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Cancer

Cover image for Cancer

1 April 2003

Volume 97, Issue 7

Pages 1591–1820

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    4. Book Review
    1. Disease Site

      Breast Disease
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      Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status : Results from International Breast Cancer Study Group Trial V (pages 1591–1600)

      Vito J. Spataro, Heather Litman, Giuseppe Viale, Fausto Maffini, Michele Masullo, Rastko Golouh, Francisco J. Martinez-Tello, Piergioranni Grigolato, Keith B. Shilkin, Barry A. Gusterson, Monica Castiglione-Gertsch, Karen Price, Jurii Lindtner, Hernan Cortés-Funes, Edda Simoncini, Michael J. Byrne, John Collins, Richard D. Gelber, Alan S. Coates and Aron Goldhirsch

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11224

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      Reduced immunoreactivity of the p27 protein has been associated with a poor prognosis in patients with early-stage breast carcinoma. This study showed that there is no difference in prognosis and treatment response according to p27 expression; although, in patients with negative lymph node status, reduced p27 expression is associated with HER-2/neu overexpression and may predict a benefit from the early administration of adjuvant chemotherapy.

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      Epithelial lesions in prophylactic mastectomy specimens from women with BRCA mutations (pages 1601–1608)

      Noah D. Kauff, Edi Brogi, Lauren Scheuer, Dorothy R. Pathak, Patrick I. Borgen, Clifford A. Hudis, Kenneth Offit and Mark E. Robson

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11225

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      Previous studies have suggested that there is a low incidence of identifiable premalignant breast lesions in women with BRCA mutations. The authors demonstrate that ductal carcinoma in situ and other proliferative lesions associated with an increased risk of subsequent malignancy are more common in prophylactic mastectomy specimens from women with BRCA mutations than in breast tissue specimens obtained at autopsy from age and race-matched controls.

    3. Endocrine Disease
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      Carcinoid heart disease : The role of urinary 5-hydroxyindoleacetic acid excretion and plasma levels of atrial natriuretic peptide, transforming growth factor-β and fibroblast growth factor (pages 1609–1615)

      Johanna M. Zuetenhorst, Johannes M. G. M. Bonfrer, Catharina M. Korse, Rob Bakker, Harm van Tinteren and Babs G. Taal

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11226

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      High levels of 24-hour urinary 5-hydroxyindoleacetic acid excretion, as a measure of serotonin overproduction, was be associated with the presence of heart valve fibrosis in carcinoid disease. Transforming growth factor-β and fibroblast growth factor have been described to be related to the development of pulmonary and renal fibrosis. However, in this study of 37 patients, these factors were not found to be correlated to carcinoid heart disease, most likely because the plasma levels are not an adequate reflection of the local process.

    4. Gastrointestinal Tract
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      Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease (pages 1616–1623)

      Christophe Mariette, Jean-Michel Balon, Guillaune Piessen, Sylvain Fabre, Isabelle Van Seuningen and Jean-Pierre Triboulet

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11228

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      Despite increasingly radical surgery for esophageal carcinoma, a large number of patients still experience recurrent disease soon after operation. Histologic depth of tumor invasion should be used to identify patients who will have recurrence within 12 months of operation, so that these patients may be either entered into trials of multimodality treatment or offered nonsurgical palliation.

    5. Genitourinary Tract
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      Sperm banking and rate of assisted reproduction treatment : Insights from a 15-year cryopreservation program for male cancer patients (pages 1624–1629)

      Guido Ragni, Edgardo Somigliana, Liliana Restelli, Roberta Salvi, Mariangela Arnoldi and Alessio Paffoni

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11229

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      The rate of patients referred for assisted reproductive techniques using frozen spermatozoa is low but tends to rapidly increase, extending the length of follow-up. A diagnosis of testicular carcinoma is associated with a lower rate of frozen material use when compared with other cancers.

