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Cancer

Cover image for Cancer

15 April 2003

Volume 97, Issue 8

Pages 1821–2047

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Book Reviews
    5. Erratum
    1. General Topic

      Editorial
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      The sentinel lymph node: More than just another blue lymph node (pages 1821–1823)

      Jeffrey D. Wagner and Vernon K. Sondak

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11270

      In the majority of solid tumors, the demonstration of regional or distant metastases provides prognostic information that supercedes any primary tumor characteristic. The development of sentinel lymph node technology has been a significant advance in the management of patients with melanoma and breast carcinoma, and its application in other solid tumors continues to emerge. In the current study, Kahle et al. have provided a detailed description of their prospective study of the use of preoperative ultrasound for localization of the sentinel lymph node in patients undergoing lymph node staging for melanoma.

      See also pages 1947–54.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Book Reviews
    5. Erratum
    1. Disease Site

      Breast Disease
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      False-negative core needle biopsies of the breast : An analysis of clinical, radiologic, and pathologic findings in 27 consecutive cases of missed breast cancer (pages 1824–1831)

      Varsha I. Shah, Usha Raju, Dhananjay Chitale, Vikram Deshpande, Nancy Gregory and Vernon Strand

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11278

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      When a false-negative core needle biopsy of a suspicious breast lesion occurs, a definite diagnosis of cancer may be delayed if clinical and pathologic discordance is not recognized. This study addressed the false-negative rate of core needle biopsies by different techniques with emphasis on clinical, radiologic, and pathologic correlations that are currently mandated for image-guided core needle biopsies performed by radiologists but not routine for nonimage-guided core needle biopsies.

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      Angiosarcoma after breast-conserving therapy (pages 1832–1840)

      Alan T. Monroe, Steven J. Feigenberg and Nancy Price Mendenhall

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11277

      Angiosarcoma after breast-conserving therapy is increasingly diagnosed in a small but significant portion of breast carcinoma survivors. The aggressive natural course of this disease demands further investigation of adjuvant therapies.

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      Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors (pages 1841–1848)

      Idris Tolgay Ocal, Marisa Dolled-Filhart, Thomas G. D'Aquila, Robert L. Camp and David L. Rimm

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11335

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      Tissue microarray technology is a new technology that provides an excellent method for comparison of expression of multiple markers. In this study, the authors examined a series of receptor tyrosine kinases and found that Met and fibroblast growth factor receptor are related, but HER-2 and epidermal growth factor receptor are not related to either, although they are related to each other. Only Met predicted poor outcome in a cohort of patients with lymph node negative breast carcinoma.

    4. Gastrointestinal Tract
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      Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting (pages 1849–1858)

      Nathalie Nagy, Hugues Legendre, Olivier Engels, Sabine André, Herbert Kaltner, Kojiro Wasano, Yehiel Zick, Jean-Claude Pector, Christine Decaestecker, Hans-Joachim Gabius, Isabelle Salmon and Robert Kiss

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11268

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      Galectins-1, -3, and -4 seem to be involved in the early stages of human colon carcinoma development and to provide more useful prognostic information than Dukes A and B staging. In contrast, galectin-8 would be involved in the later stages of carcinoma development.

    5. Genitourinary Disease
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      Analysis of the Na,K-ATPase α- and β-subunit expression profiles of bladder cancer using tissue microarrays (pages 1859–1868)

      Cromwell Espineda, David B. Seligson, William James Ball Jr., JianYu Rao, Aarno Palotie, Steve Horvath, Yunda Huang, Tao Shi and Ayyappan K. Rajasekaran

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11267

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      In this study, Na,K-ATPase α- and β-subunit levels were shown to be altered during the progression of bladder cancer. Patients with high α- and low β-subunit expression were found to have a high risk for early recurrence, whereas patients with a low α- and high β-subunit expression were found to have longer recurrence-free time, indicating that Na,K-ATPase α- and β-subunit expression levels may be useful predictors of recurrence-free time distribution of bladder cancer patients.

