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Cancer Cytopathology

Cover image for Vol. 118 Issue 6

25 December 2010

Volume 118, Issue 6

Pages 413–490

  1. CytoSource

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Original Articles
    5. Thanks to Authors and Peer Reviewers
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  2. Commentaries

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Original Articles
    5. Thanks to Authors and Peer Reviewers
    1. You have free access to this content
      Diagnostic criteria and risk-adapted approach to indeterminate thyroid cytodiagnosis (pages 415–422)

      John S. Abele and Robert A. Levine

      Article first published online: 8 NOV 2010 | DOI: 10.1002/cncy.20122

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      Significant numbers of overdiagnoses of thyroid needle biopsies as “indeterminate” create a risk of surgery for benign disease. Overdiagnoses can be reduced by appropriate criteria and a risk-adapted approach to cytodiagnosis.

  3. Original Articles

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Original Articles
    5. Thanks to Authors and Peer Reviewers
    1. You have free access to this content
      Experience with standardized thyroid fine-needle aspiration reporting categories : Follow-up data from 529 cases with “indeterminate” or “atypical” reports (pages 423–433)

      Min-En Nga, Marian P. Kumarasinghe, Bibiana Tie, Gregory F. Sterrett, Benjamin Wood, John Walsh, Hue Nguyen, Andrew Whyte and Felicity A. Frost

      Article first published online: 13 OCT 2010 | DOI: 10.1002/cncy.20111

      The authors conducted this audit as a timely analysis of the efficacy and usefulness of specific diagnostic categories in thyroid fine-needle aspiration nodules, including a comparison with other proposed classification systems. The results validated the subdivision of inconclusive cases into 2 clinically distinct categories based on actual follow-up data.

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      High-grade atypical epithelial cells in pancreatic mucinous cysts are a more accurate predictor of malignancy than “positive” cytology (pages 434–440)

      Martha Bishop Pitman, Muriel Genevay, Kurt Yaeger, Ivan Chebib, Brian G. Turner, Mari Mino-Kenudson and William R. Brugge

      Article first published online: 7 OCT 2010 | DOI: 10.1002/cncy.20118

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      High-grade atypical epithelial cells (AEC) are a more accurate (80%) predictor of malignancy in cyst fluid aspirated from pancreatic mucinous cysts than “positive” cytology (75%), including in small branch duct intraductal papillary mucinous neoplasms (84%). AEC warrant a “suspicious” interpretation for appropriate surgical triage.

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      The utility of napsin-A in the identification of primary and metastatic lung adenocarcinoma among cytologically poorly differentiated carcinomas (pages 441–449)

      Lisa M. Stoll, Michael W. Johnson, Edward Gabrielson, Fredrick Askin, Douglas P. Clark and Qing Kay Li

      Article first published online: 9 SEP 2010 | DOI: 10.1002/cncy.20108

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      The results from this study indicated that, although thyroid transcription factor-1 has higher sensitivity, napsin-A is a useful surrogate marker when encountering a poorly differentiated lung adenocarcinoma or unknown primary tumor, particularly in cytology specimens and difficult cases.

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      Detection of EGFR and KRAS mutations in fine-needle aspirates stored on Whatman FTA cards : Is this the tool for biobanking cytological samples in the molecular era? (pages 450–456)

      Gilda da Cunha Santos, Ni Liu, Ming-Sound Tsao, Suzanne Kamel-Reid, Kayu Chin and William R. Geddie

      Article first published online: 31 AUG 2010 | DOI: 10.1002/cncy.20102

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      Mutational analyses for EGFR and KRAS were successfully performed using DNA extracted from cytological samples collected on FTA cards. The FTA card is a simple alternative that can be used routinely for specimen procurement, allowing multiple subsequent molecular analyses requiring high-quality DNA.

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      Cytologic diagnosis and differential diagnosis of lung carcinoid tumors a retrospective study of 63 cases with histologic correlation (pages 457–467)

      Lisa Marie Stoll, Michael W. Johnson, Frances Burroughs and Qing Kay Li

      Article first published online: 31 AUG 2010 | DOI: 10.1002/cncy.20105

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      The authors correlated the cytomorphology of 63 cases of lung carcinoids with the corresponding surgical specimens, and discussed the potential diagnostic pitfalls, particularly in those cases that were misclassified on cytology.

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      Fine-needle aspiration cytopathology—An accurate diagnostic modality in mammary carcinoma with osteoclast-like giant cells : A study of 8 consecutive cases (pages 468–473)

      Solène-Florence Jacquet, Corinne Balleyguier, Jean-Rémi Garbay, Céline Bourgier, Marie-Christine Mathieu, Suzette Delaloge and Philippe Vielh

      Article first published online: 13 OCT 2010 | DOI: 10.1002/cncy.20112

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      The results from this investigation indicated that fine-needle aspiration cytopathology is a very efficient way to diagnose breast carcinoma with osteoclast-like giant cells (OGCs), because it detects forms with only a few OGCs that usually are not observed at histologic diagnosis. Consequently, the frequency of mammary carcinoma with OGCs may be greater than previously reported.

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      Should adequacy criteria in cervicovaginal cytology be modified after radiotherapy, chemotherapy, or hysterectomy? (pages 474–481)

      Chien-Hsing Lu, Chia-Che Chang, Esther Shih-Chu Ho, Su-Ju Chen, Shu-Jiuan Lin, Tsai-Feng Fu and Ming-Chen Chang

      Article first published online: 22 SEP 2010 | DOI: 10.1002/cncy.20110

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      In patients who received pelvic radiotherapy and/or chemotherapy, the incidence of low-cellularity smears was unacceptably high. A lower cellularity (estimated 2000 cells/slide) could be safely used as a satisfactory threshold. In patients who were treated with hysterectomy alone, the general criteria of specimen adequacy should not be modified.

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      Human papillomavirus genotype detection from archival papanicolaou-stained cervical tests (pages 482–489)

      Sepehr N. Tabrizi, Nicole Taylor, Michael J. McCullough, Gillian Phillips, John Wark, Dorota Gertig, Rodney W. Petersen, Marion Saville and Suzanne M. Garland

      Article first published online: 12 OCT 2010 | DOI: 10.1002/cncy.20117

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      Accurate human papillomavirus detection and genotyping that is comparable to endocervical brush-collected liquid-based samples can be obtained from archival cervical smears.

  4. Thanks to Authors and Peer Reviewers

    1. Top of page
    2. CytoSource
    3. Commentaries
    4. Original Articles
    5. Thanks to Authors and Peer Reviewers
    1. You have free access to this content

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