You have full text access to this OnlineOpen article

Cancer

Cover image for Cancer

15 February 2003

Volume 97, Issue 4

Pages 893–1137

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Errata
    1. Disease Site

      Breast Disease
      You have full text access to this OnlineOpen article
      Compliance with breast-conservation standards for patients with early-stage breast carcinoma (pages 893–904)

      Julia White, Monica Morrow, Jennifer Moughan, Jean Owen, Thomas Pajak, Susan DesHarnais, David P. Winchester and J. Frank Wilson

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11141

      A population of 16,643 analyzable patients with early-stage breast carcinoma submitted from cancer registries were studied to determine the compliance rate, to established practice standards for breastconserving therapy and to discern whether treatment compliance varied by patient or by hospital factors. Compliance was ≥80% for 16 of 22 standards studied, with significant variation across the type of hospital cancer program and geographic location. Six standards had poor compliance and represent a need for targeted physician education.

    2. You have full text access to this OnlineOpen article
      Breast boost: Are we missing the target? : A dosimetric comparison of two boost techniques (pages 905–909)

      Rashmi K. Benda, Gopika Yasuda, Anil Sethi, Sheryl G.A. Gabram, Russell W. Hinerman and Nancy Price Mendenhall

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11142

      Randomized trials have shown improved local control with the use of a breast boost for patients given breast-conserving treatment for breast carcinoma. Although the use of a breast boost is routine practice, no standard technique has been established. The authors compared the commonly used clinical technique with a technique based on computed tomography (CT) imaging of the tumor bed.

    3. You have full text access to this OnlineOpen article
      Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy? (pages 910–919)

      Frank A. Vicini, Larry Kestin, Raywin Huang and Alvaro Martinez

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11143

      In patients with early-stage breast carcinoma who underwent breast-conserving surgery (macroscopic total resection of the primary tumor with a variable rim of uninvolved breast tissue) and received postoperative radiotherapy, the authors found that local recurrence may have been responsible for an increase the incidence of in distant metastases and disease specific mortality.

    4. You have full text access to this OnlineOpen article
      Electronic support groups for breast carcinoma : A clinical trial of effectiveness (pages 920–925)

      Morton A. Lieberman, Mitch Golant, Janine Giese-Davis, Andy Winzlenberg, Harold Benjamin, Keith Humphreys, Carol Kronenwetter, Stefani Russo and David Spiegel

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11145

      In a study of breast carcinoma patients participating in professionally led Internet chat rooms, the authors found significant pregroup and postgroup changes, reduced depression (according to the Center for Epidemiologic Studies-Depression [CES-D] scale), and reactions to pain. These patients also demonstrated a trend toward an increase in the Posttraumatic Growth Inventory on two subscales: New Possibilities and Spirituality.

    5. You have full text access to this OnlineOpen article
      Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy (pages 926–933)

      Funda Meric, Nadeem Q. Mirza, Georges Vlastos, Thomas A. Buchholz, Henry M. Kuerer, Gildy V. Babiera, S. Eva Singletary, Merrick I. Ross, Frederick C. Ames, Barry W. Feig, Savitri Krishnamurthy, George H. Perkins, Marsha D. McNeese, Eric A. Strom, Vicente Valero and Kelly K. Hunt

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11222

      A review of 1043 consecutive patients with Stage I and II breast carcinoma treated with breast-conserving surgery followed by radiation therapy showed that positive surgical margins and ipsilateral breast tumor recurrence were predictors of systemic recurrence and disease-specific survival. Aggressive local therapy is necessary to ensure adequate surgical margins and minimize ipsilateral breast tumor recurrence.

    6. Endocrine Disease
      You have full text access to this OnlineOpen article
      A 5-decade analysis of 13,715 carcinoid tumors (pages 934–959)

      Irvin M. Modlin, Kevin D. Lye and Mark Kidd

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11105

      Analysis of the largest known accumulation of carcinoid tumors reveals changing trends in the incidence of these tumors in sites such as the stomach and the appendix. Examination of incidence by race and gender suggests a genetic predisposition for carcinoid tumors at certain sites within certain groups.

