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Cancer

Cover image for Cancer

15 January 2003

Volume 97, Issue 2

Pages 343–525

  1. In Memoriam

    1. Top of page
    2. In Memoriam
    3. Original Articles
    4. Book Review
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      H. Preisler, M.D. : In memoriam (pages 343–344)

      Hagop M. Kantarjian and Emil J. Freireich

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11069

  2. Original Articles

    1. Top of page
    2. In Memoriam
    3. Original Articles
    4. Book Review
    1. Disease Site

      Breast Disease
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      Fourteen-gauge needle core biopsy of mammographically evident radial scars : Is excision necessary? (pages 345–351)

      Jennifer N. Cawson, Frank Malara, Anne Kavanagh, Prue Hill, Gnani Balasubramanium and Michael Henderson

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11070

      A sensitivity rate of 85% was demonstrated for stereotactic needle core biopsy followed by surgical biopsy as the gold standard performed in 54 patients who had radial scars.

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      Mammography screening matters for young women with breast carcinoma : Evidence of downstaging among 42–49-year-old women with a history of previous mammography screening (pages 352–358)

      Sandra Buseman, Judy Mouchawar, Ned Calonge and Tim Byers

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11050

      Two hundred forty-seven women diagnosed with breast carcinoma at ages 42–49 in a health maintenance organization were studied. Patients with a history of mammographic screening were more likely to be diagnosed at an early stage.

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      Sentinel lymph node versus axillary lymph node dissection for early-stage breast carcinoma : A comparison using a utility-adjusted number needed to treat analysis (pages 359–366)

      Ashesh B. Jani, Anirban Basu, Ruth Heimann and Samuel Hellman

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11081

      In the current study, the authors used the number needed to treat methodology to compare two treatment options for patients with early-stage breast carcinoma, sentinel lymph node dissection and axillary lymph node dissection.

    4. Chest
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      Primary germ cell tumors in the mediastinum : A 50-year experience at a single Japanese institution (pages 367–376)

      Shin-ichi Takeda, Shinichiro Miyoshi, Mitsunori Ohta, Masato Minami, Akira Masaoka and Hikaru Matsuda

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11068

      Our institutional experience indicates the benign nature of mediastinal mature teratomas and excellent prognosis for patients with seminomas after resection. An improved survival advantage was ensured with cisplatin-based preoperative chemotherapy in patients with nonseminomatous germ cell tumors.

    5. Genitourinary Disease
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      Health related quality of life in prostate carcinoma patients : A systematic review of randomized controlled trials (pages 377–388)

      Fabio Efficace, Andrew Bottomley and George van Andel

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11065

      A systematic review to evaluate quality of life in prostate carcinoma patients enrolled in randomized controlled clinical trials was undertaken. The study revealed a lack of a uniform approach to quality of life assessment and several methodologic limitations.

    6. Gynecologic Oncology
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      A review of p53 expression and mutation in human benign, low malignant potential, and invasive epithelial ovarian tumors (pages 389–404)

      Leanne M. Kmet, Linda S. Cook and Anthony M. Magliocco

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11064

      Although p53 overexpression and mutation are present in human epithelial ovarian tumors and the authors provided pooled estimates of their prevalence in the current review, it is their opinion that these results contribute little to the current understanding of the role these abnormalities play in the initiation and progression of ovarian carcinoma. Future studies will require innovative methods to address the limitations of many previous investigations.

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      Patterns of disease recurrence influenced by hematogenous tumor cell dissemination in patients with cervical carcinoma of the uterus (pages 405–411)

      Wolfgang Janni, Florian Hepp, Barbara Strobl, Brigitte Rack, Dorothea Rjosk, Christina Kentenich, Christian Schindlbeck, Peer Hantschmann, Klaus Pantel, Harald Sommer and Stephan Braun

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11066

      Twenty-nine percent of patients with cervical carcinoma present with evidence of isolated tumor cells in the bone marrow at the time of primary diagnosis. These patients face a reduced distant disease-free survival rate compared with patients with negative bone marrow status as demonstrated by multivariate analysis.

