488–498)

      Sin-Ming Chow, Stephen C. K. Law, William M. Mendenhall, Siu-Kie Au, Stephen Yau, Kam-Tong Yuen, Chi-Ching Law and Wai-Hon Lau

      Article first published online: 22 JUL 2002 | DOI: 10.1002/cncr.10683

      Radioiodine reduces both the locoregional failure rate and the mortality rate of patients with follicular thyroid carcinoma to approximately 25%.

    5. Gastrointestinal Tract
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      Study of p53 immunostaining in the gastric epithelium of cagA-positive and cagA-negative Helicobacter pylori gastritis (pages 499–505)

      Ming Teh, Kong Bing Tan, Bee Leng Seet and Khay Guan Yeoh

      Article first published online: 22 JUL 2002 | DOI: 10.1002/cncr.10697

      p53 is detected in nonneoplastic gastric mucosa of Helicobacter pylori gastritis. The intensity and extent of staining are higher when the organism is cagA positive.

    6. Genitourinary Disease
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      Plasma osteopontin : Associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma (pages 506–512)

      Sebastien J. Hotte, Eric W. Winquist, Larry Stitt, Sylvia M. Wilson and Ann F. Chambers

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10709

      This report contains new and exciting evidence suggesting that, in a population of men with hormone-refractory prostate carcinoma, plasma levels of osteopontin, a secreted glycoprotein, are associated strongly with measures of tumor burden, including the presence of metastases to bone, and are correlated independently and negatively with survival. In this same population, serum prostate specific antigen levels were not helpful in assessing tumor burden and were not predictive of survival.

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      The relevance of prostatectomy findings for brachytherapy selection in patients with localized prostate carcinoma (pages 513–519)

      Thomas M. Pisansky, Michael L. Blute, David W. Hillman, Brian J. Davis, Michael G. Haddock, Vera J. Suman, Torrence M. Wilson and Horst Zincke

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10698

      Complete radiotherapeutic coverage of the primary tumor is a prerequisite for the long-term control of prostate carcinoma. The authors present a predictive model derived from a large surgical cohort to identify patients in whom there would be a high likelihood of encompassing the disease with prostate brachytherapy alone. This model suggests that current selection criteria for prostate brachytherapy as the sole radiotherapeutic treatment may be broadened.

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      Late recurrence in 1263 men with testicular germ cell tumors : Multivariate analysis of risk factors and implications for management (pages 520–530)

      Mehdi Shahidi, Andrew R. Norman, David P. Dearnaley, Judy Nicholls, Alan Horwich and Robert A. Huddart

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10691

      The risk of late recurrence in testicular germ cell tumors is small and follow-up beyond 5 years may not be necessary except for those presenting with metastatic nonseminomatous tumors.

    9. Gynecologic Oncology
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      Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy (pages 531–539)

      Yong Bae Kim, Gwi Eon Kim, Nam Hoon Cho, Hong Ryull Pyo, Su Jung Shim, Sei Kyung Chang, Hee Chul Park, Chang Ok Suh, Tchan Kyu Park and Byung Soo Kim

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10684

      Seventy-five patients with International Federation of Gynecology and Obstetrics Stage IIB squamous cell carcinoma of the uterine cervix who were treated with radiotherapy and concurrent chemotherapy were divided into two groups according to their cyclooxygenase-2 (COX-2) expression status in an immunohistochemical study. Compared with patients in the COX-2 negative group, patients in the COX-2 positive group had high incidence rates of treatment failure and unfavorable prognosis, indicating that COX-2 overexpression can be used as a potent molecular risk factor.

    10. Head and Neck Disease
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      Changes in presentation and survival of head and neck carcinomas in Northeastern Italy, 1975–1998 (pages 540–552)

      Luigi Barzan, Renato Talamini, Gianni Franchin, Emanuela Vaccher, Doriano Politi, Emilio Minatel and Carlo Gobitti

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10682

      Changes in clinical presentation and survival across five subsequent periods, between 1975 and 1998, among 2143 patients with head and neck carcinoma were examined at a single institution in Northeast Italy. In contrast with survival rates in the United States and Europe, our findings show a significant increase in survival rates during the last 20 years. This could be due to changes in diagnostic-therapeutic approaches, to educational campaigns, and to early consultation with a physician for symptoms arising in the head and neck region.