    7. Gastrointestinal Disease
      You have full text access to this OnlineOpen article
      Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma : A role for the host response in prognosis (pages 960–968)

      Alok A. Khorana, Charlotte K. Ryan, Christopher Cox, Shirley Eberly and Deepak M. Sahasrabudhe

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11152

      In the current study, vascular endothelial growth factor-expressing tumor-associated macrophages were found to be predictive of improved survival in patients with American Joint Committee on Cancer Stage II and Stage III colon carcinoma, suggesting a role for the host response in prognosis. Epidermal growth factor receptor (EGFR) overexpression in tumors may be associated with worsened survival, providing a rationale for adjuvant trials of anti-EGFR therapies.

    8. Genitourinary Tract
      You have full text access to this OnlineOpen article
      Quantitative biopsy pathology for the prediction of pathologically organ-confined prostate carcinoma : A multiinstitutional validation study (pages 969–978)

      Alexander Haese, Manisha Chaudhari, M. Craig Miller, Jonathan I. Epstein, Hartwig Huland, Juri Palisaar, Markus Graefen, Peter Hammerer, Edward C. Poole, Gerard J. O'Dowd, Alan W. Partin and Robert W. Veltri

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11153

      The authors present a validation for the prediction of pathologically organ-confined prostate carcinoma based on the comparative performance of two computational models, one utilizing ordinal logistic regression and the other using a modified error back-propagation neural network. This validated predictive staging tool provides important information for the more accurate selection of candidates with clinically localized prostate carcinoma for therapy.

    9. You have full text access to this OnlineOpen article
      Long-term outcomes after treatment with external beam radiation therapy and palladium 103 for patients with higher risk prostate carcinoma : Influence of prostatic acid phosphatase (pages 979–983)

      Michael Dattoli, Kent Wallner, Lawrence True, Jennifer Cash and Richard Sorace

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11154

      One hundred sixty-one consecutive patients with prostate carcinoma who had Gleason scores ≥ 7 and/or prostate specific antigen levels > 10 ng/mL were treated with 41-gray external beam radiation therapy to a limited pelvic field followed 4 weeks later by a palladium 103 boost. The biochemical cure rate was remarkably high. The prostatic acid phosphatase (PAP) level was the strongest predictor of long-term biochemical failure in patients with otherwise higher risk features reported here, suggesting that it may be a more accurate indicator of micrometastatic disease. This report adds to the rational for reintroducing the measurement of PAP into general practice.

    10. You have full text access to this OnlineOpen article
      Syndromic aspects of testicular carcinoma (pages 984–992)

      Martijn F. Lutke Holzik, Rolf H. Sijmons, Dirk T. Sleijfer, Dirk J. A. Sonneveld, Josette E. H. M. Hoekstra-Weebers, Jannie van Echten-Arends and Harald J. Hoekstra

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11155

      In patients with hereditary or constitutional chromosomal anomalies, testicular carcinoma can develop sporadically or on the basis of an underlying hereditary genetic defect. A total of 25 different disorders were found of hereditary or syndromic abnormalities in patients who developed seminomatous or nonseminomatous testicular carcinoma.

    11. You have full text access to this OnlineOpen article
      Evaluation of an instrument to assess the needs of men diagnosed with prostate carcinoma : An assessment of the validity and reliability of a self-administered questionnaire developed to measure the needs experienced by men diagnosed with prostate carcinoma (pages 993–1001)

      Janine M. Duke, Carla J. Treloar and Julie E. Byles

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11156

      The results of this study provide empiric evidence of the reliability, validity, and acceptability of the Prostate Cancer Needs Questionnaire (PCNQv1.1) constructed to assess the needs of men diagnosed with prostate carcinoma. The information gained from use of the PCNQv1.1 allows clinicians and heath service providers an opportunity to better understand and meet the needs of men diagnosed with prostate carcinoma.

