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Cancer

Cover image for Cancer

1 November 2002

Volume 95, Issue 9

Pages 1817–2039

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. Disease Site

      Breast Disease
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      Estrogen replacement therapy for menopausal women with a history of breast carcinoma : Results of a 5-year, prospective study (pages 1817–1826)

      Rena Vassilopoulou-Sellin, Deborah S. Cohen, Gabriel N. Hortobagyi, Mary Jean Klein, Marsha McNeese, S. Eva Singletary, Terry L. Smith and Richard L. Theriault

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10913

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      Estrogen replacement therapy did not compromise disease free survival in select patients who were treated previously for localized breast carcinoma.

    2. Endocrine Disease
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      Tumor necrosis factor α induces three-dimensional cytomorphologic differentiation of human anaplastic thyroid carcinoma cells through activation of nuclear factor κB (pages 1827–1833)

      Chih-Yuan Wang, Wen-Bin Zhong, Tien-Chun Chang, Shu-Mei Lai and Yuan-Feen Tsai

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10857

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      The objective of this study was to determine whether tumor necrosis factor α (TNF-α) is capable of inducing three-dimensional cytomorphologic differentiation of anaplastic thyroid carcinoma cells. The results suggest that TNF-α can induce such differentiation through nuclear factor κB and that it merits investigation as differentiation therapy for the treatment of patients with anaplastic thyroid carcinoma.

    3. Gastrointestinal Tract
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      Telomerase activity in Stage II colorectal carcinoma : Telomerase-negative tumors are correlated with poor prognosis (pages 1834–1839)

      Rika Kawanishi-Tabata, Francisco Lopez, Sam Fratantonio, Nam Kim, John Goldblum, Raymond Tubbs, Paul Elson, Ian Lavery, Ronald M. Bukowski, Ram Ganapathi and Mahrukh K. Ganapathi

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10911

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      In the current study, telomerase activity, which often is reactivated during carcinogenesis, was detected in 80% of cases of Stage II colorectal carcinoma. However, the prognosis for patients with telomerase-positive tumors was found to be better than that for patients with telomerase-negative tumors.

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      Association of proline-directed protein kinase FA with tumorigenesis, invasion, and poor prognosis of human colon carcinoma (pages 1840–1847)

      Yuan-Chiang Chung, King-Jen Chang, Chuan-Ching Yang, Ming-Tsung Lai, Chih-Ping Hsu, Sheng-Feng Hsueh, Chien-Chung Peng, Hsiao-Hui Fu, Ya-Fen Chang and Shiaw-Der Yang

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10904

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      Combined immunohistologic, molecular, cellular, animal, and clinicopathologic studies demonstrate that overexpression of the signal molecule proline-directed protein kinase FA(PDPK FA) plays an essential and critical role in human colon carcinoma progression. They also point to a poor prognosis of the PDPK FA-positive colon carcinoma patients with Dukes Stage B/C.

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      Comparison of selection strategies for genetic testing of patients with hereditary nonpolyposis colorectal carcinoma : Effectiveness and cost-effectiveness (pages 1848–1856)

      Carolina M. Reyes, Brian A. Allen, Jonathan P. Terdiman and Leslie S. Wilson

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10910

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      This study compares the relative effectiveness and cost-effectiveness of currently used strategies of genetic testing in patients with hereditary nonpolyposis colorectal carcinoma. A mixed strategy, which consists of germline testing of probands who meet the Amsterdam criteria and microsatellite instability testing of probands who meet a less stringent set of criteria, has a high effectiveness (59.6 mutation carriers per 1000 colorectal carcinoma cases) and a reasonable cost compared to other commonly used strategies. It has a cost-effectiveness of $6441 per gene carrier detected compared with testing only those meeting the Amsterdam criteria.

    6. Genitourinary Disease
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      Testicular carcinoma and HLA Class II genes (pages 1857–1863)

      Dirk J. A. Sonneveld, Martijn F. Lutke Holzik, Ilja M. Nolte, Dirk Th. Sleijfer, Winette T. A. van der Graaf, Marcel Bruinenberg, Rolf H. Sijmons, Harald J. Hoekstra and Gerard J. Te Meerman

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10903

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      The current genotyping study, comprising a large number of patients and controls, did not confirm the previously reported association between histocompatibility antigen Class II genes and testicular germ cell tumors.

