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Cancer

Cover image for Cancer

15 August 2002

Volume 95, Issue 4

Pages 675–906

  1. Editorials

    1. Top of page
    2. Editorials
    3. Original Articles
    1. General Topic

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      Treatment of micropapillary serous ovarian carcinoma (the aggressive variant of serous borderline tumors) (pages 675–676)

      Jeffrey D. Seidman and Robert J. Kurman

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10777

      Ovarian serous borderline tumors recently were categorized into benign and malignant types. A subset of these tumors, termed “micropapillary serous carcinoma (MPSC),” is reported to behave in a manner similar to low-grade carcinoma. In this issue of Cancer, Bristow et al. report their experience with 26 patients with recurrent MPSC.

      See also pages 677–80 and pages 791–800.

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      Is micropapillary serous carcinoma for real? (pages 677–680)

      David M. Gershenson

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10778

      Approximately 3000 American women are diagnosed with borderline ovarian tumors annually. The most common histologic type of borderline ovarian tumor is the serous type. The article by Bristow et al. focuses on two of the major clinical controversies regarding serous borderline tumors: the significance and classification of the micropapillary pattern and the optimal treatment of recurrence, specifically the role of secondary cytoreductive surgery.

      See also pages 675–6 and 791–800.

  2. Original Articles

    1. Top of page
    2. Editorials
    3. Original Articles
    1. General Topic

      Breast Disease
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      Pathobiology of preoperative chemotherapy : Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-18 (pages 681–695)

      Edwin R. Fisher, Jiping Wang, John Bryant, Bernard Fisher, Eletherios Mamounas and Norman Wolmark

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10741

      In the current study, pathologic alterations induced by chemotherapy in patients with breast carcinoma are described in detail. Their nature and influence on various pathologic and clinical events, including parameters of survival, are discussed.

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      Concurrent cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy and radiotherapy for breast carcinoma : A well tolerated adjuvant regimen (pages 696–703)

      Neil Isaac, Tony Panzarella, Anthea Lau, Catherine Mayers, Peter Kirkbride, Ian F. Tannock and Katherine A. Vallis

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10744

      This is a retrospective review of a group of 202 patients with early breast carcinoma who were treated with concomitant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy and radiotherapy. The main finding of the current study was that concurrent treatment was well tolerated and appears to carry a low risk for serious complications. The authors concluded that when CMF is selected as adjuvant chemotherapy for early breast carcinoma patients, it is safe and feasible to administer simultaneous radiotherapy.

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      Provider case volume and outcome in the evaluation and treatment of patients with mammogram-detected breast carcinoma (pages 704–712)

      Mark D. McKee, Michael D. Cropp, Andrew Hyland, Nancy Watroba, Brian McKinley and Stephen B. Edge

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10737

      Community-wide evaluation of the diagnosis and treatment of patients with mammogram-detected breast carcinoma showed that there is wide variation in outcomes and that most providers treat a low volume of cases. Variation in outcomes for patients who were treated by high-volume physicians suggests that volume alone is not a surrogate for quality.

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      Predicting the survival of patients with breast carcinoma using tumor size (pages 713–723)

      James S. Michaelson, Melvin Silverstein, John Wyatt, Griffin Weber, Richard Moore, Elkan Halpern, Daniel B. Kopans and Kevin Hughes

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10742

      Although tumor size has been recognized as the strongest predictor of outcome in patients with invasive breast carcinoma, it has not been determined whether the correlation between tumor size and mortality is independent of the method of detection. In this report, the authors provide a method for translating tumor size at the time of treatment into a specific expectation of survival for patients with invasive breast carcinoma.

    5. Endocrine Disease
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      Childhood and adolescent thyroid carcinoma (pages 724–729)

      Perry W. Grigsby, Anat Gal-or, Jeff M. Michalski and Gerard M. Doherty

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10725

      Carcinoma of the thyroid in children and adolescents has little risk of mortality but a high risk of recurrence. Younger patients present with a more advanced stage of disease and are more likely to have disease recurrence.

