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Cancer

Cover image for Cancer

15 September 2002

Volume 95, Issue 6

Pages 1185–1395

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Disease Site

      Breast Disease
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      Factors that influence surgical choices in women with breast carcinoma (pages 1185–1190)

      Valerie L. Staradub, Yi-Ching Hsieh, Jennifer Clauson, Alexander Langerman, Alfred W. Rademaker and Monica Morrow

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10824

      This study indicates that the majority of women will opt for breast-conserving therapy after an explanation of treatment choices. The less frequent selection of conserving therapy in some groups of women suggests that educational messages to patients should emphasize the lack of importance of these factors in treatment selection.

    2. You have full text access to this OnlineOpen article
      Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy (pages 1191–1198)

      Sibylle Loibl, Gunter von Minckwitz, Sonja Weber, Hans-Peter Sinn, Valérie B. Schini-Kerth, Irina Lobysheva, Françoise Nepveu, Georg Wolf, Klaus Strebhardt and Manfred Kaufmann

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10817

      Nitric oxide synthase (NOS) is expressed predominantly in in situ and invasive breast lesions but not in benign breast lesions. The expression levels of endothelial NOS and induced NOS were examined in various types of breast tumors by measuring nitric oxide in tumor tissue with electron paramagnetic resonance spectroscopy.

    3. Gastrointestinal Tract
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      The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma (pages 1199–1205)

      Yasuhiro Komuro, Toshiaki Watanabe, Yoshio Hosoi, Yoshihisa Matsumoto, Keiichi Nakagawa, Nelson Tsuno, Shinsuke Kazama, Joji Kitayama, Norio Suzuki and Hirokazu Nagawa

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10807

      A significant correlation was found between the expression pattern of tumor Ku protein and tumor radiosensitivity. The authors used multivariate analysis to demonstrate that the expression pattern of the 70-kDa Ku protein was prognostic for survival in patients with rectal carcinoma who were undergoing radiotherapy.

    4. You have full text access to this OnlineOpen article
      Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface : Impact on human pancreatic carcinoma cell growth by autocrine regulation (pages 1206–1214)

      Hideki Hidaka, Takatoshi Ishiko, Takashi Furuhashi, Hidenobu Kamohara, Shunji Suzuki, Masashi Miyazaki, Osamu Ikeda, Seiji Mita, Toshiaki Setoguchi and Michio Ogawa

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10812

      The authors investigated the effect of the food derivative curcumin on human carcinoma cell lines to determine whether the production of constitutive interleukin-8 (IL-8) in tumor cells was correlated with nuclear factor κB (NF-κB) activation and cell growth activity. Curcumin reduced the constitutive production of IL-8 due to the prevention and inhibition of NF-κB activation. Moreover, curcumin enhanced the expression of IL-8 receptors by blocking their internalization after curcumin treatment. These findings suggest that curcumin is a potent anticancer agent that inhibits the production of proinflammatory cytokines, including IL-8, by tumor cells.

    5. Genitourinary Disease
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      Prognostic significance of positive surgical margins in patients with extraprostatic carcinoma after radical prostatectomy (pages 1215–1219)

      Sankar J. Kausik, Michael L. Blute, Thomas J. Sebo, Bradley C. Leibovich, Erik J. Bergstralh, Jeff Slezak and Horst Zincke

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10871

      A significant number of patients who undergo radical prostatectomy are found to have microscopic extraprostatic disease extension. In the current study, the authors evaluated the impact of positive surgical margins as an independent predictive factor for prostate specific antigen progression in patients with focal extraprostatic disease extension.

    6. You have full text access to this OnlineOpen article
      Phase I trial of interferon α2b and liposome-encapsulated all-trans retinoic acid in the treatment of patients with advanced renal cell carcinoma (pages 1220–1227)

      Jonathan S. Goldberg, Manuel Vargas, Alyssa S. Rosmarin, Matthew I. Milowsky, Nicholas Papanicoloau, Lorraine J. Gudas, Gary Shelton, Kevie Feit, Daniel Petrylak and David M. Nanus

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10809

      Based on previous studies showing that liposome-encapsulated all-trans retinoic acid (ATRA-IV) was well tolerated as a single agent, the authors conducted a dose-finding study to investigate the combination of ATRA-IV with interferon in the treatment of patients with advanced renal cell carcinoma. The acceptable toxicity profile and preliminary efficacy results suggest that the regimen presented warrants further evaluation.