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      Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors : Final analysis of an intergroup trial (pages 1869–1875)

      Stuart Hinton, Paul J. Catalano, Lawrence H. Einhorn, Craig R. Nichols, E. David Crawford, Nicholas Vogelzang, Donald Trump and Patrick J. Loehrer Sr.

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11271

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      In this study, the authors used the International Germ Cell Cancer Collaborative Group staging system to reclassify germ cell tumors after treatment with the standard therapy of bleomycin, etoposide, and cisplatin (BEP) versus etoposide, ifosfamide, and cisplatin (VIP). Progression-free survival and overall survival were comparable between BEP and VIP treatment.

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      Cytokeratin expression patterns in low-grade papillary urothelial neoplasms of the urinary bladder (pages 1876–1883)

      David Ramos, Samuel Navarro, Rafael Villamón, Manuel Gil-Salom and Antonio Llombart-Bosch

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11265

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      The differential expression patterns of cytokeratin 20 and 34βE12 antigen are associated strongly with recurrence prediction and relapse-free interval (P < 0.001) in patients with low-grade papillary urothelial tumors of the urinary bladder. For these patients, combined analysis of both cytokeratins provides some benefits in predicting tumor recurrences.

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      Prognostic significance of preoperative factors in localized prostate carcinoma treated with radical prostatectomy : Importance of percentage of biopsies that contain tumor and the presence of biopsy perineural invasion (pages 1884–1893)

      David I. Quinn, Susan M. Henshall, Phillip C. Brenner, Raji Kooner, David Golovsky, Gordon F. O'Neill, Jennifer J. Turner, Warick Delprado, John J. Grygiel, Robert L. Sutherland and Phillip D. Stricker

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11263

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      In patients with clinical localized prostate carcinoma undergoing radical prostatectomy, the proportion of diagnostic prostate biopsy cores containing tumor was found to be an independent predictor of outcome, and perineural invasion was found to have a predictive role in patients with a preoperative prostate specific antigen > 10 ng/mL.

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      Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma : A meta–analysis (pages 1894–1903)

      Maurice P.A. Zeegers, Annemarie Jellema and Harry Ostrer

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11262

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      Based on a meta–analysis of 33 epidemiologic studies concerning the association between family history and prostate carcinoma risk, the authors estimated that men who have first–degree family members with prostate carcinoma have an approximately 2-fold higher risk of prostate carcinoma than men who do not have family members with this disease.

    10. Gynecologic Oncology
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      Histopathologic score predicts recurrence free survival after radical surgery in patients with stage IA2–IB1–2 cervical carcinoma (pages 1904–1908)

      Dan A. Grisaru, Allan Covens, Edmee Franssen, William Chapman, Patricia Shaw, Terence Colgan, Joan Murphy, Denny DePetrillo, Gordon Lickrish, Stefane Laframboise and Barry Rosen

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11269

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      The authors evaluated clinical and pathologic factors that predicted recurrence after patients underwent radical surgery for International Federation of Gynecology and Obstetrics Stage IA2–IB1,2 cervical carcinoma. A simple method of scoring was developed based on maximal depth of invasion, the presence of capillary lymphatic space, and pelvic node metastasis that identified four strata of patients with distinct recurrence free survival.

    11. Head and Neck Disease
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      Screening nasopharyngeal carcinoma by detection of the latent membrane protein 1 (LMP-1) gene with nasopharyngeal swabs (pages 1909–1913)

      Sheng-Po Hao, Ngan-Ming Tsang and Kai-Ping Chang

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11312

      Detecting Epstein–Barr Virus (EBV) genomic latent membrane protein 1 (LMP-1) DNA by a nasopharyngeal swab technique predicted nasopharyngeal carcinoma with a sensitivity of 87.3% and a specificity of 98.4%; after additional testing for the Epstein–Barr nuclear antigen gene (EBNA), sensitivity reached 90.6%, and specificity was 98%. EBV genomic DNA usually is not detected by polymerase chain reaction–based methods in the nasopharyngeal space; its incidence is estimated to be as low as 0.2% among the general population.