    6. Gastrointestinal Tract
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      Hepatic vascular isolation and perfusion for patients with progressive unresectable liver metastases from colorectal carcinoma refractory to previous systemic and regional chemotherapy (pages 730–736)

      H. Richard Alexander Jr., Steven K. Libutti, David L. Bartlett, James F. Pingpank, Karen Kranda, Cynthia Helsabeck and Tatiana Beresnev

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10686

      Many patients with colorectal carcinoma develop unresectable liver metastases that remain the life-limiting component of the disease, despite best available systemic or regional chemotherapy. In the current study, the authors analyzed a cohort of seven patients with colorectal carcinoma who underwent isolated hepatic perfusion (IHP) after failing both previous systemic and hepatic artery infusion therapy to determine the potential utility of IHP in this setting.

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      Decreased Smad4 expression in the transforming growth factor-β signaling pathway during progression of esophageal squamous cell carcinoma (pages 737–743)

      Minoru Fukuchi, Norihiro Masuda, Tatsuya Miyazaki, Masanobu Nakajima, Hidenobu Osawa, Hiroyuki Kato and Hiroyuki Kuwano

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10727

      In patients with esophageal squamous cell carcinoma (SCC), decreased Smad4 expression was correlated with depth of invasion and pathologic stage. Lower Smad4 expression may contribute to the progression or development of esophageal SCC through its effects on the transforming growth factor-β signaling pathway.

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      Gastric carcinoma : Pathology findings in a multiethnic population (pages 744–750)

      Grant N. Stemmermann, Abraham M.Y. Nomura, Laurence N. Kolonel, Marc T. Goodman and Lynne R. Wilkens

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10734

      This study assesses 532 sequentially accessioned stomach carcinomas in a multiethnic population and confirms that carcinoma of the cardia is predominantly a tumor of white males that develops in the absence of multifocal gastritis. Diffuse gastric carcinoma shows no ethnic predilection, but is clearly related to both gender and age.

    9. Genitourinary Disease
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      Pretreatment prognostic factors for survival in patients with advanced urothelial tumors treated in a phase I/II trial with paclitaxel, cisplatin, and gemcitabine (pages 751–757)

      Joaquim Bellmunt, Joan Albanell, Luis Paz-Ares, Miguel A. Climent, Jose L. González-Larriba, Joan Carles, Juan J. de la Cruz, Vicente Guillem, Eduardo Díaz-Rubio, Hernan Cortés-Funes and José Baselga

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10762

      Pretreatment prognostic factors in patients with advanced urothelial carcinoma treated with a novel regimen of paclitaxel, cisplatin, and gemcitabine (TCG) have been characterized. The analysis indicated that among eight potential pretreatment prognostic factors analyzed, two of them, performance status > 0 and visceral metastatic disease, are independent adverse prognostic factors for predicting survival in patients treated with this TCG regimen.

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      A pilot study of thalidomide in patients with progressive metastatic renal cell carcinoma (pages 758–765)

      Danai D. Daliani, Christos N. Papandreou, Peter F. Thall, Xuemei Wang, Cherie Perez, Rose Oliva, Lance Pagliaro and Robert Amato

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10740

      Thalidomide treatment is feasible and safe and produces rare, delayed clinical responses in patients with metastatic renal cell carcinoma. Prolonged stability of metastatic disease is seen in some patients, warranting further investigation in controlled, randomized trials.

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      Extragonadal germ cell tumors in Taiwan : An analysis of treatment results of 59 patients (pages 766–774)

      Yu-Juei Hsu, Lu Pai, Yeu-Chin Chen, Ching-Liang Ho, Woei-Yau Kao and Tsu-Yi Chao

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10738

      Treatment results of our extragonadal germ cell tumor cases were analyzed and compared with those from other countries.

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      Association of overexpressed proline-directed protein kinase FA with chemoresistance, invasion, and recurrence in patients with bladder carcinoma (pages 775–783)

      Sheng-Fen Hsueh, Ming-Tsung Lai, Chuan-Ching Yang, Yuan-Chiang Chung, Chih-Ping Hsu, Chien-Chung Peng, Hsiao-Hui Fu, Yung-Ming Cheng, King-Jen Chang and Shiaw-Der Yang

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10731

      Immunohistologic, molecular, cellular, and clinicopathologic studies combined together demonstrate that the overexpression of the signal molecule, proline-directed protein kinase FA (PDPK FA), plays an essential critical role in disease progression and chemoresistance in patients with bladder carcinoma and indicates a poor clinical outcome in patients with PDPK FA positive bladder carcinoma who have primary transitional cell carcinoma.