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      Bilateral testicular germ cell tumors : Twenty-year experience at M. D. Anderson Cancer Center (pages 1228–1233)

      Mingxin Che, Pheroze Tamboli, Jae Y. Ro, Dong Soo Park, Jung Sil Ro, Robert J. Amato and Alberto G. Ayala

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10804

      The overall incidence of bilateral testicular germ cell tumors was 1% in patients who were treated at The University of Texas M. D. Anderson Cancer Center over the past 2 decades. The incidence of bilateral germ cell tumors was related to the histologic type of the initial tumor and also was related to age at initial presentation in patients with seminoma.

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      Role of 5-aminolevulinic acid in the detection of urothelial premalignant lesions (pages 1234–1238)

      Dirk Zaak, Edwin Hungerhuber, Peter Schneede, Herbert Stepp, Dominic Frimberger, Stefan Corvin, Nikolaus Schmeller, Martin Kriegmair, Alfons Hofstetter and Ruth Knöchel

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10821

      This study provides evidence that 5-aminolevulinic acid-induced fluorescence endoscopy is highly efficient in the detection of flat urothelial lesions compared with standard white-light endoscopy.

    9. You have full text access to this OnlineOpen article
      Patterns of multiple recurrences of superficial (Ta/T1) transitional cell carcinoma of bladder and effects of clinicopathologic and biochemical factors (pages 1239–1246)

      Yan Yan, Gerald L. Andriole, Peter A. Humphrey and Adam S. Kibel

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10822

      Among superficial transitional cell bladder carcinoma patients, multiple recurrences are common. The time for recurrence becomes shorter as the number of recurrences increases. In addition to tumor stage and grade, Ki-67 can be used to identify patients at high risk for the first recurrence, and p53 can be used to identify patients at high risk for the second recurrence.

    10. You have full text access to this OnlineOpen article
      Tissue microarray analysis of cytoskeletal actin-associated biomarkers gelsolin and E-cadherin in urothelial carcinoma (pages 1247–1257)

      JianYu Rao, David Seligson, Harri Visapaa, Steve Horvath, Mervi Eeva, Kia Michel, Allan Pantuck, Arie Belldegrun and Aarno Palotie

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10823

      Gelsolin and E-cadherin have distinctive expression patterns. Gelsolin, but not E-cadherin, provides independent prognostic information for high-grade urothelial carcinomas.

    11. Head and Neck Disease
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      The effect of retinoids on premalignant oral lesions : Focus on topical therapy (pages 1258–1264)

      Meir Gorsky and Joel B. Epstein

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10874

      Topical application of retinoids may provide adjunctive treatment for patients with dysplastic oral lesions.

    12. Lung Disease
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      Second-line, low-dose, weekly paclitaxel in patients with stage IIIB/IV nonsmall cell lung carcinoma who fail first-line chemotherapy with carboplatin plus paclitaxel (pages 1265–1273)

      Mark A. Socinski, Michael J. Schell, Kamal Bakri, Amy Peterman, Ji-Hyun Lee, Paul Unger, Steven Yates, Stacie Hudgens and Merrill S. Kies

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10835

      Second-line, low-dose, weekly paclitaxel had activity in patients with advanced nonsmall cell lung carcinoma who received previous treatment with first-line carboplatin plus paclitaxel. The toxicity profile of this approach was quite favorable, and survival outcomes were similar to the outcomes achieved with other single agents in the second-line setting.

    13. You have full text access to this OnlineOpen article
      A Phase II trial of topotecan and gemcitabine in patients with previously treated, advanced nonsmall cell lung carcinoma (pages 1274–1278)

      David A. Rinaldi, Nancy A. Lormand, Joseph E. Brierre, James L. Cole, Brian C. Barnes, Glen Mills, Siva Yadlapati, M. Felicia Fontenot, Eric J. Buller and John M. Rainey

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10806

      The combination of topotecan and gemcitabine demonstrated similar response rates and survival periods as other second-line treatment regimens for patients with advanced nonsmall cell lung carcinoma, with less toxicity. The response rates and survival periods were similar in patients with refractory disease, a group with an expected poorer prognosis.