    8. Head and Neck Disease
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      Docetaxel, cisplatin, and 5-fluorouracil-based induction chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck : The Dana Farber Cancer Institute experience (pages 412–418)

      Robert Haddad, A. Dimitrios Colevas, Roy Tishler, Paul Busse, Laura Goguen, Christopher Sullivan, Charles M. Norris, Bernadette Lake-Willcutt, Mary Ann Case, Rosemary Costello and Marshall Posner

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11063

      Induction chemotherapy with taxotere, cisplatin, and 5-fluorouracil followed by hyperfractionated radiotherapy is highly effective in the treatment of patients with head and neck carcinoma. After a median follow-up of more than 4 years (49 months), 65 of 101 patients (64%) remain alive with no evidence of disease.

    9. Hematologic Malignancies
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      Ciprofloxacin prophylaxis in patients with acute leukemia and granulocytopenia in an area with a high prevalence of ciprofloxacin-resistant Escherichia coli (pages 419–424)

      Lucia Gomez, Javier Garau, Cristina Estrada, Montserrat Marquez, David Dalmau, Mariona Xercavins, Josep Maria Martí and Cristina Estany

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11044

      The authors analyzed clinical and microbiologic outcomes of 144 episodes of febrile neutropenia in adult patients with acute leukemia. Forty-three consecutive episodes occurred in patients who were on ciprofloxacin prophylaxis during 1993–1996 (ciprofloxacin group), and 101 subsequent episodes occurred in patients who were not exposed to ciprofloxacin prophylaxis (control group). The rate of bacteremia was similar (12 of 43 patients [28%] vs. 26 of 101 patients [(26%], respectively). Resistance to fluoroquinolones was higher in Escherichia coli blood isolates from patients in the ciprofloxacin group (7 of 8 patients vs. 2 of 9 patients; P = 0.02). These results suggest that fluoroquinolone prophylaxis in patients with febrile neutropenia may be abandoned safely in areas with a high prevalence of ciprofloxacin-resistant enterobacteria.

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      Cancer in Fanconi anemia, 1927–2001 (pages 425–440)

      Blanche P. Alter

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11046

      Patients with Fanconi anemia (FA) have a very high risk of leukemia and an even higher risk of specific types of solid tumors (aerodigestive and gynecologic carcinomas) that occur at younger ages than in the general population. Cancer is a much more important outcome than bone marrow failure in older patients with this autosomal recessive inherited bone marrow failure syndrome.

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      The prognostic significance of bone marrow levels of neurofibromatosis-1 protein and ras oncogene mutations in patients with acute myeloid leukemia and myelodysplastic syndrome (pages 441–449)

      Di Lu, Randa Nounou, Miloslav Beran, Elihu Estey, Taghi Manshouri, Hagop Kantarjian, Michael J. Keating and Maher Albitar

      Article first published online: 15 JAN 2003 | DOI: 10.1002/cncr.11037

      Ras oncogene and neurofibromatosis (NF) gene overlap in activating the Ras-GTP pathway. Both can be abnormal in acute myeloid leukemia (AML) and myelodysplastic syndrome. Patients with Ras mutations do not have NF1 abnormalities, and vice versa. Patients who have AML with either a Ras mutation or an NF1 abnormality had remissions of greater duration.

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      Liposomal amphotericin B versus the combination of fluconazole and itraconazole as prophylaxis for invasive fungal infections during induction : Chemotherapy for patients with acute myelogenous leukemia and myelodysplastic syndrome (pages 450–456)

      Gloria N. Mattiuzzi, Elihu Estey, Issam Raad, Francis Giles, Jorge Cortes, Yu Shen, Dimitrios Kontoyiannis, Charles Koller, Mark Munsell, Miloslav Beran and Hagop Kantarjian

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11094

      Fungal infections are a major cause of mortality in patients with acute leukemia. Antifungal prophylaxis may prevent this type of complications and reduce mortality in patients with acute leukemia.

    13. Lung Disease
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      Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma (pages 457–464)

      Mitsuyuki Arinaga, Tsuyoshi Noguchi, Shinsuke Takeno, Masao Chujo, Takashi Miura and Yuzo Uchida

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11073

      Patients who showed positive staining for vascular endothelial growth factor C showed significantly unfavorable survival compared with patients who showed negative staining. Vascular endothelial growth factor receptor 3 expression was an independent negative prognostic factor for nonsmall cell lung carcinoma.