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      Selective aromatase inhibition for patients with androgen-independent prostate carcinoma : A Phase II study of letrozole (pages 1864–1868)

      Matthew R. Smith, Donald Kaufman, Daniel George, William K. Oh, Maryanne Kazanis, Judith Manola and Philip W. Kantoff

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10844

      Treatment with letrozole, a potent and selective third-generation aromatase inhibitor, was inactive in men with androgen-independent prostate carcinoma. These results suggest that the reported activity of nonselective first and second-generation aromatase inhibitors results from inhibition of other steroidogenic enzymes.

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      Metastatic renal cell carcinoma to the thyroid gland : A clinicopathologic study of 36 cases (pages 1869–1878)

      Clara S. Heffess, Bruce M. Wenig and Lester D. Thompson

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10901

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      Metastatic renal cell carcinoma to the thyroid gland can simulate a primary thyroid gland neoplasm both clinically and histologically. A detailed clinical history, the presence of a distinctive light microscopic growth pattern, and histochemical and immunohistochemical studies can be used to discriminate between a primary neoplasm and metastatic disease.

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      Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors (pages 1879–1885)

      Tsuneharu Miki, Yoichi Mizutani, Norio Nonomura, Takeshi Nomoto, Masahiro Nakao, Shigeru Saiki, Toshihiko Kotake and Akihiko Okuyama

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10918

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      Chemotherapy with irinotecan in combination with cisplatin or nedaplatin showed significant anticancer activity for patients with refractory germ cell tumors, without serious side effects. This combination chemotherapy may be one of the options of salvage chemotherapy for patients with refractory germ cell tumor.

    10. Gynecologic Oncology
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      Comparative analysis of CA125, tissue polypeptide specific antigen, and soluble interleukin-2 receptor α levels in sera, cyst, and ascitic fluids from patients with ovarian carcinoma (pages 1886–1893)

      Paweł Sedlaczek, Irena Frydecka, Marian Gabryś, Arie van Dalen, Roland Einarsson and Antonina Harłozińska

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10917

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      CA125, tissue polypeptide specific antigen (TPS), and soluble interleukin-2 receptor α (sIL-2Rα) levels were measured in sera, cyst, and ascitic fluids from patients with malignant and benign ovarian neoplasms. It was revealed that the concentrations of TPS and CA125 were significantly greater in the location of their production compared with concentrations in circulating blood. sIL-2Rα levels were greater in ascites compared with the levels in serum; however, sIL-2Rα levels in sera and cyst fluids were comparable. The assessment of sIL-2Rα concentration seems to possess value that is complementary to the value of CA125 for the detection of early stages of ovarian carcinoma; however, a 9% of false positive rate limited the significance of cumulative value for a combination of these circulating markers.

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      Analysis of survival after laparoscopy in women with endometrial carcinoma (pages 1894–1901)

      Gamal H. Eltabbakh

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10928

      The short-term survival of women with early-stage endometrial carcinoma does not appear to worsen after laparoscopy. However, the effect of a laparoscopic surgical approach on the survival of such women remains to be determined.

    12. Head and Neck Disease
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      Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck : Correlation with p53 status, inducible nitric oxide synthase activity, and angiogenesis (pages 1902–1910)

      Alessandro Franchi, Marco Santucci, Emanuela Masini, Iacopo Sardi, Milena Paglierani and Oreste Gallo

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10916

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      Matrix metalloproteinase (MMP) 9 overexpression in head and neck squamous cell carcinoma is associated strongly with p53 gene mutation, activation of the nitric oxide (NO) pathway, and angiogenesis. This suggests that p53 mutation, which is present frequently in these tumors, may result in increased angiogenesis and invasiveness related to increased NO and MMP production by tumor cells, ultimately contributing to tumor progression.

    13. Hematologic Malignancies
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      Effects of cyclosporine on hematopoietic and immune functions in patients with hypoplastic myelodysplasia : In vitro and in vivo studies (pages 1911–1922)

      Carmine Selleri, Jaroslaw P. Maciejewski, Lucio Catalano, Patrizia Ricci, Claudia Andretta, Luigiana Luciano and Bruno Rotoli

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10915

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      The increased frequency of interferon-γ (IFN-γ)–producing CD4+ cells in myelodysplastic patients (MDS) with unilinear or plurilinear marrow hypoplasia further supports the involvement of lymphocyte-mediated suppression of hematopoiesis in the development of cytopenia. The ability of cyclosporine to decrease IFN-γ production may improve hematopoietic function, thus explaining the possible beneficial effect of this drug in this subgroup of MDS patients.

