Disruption of the expected positive correlation between breast tumor size and lymph node status in BRCA1-related breast carcinoma (pages 1569–1577)
William D. Foulkes, Kelly Metcalfe, Wedad Hanna, Henry T. Lynch, Parviz Ghadirian, Nadine Tung, Olofunmilayo Olopade, Barbara Weber, Jane McLennan, Ivo A. Olivotto, Ping Sun, Pierre O. Chappuis, Louis R. Bégin, Jean-Sébastien Brunet and Steven A. Narod
Version of Record online: 8 SEP 2003 | DOI: 10.1002/cncr.11688
Breast tumor size and the number of positive lymph nodes found at axillary dissection are related directly. This relation is much less strong in BRCA1-related breast carcinoma compared with other types of breast carcinoma, suggesting that the pattern of metastatic spread of BRCA1-related breast carcinoma may differ from both BRCA2-related and nonhereditary breast carcinoma.