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Cancer

Cover image for Cancer

1 February 2003

Volume 97, Issue 3

Pages 527–717

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. Disease Site

      Breast Disease
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      Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma : 10-Year follow-up data (pages 527–536)

      John R. Goffin, Pierre O. Chappuis, Louis R. Bégin, Nora Wong, Jean-Sébastien Brunet, Nancy Hamel, Ann-Josée Paradis, Jeff Boyd and William D. Foulkes

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11080

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      Breast carcinoma patients with germline BRCA1 mutations and p53 overexpression have a poor prognosis in breast cancer. Lymph node-negative women carrying BRCA1 mutations have a particularly poor outcome. This may be due to the less frequent use of adjuvant therapy in lymph node-negative women.

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      A Phase II trial of docetaxel and estramustine in patients with refractory metastatic breast carcinoma (pages 537–544)

      Amy D. Tiersten, Caron Nelsen, Susan Talbot, Linda Vahdat, Robert Fine, Andrea Troxel, Lois Brafman, Laureen Shriberg, Karen Antman and Daniel P. Petrylak

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11082

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      The combination of docetaxel and estramustine in patients with refractory metastatic breast carcinoma lead to an overall response rate of 29% and a median overall survival of 17 months despite the heavily pretreated patient population that was studied. Quality of life was maintained, with 75% of patients experiencing either an improvement or no change in quality of life.

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      Survival of patients with metastatic breast carcinoma : Importance of prognostic markers of the primary tumor (pages 545–553)

      Jenny Chang, Gary M. Clark, D. Craig Allred, Syed Mohsin, Gary Chamness and Richard M. Elledge

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11083

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      The authors tested the hypothesis that the characteristics of primary breast tumors are important determinants of prognosis and survival in patients with metastatic breast carcinoma. They found that biologic features of the primary tumor are correlated independently with outcome after first recurrence and can be used as indicators of prognosis in the metastatic setting.

    4. Endocrine Disease
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      Radiofrequency ablation of adrenal tumors and adrenocortical carcinoma metastases (pages 554–560)

      Bradford J. Wood, Jame Abraham, Julia L. Hvizda, H. Richard Alexander and Tito Fojo

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11084

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      Percutaneous, image-guided radiofrequency ablation is a safe and well tolerated procedure for the treatment of unresectable primary or metastatic adrenocortical carcinoma. It is effective for the short-term local control of small adrenal tumors, and is most effective for tumors less than 5 cm.

    5. Genitourinary Disease
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      Phase II trial of cyclophosphamide, vincristine, and dexamethasone in the treatment of androgen-independent prostate carcinoma (pages 561–567)

      Danai D. Daliani, Vasily Assikis, Shi-Ming Tu, Christos N. Papandreou, Lance C. Pagliaro, Tammy Holtkamp, Xumei Wang, Peter F. Thall and Christopher J. Logothetis

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11078

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      Cyclophosphamide, vincristine, dexamethasone (CVD) chemotherapy is a nontoxic combination that was found to produce a prostate specific antigen (PSA) decline of ≥ 50% in 29% of patients with androgen-independent prostate carcinoma (AI-PCa) associated with 25% measurable disease response. It is an alternative treatment option for patients who have failed or cannot tolerate estramustine-containing chemotherapy.

    6. Gynecologic Oncology
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      Prognostic factors in neuroendocrine small cell cervical carcinoma : A multivariate analysis (pages 568–574)

      John K. Chan, Vera Loizzi, Robert A. Burger, Joanne Rutgers and Bradley J. Monk

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11086

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      Smoking and advanced stage are poor prognostic factors for survival in patients with neuroendocrine tumors of the cervix. Only those with early lesions amenable to extirpation reportedly are cured.

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      R-Ras promotes tumor growth of cervical epithelial cells (pages 575–585)

      Héctor Rincón-Arano, Ricardo Rosales, Nancy Mora, Armando Rodriguez-Castañeda and Carlos Rosales

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11093

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      C33A human cervical epithelium cells transfected with an active R-Ras oncogene had a higher growth rate in nude mice compared with control cells. Cells with active R-Ras also had increased phosphatidylinositol-3-kinase (PI 3-K) activity but showed no increase in extracellular signal-regulated kinase activity. Thus, R-Ras promotes tumor growth through a pathway that involves PI 3-K.

