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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 December 2002

Volume 96, Issue 6

Pages 319–379

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Research Articles
    6. Original Articles
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      Adenocarcinoma in situ of the cervix: Sensitivity of detection by cervical smear : Will cytologic screening for adenocarcinoma in situ reduce incidence rates for adenocarcinoma? (pages 319–322)

      Harriet O. Smith and Luis A. Padilla

      Article first published online: 25 SEP 2002 | DOI: 10.1002/cncr.10887

      The sensitivity of routine cytologic screening for the detection of adenocarcinoma in situ (AIS) is comparable to that for high-grade squamous lesions (approximately 50%). Although the authors of the current study are cautiously optimistic that screening for AIS will reduce the incidence of invasive cervical carcinoma, population-based studies published to date continue to demonstrate a rise in adenocarcinoma incidence rates.

  2. Commentary

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Research Articles
    6. Original Articles
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      Misclassification of cytologic diagnoses in patients with follicular lesions or follicular neoplasms of the thyroid gland : Implications for patient care and clinical research (pages 323–324)

      Nicholas J. Sarlis, Loukas Gourgiotis and Armando C. Filie

      Article first published online: 25 SEP 2002 | DOI: 10.1002/cncr.10884

      The issue of an optimal preoperative diagnostic approach in patients with thyroid nodules who are cytologically found to have follicular lesions or neoplasms is problematic. The authors suggest that additional efforts be made for the accurate and detailed description of the cytomorphologic features of thyroid nodules in which a definitive diagnosis cannot be made. Follicular neoplasms should be distinguished from follicular lesions, especially those lesions with low index of suspicion for malignancy.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Research Articles
    6. Original Articles
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      One hundred percent thorough quality control rescreening of liquid-based monolayers in cervicovaginal cytopathology (pages 325–329)

      Leslie R. Rowe, C. Jay Marshall and Joel S. Bentz

      Article first published online: 9 SEP 2002 | DOI: 10.1002/cncr.10883

      Quality control (QC) of Papanicolaou smear testing focuses on the identification of screening errors using 10% random, rapid, or thorough manual rescreening of some portion of negative smears. However, 100% thorough manual rescreening is believed by some to be the most effective method of identifying screening errors in conventional Papanicolaou smears. In the current study, the authors report the estimated screening error rate of ThinPrep as determined by a QC program using 100% thorough rescreening.

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      Adenocarcinoma in situ of the cervix : Sensitivity of detection by cervical smear (pages 330–337)

      Meike Schoolland, Amanda Segal, Stephen Allpress, Alina Miranda, Felicity A. Frost and Gregory F. Sterrett

      Article first published online: 9 OCT 2002 | DOI: 10.1002/cncr.10886

      For each of 2 laboratories, approximately 50% of the cervical smears examined in the 36 months before a biopsy diagnosis of adenocarcinoma in situ (AIS) of the cervix were reported to demonstrate possible or definite AIS by cytology. The results were similar or slightly better for AIS combined with a high-grade squamous intraepithelial lesion, and in the authors' opinion represent encouraging baseline data regarding this little-studied aspect of diagnosis.

      See also pages 000–000, this issue.

  4. Research Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Research Articles
    6. Original Articles
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      ThinPrep detection of cervical and endometrial adenocarcinoma : A retrospective cohort study (pages 338–343)

      John O. Schorge, M. Hossein Saboorian, Linda Hynan and Raheela Ashfaq

      Article first published online: 24 JUL 2002 | DOI: 10.1002/cncr.10761

      The ThinPrep™ Papanicolaou (Pap) test is a more sensitive method of detecting cervical and endometrial adenocarcinomas than the conventional Pap smear.

  5. Original Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Research Articles
    6. Original Articles
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      Fine needle aspiration cytology of CD56-positive natural killer/T-cell lymphoma of soft tissue (pages 344–350)

      Eun Yoon Cho, Gyungyub Gong, Shin Kwang Khang, Yoon-Koo Kang and Jooryung Huh

      Article first published online: 9 OCT 2002 | DOI: 10.1002/cncr.10885

      Fine needle aspiration cytology can be helpful in the diagnosis of CD56-positive natural killer/T-cell lymphomas involving soft tissue and in the differential diagnosis between primary or recurrent lymphoma and an inflammatory condition. The smear is characterized by extensive necrosis, an abundance of highly characteristic apoptotic bodies, and discohesive, variably anaplastic lymphoma cells.

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      Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberans (pages 351–361)

      Henryk A. Domanski and Pelle Gustafson

      Article first published online: 15 AUG 2002 | DOI: 10.1002/cncr.10760

      The diagnosis of recurrent dermatofibrosarcoma protuberans (DFSP) can be made relatively easily in fine-needle aspiration smears. However, as this rare tumor shares some features with other spindle cell lesions, the cytologic evaluation of primary DFSP must be complemented by ancillary studies and strongly correlated to the clinical appearance.

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      Endoscopic ultrasound guided fine-needle aspiration cytology of pancreatic carcinoma : A 3-year experience and review of the literature (pages 362–369)

      Lourdes R. Ylagan, Steven Edmundowicz, Kay Kasal, Douglas Walsh and Danielle W. Lu

      Article first published online: 15 JUL 2002 | DOI: 10.1002/cncr.10759

      Endoscopic ultrasound-guided fine-needle aspiration biopsy is a viable technique in the procurement of cells for the diagnosis of pancreatic carcinoma. Using strict cytologic criteria in the evaluation of these samples can be both highly sensitive and specific in the diagnosis of ductal adenocarcinoma of the pancreas.

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      The clinical utility of the Das-1 monoclonal antibody in identifying adenocarcinoma of the colon metastatic to the liver in fine-needle aspiration tissue (pages 370–373)

      Robert L. Zimmerman, Kiron M. Das, Melissa A. Burke, Nancy A. Young, Charalambos C. Solomides and Marluce Bibbo

      Article first published online: 15 AUG 2002 | DOI: 10.1002/cncr.10882

      The Das-1 immunostain, directed against a colon specific antigen, is sensitive and highly specific for metastatic adenocarcinoma of the colon as diagnosed in fine-needle aspiration cell block material from the liver.

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      DNA image cytometry and fluorescence in situ hybridization for noninvasive detection of urothelial tumors in voided urine (pages 374–379)

      Peter Dalquen, Brigitte Kleiber, Bruno Grilli, Michelle Herzog, Lukas Bubendorf and Martin Oberholzer

      Article first published online: 9 OCT 2002 | DOI: 10.1002/cncr.10881

      The current study shows that both fluorescence in situ hybridization (FISH) and image cytometry (ICM) can successfully be used as supplementary methods to detect the most clinically relevant group of invasive bladder carcinomas. However, UroVysion™ FISH is more sensitive in the detection of pTa tumors than ICM is, as it recognizes individual chromosomal alterations that frequently prevail in urothelial tumors.

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