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      Weight loss predicts mortality after recurrent oral cavity and oropharyngeal carcinomas (pages 553–562)

      Thao V. Nguyen and Bevan Yueh

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10711

      The combination of two readily available clinical variables—weight loss and previous radiation—produced a clinically practical staging scheme with more prognostic power than the TNM staging system. Greater attention needs to be given to the utility of simple, inexpensive, and surprisingly powerful clinical variables.

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      BPDE-induced lymphocytic 3p21.3 aberrations may predict head and neck carcinoma risk (pages 563–568)

      Yong Zhu, Margaret R. Spitz, Yun-Ling Zheng, Waun K. Hong and Xifeng Wu

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10689

      Tobacco exposure is an established risk factor for head and neck squamous cell carcinoma. Benzo[α]pyrene diol epoxide (BPDE) induces chromosomal aberrations at specific loci. Chromosome aberrations in peripheral blood lymphocytes induced by BPDE may reflect an individual's genetic susceptibility to tobacco carcinogens.

    13. Hematologic Malignancies
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      Phase II trial of interferon-α-2a plus psolaren with ultraviolet light A in patients with cutaneous T-cell lymphoma (pages 569–575)

      Vanna Chiarion-Sileni, Antonio Bononi, Cleto Veller Fornasa, Mariella Soraru, Mauro Alaibac, Eros Ferrazzi, Roberta Redelotti, Andrea Peserico, Silvio Monfardini and Luigi Salvagno

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10706

      The combination of interferon-alpha-2a and phototherapy is an effective and safe therapy for patients with symptomatic mycosis fungoides.

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      Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-hodgkin lymphoma (pages 576–580)

      Naoto Tomita, Fumio Kodama, Heiwa Kanamori, Shigeki Motomura and Yoshiaki Ishigatsubo

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10699

      The value of central nervous system (CNS) prophylaxis in patients with aggressive non-Hodgkin lymphoma has not been studied thoroughly enough. Although we conducted a retrospective study, we conclude that prophylactic intrathecal methotrexate and hydrocortisone reduces the incidence of CNS recurrence after complete remission of disease and improves survival rates.

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      A single, high dose of idarubicin combined with cytarabine as induction therapy for adult patients with recurrent or refractory acute lymphoblastic leukemia (pages 581–587)

      Mark A. Weiss, Timothy B. Aliff, Martin S. Tallman, Stanley R. Frankel, Matt E. Kalaycio, Peter G. Maslak, Joseph G. Jurcic, David A. Scheinberg and Todd E. Roma

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10707

      The authors tested a novel regimen that emphasized dose intensity of both cytarabine and idarubicin as salvage therapy for patients with recurrent or refractory lymphoblastic disease. This combination was moderately active and acceptably tolerable. It may be a useful regimen for patients attempting to attain a second complete response prior to undergoing potentially curative transplantation.

    16. Hepatobiliary Tract
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      Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis : Analysis of 48 cases (pages 588–595)

      Eiji Ando, Masatoshi Tanaka, Fumihiko Yamashita, Ryoko Kuromatsu, Shigeru Yutani, Kazuta Fukumori, Shuji Sumie, Yoichi Yano, Koji Okuda and Michio Sata

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10694

      Hepatic arterial infusion chemotherapy using low-dose cisplatin and 5-fluorouracil may be a useful therapeutic option for patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis.

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      Usefulness of tumor pressure as a prognostic factor in cases of hepatocellular carcinoma where the diameter of the tumor is 3 cm or less (pages 596–604)

      Toshiharu Ueki, Seigo Sakaguchi, Yasushi Miyajima, Nagafusa Hatono, Keiji Tohara, Shoichi Nakabayashi, Tsuneyoshi Yao, Hiroshi Kokawa, Motoi Hirano and Makoto Okumura

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10690

      In patients with small hepatocellular carcinomas, the only significant predictive factor independently associated with survival was tumor pressure. However, there were significant predictive factors independently associated with local recurrence, these being tumor pressure, α-fetoprotein (AFP) level, and age, and with distant recurrence, namely, tumor pressure and AFP level.

    18. Lung Disease
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      Brain metastases in locally advanced nonsmall cell lung carcinoma after multimodality treatment : Risk factors analysis (pages 605–612)

      Giovanni Luca Ceresoli, Michele Reni, Giuseppe Chiesa, Angelo Carretta, Stefano Schipani, Paolo Passoni, Angelo Bolognesi, Piero Zannini and Eugenio Villa

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10687

      Brain metastases are frequent in patients with locally advanced nonsmall cell lung carcinoma after multimodality treatments. Age younger than 60 years and the presence of bulky mediastinal disease at diagnosis are associated with an increased risk of recurrence in the central nervous system.