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      Proliferative activity is the most significant predictor of recurrence in noninvasive papillary urothelial neoplasms of low malignant potential and grade 1 papillary carcinomas of the bladder (pages 784–790)

      Achille Pich, Luigi Chiusa, Andrea Formiconi, Diego Galliano, Paola Bortolin, Alberto Comino and Roberto Navone

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10733

      High proliferative activity and p53 overexpression were associated with recurrence of disease in 62 patients with superficial low malignant potential and Grade 1 papillary carcinomas of the bladder. MIB-1 immunostaining was the only independent predictor of recurrence-free survival in multivariate analysis.

    14. Gynecologic Oncology
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      Recurrent micropapillary serous ovarian carcinoma : The role of secondary cytoreductive surgery (pages 791–800)

      Robert E. Bristow, Dana R. Gossett, David R. Shook, Mariana L. Zahurak, Rafael S. Tomacruz, Deborah K. Armstrong and Fredrick. J. Montz

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10789

      Optimal secondary cytoreductive surgery is an independent predictor of survival in patients with recurrent micropapillary serous ovarian carcinoma. Surgical intervention should be considered for patients with recurrent disease. See also pages 675–6 and 677–80.

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      Cyclooxygenase-2 expression in endometrial carcinoma : Correlation with clinicopathologic parameters and clinical outcome (pages 801–807)

      Gabriella Ferrandina, Francesco Legge, Franco O. Ranelletti, Gian F. Zannoni, Nicola Maggiano, Antonella Evangelisti, Salvatore Mancuso, Giovanni Scambia and Libero Lauriola

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10736

      Cyclooxygenase-2 (COX-2) is expressed in a high percentage of primary endometrial tumors and its expression may be associated closely with parameters of tumor aggressiveness. The possible prognostic role of COX-2 in endometrial carcinoma deserves further study.

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      Vascular endothelial growth factor and social support in patients with ovarian carcinoma (pages 808–815)

      Susan K. Lutgendorf, Erica L. Johnsen, Brian Cooper, Barrie Anderson, Joel I. Sorosky, Richard E. Buller and Anil K. Sood

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10739

      Associations of serum vascular endothelial growth factor (VEGF) levels with social support and depressive symptoms were analyzed in presurgical patients with ovarian carcinoma. Higher levels of social support were related to lower VEGF levels. This relationship between a biobehavioral factor and a proangiogenic cytokine suggests a novel mechanism by which biobehavioral factors may be related to disease progression.

    17. Hepatobiliary Tract
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      Hepatocellular carcinoma in elderly patients : Beneficial therapeutic efficacy using percutaneous ethanol injection therapy (pages 816–823)

      Takuma Teratani, Takashi Ishikawa, Yasushi Shiratori, Shuichiro Shiina, Haruhiko Yoshida, Masatoshi Imamura, Shuntaro Obi, Shinpei Sato, Keisuke Hamamura and Masao Omata

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10735

      A retrospective cohort study of 653 patients with hepatocellular carcinoma (HCC) who received percutaneous ethanol injection therapy (PEIT) showed that there was no difference in mortality from extrahepatic disease or liver-related disease between patients age ≥ 70 years and patients age < 70 years. These data provide support for the treatment of patients with HCC age ≥ 70 years with tumor ablation using PEIT.

    18. You have full text access to this OnlineOpen article
      Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases (pages 824–834)

      Hiroaki Yamagamim, Mitsuhiko Moriyama, Hiroshi Matsumura, Hiroshi Aoki, Toshihiro Shimizu, Takahide Saito, Miki Kaneko, Atsuo Shioda, Naohide Tanaka and Yasuyuki Arakawa

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10732

      The serum level of hepatocyte growth factor (HGF) represents the degree of the carcinogenic state in the liver of patients with C-viral chronic hepatitis and cirrhosis. Therefore, the determination of serum HGF concentrations may be useful as a third marker of hepatocellular carcinoma in detection and follow-up therapy.