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      Molecular markers of outcome after radiotherapy in patients with prostate carcinoma : Ki-67, bcl-2, bax, and bcl-x (pages 1630–1638)

      Alan Pollack, Didier Cowen, Patricia Troncoso, Gunar K. Zagars, Andrew C. von Eschenbach, Marvin L. Meistrich and Timothy McDonnell

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11230

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      The predictive value of abnormal bcl-2 and bax expression, assessed by immunohistochemical staining, was evaluated in 106 patients who were treated with external beam radiotherapy for prostate carcinoma. Both markers were associated significantly with biochemical failure, independent of classic clinical parameters, as well as Ki-67 status.

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      Anatomic distribution of periprostatic adipose tissue : A mapping study of 100 radical prostatectomy specimens (pages 1639–1643)

      Heng Hong, Michael O. Koch, Richard S. Foster, Richard Bihrle, Thomas A. Gardner, Joanne Fyffe, Thomas M. Ulbright, John N. Eble and Liang Cheng

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11231

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      Less than half of the prostatic surfaces examined were covered by adipose tissue. The absence of adipose tissue over large areas of the prostatic surface, especially the posterior surface, makes the evaluation of extraprostatic extension difficult and unreliable. Further refinement of the prostate carcinoma staging system is needed.

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      Can patient selection for bladder preservation be based on response to chemotherapy? (pages 1644–1652)

      Cora N. Sternberg, Vito Pansadoro, Fabio Calabrò, Sylvia Schnetzer, Diana Giannarelli, Paolo Emiliozzi, Francesco De Paula, Paolo Scarpone, Piero De Carli, Maurizio Pizzo, Andrea Platania and Mostafà Amini

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11232

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      In carefully chosen patients with muscle-invasive bladder carcinoma who respond to neoadjuvant chemotherapy, bladder preservation may be achievable without compromising survival. Selected elderly patients also are candidates for neoadjuvant chemotherapy and bladder preservation. The results for these patients were comparable to what was achieved in radical cystectomy series.

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      Patient satisfaction with treatment decisions for clinically localized prostate carcinoma. Results from the Prostate Cancer Outcomes Study (pages 1653–1662)

      Richard M. Hoffman, William C. Hunt, Frank D. Gilliland, Robert A. Stephenson and Arnold L. Potosky

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11233

      In a population-based study of men diagnosed with clinically-localized prostate carcinoma between October 1994 and October 1995, the majority of men were satisfied with their treatment decisions. Receiving an active treatment, believing oneself to be free of cancer, avoiding treatment complications, and having good overall health and social support were positively associated with satisfaction.

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      Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma : A stratification tool for prospective clinical trials (pages 1663–1671)

      Bradley C. Leibovich, Michael L. Blute, John C. Cheville, Christine M. Lohse, Igor Frank, Eugene D. Kwon, Amy L. Weaver, Alexander S. Parker and Horst Zincke

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11234

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      Disease progression after patients undergo nephrectomy for clear cell renal cell carcinoma (RCC) is associated with tumor stage, regional lymph node status, tumor size, nuclear grade, and histologic tumor necrosis. The authors present a scoring algorithm based on these features that can be used to predict disease progression after radical nephrectomy in patients with clinically localized clear cell RCC.

    11. Gynecologic Oncology
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      Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method (pages 1672–1680)

      Hee Jung An, Nam Hoon Cho, Sun Young Lee, In Ho Kim, Chan Lee, Seung Jo Kim, Mi Sook Mun, Se Hyun Kim and Jeongmi Kim Jeong

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11235

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      The authors found that the human papillomavirus (HPV) DNA chip was a very sensitive method for detecting the 22 HPV genotypes: It had reasonable positive and negative predictive value, and it substantially overcame the low sensitivity problem of cytologic screening for the detection of high-grade squamous intraepithelial lesion (HSIL) and carcinoma. HPV-58, HPV-52, and HPV-56, as well as HPV-16 and HPV-18, were associated highly with HSIL and carcinoma in the current study.