    12. Gynecologic Oncology
      You have full text access to this OnlineOpen article
      Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma (pages 1002–1009)

      Tsuyoshi Saito, Makoto Nishimura, Hiroshi Yamasaki and Ryuichi Kudo

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11157

      In the current study, the authors analyzed the methylation status and immunohistochemical expression of E-cadherin in 142 endometrial tissues: 21 normal endometria, 17 endometrial hyperplasias, and 104 endometrial carcinomas. In endometrial carcinoma, the positive ratio of methylation was higher and was associated with tumor dedifferention and myometrial invasion. The evidence suggests that methylation of the E-cadherin gene occurs in association with the acquisition of invasive capacity.

    13. Head and Neck Disease
      You have full text access to this OnlineOpen article
      Characterization of laryngopharyngeal reflux in patients with premalignant or early carcinomas of the larynx (pages 1010–1014)

      Jan S. Lewin, Ann M. Gillenwater, J. David Garrett, Julie K. Bishop-Leone, Dominic D. Nguyen, David L. Callender, Gregory D. Ayers and Jeffrey N. Myers

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11158

      An association between laryngeal carcinoma and laryngopharyngeal reflux (LPR) has been suggested but not proven. Twenty-four hour pH monitoring revealed an 85% incidence of LPR in a cohort of patients with premalignant and early carcinomatous lesions of the larynx. LPR did not correlate with histologic classification, smoking status, or symptoms of heartburn, and occurred most commonly in the upright body position. A matched-control study is needed as the next step in evaluating LPR as a potential predisposing factor for laryngeal carcinoma.

    14. You have full text access to this OnlineOpen article
      Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma (pages 1015–1024)

      Martin Kunkel, Torsten E. Reichert, Peter Benz, Hans-Anton Lehr, Jong-Hyeon Jeong, Samuel Wieand, Peter Bartenstein, Wilfried Wagner and Theresa L. Whiteside

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11159

      A definition of the glycolytic tumor phenotype by immunohistology (Glut-1 expression) and labeled glucose uptake has a significant prognostic value in patients with oral squamous cell carcinoma.

    15. Hematologic Malignancies
      You have full text access to this OnlineOpen article
      Refractory Aspergillus pneumonia in patients with acute leukemia : Successful therapy with combination caspofungin and liposomal amphotericin (pages 1025–1032)

      Timothy B. Aliff, Peter G. Maslak, Joseph G. Jurcic, Mark L. Heaney, Kathleen N. Cathcart, Kent A. Sepkowitz and Mark A. Weiss

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11115

      In the current study, the authors conducted a retrospective analysis to investigate the safety and effectiveness of combination caspofungin and amphotericin in patients with amphotericin-refractory fungal infections that complicated hematologic malignancies. This novel antifungal combination was well tolerated in this high-risk population and may possess significant efficacy that warrants further clinical evaluation.

    16. You have full text access to this OnlineOpen article
      Complete cytogenetic and molecular responses to interferon-α-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis (pages 1033–1041)

      Hagop M. Kantarjian, Susan O'Brien, Jorge E. Cortes, Jianqin Shan, Francis J. Giles, Mary Beth Rios, Stefan H. Faderl, William G. Wierda, Alessandra Ferrajoli, Srdan Verstovsek, Michael J. Keating, Emil J. Freireich and Moshe Talpaz

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11223

      Few data are available regarding the long-term prognosis of patients with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) who are able to achieve a complete cytogenetic response after treatment with interferon-α. In the current study, the authors analyzed patients with Ph-positive, early chronic-phase CML who were treated with interferon-based therapies. They observed that complete cytogenetic or molecular response on interferon-α therapy was associated with excellent long-term prognosis.

    17. Hepatobiliary Tract
      You have full text access to this OnlineOpen article
      Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma (pages 1042–1050)

      Osama M. Ebied, Michael P. Federle, Brian I. Carr, Karen M. Pealer, Wei Li, Nikhil Amesur and Albert Zajko

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11111

      Transcatheter arterial chemoembolization results in improved survival among patients with hypervascular tumors and hepatocellular carcinoma. However, even patients classified by computed tomographic scan as hypervascular nonresponders and hypovascular responders have improved survival.