    12. Hematologic Malignancies
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      Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell chronic lymphocytic leukemia (pages 1914–1919)

      Sherif Ibrahim, Iman Jilani, Susan O'Brien, Anna Rogers, Taghi Manshouri, Francis Giles, Stefan Faderl, Deborah Thomas, Hagop Kantarjian, Michael Keating and Maher Albitar

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11264

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      The authors previously showed that a transmembrane glycoprotein, CD38, was expressed on the surface of leukemic cells in many patients with B-cell chronic lymphocytic leukemia (B-CLL). In the current study, blood samples from patients with B-CLL were examined to identify surface marker expression of the ligand for CD38, CD31,and the expression of CD31 was correlated with several other known prognostic variables, including CD38. The expression of CD31 further defined a subgroup of patients with B-CLL who had a different survival outcome.

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      Phase II study of SU5416—a small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor—in patients with refractory myeloproliferative diseases (pages 1920–1928)

      Francis J. Giles, Maureen A. Cooper, Lewis Silverman, Judith E. Karp, Jeffrey E. Lancet, Maurizio Zangari, Paul J. Shami, Khuda D. Khan, Alison L. Hannah, Julie M. Cherrington, Deborah A. Thomas, Guillermo Garcia-Manero, Maher Albitar, Hagop M. Kantarjian and Alison T. Stopeck

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11315

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      A Phase II, multicenter study of SU5416, a small-molecule receptor tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2, was conducted in 32 patients with advanced myeloproliferative diseases. One patient (3%) with agnogenic myeloid metaplasia achieved an objective response.

    14. Hepatobiliary Disease
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      Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma (pages 1929–1940)

      Tsung-Hui Hu, Chao-Cheng Huang, Pey-Ru Lin, Hsueh-Wen Chang, Luo-Ping Ger, Yu-Wei Lin, Chi-Sin Changchien, Chuan-Mo Lee and Ming-Hong Tai

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11266

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      Immunohistochemical analysis revealed that expression levels of the tumor suppressor gene PTEN were reduced in approximately 40% of resected specimens from 105 patients with hepatocellular carcinoma (HCC). Furthermore, reduced PTEN expression was correlated with advanced tumor stages, high serum α-fetoprotein levels, p53 overexpression, tumor recurrence, and poor prognosis in patients with HCC.

    15. Melanoma
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      Surgical margins in cutaneous melanoma (2 cm versus 5 cm for lesions measuring less than 2.1-mm thick) : Long-term results of a large European multicentric phase III study (pages 1941–1946)

      David Khayat, Olivier Rixe, Ginette Martin, Claude Soubrane, Martine Banzet, Jacques-André Bazex, Philippe Lauret, Olivier Vérola, Gérard Auclerc, Peter Harper and Pierre Banzet

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11272

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      A surgical margin of 2 cm is sufficient for melanomas less than 2.1-mm thick. A larger margin of 5 cm has no apparent impact on either the rate or the time to disease recurrence or on survival.

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      Preoperative ultrasonographic identification of the sentinel lymph node in patients with malignant melanoma (pages 1947–1954)

      Birgit Kahle, Johannes Hoffend, Jörg Wacker and Wolfgang Hartschuh

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11261

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      The results of the current study indicate that the sentinel lymph node in malignant melanoma presents a particular ultrasonographic morphology. Ultrasound could be an important addition to lymphoscintigraphy in planning the surgical procedure.See also pages 1821–3.

    17. Neuro-Oncology
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      Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells (pages 1955–1962)

      Tamara Utermark, Alexi Alekov, Holger Lerche, Vincent Abramowski, Marco Giovannini and Clemens Oliver Hanemann

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11275

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      Human malignant mesothelioma (HMM) is an aggressive tumor that responds poorly to conventional tumor treatment. In most cases, outcome is fatal. In the current study, the authors demonstrate that quinidine selectively reduces the proliferation of NF2-/- HMM cells.