    14. Melanoma
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      A prognostic model and staging for metastatic uveal melanoma (pages 465–475)

      Sebastian Eskelin, Seppo Pyrhönen, Marjo Hahka-Kemppinen, Seppo Tuomaala and Tero Kivelä

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11113

      This study categorized patients who would normally be eligible for chemotherapy into three groups based on predicted median overall survival adjusted for confounding effect of time on chemotherapy. The working formulation can be tested as a guide in estimating overall survival in clinical practice and in treatment trials.

    15. Neuro-Oncology
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      Clinical outcome and survival after palliative surgery for spinal metastases : Palliative surgery in spinal metastases (pages 476–484)

      Hiroki Hirabayashi, Sohei Ebara, Tetsuya Kinoshita, Yohei Yuzawa, Isao Nakamura, Jun Takahashi, Mikio Kamimura, Kuniyoshi Ohtsuka and Kunio Takaoka

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11039

      By multivariate analysis, the site of the primary tumor and postoperative ambulatory function were found to independently influence survival after surgery for metastatic spinal tumor. When ambulation is attained after surgery, it can be preserved until late in remaining life for unfavorable as well as favorable primary tumor sites. Palliative surgery for spinal metastasis can improve both quality and quantity of life.

    16. Sarcoma
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      The influence of anatomic location on outcome in patients with soft tissue sarcoma of the extremity (pages 485–492)

      Craig H. Gerrand, Robert S. Bell, Jay S. Wunder, Rita A. Kandel, Brian O'Sullivan, Charles N. Catton, Anthony M. Griffin and Aileen M. Davis

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11076

      The anatomic location of an extremity soft tissue sarcoma determines the patient's presentation, treatment, and management. Local recurrence is more frequent after the treatment of upper extremity soft tissue sarcomas, and metastasis is more frequent in the lower extremity.

    17. Discipline

      Epidemiology
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      Racial differences in the outcome of patients with colorectal carcinoma (pages 493–498)

      Rangaswamy Govindarajan, Rajesh V. Shah, Linda G. Erkman and Laura F. Hutchins

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11067

      African Americans with colorectal carcinoma have a worse prognosis compared with Caucasians. Radiation and chemotherapy are used less frequently among African Americans than among Caucasians. Causes other than socioeconomic factors and education may account for this disparity.

    18. Pathology
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      Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions : A report on 18 patients (pages 499–507)

      Lyndon D. Su, Douglas R. Fullen, Vernon K. Sondak, Timothy M. Johnson and Lori Lowe

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11074

      Histologically atypical or borderline spitzoid melanocytic tumors are a distinct subset of diagnostically challenging and controversial melanocytic lesions, some of which represent unrecognized melanomas. Sentinel lymph node biopsy aids in confirming a diagnosis of melanoma and identifies those patients who may benefit from early therapeutic lymph node dissection and/or adjuvant therapy.

    19. Pediatric Oncology
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      A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line who are treated with L-asparaginase : Results of the Prophylactic Antithrombin Replacement in Kids with Acute Lymphoblastic Leukemia Treated with Asparaginase (PARKAA) Study (pages 508–516)

      Lesley G. Mitchell and and the PARKAA Group

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11042

      The objective of this study was to determine the prevalence of thrombosis in children with acute lymphoblastic leukemia who are treated with L-asparaginase. Results of the study show that there is a clinically significant prevalence of thrombosis (36.7%; 95% confidence interval, 24.4–48.8%) in these patients.

    20. Radiation Oncology
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      Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma (pages 517–524)

      Christopher H. Crane, John M. Skibber, Barry W. Feig, Jean-Nicolas Vauthey, Howard D. Thames, Steve A. Curley, Miguel A. Rodriguez-Bigas, Robert A. Wolff, Lee M. Ellis, Marc E. Delclos, Edward H. Lin and Nora A. Janjan

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11075

      The current article investigates the relationship between objective tumor response and the use of sphincter-preserving surgery among patients receiving preoperative chemoradiation. The findings indicate that clinical response independently increases the use of sphincter-preserving surgery among patients with low rectal carcinoma.

  3. Book Review

    1. Top of page
    2. In Memoriam
    3. Original Articles
    4. Book Review
    1. You have free access to this content
      Book review (page 525)

      Saul Suster

      Article first published online: 3 JAN 2003 | DOI: 10.1002/cncr.11071

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