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      Standards of care for anemia management in oncology : Focus on lung carcinoma (pages 613–623)

      Corey J. Langer, Hak Choy, John A. Glaspy and Alan Colowick

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10712

      Despite the knowledge that anemia is common among lung carcinoma patients and can have a profound effect on quality of life, this condition generally is undertreated, most likely because of a historic mindset that holds that mild and moderate degrees of anemia are clinically irrelevant. Data have shown that this is not the case and clinical trials with darbepoetin-α, a new erythropoiesis-stimulating protein, provide an opportunity for understanding the optimal erythropoietic management of patients with lung carcinoma.

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      Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis (pages 624–633)

      Toru Takahashi, Mitsuru Munakata, Yoshinori Ohtsuka, Hiroshi Nisihara, Yasuyuki Nasuhara, Atsuko Kamachi-Satoh, Hirotoshi Dosaka-Akita, Yukihiko Homma and Yoshikazu Kawakami

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10708

      The expression of ras protein in type II alveolar pneumocytes with point mutations in codon 12 of the K-ras gene in lung tissue may contribute to the induction of lung carcinoma in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis (IPF), and the presence of multiple mutations in the p53 gene may explain the high incidence of IPF complicated by lung carcinoma.

    21. Melanoma
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      Evaluation of the proliferation marker MIB-1 in the prognosis of cutaneous malignant melanoma (pages 634–640)

      Carole Hazan, Kate Melzer, Katherine S. Panageas, Eric Li, Hideko Kamino, Alfred Kopf, Carlos Cordon-Cardo, Iman Osman and David Polsky

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10685

      In a cohort of primarily intermediate thickness melanomas, MIB-1 expression correlates with histopathologic factors associated with decreased survival, but is not an independent prognostic factor.

    22. Neuro-Oncology
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      Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy (pages 641–655)

      Fabrice Branle, Florence Lefranc, Isabelle Camby, Judith Jeuken, Anneke Geurts-Moespot, Sandra Sprenger, Fred Sweep, Robert Kiss and Isabelle Salmon

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10710

      The authors created experimental models of a human anaplastic oligodendroglioma and a human anaplastic astrocytoma developing in the brains of nude mice. The response patterns of these tumors to different chemotherapies, including carmustine (BCNU), fotemustin, and temozolomide, were related dramatically to whether they exhibited 1p19q deletions. The use of the orthotopic C6 glioma model enabled the authors to establish comparisons between the efficiency of BCNU chemotherapy and surgery alone and between the two types of treatment taken together.

    23. Discipline

      Radiation Oncology
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      Quantitative measurement of post-irradiation neck fibrosis based on the young modulus : Description of a new method and clinical results (pages 656–662)

      Sing-Fai Leung, Yongping Zheng, Charles Y. K. Choi, Suzanne S. S. Mak, Samuel K. W. Chiu, Benny Zee and Arthur F. T. Mak

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10700

      An objective and quantitative method for the quantification of postirradiation neck fibrosis based on the Young Modulus is described. The results, expressed in absolute units of kPa, were correlated significantly with hand palpation score, neck rotation range, and symptoms, and the method was capable of discriminating regions of the neck that had received a boost dose of radiation.

    24. Translational Research
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      Clinical importance of serum interleukin-18 and nitric oxide activities in breast carcinoma patients (pages 663–667)

      Nazan Günel, Uğur Coşkun, Banu Sancak, Uğur Günel, Oğuz Hasdemir and Şükrü Bozkurt

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10705

      Serum concentrations of interleukin-18 and nitric oxide activity may be a sensitive marker in breast carcinoma patients. The clinical significance of these parameters is worth investigating in breast carcinoma patients, especially for those with bone metastasis.

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  3. Correspondence

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
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      Serum CYFRA 21-1 is one of the most reliable tumor markers for breast carcinoma (pages 670–671)

      César A. Rodríguez, Juan J. Cruz, Teresa Martín, Amalia Gómez, Amaya Olaverri and Marisa Hernández

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10692

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      Author reply (page 671)

      Bunzo Nakata, Yoshinari Ogawa and Kosei Hirakawa

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10693

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      Author reply (pages 672–673)

      Peter J. Heenan and John M. Taran

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10702

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      Author reply (page 674)

      David J. Adelstein

      Article first published online: 23 JUL 2002 | DOI: 10.1002/cncr.10704

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