    18. You have full text access to this OnlineOpen article
      Angiographic subsegmentectomy for the treatment of patients with small hepatocellular carcinoma (pages 1051–1056)

      Shozo Iwamoto, Hayato Sanefuji and Kunio Okuda

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11106

      A new nonsurgical angiographic subsegmentectomy was performed in 23 patients with hepatocellular carcinoma (< 20 mm) with success. It involves induction of infarct necrosis by occluding the feeding artery with gel particles and the portal vein by regurgitated excess lipiodol-farmorubicin.

    19. Lung Disease
      You have full text access to this OnlineOpen article
      Detection of tumor specific gene expression in bone marrow and peripheral blood from patients with small cell lung carcinoma (pages 1057–1062)

      Masato Shingyoji, Yuichi Takiguchi, Reiko Watanabe, Kenzo Hiroshima, Ken Motoori, Katsushi Kurosu, Yasunori Kasahara, Nobuhiro Tanabe, Koichiro Tatsumi and Takayuki Kuriyama

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11108

      Tumor specific gene expressions were detected by reverse transcriptase polymerase chain reaction in peripheral blood and bone marrow aspirate from patients with small cell lung carcinoma. Prepro-gastrin-releasing peptide expression in bone marrow was related to poor patient prognosis.

    20. Neuro-Oncology
      You have full text access to this OnlineOpen article
      Prognostic implication of clinical, radiologic, and pathologic features in patients with anaplastic gliomas (pages 1063–1071)

      Avelina Tortosa, Núria Viñolas, Salvador Villà, Eugènia Verger, Juan M. Gil, Marta Brell, Lluís Caral, Teresa Pujol, Juan J. Acebes, Teresa Ribalta, Isidre Ferrer and Francesc Graus

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11120

      Computed tomographic scan ring enhancement, age, Karnofsky performance status score and proliferation index are independent prognostic factors in patients with anaplastic glioma. In addition, the presence of oligodendroglial features might have predictive value in these patients.

    21. You have full text access to this OnlineOpen article
      Primitive neuroectodermal tumors in the central nervous system following cranial irradiation : A report of four cases (pages 1072–1076)

      Walter J. Hader, Katerina Drovini-Zis and John A. Maguire

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11121

      The development of primitive neuroectodermal tumors in the central nervous system is possible after cranial irradiation and therefore should be considered in the differential diagnosis of an irradiation-induced neoplasm.

    22. You have full text access to this OnlineOpen article
      Expression of survivin in astrocytic tumors : Correlation with malignant grade and prognosis (pages 1077–1083)

      Yoshinori Kajiwara, Fumiyuki Yamasaki, Seiji Hama, Kaita Yahara, Hiroyuki Yoshioka, Kazuhiko Sugiyama, Kazunori Arita and Kaoru Kurisu

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11122

      The expression of survivin significantly correlates with malignant grade and prognosis of astrocytic tumors.

    23. You have full text access to this OnlineOpen article
      Survival and functional outcome of children with hypothalamic/chiasmatic tumors (pages 1084–1092)

      Maryam Fouladi, Dana Wallace, James W. Langston, Raymond Mulhern, Susan R. Rose, Amar Gajjar, Robert A. Sanford, Thomas E. Merchant, Jesse J. Jenkins, Larry E. Kun and Richard L. Heideman

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11119

      The current study reports the impact of clinical parameters and primary therapy on overall (OS) and progression-free (PFS) survival and neuroendocrine and neurocognitive outcome in 73 children with hypothalamic and/or chiasmatic tumors. We found that the presence of intracranial NF1 lesions and initial treatment with radiation are positive predictors of PFS. Initial observation in relatively asymptomatic patients does not affect OS. Mean intelligence quotient score, although significantly compromised at diagnosis, does not change over time or with irradiation.