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      Phase I study of temozolomide and escalating doses of oral etoposide for adults with recurrent malignant glioma (pages 1963–1968)

      David N. Korones, Michal Benita-Weiss, Thomas E. Coyle, Laszlo Mechtler, Peter Bushunow, Brandon Evans, David A. Reardon, Jennifer A. Quinn and Henry Friedman

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11260

      A Phase I study of temozolomide and escalating doses of oral etoposide was conducted in patients with recurrent malignant gliomas. Although significant toxicity was observed in some patients, the regimen was well tolerated by many, and a maximum tolerated dose was established for further study in Phase II trials.

    19. Sarcoma
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      Phase II trial of gemcitabine in patients with advanced sarcomas (E1797) : A trial of the Eastern Cooperative Oncology Group (pages 1969–1973)

      Scott Okuno, Louise M. Ryan, John H. Edmonson, Dennis A. Priebat and Ronald H. Blum

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11290

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      The use of gemcitabine for the treatment of advanced sarcoma cases with varying histologies reportedly has had limited activity. However, there may be a role for gemcitabine for specific sarcoma histologies.

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      Role of surgery for nonmetastatic abdominal rhabdomyosarcomas : A report from the Italian and German Soft Tissue Cooperative Groups studies (pages 1974–1980)

      Giovanni Cecchetto, Gianni Bisogno, Jorn Treuner, Andrea Ferrari, Adrian Mattke, Michela Casanova, Patrizia Dall'Igna, Ilaria Zanetti, Sandra Volpato, Fortunato Siracusa, Gianni Scarzello, Camillo Boglino and Modesto Carli

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11285

      The clinical features and treatment results of 161 patients with abdominal rhabdomyosarcomas who were enrolled in the Italian and German studies of pediatric soft tissue sarcomas were analyzed, with an emphasis on the role of surgery. Age, tumor size, alveolar subtype, and complete tumor excision have been identified as factors influencing outcome; almost all relapsed patients died of disease.

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      Primary transcrotal excision for paratesticular rhabdomyosarcoma : Is hemiscrotectomy really mandatory? (pages 1981–1984)

      Patrizia Dall'Igna, Gianni Bisogno, Andrea Ferrari, Jörn Treuner, Modesto Carli, Ilaria Zanetti, Maurizio Guglielmi and Giovanni Cecchetto

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11284

      The role of hemiscrotectomy as the primary reexcision in nonmetastatic paratesticular rhabdomyosarcomas is evaluated. This study compared patients who underwent this procedure after a noncorrect scrotal approach, as requested by the protocol guidelines, with patients who did not undergo the procedure. Although hemiscrotectomy is still recommended after a noncorrect surgical approach, the results obtained in the patients not treated according to the protocol guidelines warrant further investigation.

    22. Discipline

      Medical Oncology
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      Dose escalation study of tezacitabine in combination with cisplatin in patients with advanced cancer (pages 1985–1990)

      Keith T. Flaherty, James P. Stevenson, Maryann Gallagher, Bruce Giantonio, Kenneth M. Algazy, Weijing Sun, Daniel G. Haller and Peter J. O'Dwyer

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11273

      Twenty-three patients with advanced cancer were accrued to 3 dose levels of tezacitabine (150–270 mg/m2) and cisplatin (50 mg/m2). Hematologic toxicity was dose limiting and two patients with upper gastrointestinal malignancies had partial responses.

    23. Pediatric Oncology
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      Late anthracycline cardiotoxicity after childhood cancer : A prospective longitudinal study (pages 1991–1998)

      Keld Sorensen, Gill A. Levitt, Catherine Bull, Inge Dorup and Ian D. Sullivan

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11274

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      Prospective longitudinal echocardiographic studies in childhood cancer survivors revealed that total anthracycline dose is the most powerful predictor of late cardiotoxicity. As a group, patients who received < 250 mg/m2 exhibited no deterioration of left ventricular function at 10 years follow-up.