    14. You have full text access to this OnlineOpen article
      Prospective randomized study of four novel chemotherapy regimens in patients with advanced nonsmall cell lung carcinoma : A Minnie Pearl Cancer Research Network trial (pages 1279–1285)

      F. Anthony Greco, James R. Gray Jr., Dana S. Thompson, Howard A. Burris III, Joan B. Erland, John H. Barton Jr., Sharlene Litchy, Gerry A. Houston, James A. Butts, Charles Webb, Charles Scott and John D. Hainsworth

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10810

      The authors compared four different chemotherapy regimens for patients with advanced (Stage IIIB and IV) nonsmall cell lung carcinoma to obtain a better understanding of the relative differences of these therapies. The two two-drug regimens, which did not contain a platinum agent, were less toxic than the two platinum-based, three-drug regimens. No significant differences in objective response rates or progression free survival were found.

    15. Melanoma
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      The long-term clinical course of patients with cutaneous melanoma (pages 1286–1293)

      John W. Gamel, Stephen L. George, Michael J. Edwards and Hilliard F. Seigler

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10813

      Parametric statistical analysis provides quantitative measures of long-term survival for patients with cutaneous melanoma. These measures suggest that a significant portion of patients with cutaneous melanoma will remain at risk of disease recurrence more than a decade after treatment, although the probability of cure increases with progressive recurrence free survival.

    16. Neuro-Oncology
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      Phase I study of fotemustine in pediatric patients with refractory brain tumors (pages 1294–1301)

      Darren R. Hargrave, Eric Bouffet, Janet Gammon, Nauman Tariq, Ron M. Grant and Sylvain Baruchel

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10814

      Monotherapy with fotemustine in a 3-week schedule is well tolerated in children with refractory brain tumors. Myelosuppression was the main dose-limiting toxicity and antitumor activity was seen.

    17. You have full text access to this OnlineOpen article
      Clinical and survival covariates of eight classes of childhood supratentorial neuroglial tumors (pages 1302–1310)

      Floyd H. Gilles, Alan Leviton, C. Jane Tavaré, Lester Adelman, Lucy B. Rorke, Eugene L. Sobel, E. Tessa Hedley-Whyte, Richard L. Davis and The Childhood Brain Tumor Consortium

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10815

      Survival covariates such as age, amount of tumor removed, and specific histologic characteristics appear to change the survival expectancy for only specific, quantitatively defined classes of supratentorial neuroglial tumors only.

    18. You have full text access to this OnlineOpen article
      Pretreatment cognitive performance predicts survival in patients with leptomeningeal disease (pages 1311–1316)

      Audrey M. Sherman, Kurt Jaeckle and Christina A. Meyers

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10816

      Cognitive functioning, as measured by the Dementia Rating Scale, is used to predict survival time in patients with leptomeningeal disease at time of initial diagnosis. The pattern of cognitive impairment is consistent with frontal-subcortical dysfunction.

    19. Sarcoma
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      Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization (pages 1317–1325)

      Patrick P. Lin, Volkan B. Guzel, Marcio F. Moura, Sidney Wallace, Robert S. Benjamin, Kristin L. Weber, Frank A. Morello Jr., Ziya L. Gokaslan and Alan W. Yasko

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10803

      Selective arterial embolization is a useful modality alone or in conjunction with other treatment modalities for the treatment of patients with sacral giant cell tumors. A durable response to treatment that lasts at least 10 years occurs in one half of the patients.

    20. Discipline

      Diagnostic Imaging
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      Nonneutropenic febrile episodes associated with docetaxel-based chemotherapy in patients with solid tumors (pages 1326–1333)

      John Souglakos, Athanaslos Kotsakis, Charalambos Kouroussis, Stylianos Kakolyris, Dimitrios Mavroudis, Konstadinos Kalbakis, Sofia Agelaki, John Vlachonikolis, Vassilis Georgoulias and George Samonis

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10802

      This study investigated the incidence of nonneutropenic infections and/or febrile episodes in patients with solid tumors receiving frontline docetaxel-based chemotherapy. During a 2-year period, 680 patients received 2867 cycles of docetaxel-containing chemotherapy. Fifty-three patients (7.8%) developed nonneutropenic infections and/or febrile episodes. Conversely, 175 patients who received 752 cycles with paclitaxel-containing regimens and 410 patients who received 2174 cycles with nontaxane-based regimens developed 6 (3.4%; P = 0.042) and 12 (3%; P = 0.001) nonneutropenic infections and/or febrile episodes, respectively. Patients treated with docetaxel-based chemotherapy are at risk of developing nonneutropenic infections, probably due to severe postchemotherapy CD4+ lymphopenia.