    24. You have full text access to this OnlineOpen article
      Stereotactic linear accelerater-based radiosurgery for the treatment of patients with glomus jugulare tumors (pages 1093–1098)

      Mohammad Maarouf, Jürgen Voges, Peter Landwehr, Rainer Bramer, Harald Treuer, Martin Kocher, Rolf-Peter Müller and Volker Sturm

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11118

      Fourteen patients with glomus jugulare tumors (GJT) were treated with stereotactic linear accelerator-based radiosurgery. The method is well suited for the management of patients with GJT and provides a viable alternative to surgery and fractionated radiotherapy.

    25. Discipline

      Epidemiology
      You have full text access to this OnlineOpen article
      Recent trends and racial/ethnic differences in the incidence and treatment of ductal carcinoma in situ of the breast in California women (pages 1099–1106)

      Kaire Innos and Pamela L. Horn-Ross

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11104

      The incidence of ductal carcinoma in situ (DCIS) of the breast was reported to have increased in California women between 1988 and 1999. DCIS incidence as well as the change in incidence was found to differ considerably by race/ethnicity and age.

    26. Medical Oncology
      You have full text access to this OnlineOpen article
      Can older cancer patients tolerate chemotherapy? : A prospective pilot study (pages 1107–1114)

      Hongbin Chen, Alan Cantor, Julie Meyer, Mary Beth Corcoran, Edward Grendys, Denise Cavanaugh, Shirley Antonek, Angela Camarata, William Haley, Lodovico Balducci and Martine Extermann

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11110

      Older cancer patients undergoing chemotherapy may experience toxicity but generally are able to tolerate it with limited impact on independence, comorbidity, and quality of life. It is important to recognize and monitor these changes during geriatric oncology treatment.

    27. Pediatric Oncology
      You have full text access to this OnlineOpen article
      Utilization of special education services and educational attainment among long-term survivors of childhood cancer : A report from the childhood cancer survivor study (pages 1115–1126)

      Pauline A. Mitby, Leslie L. Robison, John A. Whitton, Michael A. Zevon, Iris C. Gibbs, Jean M. Tersak, Anna T. Meadows, Marilyn Stovall, Lonnie K. Zeltzer and Ann C. Mertens

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11117

      The Childhood Cancer Survivor Study was created to serve as a resource for the investigation of a broad spectrum of outcomes among long-term survivors of childhood cancer. In this report, the authors compare self-reported rates of special education and educational attainment among specific groups of childhood survivors of malignant disease. The results show that survivors of all major types of childhood cancer use special education more often than siblings, and when special education is utilized, survivors are generally as likely as siblings to graduate high school.

    28. Radiation Oncology
      You have full text access to this OnlineOpen article
      Validation of a treatment policy for patients with prostate specific antigen failure after three-dimensional conformal prostate radiation therapy (pages 1127–1133)

      Wayne H. Pinover, Eric M. Horwitz, Alexandra L. Hanlon, Robert G. Uzzo and Gerald E. Hanks

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11166

      Prostate specific antigen (PSA) doubling times ≥ 12 months or < 12 months indicate patients who may be observed and patients who should be treated with androgen-deprivation therapy for PSA failure after receiving three-dimensional, conformal radiation therapy.

    29. Sarcoma
      You have full text access to this OnlineOpen article
      Combination chemotherapy for desmoid tumors (pages 1134–1135)

      Scott H. Okuno and John H. Edmonson

      Article first published online: 3 FEB 2003 | DOI: 10.1002/cncr.11189

      Combination chemotherapy for progressive, unresectable desmoid tumors appears to provide palliative benefits. In the current study, the authors identified seven patients, five of whom had recurrent desmoid tumors. The combination chemotherapy was comprised of combinations of cyclophosphamide and doxorubicin; ifosfamide and etoposide; and mitomycin, doxorubicin, and cisplatin. The duration of chemotherapy was 3–12 months. An objective response was noted in three patients. A clinical benefit was noted in 6 patients, with the duration of benefit ranging from 3 months to 15 years.

  2. Errata

    1. Top of page
    2. Original Articles
    3. Errata
    1. You have free access to this content
    2. You have free access to this content

SEARCH

SEARCH BY CITATION