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      Multidrug resistance proteins in rhabdomyosarcomas : Comparison between children and adults (pages 1999–2005)

      Rudy Komdeur, Jenneke Klunder, Winette T. A. van der Graaf, Eva van den Berg, Eveline S. J. M. de Bont, Harald J. Hoekstra and Willemina M. Molenaar

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11259

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      Expression of lung resistance-related protein (LRP) was more pronounced in adult rhabdomyosarcomas (RMS) than in pediatric RMS. The expression of LRP might contribute to the less favorable prognosis reported for adult RMS patients.

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      Fibrolamellar hepatocellular carcinoma in children and adolescents (pages 2006–2012)

      Howard M. Katzenstein, Mark D. Krailo, Marcio H. Malogolowkin, Jorge A. Ortega, Wenchun Qu, Edwin C. Douglass, James H. Feusner, Marleta Reynolds, John J. Quinn, Kurt Newman, Milton J. Finegold, Joel E. Haas, Martha G. Sensel, Robert P. Castleberry and Laura C. Bowman

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11292

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      Children with hepatocellular carcinoma were treated on a prospective, randomized trial and were analyzed to determine the implications and importance of histologic variant. There were no differences in stage of disease at presentation, surgical resectability, response to therapy, or outcome between patients with typical hepatocellular carcinoma and children with the fibrolamellar histologic variant.

    26. Radiation Oncology
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      Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis (pages 2013–2018)

      Samuel Ryu, Fang Fang Yin, Jack Rock, Jingeng Zhu, Archie Chu, Eduard Kagan, Lisa Rogers, Munther Ajlouni, Mark Rosenblum and Jae Ho Kim

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11296

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      The authors demonstrated the accuracy and precision of spinal radiosurgery in the treatment of patients with spinal metastasis. Rapid clinical improvement of pain and neurologic function were achieved. The current study demonstrated the potential role of spinal radiosurgery in the treatment of spinal metastasis, especially for patients with solitary sites of spine involvement.

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      Impact of radionecrosis on cognitive dysfunction in patients after radiotherapy for nasopharyngeal carcinoma (pages 2019–2026)

      Mei-Chun Cheung, Agnes S. Chan, Stephen C. Law, John H. Chan and Vincent K. Tse

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11295

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      The severity of cognitive impairment was correlated significantly with the location and volume of radionecrosis found in patients after they received radiotherapy for nasopharyngeal carcinoma. In addition, patient age at the time radiotherapy was completed predicted the volume of radionecrosis.

    28. Translational Research
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      Induction of intensive tumor suppression by antiangiogenic photodynamic therapy using polycation-modified liposomal photosensitizer (pages 2027–2034)

      Yoshito Takeuchi, Kohta Kurohane, Kanae Ichikawa, Sei Yonezawa, Mamoru Nango and Naoto Oku

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11283

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      Blood vessel-targeted photosensitizer-entrapped liposomes for photodynamic therapy (PDT) usage were prepared by modification of the liposomes with polycations. The polycation liposome (PCL) containing a low dose of the photosensitizer caused strong suppression of tumor growth by vessel occlusion following antiangiogenic scheduling of PDT treatment.

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      Expression and localization of GLUT1 and GLUT12 in prostate carcinoma (pages 2035–2042)

      Jenalle D. Chandler, Elizabeth D. Williams, John L. Slavin, James D. Best and Suzanne Rogers

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11293

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      Protein and mRNA of glucose transporters GLUT1 and GLUT12 are expressed by prostate carcinoma cells and may play a role in meeting the high-energy requirements of these malignant cells.

  3. Book Reviews

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Book Reviews
    5. Erratum
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      Prostate cancer: Biology, diagnosis, and management (page 2043)

      Anthony V. D'Amico

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11276

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      American Cancer Society Atlas of Clinical Oncology: Lung cancer (page 2044)

      Gregory A. Masters

      Version of Record online: 1 APR 2003 | DOI: 10.1002/cncr.11333

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  4. Erratum

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Book Reviews
    5. Erratum
    1. You have free access to this content

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