    8. Hematologic Malignancies
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      Frequency of gastrointestinal involvement and its clinical significance in mantle cell lymphoma (pages 586–591)

      Jorge E. Romaguera, L. Jeffrey Medeiros, Frederick B. Hagemeister, Luis E. Fayad, Maria A. Rodriguez, Barbara Pro, Anas Younes, Peter McLaughlin, Andre Goy, Andreas H. Sarris, Nan H. Dang, Felipe Samaniego, H. M. Brown, Harish K. Gagneja and Fernando Cabanillas

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11096

      In a prospective endoscopic study, the authors found that patients with mantle cell lymphoma (MCL) have a high frequency of gastrointestinal tract involvement. The authors suggest that MCL homes to this anatomic site. Intensive endoscopic surveillance was found to have little impact on the management of MCL patients in the current study.

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      Treatment options for patients with acute myeloid leukemia with a matched sibling donor : A decision analysis (pages 592–600)

      Lillian Sung, Rena Buckstein, John J. Doyle, Michael Crump and Allan S. Detsky

      Version of Record online: 23 JAN 2003 | DOI: 10.1002/cncr.11098

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      Using decision analysis, consolidation strategies for patients with acute myeloid leukemia with matched sibling donors were examined. The strategy associated with the highest expected quality-adjusted life years was chemotherapy alone for patients who had favorable cytogenetics and allogeneic bone marrow transplantation for patients who had nonfavorable cytogenetics.

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      Fluorescence in situ hybridization analysis of aneuploidization patterns in monoclonal gammopathy of undetermined significance versus multiple myeloma and plasma cell leukemia (pages 601–609)

      Rasillo Ana, Tabernero María Dolores, Sánchez María Luz, Pérez de Andrés Martín, Martín Ayuso Marta, Hernández José, Moro María Jesús, Fernández-Calvo Javier, Sayagués José María, Bortoluci Aglae, San Miguel Jesús Fernando and Orfao Alberto

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11100

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      Monoclonal gammopathy of undetermined significance (MGUS) patients were found to have a high incidence of numerical abnormalities of chromosomes 6, 9, 13, and 17. The cytogenetic patterns observed in the aneuploid plasma cell clones from MGUS patients were frequently found to be different from those observed in multiple myeloma and plasma cell leukemia patients.

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      Cytotoxic/natural killer cell cutaneous lymphomas : Report of the EORTC Cutaneous Lymphoma Task Force Workshop (pages 610–627)

      Marco Santucci, Nicola Pimpinelli, Daniela Massi, Marshall E. Kadin, Chris J. L. M. Meijer, Hans Konrad Müller-Hermelink, Marco Paulli, Janine Wechsler, Rein Willemze, Heike Audring, Maria Grazia Bernengo, Lorenzo Cerroni, Sergio Chimenti, Andreas Chott, José L. Díaz-Pérez, Edgard Dippel, Lyn M. Duncan, Alfred C. Feller, Marie-Louise Geerts, Christian Hallermann, Werner Kempf, Robin Russell-Jones, Christian Sander and Emilio Berti

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11107

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      Primary cutaneous lymphomas expressing the cytotoxic granule-associated protein (TIA-1) and/or the natural killer cell marker (CD56) include distinct groups of diseases, both clinically and biologically.

    12. Melanoma
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      Moderate sun exposure and nevus counts in parents are associated with development of melanocytic nevi in childhood : A risk factor study in 1812 kindergarten children (pages 628–638)

      Tine Sander Wiecker, Heike Luther, Petra Buettner, Jürgen Bauer and Claus Garbe

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11114

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      Children of parents with high nevus counts were found to develop significantly higher numbers of melanocytic nevi and, therefore, are at increased risk for cutaneous melanoma. Sun holidays and even moderate sun exposure have been identified as the major risk factors for melanocytic nevus growth.

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      A population-based analysis of risk factors for a second primary cutaneous melanoma among melanoma survivors (pages 639–643)

      William B. Goggins and Hensin Tsao

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11116

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      Using data from the U.S. Surveillance, Epidemiology, and End Results cancer registries, the current study examined overall risk of, and patient-specific risk factors for, a second primary melanoma in melanoma survivors. The estimated cumulative probability of a second primary melanoma was 2.06% at 5 years and 3.17% at 10 years, with males; older patients; patients with face, neck, or trunk melanomas; and more recently diagnosed patients having significantly higher risks.

    14. Neuro-Oncology
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      Low expression of p27 indicates a poor prognosis in patients with high-grade astrocytomas (pages 644–648)

      Ruut M. Kirla, Hannu K. Haapasalo, Hannu Kalimo and Eeva K. Salminen

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11079

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      Immunohistochemically detectable p27 has independent prognostic value in patients with malignant astrocytomas, with low expression levels of p27 indicating poor survival.

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      The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence (pages 649–656)

      Carol L. Armstrong, Bram Goldstein, David Shera, George E. Ledakis and Emily M. Tallent

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11099

      Two neurocognitive methods to predict the growth or recurrence of low-grade brain tumors were compared in a study to identify a method for earlier tumor detection and control. Results showed that although brain tumors are associated with highly variable cognitive impairments, a tumor-specific model was superior to a general model in predicting tumor growth prior to clinically scheduled magnetic resonance imaging scans.