    12. Head and Neck Disease
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      Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma (pages 1681–1692)

      Markus G. Müller, Tulio A. Valdez, Irene Georgakoudi, Vadim Backman, Cesar Fuentes, Sadru Kabani, Nora Laver, Zimmern Wang, Charles W. Boone, Ramachandra R. Dasari, Stanley M. Shapshay and Michael S. Feld

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11255

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      Spectroscopically extracted optical tissue parameters provide tissue biochemical and structural information regarding tissue in vivo without the need for tissue excision. This information has been shown to be useful in the diagnosis of tissue abnormalities such as dysplasia, with a high sensitivity and specificity.

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      Stricture of the proximal esophagus in head and neck carcinoma patients after radiotherapy (pages 1693–1700)

      Göran Laurell, Thomas Kraepelien, Panayiotis Mavroidis, Bengt K. Lind, Jan-Olof Fernberg, Mats Beckman and Magnus G. Lind

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11236

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      In head and neck carcinoma patients with postradiotherapeutic nonneoplastic stricture of the proximal esophagus, the first 2 cm of the esophagus received at least 60 grays in > 80% of the volume. Treatment results in patients with esophageal stricture were found to depend on the degree of stricture and the general condition of the patient.

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      Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck (pages 1701–1710)

      Patricia J. McLaughlin, Brendan C. Stack Jr., Roger J. Levin, Fred Fedok and Ian S. Zagon

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11237

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      Opioid growth factor (OGF) is an endogenous peptide that interacts with the OGF receptor (OGFr) to regulate growth through an inhibitory pathway. The authors show that OGFr binding activity and protein levels, but not gene expression, are subnormal for squamous cell carcinoma of the head and neck (SCCHN) compared with normal mucosa. The authors suggests that increased proliferation of SCCHN cells may result from the failure of this signaling cascade.

    15. Hematologic Malignancies
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      Fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte-macrophage–colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GM-CSF in patients with Richter syndrome or fludarabine-refractory chronic lymphocytic leukemia (pages 1711–1720)

      Apostolia M. Tsimberidou, Hagop M. Kantarjian, Jorge Cortes, Deborah A. Thomas, Stefan Faderl, Guillermo Garcia-Manero, Srdan Verstovsek, Alessandra Ferrajoli, William Wierda, Yesid Alvarado, Susan M. O'Brien, Maher Albitar, Michael J. Keating and Francis J. Giles

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11238

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      The authors conducted a Phase II study to evaluate an alternating combination cytotoxic regimen (fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone [hyper-CVXD]) with rituximab and granulocyte-macrophage–colony stimulating factor in patients with Richter syndrome (RS) or with chronic lymphocytic leukemia (CLL). The study regimen had activity and significant toxicity in patients with RS or fludarabine-refractory CLL, and it was not clearly better compared with hyper-CVXD alone in the target patient population.

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      Comparison of allogeneic stem cell transplantation, high-dose cytarabine, and autologous peripheral stem cell transplantation as postremission treatment in patients with de novo acute myelogenous leukemia (pages 1721–1731)

      Apostolia-Maria Tsimberidou, Niki Stavroyianni, Nora Viniou, Maria Papaioannou, Maria Tiniakou, Theodoros Marinakis, Anastasia Skandali, Ioanna Sakellari and Xenophon Yataganas

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11240

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      Allogeneic stem cell transplantation (SCT; n =15), high-dose cytarabine (HiDAC; n =15), and autologous SCT (n =19), as postremission therapy, were compared in patients with de novo acute myelogenous leukemia. In the allogeneic SCT group, both the 3-year survival and failure-free survival (FFS) rates were 73%. In the autologous SCT and HiDAC groups, the 3-year survival rates were 58% and 46%, respectively (P = 0.80), and the 3-year FFS rates were 42% and 33%, respectively (P = 0.83).

