Toward a multimodal cell analysis of brush biopsies for the early detection of oral cancer (pages 228–235)
Torsten W. Remmerbach, Dietrich Meyer-Ebrecht, Til Aach, Thomas Würflinger, Andre A. Bell, Timna E. Schneider, Nadja Nietzke, Bernhard Frerich and Alfred Böcking
Article first published online: 16 APR 2009 | DOI: 10.1002/cncy.20028
The authors investigated the clinical application of semiautomated multimodal cell analysis (MMCA), a novel technique for the early detection of oral cancer in patients who have a limited number of suspicious cells. The results indicated that semiautomated MMCA may become a sensitive and highly specific, objective, and reproducible adjuvant diagnostic tool for the identification of early neoplastic transformation in oral brush biopsies that contain only a few abnormal cells.