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      Plasma vascular endothelial growth factor levels have prognostic significance in patients with acute myeloid leukemia but not in patients with myelodysplastic syndromes (pages 1923–1930)

      Alvaro Aguayo, Hagop M. Kantarjian, Elihu H. Estey, Francis J. Giles, Srdan Verstovsek, Taghi Manshouri, Christy Gidel, Susan O'Brien, Michael J. Keating and Maher Albitar

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10900

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      Plasma concentrations of vascular endothelial growth factor are associated with survival in patients with acute myeloid leukemia (AML) but not in patients with myelodysplastic syndromes (MDS). Plasma concentrations of basic fibroblast growth factor have no effect on outcome in patients with AML or MDS.

    15. Hepatobiliary Tract
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      Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features (pages 1931–1937)

      Takuji Okusaka, Shuichi Okada, Hideki Ueno, Masafumi Ikeda, Kazuaki Shimada, Junji Yamamoto, Tomoo Kosuge, Susumu Yamasaki, Noriyoshi Fukushima and Michiie Sakamoto

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10892

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      The macroscopic type and tumor differentiation were significantly associated with the prevalence of satellite lesions in patients with small hepatocellular carcinoma (HCC). In the single nodular type with extranodular growth, the confluent multinodular type, or poorly differentiated HCC, extensive treatment (providing a large safety margin) and/or frequent follow-up examinations may be needed because of the high prevalence of satellite lesions.

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      Quantitative analysis of apoptosis-related gene expression in hepatocellular carcinoma (pages 1938–1945)

      Masahide Ikeguchi, Yasuaki Hirooka and Nobuaki Kaibara

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10898

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      In patients with hepatocellular carcinoma, bcl-2 or bax messenger RNA expression did not correlate with apoptosis, whereas survivin messenger RNA expression was found to correlate negatively with the occurrence of apoptosis. Moreover, messenger RNA expression of survivin was found to be correlated positively with poor patient survival.

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      Helicobacter pylori and the risk of benign and malignant biliary tract disease (pages 1946–1953)

      Milutin Bulajic, Patrick Maisonneuve, Wulf Schneider-Brachert, Petra Müller, Udo Reischl, Bojan Stimec, Norbert Lehn, Albert B. Lowenfels and Matthias Löhr

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10893

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      Investigating the presence of Helicobacter pylori in the stomach and bile of patients with gallstone disease and biliary tract carcinoma, H. pylori was 9.9 times more frequent in patients with biliary tract carcinoma compared with participants in a control group (95% confidence interval, 1.4–70.5; P = 0.022) both in the stomach and in the bile.

    18. Lung Disease
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      Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma : The possibility of its clinical use as a tumor marker and a target antigen in cancer immunotherapy (pages 1954–1962)

      Yoshitomo Ozaki, Keiichi Kontani, Jun Hanaoka, Tokuhiro Chano, Koji Teramoto, Noriaki Tezuka, Satoru Sawai, Shozo Fujino, Tatsuhiro Yoshiki, Hidetoshi Okabe and Iwao Ohkubo

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10899

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      In the current study, 90K/Mac-2 binding protein was highly expressed in lung carcinoma cells and was sufficiently immunogenic to elicit anti-tumor immunity. 90K/Mac-2 binding protein is expected to be useful not only as a tumor marker but also as a tumor antigen in cancer immunotherapy.

    19. Melanoma
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      Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions (pages 1963–1970)

      Oriana Simonetti, Guendalina Lucarini, Donatella Brancorsini, Petronela Nita, Maria Luisa Bernardini, Graziella Biagini and Annamaria Offidani

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10888

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      The objective of this study was to evaluate the immunohistochemical expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP-2), and MMP-9 in paraffin embedded biopsy specimens of malignant melanomas; dysplastic nevi with architectural disorder and cytologic atypia of melanocytes; Spitz nevi; and compound or predominantly intradermal, ordinary, benign melanocytic nevi. The results suggest that VEGF may be used as a discriminating factor to distinguish malignant melanoma from lesions of uncertain histology.

