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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 February 2009

Volume 117, Issue 1

Pages 1–72

  1. Commentaries

    1. Top of page
    2. Commentaries
    3. Editorial
    4. Original Articles
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      A note of thanks (page 1)

      Esmeralda Galán Buchanan

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20013

    2. You have free access to this content
      Welcome to the new editor (pages 2–3)

      William J. Frable

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20018

      This article welcomes the new editor of Cancer Cytopathology, Dr. Celeste N. Powers.

  2. Editorial

    1. Top of page
    2. Commentaries
    3. Editorial
    4. Original Articles
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      Continuing excellence and embracing the future (pages 4–6)

      Celeste N. Powers

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20017

      In this editorial, Cancer Cytopathology's new Principal Editor, Dr. Celeste Powers, discusses future directions for the journal and introduces readers to its new Associate Editors.

  3. Original Articles

    1. Top of page
    2. Commentaries
    3. Editorial
    4. Original Articles
    1. Gynecologic Cytopathology

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      Reflex UroVysion testing in suspicious urine cytology cases (pages 7–14)

      Susana Ferra, Ryan Denley, Harry Herr, Guido Dalbagni, Suresh Jhanwar and Oscar Lin

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20016

      UroVysion is a US Food and Drug Administration–approved test that is used for the detection of recurrent urothelial carcinoma and patients with hematuria. The objective of the current study was to evaluate the usefulness of UroVysion as a reflex test in patients with a suspicious urine cytology diagnosis.

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      Unsatisfactory SurePath liquid-based Papanicolaou tests : Causes and Significance (pages 15–26)

      Mariam Alsharif, Dan M. McKeon, H. Evin Gulbahce, Kay Savik and Stefan E. Pambuccian

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20009

      Unsatisfactory Papanicolaou (Pap) tests were rare in a predominantly SurePath liquid-based Pap test practice. They were caused most often by scant cellularity and exhibited significantly more follow-up cytologic and biopsy abnormalities than negative Pap tests.

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      The use of reflex high-risk human papillomavirus testing for atypical squamous cells of undetermined significance interpretations on vaginal specimens (pages 27–31)

      Brian S. Kendall and Christopher M. Zahn

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20012

      Follow-up results of patients with reflex high-risk human papillomavirus testing (hrHPV) testing performed on liquid-based vaginal specimens were examined. There was a significantly higher rate of squamous abnormalities present on the follow-up of those in whom hrHPV was detected compared with those in whom hrHPV was not detected.

    4. Fine-Needle Aspiration

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      Fine-needle aspiration for nucleic acid-ased molecular analyses in breast cancer (pages 32–39)

      Catherine Uzan, Fabrice Andre, Veronique Scott, Isabelle Laurent, Elie Azria, Voichita Suciu, Corinne Balleyguier, Ludovic Lacroix, Suzette Delaloge and Philippe Vielh

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20008

      The objective of the current study was to evaluate the quality and potential use of material obtained from fine-needle aspiration cytology (FNAC). In breast lesions, FNAC allowed the extraction of a high percentage of tumor cells and a quite reasonable quantity of messenger RNA of good quality suitable for gene expression analysis in most patients.

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      Proliferative rate in endoscopic ultrasound fine-needle aspiration of pancreatic endocrine tumors : Correlation With Clinical Behavior (pages 40–45)

      Borislav A. Alexiev, Peter E. Darwin, Olga Goloubeva and Olga B. Ioffe

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20014

      The authors evaluated the role of endoscopic ultrasonography-guided fine-needle aspiration in the preoperative diagnosis of pancreatic endocrine tumors (PETs) and investigated whether the Ki-67 index determined on cytologic material could help predict tumor behavior. Although metastatic PETs tended to have a higher Ki-67 index, tumors that had a very low proliferation rate still were capable of behaving aggressively; therefore, the Ki-67 index did not predict the risk of disease progression.

    6. Immunocytochemistry

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      P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples : Implications in Treatment Selection (pages 46–50)

      Merce Jorda, Carmen Gomez-Fernandez, Monica Garcia, Fatemeh Mousavi, Gail Walker, Aldo Mejias, Gustavo Fernandez-Castro and Parvin Ganjei-Azar

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20015

      Immunocytochemical analysis for p63 may be used in pulmonary cytologic samples with the diagnosis of nonsmall cell carcinoma to detect squamous differentiation and improve the therapeutic selection of patients.

    7. Analytical Cytopathology

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      Analysis of ThinPrep cytology in establishing the diagnosis of small cell carcinoma of lung (pages 51–56)

      Stacey Kim and Christopher L. Owens

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20007

      The results of this study indicate that lung specimens processed entirely with ThinPrep are comparable to conventional smears in accurately establishing a diagnosis of small cell carcinoma of lung. Thus, ThinPrep can be used as an adjunct or a safe alternative to conventional preparations in this setting.

    8. Molecular Diagnostics

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      Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy (pages 57–66)

      Xiaoqi Lin, Sydney D. Finkelstein, Bing Zhu, Beth J. Ujevich and Jan. F. Silverman

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20010

      Detection of loss of heterozygosities targeting tumor suppressor genes can be useful in evaluating gastroesophageal lesions; studying oncogenesis of gastroesophageal adenocarcinoma; and, in combination with esophageal brushing cytology and gastroesophageal biopsy, determining surveillance for Barrett esophagus and low-grade dysplasia and/or treatment for high-grade dysplasia and adenocarcinoma.

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      EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer (pages 67–72)

      Jason H. Smouse, Edmund S. Cibas, Pasi A. Jänne, Victoria A. Joshi, Kelly H. Zou and Neal I. Lindeman

      Article first published online: 29 JAN 2009 | DOI: 10.1002/cncy.20011

      The claim that cytology specimens of lung adenocarcinoma are inadequate for genetic testing for EGFR mutations, which guide the use of tyrosine kinase inhibitor therapy, was investigated in a retrospective review. Cytologic specimens with at least 25% tumor cells were suitable for EGFR sequencing and showed comparable sensitivity for mutation detection as compared with surgical biopsy or resection specimens.

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