    17. Lung Disease
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      Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs (pages 1732–1736)

      Joshua E. Muscat, Shu-Quan Chen, John P. Richie Jr., Nasser K. Altorki, Marc Citron, Sara Olson, Alfred I. Neugut and Steven D. Stellman

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11242

      Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. There are little data concerning whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. This study suggests a possible chemoprotective benefit of using NSAIDs among individuals who are former or current smokers.

    18. Melanoma
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      Diagnostic value and prognostic significance of protein S-100β, melanoma-inhibitory activity, and tyrosinase/MART-1 reverse transcription-polymerase chain reaction in the follow-up of high-risk melanoma patients (pages 1737–1745)

      Claus Garbe, Ulrike Leiter, Ulf Ellwanger, Hans-Juergen Blaheta, Friedegund Meier, Gernot Rassner and Birgit Schittek

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11250

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      In Stage II and III melanoma patients, who have an increased risk of developing metastasis, protein S-100β and melanoma-inhibitory activity (MIA) are superior for detection of recurrent disease compared with reverse transcription-polymerase chain reaction (tyrosinase/MART-1) or the tumor markers lactate dehydrogenase and alkaline phosphatase. Effective tumor markers, such as protein S-100β or MIA, may therefore be useful in the follow-up of disease-free Stage II and III melanoma patients.

    19. Discipline

      Epidemiology
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      Physical activity levels before and after a diagnosis of breast carcinoma : The health, eating, activity, and lifestyle (HEAL) study (pages 1746–1757)

      Melinda L. Irwin, Diane Crumley, Anne McTiernan, Leslie Bernstein, Richard Baumgartner, Frank D. Gilliland, Andrea Kriska and Rachel Ballard-Barbash

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11227

      This prospective, population-based cohort study included 812 patients with incident breast carcinoma (from in situ to Stage IIIa). The authors observed significant decreases in physical activity levels after diagnosis compared with activity levels 1 year before diagnosis.

    20. Medical Oncology
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      Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma (pages 1758–1765)

      Fan Zhang, Ying Yang, Terry Smith, Shu-Wan Kau, Judy M. McConathy, Francisco J. Esteva, Henry M. Kuerer, W. Fraser Symmans, Aman U. Buzdar, Gabriel N. Hortobagyi and Lajos Pusztai

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11245

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      The goal of the current study was to assess whether HER-2 overexpression is associated with an improved response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide for breast carcinoma. Response was assessed by physical examination, imaging, and pathologic assessment at the time of surgery. Concordance between methods of response assessment was modest, and was best seen between clinical and imaging assessment. HER-2 status did not appear to be correlated with pathologic or clinical findings, although a nonsignificant trend was noted toward better response in those cases that overexpressed HER-2.

    21. Pathology
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      Clinical importance of molecular determinations in gynecologic patients with multiple tumors (pages 1766–1774)

      Winand N. M. Dinjens, Maria E. L. van der Burg, Savi Chadha, Hein F. B. M. Sleddens, Curt W. Burger and Patricia C. Ewing

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11249

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      In patients with multiple gynecologic tumors, treatment may depend on the correlation between the tumors: multiple primary tumors, recurrent tumors, or metastatic disease. In the current study, the authors demonstrate that it is possible to detect DNA aberrations in routinely processed tumor specimens and that the results can be of clinical importance in helping to determine the management or prognosis of patients with gynecologic malignancies.

    22. Pediatric Oncology
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      Outpatient, sequential, parenteral-oral antibiotic therapy for lower risk febrile neutropenia in children with malignant disease : A single-center, randomized, controlled trial in Argentina (pages 1775–1780)

      Hugo Paganini, Sandra Gómez, Silvina Ruvinsky, Pedro Zubizarreta, Antonio Latella, Lidia Fraquelli, Alejandro Santillán Iturres, Lidia Casimir and Roberto Debbag

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11251

      Recent reports and previous randomized trials conducted at the authors' institution suggested that patients with lower risk febrile neutropenia (LRFN) may benefit from an abridged oral antibiotic outpatient therapy regimen. In children with LRFN who were receiving therapy for malignant disease, outpatient oral ciprofloxacin 24 hours after a single, intravenous dose of ceftriaxone and amikacin (Group A) was as safe and efficacious as parenteral ceftriaxone (Group B). Outpatient management and early antibiotic withdrawal were safe for both groups.