    20. Neuro-Oncology
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      Delirium in patients undergoing hematopoietic stem cell transplantation : Incidence and pretransplantation risk factors (pages 1971–1981)

      Jesse R. Fann, Sari Roth-Roemer, Bart E. Burington, Wayne J. Katon and Karen L. Syrjala

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10889

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      Half of patients who undergo hematopoietic stem cell transplantation experience a delirium episode during the 4 weeks posttransplantation. Pretransplantation risk factors can assist in identifying patients who are more likely to develop delirium posttransplantation.

    21. Sarcoma
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      Classical Kaposi sarcoma : Prognostic factor analysis of 248 patients (pages 1982–1987)

      Baruch Brenner, Alina Weissmann-Brenner, Erica Rakowsky, Sara Weltfriend, Eyal Fenig, Rachel Friedman-Birnbaum, Aaron Sulkes and Shai Linn

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10907

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      Immunosuppression and an age of 50 years or older were strongly associated with poorer outcome among patients with classical Kaposi sarcoma. The two end points used in the current study are suitable for future prognostic factor analysis.

    22. Discipline

      Epidemiology
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      Race, socioeconomic status, and breast carcinoma in the U.S. : What have we learned from clinical studies? (pages 1988–1999)

      Chaundré K. Cross, Jay Harris and Abram Recht

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10830

      Socioeconomic status replaces race as a predictor of worse outcome after women are diagnosed with breast carcinoma in many studies. However, African-American women present with more advanced disease that appears more aggressive biologically and present at a younger age compared with white women.

    23. Medical Oncology
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      A phase I study of a weekly schedule of paclitaxel and carboplatin in patients with advanced carcinoma (pages 2000–2005)

      Wallace Akerley, Ritesh Rathore, Neil Ready, Louis Leone, William Sikov, Howard Safran and Teresa Kennedy

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10902

      A Phase I trial of paclitaxel and carboplatin administered on a weekly schedule permits greater dose intensity.

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      An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane (pages 2006–2016)

      Aman U. Buzdar, John F. R. Robertson, Wolfgang Eiermann and Jean-Marc Nabholtz

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10908

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      The authors undertook an extensive review of the literature on the use of anastrozole, letrozole, and exemestane in first-line treatment and adjuvant therapy for patients with breast carcinoma. It was found that, although all three agents offer significant efficacy advantages over preexisting treatments, there are many differences in drug pharmacokinetics and in the effects on lipid profiles, bone absorption, and steroidogenesis that may influence long-term safety profiles.

    25. Psychological Oncology
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      Relations between fatigue, neuropsychological functioning, and physical activity after treatment for breast carcinoma : Daily self-report and objective behavior (pages 2017–2026)

      Petra Servaes, Constans A. H. H. V. M. Verhagen and Gijs Bleijenberg

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10891

      In a sample of disease free breast carcinoma survivors, fatigue complaints were related to daily self-reported neuropsychological complaints (memory and concentration problems). However, there was no relation between fatigue and a standardized measure of the ability to concentrate, and only a weak relation was found between fatigue and a reaction time task. Furthermore, no relations were demonstrated between fatigue and daily reported and objective physical activity.

    26. Radiation Oncology
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      Gliomatosis cerebri : Treatment results with radiotherapy alone (pages 2027–2031)

      Mohamed A. Elshaikh, Glen H.J. Stevens, David M. Peereboom, Bruce H. Cohen, Richard A. Prayson, Shih-Yuan Lee, Gene H. Barnett and John H. Suh

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10909

      In the current series of 12 patients with gliomatosis cerebri, brain radiotherapy improved or stabilized the disease process in most patients and improved survival. Brain radiotherapy should be considered in the current management of patients with this rare brain tumor.

    27. Translational Research
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      Intravenous gamma globulin inhibits the production of matrix metalloproteinase-9 in macrophages (pages 2032–2037)

      Sarah Shapiro, Yehuda Shoenfeld, Boris Gilburd, Esther Sobel and Nitza Lahat

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10905

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      High-dose intravenous gamma globulins inhibit metastatic spread of tumors in mice and humans. Inhibition of matrix metalloproteinase-9 activity may be among the variety of mechanisms suggested to explain this effect.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
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    2. You have free access to this content
      Author reply (page 2039)

      Thomas Leung

      Version of Record online: 25 OCT 2002 | DOI: 10.1002/cncr.10895

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