    21. Epidemiology
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      Magnetic resonance imaging as a supplement for the clinical staging system of Durie and Salmon? (pages 1334–1345)

      Andrea Baur, Axel Stäbler, Dorothea Nagel, Rolf Lamerz, Reiner Bartl, Erhard Hiller, Clemens Wendtner, Fridleif Bachner and Maximilian Reiser

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10818

      A three-grade staging system of spinal involvement using magnetic resonance imaging in patients with multiple myeloma provided highly significant results for survival rates and enhanced the standard staging system of Durie and Salmon.

    22. Medical Oncology
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      Age specific and attributable risks of familial prostate carcinoma from the family-cancer database (pages 1346–1353)

      Kari Hemminki and Kamila Czene

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10819

      The familial risk for prostate carcinoma in men age 0–66 years was 2.38 for men with prostate carcinoma in the father only, 3.75 for men with prostate carcinoma in a brother only, and 9.44 for men with prostate carcinoma in both the father and a brother. The familial population-attributable fraction from male relatives was 11.63%.

    23. Pediatric Oncology
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      Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas (pages 1354–1365)

      Douglas S. Hawkins, Judy Felgenhauer, Julie Park, Susan Kreissman, Blythe Thomson, James Douglas, Scott D. Rowley, Ted Gooley, Jean E. Sanders and Thomas W. Pendergrass

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10801

      The dose intensity of vincristine, doxorubicin, cyclophosphamide, ifosfamide, sodium mercaptoethanesulfonate (MENSA), and etoposide (VACIME), a chemotherapy regimen for pediatric patients with sarcomas, can be increased with the support of granulocyte-colony stimulating factor-mobilized peripheral blood stem cells (PBSC). The collection of PBSC after VACIME chemotherapy is feasible. Although the response rate to VACIME with PBSC support was high, the event free survival was similar to that achieved with previous regimens.

    24. You have full text access to this OnlineOpen article
      Chronic neuroblastoma : Indolent Stage 4 disease in children (pages 1366–1375)

      Brian H. Kushner, Kim Kramer and Nai-Kong V. Cheung

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10800

      The concept of indolent or smoldering neuroblastoma should not be limited to adolescents/adults. The expanding repertoire of effective treatments, including biologic therapies and chemotherapy regimens of modest toxicity, can convert childhood neuroblastoma into a chronic disease with prolonged survival after recurrence.

    25. You have full text access to this OnlineOpen article
      Metabolic characterization of childhood brain tumors : Comparison of 18F-fluorodeoxyglucose and 11C-methionine positron emission tomography (pages 1376–1386)

      Meri Utriainen, Liisa Metsähonkala, Toivo T. Salmi, Tapio Utriainen, Hannu Kalimo, Helena Pihko, Anne Mäkipernaa, Arja Harila-Saari, Sirkku Jyrkkiö, Jukka Laine, Kjell Någren and Heikki Minn

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10798

      2-[18F]fluoro-2-deoxy-D-glucose (FDG) and/or L-[methyl-11C]methionine [18F]-fluorodeoxyglucose (MET) uptake in pediatric brain tumors is associated with malignancy grade. Although FDG and MET-positron emission tomography do not compensate for histopathologic evaluation, they may give valuable additional information especially if invasive procedures to obtain histopathologic samples are not feasible.

    26. Translational Research
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      The signaling adapter protein PINCH is up-regulated in the stroma of common cancers, notably at invasive edges (pages 1387–1395)

      Jessica Wang-Rodriguez, Anna D. Dreilinger, Ghazwan M. Alsharabi and Ann Rearden

      Article first published online: 5 SEP 2002 | DOI: 10.1002/cncr.10878

      The signaling adapter protein PINCH is increased markedly in the stroma of patients with common carcinomas, especially in the stroma adjacent to invading tumors. Because PINCH functions at a key convergence point for integrin and growth factor signal transduction, it may be important in facilitating invasion and may be a new target for drug discovery aimed at the tumor-associated stroma.

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