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      A prospective study on glioblastoma in the elderly (pages 657–662)

      Alba A. Brandes, Francesca Vastola, Umberto Basso, Franco Berti, Giampietro Pinna, Antonino Rotilio, Marina Gardiman, Renato Scienza, Silvio Monfardini and Mario Ermani

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11097

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      The role of chemotherapy for glioblastoma in elderly patients is still undefined. In the authors' experience, adjuvant chemotherapy with temozolomide can be administered safely after radiotherapy in elderly patients and appears to improve the time to disease progression compared with radiotherapy alone and radiotherapy plus PCV.

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      Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors : Childhood Cancer Survivor Study (pages 663–673)

      James G. Gurney, Nina S. Kadan-Lottick, Roger J. Packer, Joseph P. Neglia, Charles A. Sklar, Judy A. Punyko, Marilyn Stovall, Yutaka Yasui, H. Stacy Nicholson, Suzanne Wolden, Dawn E. McNeil, Ann C. Mertens and Leslie L. Robison

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11095

      In this epidemiologic follow-up study of 1607 young adult survivors of childhood brain cancer, the authors quantify risk of adverse endocrine and cardiovascular late effects as a function of treatment.

    18. Discipline

      Epidemiology
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      Health-related quality of life of cancer and noncancer patients in Medicare managed care (pages 674–681)

      Frank Baker, Samuel C. Haffer and Maxine Denniston

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11085

      Cancer survivors in Medicare managed care surveyed by the Health Care Financing Administration in 1998 had lower health-related quality-of-life scores on all 10 scales of the Medical Outcomes Study Short Form-36 than a frequency aged-matched sample of noncancer patients. Differences in quality of life by type of cancer currently under treatment are being used by the American Cancer Society for planning improvement of the quality of life of cancer survivors.

    19. Pathology
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      Titration of serum p53 antibodies in 1085 patients with various types of malignant tumors : A multiinstitutional analysis by the Japan p53 antibody research group (pages 682–689)

      Hideaki Shimada, Takenori Ochiai and Fumio Nomura

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11092

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      This article describes the development of a new enzyme-linked immunosorbent assay kit for detecting serum p53 antibodies and the impact of serum p53 antibody surveillance in 1085 patients with various types of tumors.

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      Detection of chromosomal aneusomy by fluorescence in situ hybridization for patients with nipple discharge (pages 690–694)

      Daigo Yamamoto, Hideto Senzaki, Hiroyuki Nakagawa, Homa Okugawa, Hideki Gondo and Kanji Tanaka

      Version of Record online: 23 JAN 2003 | DOI: 10.1002/cncr.11091

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      Fluorescene in situ hybridization has 100% specificity in diagnosing patients with indeterminate cytologic results.

    21. Pediatric Oncology
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      Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia (pages 695–702)

      Guillermo Garcia-Manero, Sima Jeha, Jerry Daniel, Jason Williamson, Maher Albitar, Hagop M. Kantarjian and Jean-Pierre J. Issa

      Version of Record online: 23 JAN 2003 | DOI: 10.1002/cncr.11090

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      The methylation status of seven promoter-associated cytosine-guanine (CpG) islands was studied in pediatric patients with acute lymphocytic leukemia. The methylation pattern observed did not differ from that of a previously studied adult group, indicating that differences in DNA methylation do not account for the prognostic differences that characterize both age groups.

    22. Translational Research
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      Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas (pages 703–713)

      Enjing Jin, Masakazu Fujiwara, Xin Pan, Mohammad Ghazizadeh, Satoru Arai, Yoshiharu Ohaki, Keiko Kajiwara, Tamiko Takemura and Oichi Kawanami

      Version of Record online: 23 JAN 2003 | DOI: 10.1002/cncr.11087

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      Proliferation of alveolar capillary endothelial cells is initialized by protease-activated receptor activation with serum thrombin and neoplastic cell-released trypsin.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. You have free access to this content
      Breast carcinoma in women age 25 years or less (page 714)

      Selda Tez and Cenap Dener

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11112

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      Author reply (page 715)

      Nicholas Beechey-Newman and Ashutosh S. Kothari

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11088

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      Multicentric mammary carcinoma : Evidence of monoclonal proliferation (pages 715–717)

      Manuel R. Teixeira, Nikos Pandis and Sverre Heim

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11109

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      Author reply (page 717)

      Lavinia P. Middleton, S. Eva Singletary and Aysegul A. Sahin

      Version of Record online: 17 JAN 2003 | DOI: 10.1002/cncr.11089

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