    23. Radiation Oncology
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      Extended-field radiotherapy and high–dose-rate brachytherapy in carcinoma of the uterine cervix : Clinical experience with and without concomitant chemotherapy (pages 1781–1788)

      Brij M. Sood, Giridhar R. Gorla, Madhur Garg, Patrick S. Anderson, Abbie L. Fields, Carolyn D. Runowicz, Gary L. Goldberg and Bhadrasain Vikram

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11248

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      It has long been recognized that many patients with locally advanced carcinoma of the cervix harbor occult paraaortic metastases. A randomized study demonstrated that elective paraaortic irradiation improved survival and reduced distant metastases. More recently, concomitant chemotherapy with pelvic irradiation has improved survival among patients with locally advanced carcinoma of the cervix. This has led to a reexamination of the role of extended-field irradiation. The authors' experience suggests that prospective randomized trials of extended field radiotherapy with and without chemotherapy are indicated.

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      Adjuvant irradiation for cervical lymph node metastases from melanoma (pages 1789–1796)

      Matthew T. Ballo, Mark D. Bonnen, Adam S. Garden, Jeffrey N. Myers, Jeffrey E. Gershenwald, Gunar K. Zagars, Naomi R. Schechter, William H. Morrison, Merrick I. Ross and K. Kian Ang

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11243

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      Risk factors for regional disease recurrence after surgery alone for lymph node metastases from melanoma include extracapsular extension, lymph nodes measuring 3 cm in size or larger, involvement of multiple lymph nodes, and recurrent disease. Adjuvant irradiation abrogates the significance of these prognostic factors.

    25. Translational Research
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      Modulation of antitumor immune responses by hematopoietic cytokines (pages 1797–1809)

      Edmund K. Waller and Marc S. Ernstoff

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11247

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      Successful strategies of immunotherapy appear to act by regulating the numbers or activities of immune-stimulatory dendritic cells as well as other effector cells. Administration of cytokines that regulate dendritic cell differentiation or function has been shown to induce antitumor responses. This review of the literature reveals the promising findings from studies of granulocyte-macrophage–colony stimulating factor, interleukin 2, and other biologic modifiers as adjunct and stand-alone treatments both for patients with solid tumors and for patients with hematologic malignancies.

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      Luteinizing hormone receptor status and clinical, pathologic, and prognostic features in patients with breast carcinomas (pages 1810–1816)

      Geri Meduri, Nathalie Charnaux, Frederique Spyratos, Kamel Hacene, Hugue Loosfelt and Edwin Milgrom

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11294

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      It has been established that pregnancy has a protective effect against breast carcinoma, and that in animal models treatment with human chorionic gonadotropin (hCG) inhibits the growth of experimental breast carcinoma. The authors analyzed tumors from 160 patients with breast carcinoma to determine the status of the luteinizing hormone receptor. The findings indicated that LHR status was related in part to the degree of differentiation in breast tumors and to metastasis free survival, confirming experimental evidence of the effect of hCG on mammary tissue.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
    4. Book Review
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    2. You have free access to this content
      Author reply (pages 1817–1818)

      Gerardo Ferrara, Giuseppe Argenziano, Lorenzo Cerroni and H. Peter Soyer

      Version of Record online: 18 MAR 2003 | DOI: 10.1002/cncr.11244

  3. Book Review

    1. Top of page
    2. Original Articles
    3. Correspondence
    4. Book Review
    1. Discipline

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