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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 August 2009

Volume 117, Issue 4

Pages 237–288

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Fine-Needle Aspiration

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      Interinstitutional consultation in fine-needle aspiration cytopathology : A study of 742 cases (pages 237–246)

      Philip E. Bomeisl Jr., Shadia Alam and Paul E. Wakely Jr

      Version of Record online: 23 JUN 2009 | DOI: 10.1002/cncy.20037

      Interinstitutional consultation (IC) of fine-needle aspiration cytology (FNAC) cases resulted in major discrepancies in 9.3% and a change in clinical management of 4.3% of cases. FNAC presents unique diagnostic challenges, and IC by a board-certified cytopathologist may lead to further error reduction.

    2. Non-Gynecologic Cytopathology

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      Cytogenetics and fluorescence in situ hybridization as adjuncts to cytology in the diagnosis of malignant mesothelioma (pages 247–253)

      Rachel E. Factor, Paola Dal Cin, Jonathan A. Fletcher and Edmund S. Cibas

      Version of Record online: 17 JUN 2009 | DOI: 10.1002/cncy.20036

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      Compared with karyotyping alone, fluorescence in situ hybridization (FISH) combined with karyotyping nearly doubled the diagnostic sensitivity of detecting malignant mesothelioma in effusions. The combination of FISH and karyotyping was a useful adjunct to cytology in the diagnosis of mesothelioma.

    3. Gynecologic Cytopathology

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      Liquid-based preparation for endometrial cytology—Usefulness for predicting the prognosis of endometrial carcinoma preoperatively (pages 254–263)

      Jun Watanabe, Yukari Nishimura, Shinpei Tsunoda, Miwa Kawaguchi, Isao Okayasu and Hiroyuki Kuramoto

      Version of Record online: 26 JUN 2009 | DOI: 10.1002/cncy.20035

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      The authors evaluated the applicability and usefulness of immunocytochemical staining for cyclin A, p53, estrogen receptor α, and progesterone receptor B as preoperative prognostic indicators for endometrial carcinoma using endometrial cytology with the liquid-based cytology method. The results indicated that liquid-based endometrial cytology is useful for predicting malignant potential and prognosis.

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      Implementation of the Thinprep imaging system in a tertiary military medical center (pages 264–270)

      Jeanne M. Duby and Megan J. DiFurio

      Version of Record online: 17 JUN 2009 | DOI: 10.1002/cncy.20033

      Implementation of the Thin Prep Imaging System at Brooke Army Medical Center significantly increased the detection of atypical squamous cells (ASC), cannot rule out high-grade squamous intraepithelial lesion (HSIL); low-grade SIL; and HSIL and had no significant impact on the ASC of undetermined significance (ASC-US) rate with decreases in the high-risk human papillomavirus-positive proportion and in the ASC:SIL ratio. The data suggested that, at least initially, the use of imager-directed screening may increase the number of clinically insignificant ASC-US Papanicolaou tests.

    5. Immunocytochemistry

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      Glypican-3 protein expression in primary and metastatic melanoma : A combined immunohistochemistry and immunocytochemistry study (pages 271–278)

      Dina Kandil, Gladwyn Leiman, Mark Allegretta and Mark Evans

      Version of Record online: 10 JUN 2009 | DOI: 10.1002/cncy.20032

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      In this study, the 1G12 monoclonal antibody to glypican-3 was shown, in a controlled retrospective study of fine-needle aspiration material and tissue sections, to be nonimmunoreactive in both primary and metastatic melanomas.

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      Immunohistochemical detection of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression in breast carcinomas : Comparison on cell block, needle-core, and tissue block preparations (pages 279–288)

      Krisztina Z. Hanley, George G. Birdsong, Cynthia Cohen and Momin T. Siddiqui

      Version of Record online: 23 JUN 2009 | DOI: 10.1002/cncy.20034

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      The evaluation of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (Her2) expression by immunohistochemistry using nonformalin-based fixatives should be validated according to the American Society of Clinical Oncology/College of American Pathologist guidelines. The current results indicated that ethanol-fixed cell block samples were not reliable for the assessment of Her2 status in breast carcinoma, but they were useful in triaging patients for tamoxifen therapy.

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