    19. Lung Disease
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      Contrast-enhanced dynamic computed tomography for the evaluation of tumor angiogenesis in patients with lung carcinoma (pages 835–842)

      Ukihide Tateishi, Masahiko Kusumoto, Hiroshi Nishihara, Kazuo Nagashima, Toshiaki Morikawa and Noriyuki Moriyama

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10730

      Contrast-enhanced dynamic computed tomography scans enable the prediction of tumor angiogenesis in patients with lung carcinoma and lymph node involvement.

    20. Sarcoma
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      Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk (pages 843–851)

      Tadashi Hasegawa, Seiichiro Yamamoto, Ryohei Yokoyama, Toru Umeda, Yoshihiro Matsuno and Setsuo Hirohashi

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10728

      Histologic grade based on three criteria (tumor differentiation/histologic type, necrosis, and MIB-1 score) and disease stage are very strong prognostic factors in adult patients with the main histologic types of soft tissue sarcoma of the extremities and trunk. In addition, specific assessment of histologic type should be carried out before deciding on treatment strategies.

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      Surgical management of soft tissue sarcomas of the hand and foot (pages 852–861)

      Patrick P. Lin, Volkan B. Guzel, Peter W. T. Pisters, Gunar K. Zagars, Kristin L. Weber, Barry W. Feig, Raphael E. Pollock and Alan W. Yasko

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10750

      Limb-sparing treatment can be compatible with satisfactory oncologic results in patients with soft tissue sarcomas of the hand and foot. Re-excision of the tumor bed and radiation therapy can improve local control in properly selected patients.

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      Human osteosarcoma expresses specific ephrin profiles : Implications for tumorigenicity and prognosis (pages 862–869)

      Antiopi Varelias, Simon A. Koblar, Prudence A. Cowled, Christopher D. Carter and Mark Clayer

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10749

      The authors report the novel finding that human osteosarcoma expresses two specific ephrin profiles. Also, ephrin-B1 may be correlated with a poorer prognosis and is expressed by osteosarcoma cells and blood vessels, suggesting a possible role in tumorigenicity.

    23. Discipline

      Epidemiology
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      Modeling the impact of the decline in distant stage disease on prostate carcinoma mortality rates (pages 870–880)

      Eric J. Feuer, Angela Mariotto and Ray Merrill

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10726

      The authors used computer modeling to determine the potential impact of a PSA screening-induced shift from distant to localized-regional disease may have had on prostate carcinoma mortality rates.

    24. Medical Oncology
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      Severe periorbital edema secondary to STI571 (Gleevec) (pages 881–887)

      Bita Esmaeli, Victor G. Prieto, Charles E. Butler, Stella K. Kim, M. Amir Ahmadi, Hagop M. Kantarjian and Moshe Talpaz

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10729

      The authors report on a male patient age 63 years who developed unusually severe periorbital edema after treatment with STI571 (imatinib mesylate; Gleevec) for chronic myelogenous leukemia. Histopathologic findings on the surgical specimin are discussed.

    25. You have full text access to this OnlineOpen article
      Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy (pages 888–895)

      Jeffrey Crawford, David Cella, Charles S. Cleeland, Pierre-Yves Cremieux, George D. Demetri, Brenda J. Sarokhan, Mitchell B. Slavin and John A. Glaspy

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10763

      An incremental analysis explored the relationship between hemoglobin levels and quality of life (QOL) in cancer patients receiving epoetin alfa therapy in community based practice. A direct and robust relationship between epoetin alfa induced hemoglobin level increases and QOL improvements was identified, with maximal incremental gain in QOL occurring when hemoglobin levels were increased into the range of 11–13 g/dL.

    26. Translational Research
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      β1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway (pages 896–906)

      Hao Zhang, Iwata Ozaki, Toshihiko Mizuta, Sachiko Matsuhashi, Tohru Yoshimura, Akitaka Hisatomi, Jutaro Tadano, Takahiro Sakai and Kyosuke Yamamoto

      Article first published online: 31 JUL 2002 | DOI: 10.1002/cncr.10751

      Overexpression of β1-integrin protected hepatoma cells from cisplatin, etoposide, and docetaxel induced apoptosis via a mitogen-activated protein kinase dependent pathway. β1 integrin mediated signals from the extracellular matrix in hepatoma cells may contribute to chemotherapy resistance.

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